Detailed information for compound 873578

Basic information

Technical information
  • TDR Targets ID: 873578
  • Name: 3-(2,5-dimethylphenyl)-1-[(6-ethyl-2-pyrrol-1 -yl-5,7-dihydro-4H-thieno[5,4-c]pyridin-3-yl) methyl]urea
  • MW: 408.56 | Formula: C23H28N4OS
  • H donors: 2 H acceptors: 1 LogP: 3.84 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1CCc2c(C1)sc(c2CNC(=O)Nc1cc(C)ccc1C)n1cccc1
  • InChi: 1S/C23H28N4OS/c1-4-26-12-9-18-19(22(29-21(18)15-26)27-10-5-6-11-27)14-24-23(28)25-20-13-16(2)7-8-17(20)3/h5-8,10-11,13H,4,9,12,14-15H2,1-3H3,(H2,24,25,28)
  • InChiKey: BNYKMQUSDACEKZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(2,5-dimethylphenyl)-1-[[6-ethyl-2-(1-pyrrolyl)-5,7-dihydro-4H-thieno[5,4-c]pyridin-3-yl]methyl]urea

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ephrin type A receptor 4 A 0.0193 0.0322 0.0322
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0508 0.115 0.115
Echinococcus granulosus peroxidasin 0.0111 0.0105 0.0105
Entamoeba histolytica protein kinase, putative 0.018 0.0287 1
Echinococcus multilocularis Immunoglobulin 0.0171 0.0264 0.0264
Schistosoma mansoni cell adhesion molecule 0.0111 0.0105 0.01
Brugia malayi protein-tyrosine kinase 0.0106 0.0094 0.0094
Echinococcus multilocularis cyclin dependent kinase 0.0088 0.0046 0.0046
Echinococcus granulosus cyclin dependent kinase 5 0.0088 0.0046 0.0046
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0508 0.115 0.1146
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.2124 0.5405 0.5405
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0118 0.0125 0.0125
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0118 0.0124 0.0124
Echinococcus granulosus epidermal growth factor receptor 0.2124 0.5405 0.5405
Loa Loa (eye worm) hypothetical protein 0.0171 0.0264 0.0264
Echinococcus granulosus tyrosine kinase 0.0078 0.0019 0.0019
Giardia lamblia Aurora kinase 0.0114 0.0114 0.7462
Brugia malayi SH2 domain containing protein 0.0078 0.0019 0.0019
Leishmania major protein kinase, putative 0.0114 0.0114 0.0141
Loa Loa (eye worm) TK/FER protein kinase 0.0078 0.0019 0.0019
Trichomonas vaginalis AGC family protein kinase 0.0114 0.0114 0.7462
Echinococcus multilocularis cyclin dependent kinase 5 0.0088 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0118 0.0125 0.0125
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0157 0.0226 0.0226
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0111 0.0105 0.0155
Brugia malayi Protein kinase domain containing protein 0.0123 0.0137 0.0137
Echinococcus multilocularis lachesin 0.0111 0.0105 0.0105
Schistosoma mansoni ephrin receptor 0.0168 0.0256 0.0251
Brugia malayi Immunoglobulin I-set domain containing protein 0.0118 0.0125 0.0125
Echinococcus multilocularis tyrosine protein kinase Blk 0.0106 0.0094 0.0094
Echinococcus multilocularis dual specificity protein kinase clk2 0.0123 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0176 0.0277 0.0277
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0046 0.0041
Entamoeba histolytica hypothetical protein 0.018 0.0287 1
Loa Loa (eye worm) TK/FER protein kinase 0.0078 0.0019 0.0019
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0123 0.0137 0.0189
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0118 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0234 0.043 0.043
Loa Loa (eye worm) hypothetical protein 0.0243 0.0454 0.0454
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0111 0.0105 0.0105
Loa Loa (eye worm) TK/EGFR protein kinase 0.387 1 1
Schistosoma mansoni nephrin 0.0226 0.0409 0.0404
Brugia malayi Immunoglobulin I-set domain containing protein 0.0111 0.0105 0.0105
Echinococcus granulosus defective proboscis extension response 0.0171 0.0264 0.0264
Trichomonas vaginalis AGC family protein kinase 0.0114 0.0114 0.7462
Brugia malayi SRC-1 0.0118 0.0124 0.0124
Brugia malayi serine/threonine protein kinase 6 0.0114 0.0114 0.0114
Echinococcus multilocularis ephrin type A receptor 4 A 0.0193 0.0322 0.0322
Brugia malayi Protein kinase domain containing protein 0.0296 0.0593 0.0593
Brugia malayi fructose-1,6-bisphosphatase 0.1905 0.4829 0.4829
Brugia malayi Immunoglobulin I-set domain containing protein 0.0111 0.0105 0.0105
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.018 0.0287 0.0503
Schistosoma mansoni tyrosine kinase 0.0078 0.0019 0.0014
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.1905 0.4829 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0111 0.0105 0.0105
Echinococcus granulosus tyrosine protein kinase Btk29A 0.009 0.0049 0.0049
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0118 0.0124 0.0124
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0046 0.0041
Brugia malayi SH2 domain containing protein 0.0078 0.0019 0.0019
Brugia malayi Immunoglobulin I-set domain containing protein 0.0111 0.0105 0.0105
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0157 0.0226 0.0226
Loa Loa (eye worm) TK/FER protein kinase 0.0078 0.0019 0.0019
Schistosoma mansoni serine/threonine protein kinase 0.0123 0.0137 0.0132
Schistosoma mansoni fructose-16-bisphosphatase-related 0.1905 0.4829 0.4826
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0118 0.0124 0.0124
Echinococcus granulosus aurora kinase A 0.0114 0.0114 0.0114
Onchocerca volvulus 0.2085 0.5302 0.9486
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.018 0.0287 0.0287
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0709 0.1679 0.3413
Brugia malayi Protein kinase domain containing protein 0.0078 0.0019 0.0019
Brugia malayi Protein kinase domain containing protein 0.0078 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0176 0.0277 0.0277
Echinococcus multilocularis dual specificity 0.018 0.0287 0.0287
Loa Loa (eye worm) TK/FER protein kinase 0.0078 0.0019 0.0019
Loa Loa (eye worm) TK/FER protein kinase 0.0078 0.0019 0.0019
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0111 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0171 0.0264 0.0264
Echinococcus granulosus tyrosine protein kinase ABL1 0.0078 0.0019 0.0019
Brugia malayi ephrin receptor 1 precursor 0.0111 0.0107 0.0107
Brugia malayi Immunoglobulin I-set domain containing protein 0.0118 0.0125 0.0125
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0123 0.0137 0.0189
Entamoeba histolytica protein kinase, putative 0.0114 0.0114 0.3535
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0109 0.01 0.01
Echinococcus granulosus tyrosine protein kinase Fyn 0.0118 0.0124 0.0124
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0118 0.0125 0.012
Echinococcus multilocularis neuroglian 0.0219 0.0389 0.0389
Echinococcus multilocularis hemicentin 1 0.0111 0.0105 0.0105
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0709 0.1679 0.3413
Loa Loa (eye worm) AUR protein kinase 0.0114 0.0114 0.0114
Echinococcus granulosus tyrosine protein kinase Src64B 0.0118 0.0124 0.0124
Schistosoma mansoni septate junction protein 0.0111 0.0105 0.01
Brugia malayi Protein kinase domain containing protein 0.0088 0.0046 0.0046
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0123 0.0137 0.0189
Brugia malayi Immunoglobulin I-set domain containing protein 0.0111 0.0105 0.0105
Echinococcus granulosus roundabout 2 0.0289 0.0575 0.0575
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0123 0.0137 0.0137
Echinococcus granulosus tyrosine protein kinase shark 0.0078 0.0019 0.0019
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0123 0.0137 0.0189
Toxoplasma gondii fructose-bisphospatase I 0.0709 0.1679 0.3413
Loa Loa (eye worm) hypothetical protein 0.0111 0.0105 0.0105
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.1905 0.4829 0.4829
Entamoeba histolytica protein kinase domain containing protein 0.0114 0.0114 0.3535
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0157 0.0226 0.0226
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0111 0.0105 0.0105
Echinococcus multilocularis tyrosine kinase 0.0078 0.0019 0.0019
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0118 0.0124 0.0124
Brugia malayi hypothetical protein 0.0243 0.0454 0.0454
Schistosoma mansoni septate junction protein 0.0111 0.0105 0.01
Brugia malayi hypothetical protein 0.0179 0.0284 0.0284
Echinococcus granulosus tyrosine kinase 0.0106 0.0094 0.0094
Echinococcus multilocularis tyrosine protein kinase Abl 0.009 0.0049 0.0049
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0088 0.0046 0.0046
Loa Loa (eye worm) TK protein kinase 0.0089 0.0049 0.0049
Echinococcus multilocularis neuroglian 0.0118 0.0125 0.0125
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0114 0.0109
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0114 0.0114 0.3535
Loa Loa (eye worm) TK/INSR protein kinase 0.1373 0.3429 0.3429
Loa Loa (eye worm) hypothetical protein 0.0111 0.0105 0.0105
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0118 0.0124 0.0124
Schistosoma mansoni tyrosine kinase 0.2124 0.5405 0.5403
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0114 0.0114 0.3535
Loa Loa (eye worm) hypothetical protein 0.0508 0.115 0.115
Leishmania major 0.1905 0.4829 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.2381 0.608 0.608
Echinococcus multilocularis peroxidasin 0.0111 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0078 0.0019 0.0019
Echinococcus granulosus twitchin 0.0222 0.0399 0.0399
Echinococcus multilocularis tyrosine protein kinase HCK 0.0089 0.0049 0.0049
Echinococcus granulosus tyrosine protein kinase Lyn 0.0121 0.0134 0.0134
Echinococcus granulosus neuroglian 0.0118 0.0125 0.0125
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0709 0.1679 0.3413
Echinococcus multilocularis cyclin dependent kinase 1 0.0088 0.0046 0.0046
Echinococcus granulosus contactin 0.0118 0.0125 0.0125
Schistosoma mansoni tyrosine kinase 0.2063 0.5244 0.5242
Brugia malayi cell division control protein 2 homolog 0.0088 0.0046 0.0046
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0234 0.043 0.043
Schistosoma mansoni tyrosine kinase 0.0157 0.0226 0.0221
Entamoeba histolytica protein kinase domain containing protein 0.018 0.0287 1
Brugia malayi Protein kinase domain containing protein 0.0078 0.0019 0.0019
Onchocerca volvulus 0.0107 0.0094 0.0135
Echinococcus granulosus tyrosine protein kinase Fyn 0.0118 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0179 0.0284 0.0284
Echinococcus granulosus c src tyrosine kinase 0.009 0.0049 0.0049
Loa Loa (eye worm) TK/EPH protein kinase 0.0197 0.0332 0.0332
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0508 0.115 0.115
Echinococcus granulosus tyrosine protein kinase HCK 0.0089 0.0049 0.0049
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0171 0.0264 0.0259
Schistosoma mansoni tyrosine kinase 0.0172 0.0266 0.0261
Echinococcus granulosus tyrosine protein kinase Srms 0.0078 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0111 0.0105 0.0105
Schistosoma mansoni tyrosine kinase 0.387 1 1
Echinococcus granulosus lachesin 0.0111 0.0105 0.0105
Brugia malayi Protein kinase domain containing protein 0.1373 0.3429 0.3429
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0123 0.0137 0.0189
Loa Loa (eye worm) hypothetical protein 0.0282 0.0556 0.0556
Loa Loa (eye worm) hypothetical protein 0.0085 0.0037 0.0037
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.009 0.0049 0.0049
Toxoplasma gondii aurora kinase 0.0114 0.0114 0.0141
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.018 0.0287 0.0503
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0118 0.0124 0.0124
Schistosoma mansoni tyrosine kinase 0.009 0.0049 0.0044
Echinococcus granulosus tyrosine protein kinase Src42A 0.0118 0.0124 0.0124
Echinococcus multilocularis cyclin dependent kinase 1 0.0088 0.0046 0.0046
Schistosoma mansoni tyrosine kinase 0.0118 0.0124 0.0119
Loa Loa (eye worm) TK protein kinase 0.0204 0.0351 0.0351
Echinococcus granulosus tyrosine protein kinase Blk 0.0106 0.0094 0.0094
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0709 0.1679 0.3413
Loa Loa (eye worm) SRC-1 0.0118 0.0124 0.0124
Brugia malayi Immunoglobulin I-set domain containing protein 0.0111 0.0105 0.0105
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.1296 0.3224 0.3224
Brugia malayi Protein kinase domain containing protein 0.0078 0.0019 0.0019
Echinococcus multilocularis Immunoglobulin 0.0171 0.0264 0.0264
Echinococcus granulosus fibroblast growth factor receptor 4 0.0157 0.0226 0.0226
Loa Loa (eye worm) hypothetical protein 0.0179 0.0284 0.0284
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0118 0.0124 0.0124
Loa Loa (eye worm) TK protein kinase 0.0106 0.0094 0.0094
Entamoeba histolytica protein kinase, putative 0.0114 0.0114 0.3535
Schistosoma mansoni cell adhesion molecule 0.0242 0.045 0.0445
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0088 0.0046 0.0046
Onchocerca volvulus Tyrosine kinase homolog 0.2194 0.5588 1
Trypanosoma brucei fructose-1,6-bisphosphatase 0.1905 0.4829 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.0105 0.0105
Brugia malayi Protein kinase domain containing protein 0.0078 0.0019 0.0019
Schistosoma mansoni neuroglian 0.0118 0.0125 0.012
Echinococcus granulosus roundabout 2 0.0118 0.0125 0.0125
Echinococcus multilocularis roundabout 2 0.0289 0.0575 0.0575
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0109 0.01 0.01
Echinococcus granulosus roundabout 2 0.0118 0.0125 0.0125
Schistosoma mansoni cell adhesion molecule 0.0118 0.0125 0.012
Brugia malayi serine/threonine kinase 12 0.0114 0.0114 0.0114
Schistosoma mansoni tyrosine kinase 0.2063 0.5244 0.5242
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0171 0.0264 0.0264
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0118 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0111 0.0105 0.0105
Entamoeba histolytica cell division protein kinase 2, putative 0.0088 0.0046 0.1016
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0171 0.0264 0.0259
Schistosoma mansoni cell adhesion molecule 0.0118 0.0125 0.012
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0088 0.0046 0.0046
Toxoplasma gondii fructose-bisphospatase II 0.1905 0.4829 1
Echinococcus multilocularis tyrosine protein kinase otk 0.0111 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0243 0.0454 0.0454
Schistosoma mansoni titin 0.0111 0.0105 0.01
Loa Loa (eye worm) TK/ALK protein kinase 0.0296 0.0593 0.0593
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0123 0.0137 0.0189
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.009 0.0049 0.0044
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0106 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0179 0.0284 0.0284
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0118 0.0125 0.0125
Brugia malayi Peroxidasin 0.0111 0.0105 0.0105
Echinococcus granulosus neuroglian 0.0219 0.0389 0.0389
Echinococcus multilocularis epidermal growth factor receptor 0.2124 0.5405 0.5405
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.018 0.0287 0.0503
Echinococcus multilocularis aurora kinase A 0.0114 0.0114 0.0114
Entamoeba histolytica protein kinase, putative 0.0089 0.0049 0.1127
Echinococcus granulosus tyrosine protein kinase otk 0.0111 0.0105 0.0105
Loa Loa (eye worm) TK/ABL protein kinase 0.0078 0.0019 0.0019
Brugia malayi Tyrosine-protein kinase abl-1 0.009 0.0049 0.0049
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0114 0.0114 0.0114
Echinococcus granulosus insulin growth factor 1 receptor beta 0.1381 0.3449 0.3449
Trichomonas vaginalis AGC family protein kinase 0.0114 0.0114 0.7462
Leishmania major protein kinase, putative 0.0123 0.0137 0.0189
Trypanosoma brucei aurora B kinase 0.0114 0.0114 0.0141
Schistosoma mansoni tyrosine kinase 0.1373 0.3429 0.3425
Schistosoma mansoni tyrosine kinase 0.009 0.0049 0.0044
Trichomonas vaginalis CMGC family protein kinase 0.0123 0.0137 1
Loa Loa (eye worm) TK/FER protein kinase 0.0078 0.0019 0.0019
Echinococcus multilocularis roundabout 2 0.0118 0.0125 0.0125
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0118 0.0125 0.0125
Echinococcus granulosus dual specificity 0.018 0.0287 0.0287
Brugia malayi Immunoglobulin I-set domain containing protein 0.0204 0.0351 0.0351
Brugia malayi hypothetical protein 0.0078 0.0019 0.0019
Echinococcus granulosus hypothetical protein 0.0119 0.0127 0.0127
Echinococcus multilocularis insulin receptor 0.1373 0.3429 0.3429
Echinococcus granulosus dual specificity protein kinase clk2 0.0123 0.0137 0.0137
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0123 0.0137 0.0189
Echinococcus granulosus fructose 16 bisphosphatase 1 0.1905 0.4829 0.4829
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0114 0.0114 0.3535
Loa Loa (eye worm) TK/FER protein kinase 0.0078 0.0019 0.0019
Echinococcus multilocularis hemicentin 1 0.0111 0.0105 0.0105
Brugia malayi Prion-like- 0.0111 0.0105 0.0105
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0088 0.0046 0.0046
Echinococcus multilocularis tyrosine protein kinase shark 0.0078 0.0019 0.0019
Echinococcus multilocularis roundabout 2 0.0118 0.0125 0.0125
Loa Loa (eye worm) AUR protein kinase 0.0114 0.0114 0.0114
Brugia malayi Protein kinase domain containing protein 0.0132 0.016 0.016
Schistosoma mansoni tyrosine kinase 0.0078 0.0019 0.0014
Echinococcus multilocularis tyrosine protein kinase Srms 0.0106 0.0094 0.0094
Loa Loa (eye worm) TK/FER protein kinase 0.0078 0.0019 0.0019
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0118 0.0124 0.0124
Schistosoma mansoni serine/threonine protein kinase 0.0123 0.0137 0.0132
Plasmodium falciparum serine/threonine protein kinase, putative 0.0114 0.0114 0.7462
Echinococcus granulosus epidermal growth factor receptor 0.387 1 1
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0106 0.0094 0.0094
Loa Loa (eye worm) TK/ROR protein kinase 0.0109 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0107 0.0094 0.0094
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.1905 0.4829 0.4829
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.1905 0.4829 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0118 0.0124 0.0124
Brugia malayi Immunoglobulin I-set domain containing protein 0.0111 0.0105 0.0105
Schistosoma mansoni tyrosine kinase 0.2124 0.5405 0.5403
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.1381 0.3449 0.3449
Entamoeba histolytica protein kinase , putative 0.0114 0.0114 0.3535
Schistosoma mansoni serine/threonine protein kinase 0.018 0.0287 0.0282
Schistosoma mansoni nephrin 0.0118 0.0125 0.012
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0078 0.0019 0.0019
Trichomonas vaginalis AGC family protein kinase 0.0114 0.0114 0.7462
Schistosoma mansoni tyrosine kinase 0.2063 0.5244 0.5242
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0078 0.0019 0.0019
Schistosoma mansoni protein kinase 0.0114 0.0114 0.0109
Loa Loa (eye worm) hypothetical protein 0.0282 0.0556 0.0556
Brugia malayi Immunoglobulin I-set domain containing protein 0.0118 0.0125 0.0125
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0114 0.0114 0.0114
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.018 0.0287 0.0503
Loa Loa (eye worm) TK/KIN16 protein kinase 0.2381 0.608 0.608
Echinococcus granulosus hemicentin 1 0.0111 0.0105 0.0105
Echinococcus granulosus Immunoglobulin 0.0171 0.0264 0.0264
Giardia lamblia Kinase, CMGC CLK 0.0123 0.0137 1
Schistosoma mansoni vesicular amine transporter 0.0171 0.0264 0.0259
Loa Loa (eye worm) TK/FER protein kinase 0.0078 0.0019 0.0019
Echinococcus multilocularis c src tyrosine kinase 0.009 0.0049 0.0049
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0118 0.0125 0.0125
Echinococcus granulosus tyrosine protein kinase Fyn 0.0118 0.0124 0.0124
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0111 0.0105 0.01
Plasmodium falciparum protein serine/threonine kinase-1 0.0123 0.0137 1
Schistosoma mansoni roundabout 0.0111 0.0105 0.01
Plasmodium vivax serine/threonine kinase-1, putative 0.0123 0.0137 1
Echinococcus granulosus insulin receptor 0.1373 0.3429 0.3429
Echinococcus multilocularis 0.1185 0.2932 0.2932
Entamoeba histolytica cell division protein kinase 2, putative 0.0088 0.0046 0.1016
Brugia malayi Protein kinase domain containing protein 0.018 0.0287 0.0287
Brugia malayi Immunoglobulin I-set domain containing protein 0.0179 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0207 0.0358 0.0358
Brugia malayi Fibronectin type III domain containing protein 0.0179 0.0284 0.0284
Echinococcus granulosus cyclin dependent kinase 0.0088 0.0046 0.0046
Echinococcus granulosus cyclin dependent kinase 1 0.0088 0.0046 0.0046
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0122 0.0135 0.0135
Leishmania major protein kinase, putative 0.0123 0.0137 0.0189
Echinococcus multilocularis 0.0119 0.0127 0.0127
Schistosoma mansoni tyrosine kinase 0.1373 0.3429 0.3425
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0078 0.0019 0.0019
Loa Loa (eye worm) AUR protein kinase 0.0114 0.0114 0.0114
Brugia malayi serine/threonine-protein kinase 6 0.0114 0.0114 0.0114
Loa Loa (eye worm) TK/FER protein kinase 0.0078 0.0019 0.0019
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0114 0.0114 0.7462
Schistosoma mansoni tyrosine kinase 0.0118 0.0124 0.0119
Loa Loa (eye worm) hypothetical protein 0.0171 0.0264 0.0264
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0118 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0119 0.0127 0.0127
Echinococcus multilocularis epidermal growth factor receptor 0.387 1 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0118 0.0125 0.0125
Entamoeba histolytica protein kinase, putative 0.018 0.0287 1
Trypanosoma cruzi aurora B kinase, putative 0.0114 0.0114 0.0141

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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