TDR Targets

Basic information

Technical information

TDR Targets ID: 873542
Name: N-(3-chlorophenyl)-4-[(4-methylpiperidin-1-yl )methyl]piperidine-1-carboxamide
MW: 349.898 | Formula: C19H28ClN3O
H donors: 1 H acceptors: 1 LogP: 3.8 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CC1CCN(CC1)CC1CCN(CC1)C(=O)Nc1cccc(c1)Cl
InChi: 1S/C19H28ClN3O/c1-15-5-9-22(10-6-15)14-16-7-11-23(12-8-16)19(24)21-18-4-2-3-17(20)13-18/h2-4,13,15-16H,5-12,14H2,1H3,(H,21,24)
InChiKey: HLCXIHMJQJAIET-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(3-chlorophenyl)-4-[(4-methyl-1-piperidyl)methyl]piperidine-1-carboxamide
N-(3-chlorophenyl)-4-[(4-methyl-1-piperidinyl)methyl]-1-piperidinecarboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	heat shock protein	0.0033	0.0685	0.0685
Loa Loa (eye worm)	carboxylesterase	0.0133	0.4839	1
Echinococcus granulosus	chromobox protein 1	0.0071	0.2265	0.2265
Schistosoma mansoni	heat shock protein	0.0033	0.0685	0.1053
Schistosoma mansoni	hypothetical protein	0.0173	0.6506	1
Leishmania major	heat shock protein 83-1	0.0033	0.0685	0.729
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.079	0.3021
Echinococcus granulosus	Ankyrin	0.0017	0.0006	0.0006
Leishmania major	heat shock protein 83-1	0.0033	0.0685	0.729
Plasmodium falciparum	basic transcription factor 3b, putative	0.0036	0.079	1
Brugia malayi	hypothetical protein	0.0022	0.0239	0.0494
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0026	0.0404	1
Echinococcus granulosus	acetylcholinesterase	0.0133	0.4839	0.4839
Brugia malayi	Carboxylesterase family protein	0.0133	0.4839	1
Leishmania major	heat shock protein 83-1	0.0033	0.0685	0.729
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0605	0.124
Schistosoma mansoni	chromobox protein	0.0071	0.2265	0.3482
Loa Loa (eye worm)	heterochromatin protein 1	0.0071	0.2265	0.4675
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.079	0.3021
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0022	0.0239	0.0368
Loa Loa (eye worm)	ICD-1 protein	0.0036	0.079	0.1622
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0026	0.0404	0.5
Leishmania major	heat shock protein 83-1	0.0033	0.0685	0.729
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0022	0.0239	0.0368
Brugia malayi	Heterochromatin protein 1	0.0071	0.2265	0.4681
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0239	0.0483
Brugia malayi	Carboxylesterase family protein	0.0133	0.4839	1
Leishmania major	heat shock protein 83-1	0.0033	0.0685	0.729
Loa Loa (eye worm)	endoplasmin	0.0033	0.0685	0.1406
Toxoplasma gondii	NAC domain-containing protein	0.0036	0.079	1
Loa Loa (eye worm)	hypothetical protein	0.0133	0.4839	1
Brugia malayi	heat shock protein 90	0.0033	0.0685	0.1416
Trypanosoma brucei	transcription factor BTF3, putative	0.0036	0.079	1
Leishmania major	heat shock protein 83-1	0.0033	0.0685	0.729
Trypanosoma cruzi	heat shock protein 85, putative	0.0033	0.0685	0.8441
Leishmania major	heat shock protein 83-1	0.0033	0.0685	0.729
Trypanosoma cruzi	heat shock protein 85, putative	0.0026	0.0404	0.4245
Plasmodium falciparum	heat shock protein 90	0.0033	0.0685	0.8363
Entamoeba histolytica	hypothetical protein	0.0036	0.079	1
Mycobacterium ulcerans	heat shock protein 90	0.0026	0.0404	1
Leishmania major	heat shock protein 83-1	0.0033	0.0685	0.729
Leishmania major	basic transcription factor 3a, putative	0.0036	0.079	1
Schistosoma mansoni	hypothetical protein	0.0173	0.6506	1
Echinococcus granulosus	carboxylesterase 5A	0.0133	0.4839	0.4839
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.109	0.444
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0022	0.0239	0.0368
Loa Loa (eye worm)	acetylcholinesterase 1	0.0133	0.4839	1
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0479	0.1551
Trypanosoma cruzi	transcription factor btf3, putative	0.0036	0.079	1
Echinococcus multilocularis	Ankyrin	0.0017	0.0006	0.0006
Treponema pallidum	heat shock protein 90	0.0026	0.0404	0.5
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0022	0.0239	0.0239
Echinococcus granulosus	heat shock protein 90	0.0026	0.0404	0.0404
Trypanosoma cruzi	heat shock protein 85, putative	0.0033	0.0685	0.8441
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0239	0.0483
Echinococcus granulosus	BC026374 protein S09 family	0.0022	0.0239	0.0239
Leishmania major	heat shock protein 83-1	0.0033	0.0685	0.729
Schistosoma mansoni	endoplasmin	0.0033	0.0685	0.1053
Leishmania major	heat shock protein 83-1	0.0033	0.0685	0.729
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0017	0.0006	0.0009
Echinococcus granulosus	transcription factor btf3	0.0036	0.079	0.079
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0239	0.0483
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0964	0.3844
Echinococcus multilocularis	heat shock protein 90	0.0026	0.0404	0.0404
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0026	0.0404	0.5
Leishmania major	heat shock protein 83-1	0.0033	0.0685	0.729
Echinococcus multilocularis	heat shock protein 90	0.0033	0.0685	0.0685
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.079	0.3021
Echinococcus multilocularis	chromobox protein 1	0.0071	0.2265	0.2265
Schistosoma mansoni	chromobox protein	0.0071	0.2265	0.3482
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0133	0.4839	0.7438
Echinococcus multilocularis	chromobox protein 1	0.0071	0.2265	0.2265
Brugia malayi	Endoplasmin precursor	0.0033	0.0685	0.1416
Echinococcus granulosus	endoplasmin	0.0026	0.0404	0.0404
Echinococcus granulosus	acetylcholinesterase	0.0133	0.4839	0.4839
Trichomonas vaginalis	heat shock protein, putative	0.0033	0.0685	0.2526
Brugia malayi	beta-NAC-like protein	0.0036	0.079	0.1632
Loa Loa (eye worm)	carboxylesterase	0.0022	0.0239	0.0483
Trypanosoma cruzi	Heat shock protein 83, putative	0.0033	0.0685	0.8441
Loa Loa (eye worm)	hypothetical protein	0.0133	0.4839	1
Schistosoma mansoni	endoplasmin	0.0033	0.0685	0.1053
Schistosoma mansoni	gliotactin	0.0022	0.0239	0.0368
Onchocerca volvulus		0.0031	0.0605	0.4303
Echinococcus multilocularis	endoplasmin	0.0026	0.0404	0.0404
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0964	0.3844
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0026	0.0404	0.0404
Brugia malayi	chromobox protein homolog 3	0.004	0.0964	0.1992
Echinococcus granulosus	para nitrobenzyl esterase	0.0022	0.0239	0.0239
Schistosoma mansoni	transcription factor btf3	0.0036	0.079	0.1214
Echinococcus multilocularis	acetylcholinesterase	0.0133	0.4839	0.4839
Echinococcus multilocularis	carboxylesterase 5A	0.0133	0.4839	0.4839
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.004	0.0964	0.8518
Echinococcus multilocularis	geminin	0.0173	0.6506	0.6506
Leishmania major	heat shock protein 83-1	0.0033	0.0685	0.729
Leishmania major	heat shock protein 83-1	0.0033	0.0685	0.729
Leishmania major	heat shock protein 83-1	0.0033	0.0685	0.729
Loa Loa (eye worm)	heat shock protein 90	0.0033	0.0685	0.1406
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0239	0.0483
Echinococcus granulosus	heat shock protein 90	0.0033	0.0685	0.0685
Brugia malayi	Carboxylesterase family protein	0.0022	0.0239	0.0494
Brugia malayi	Carboxylesterase family protein	0.0022	0.0239	0.0494
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0022	0.0239	0.0416
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0043	0.109	1
Echinococcus multilocularis	transcription factor btf3	0.0036	0.079	0.079
Echinococcus multilocularis	acetylcholinesterase	0.0133	0.4839	0.4839
Echinococcus multilocularis	heat shock protein	0.0033	0.0685	0.0685
Trichomonas vaginalis	heat shock protein, putative	0.0026	0.0404	0.1196
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0479	0.1551
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0239	0.0483
Echinococcus granulosus	geminin	0.0173	0.6506	0.6506
Leishmania major	heat shock protein 83-1	0.0033	0.0685	0.729
Leishmania major	heat shock protein 83-1	0.0033	0.0685	0.729
Schistosoma mansoni	heat shock protein	0.0033	0.0685	0.1053
Leishmania major	heat shock protein 83-1	0.0033	0.0685	0.729
Echinococcus granulosus	chromobox protein 1	0.0071	0.2265	0.2265
Trypanosoma cruzi	heat shock protein 90, putative	0.0026	0.0404	0.4245
Schistosoma mansoni	acetylcholinesterase	0.0022	0.0239	0.0368
Loa Loa (eye worm)	hypothetical protein	0.004	0.0964	0.1982
Schistosoma mansoni	BC026374 protein (S09 family)	0.0022	0.0239	0.0368
Echinococcus granulosus	neuroligin	0.0022	0.0239	0.0239
Loa Loa (eye worm)	carboxylesterase	0.0022	0.0239	0.0483
Brugia malayi	Carboxylesterase family protein	0.0022	0.0239	0.0494
Trichomonas vaginalis	spcc417.12 protein, putative	0.0022	0.0239	0.0416
Trypanosoma cruzi	heat shock protein 90, putative	0.0033	0.0685	0.8441
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0033	0.0685	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0033	0.0685	0.8441
Plasmodium vivax	basic transcription factor 3b, putative	0.0036	0.079	1
Brugia malayi	Carboxylesterase family protein	0.0022	0.0239	0.0494
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.109	0.444
Trichomonas vaginalis	heat shock protein, putative	0.0026	0.0404	0.1196
Echinococcus multilocularis	neuroligin	0.0022	0.0239	0.0239
Trichomonas vaginalis	chromobox protein, putative	0.0071	0.2265	1
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0022	0.0239	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0239	0.0483
Trypanosoma cruzi	transcription factor btf3, putative	0.0036	0.079	1
Trichomonas vaginalis	heat shock protein, putative	0.0026	0.0404	0.1196
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0022	0.0239	0.0368
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0239	0.0483
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0257	1	1
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0022	0.0239	0.0239
Echinococcus multilocularis	para nitrobenzyl esterase	0.0022	0.0239	0.0239
Entamoeba histolytica	transcription factor BTF3, putative	0.0036	0.079	1
Trichomonas vaginalis	chromobox protein, putative	0.0071	0.2265	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 873542