Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tumor protein p53 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0302 | 0.1122 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0064 | 0.0237 |
Echinococcus granulosus | tumor protein p63 | 0.0408 | 0.4652 | 0.4666 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0064 | 0.0064 |
Plasmodium vivax | SET domain protein, putative | 0.0036 | 0 | 0.5 |
Onchocerca volvulus | 0.006 | 0.0296 | 0.0947 | |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.2692 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0211 | 0.0212 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0302 | 0.1122 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 0.997 | 1 |
Echinococcus granulosus | geminin | 0.0173 | 0.1719 | 0.1724 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0064 | 0.0237 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.2692 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0408 | 0.4652 | 0.4666 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 0.997 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.1719 | 0.1724 |
Mycobacterium tuberculosis | Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. | 0.0836 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.1719 | 0.1724 |
Echinococcus multilocularis | geminin | 0.0173 | 0.1719 | 0.1724 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0296 | 0.11 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.006 | 0.0296 | 0.0297 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 0.3126 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0302 | 0.1122 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0833 | 0.997 | 1 |
Onchocerca volvulus | 0.0286 | 0.3126 | 1 | |
Mycobacterium ulcerans | proteasome PrcA | 0.0836 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0302 | 0.1122 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.