Detailed information for compound 87360

Basic information

Technical information
  • TDR Targets ID: 87360
  • Name: 2-(2,2-diethoxyethylsulfanyl)-6-[(3,5-dimethy lphenyl)methyl]-5-ethyl-1H-pyrimidin-4-one
  • MW: 390.54 | Formula: C21H30N2O3S
  • H donors: 1 H acceptors: 3 LogP: 5.11 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(CSc1nc(Cc2cc(C)cc(c2)C)c(c(n1)O)CC)OCC
  • InChi: 1S/C21H30N2O3S/c1-6-17-18(12-16-10-14(4)9-15(5)11-16)22-21(23-20(17)24)27-13-19(25-7-2)26-8-3/h9-11,19H,6-8,12-13H2,1-5H3,(H,22,23,24)
  • InChiKey: CHICPYFDBHXNEO-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-(2,2-diethoxyethylthio)-6-[(3,5-dimethylphenyl)methyl]-5-ethyl-1H-pyrimidin-4-one
  • 2-(2,2-diethoxyethylthio)-6-(3,5-dimethylbenzyl)-5-ethyl-1H-pyrimidin-4-one
  • 199851-96-2
  • AIDS072961
  • HEPT analogue
  • 4(1H)-Pyrimidinone, 2-((2,2-diethoxyethyl)thio)-6-((3,5-dimethylphenyl)methyl)-5-ethyl-
  • 4(1H)-Pyrimidinone, 2-[(2,2-diethoxyethyl)thio]-6-[(3,5-dimethylphenyl)methyl]-5-ethyl-
  • AIDS-072961

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.003 0.0038 0.0054
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0092 0.4361
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.011 0.01
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.1145 0.2738 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0015 0.0042
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0092 0.0082
Loa Loa (eye worm) hypothetical protein 0.0072 0.014 0.0198
Brugia malayi Patched family protein 0.0018 0.001 0.0014
Brugia malayi serine/threonine-protein kinase plk-2 0.0091 0.0186 0.0265
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.011 0.0822
Onchocerca volvulus 0.0028 0.0034 0.0215
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0015 0.0042
Brugia malayi Patched family protein 0.0018 0.001 0.0014
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0031 0.0044
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0027 0.0063
Entamoeba histolytica acyl-CoA synthetase, putative 0.0096 0.0199 0.2752
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0038 0.0102
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.028 0.0644 0.5216
Brugia malayi Calcitonin receptor-like protein seb-1 0.0154 0.0339 0.0483
Echinococcus multilocularis Niemann Pick C1 protein 0.0301 0.0696 0.0686
Brugia malayi hypothetical protein 0.0018 0.001 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0038 0.0247
Loa Loa (eye worm) hypothetical protein 0.0072 0.014 0.0198
Entamoeba histolytica acyl-CoA synthetase, putative 0.0096 0.0199 0.2752
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0034 0.0048
Loa Loa (eye worm) hypothetical protein 0.0027 0.0031 0.0043
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0032 0.1505
Schistosoma mansoni hypothetical protein 0.0125 0.0267 0.2117
Brugia malayi hypothetical protein 0.0018 0.001 0.0014
Brugia malayi CHE-14 protein 0.0129 0.0279 0.0397
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.001 0.0014
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0186 0.1561
Echinococcus multilocularis acetylcholinesterase 0.0067 0.0127 0.0117
Loa Loa (eye worm) hypothetical protein 0.0026 0.0027 0.0038
Echinococcus multilocularis tumor protein p63 0.0328 0.0759 0.075
Brugia malayi Patched protein homolog 1 0.0018 0.001 0.0014
Echinococcus granulosus tm gpcr rhodopsin 0.052 0.1224 0.9991
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.001 0.0037
Brugia malayi hypothetical protein 0.0229 0.0521 0.0742
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0015 0.0042
Schistosoma mansoni coup transcription factor 0.0021 0.0015 0.0042
Brugia malayi Patched family protein 0.0018 0.001 0.0014
Brugia malayi Patched family protein 0.0018 0.001 0.0014
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0032 0.1474
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0028 0.0034 0.05
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0034 0.1257
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0015 0.0022
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.052 0.1224 0.1215
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0306 0.0707 0.5734
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0096 0.0199 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0015 0.0022
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.1145 0.2738 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.028 0.0644 0.0916
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0034 0.1257
Loa Loa (eye worm) heterochromatin protein 1 0.0074 0.0144 0.0204
Schistosoma mansoni topbp1 0.003 0.0038 0.0229
Brugia malayi Patched family protein 0.0018 0.001 0.0014
Brugia malayi topoisomerase 0.003 0.0038 0.0054
Loa Loa (eye worm) carboxylesterase 0.0067 0.0127 0.0181
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0028 0.0034 0.0048
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.0221 0.0314
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0034 0.021
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0025 0.0797
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0034 0.1257
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0031 0.0043
Brugia malayi Patched family protein 0.0018 0.001 0.0014
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0015 0.0042
Schistosoma mansoni chromobox protein 0.0074 0.0144 0.1099
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0034 0.0087
Schistosoma mansoni hypothetical protein 0.052 0.1225 1
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0038 0.0102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0021
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0186 0.1561
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.013 0.6366
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0015 0.0022
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.0159 1
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0015 0.0005
Trichomonas vaginalis set domain proteins, putative 0.0485 0.1139 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.011 0.5297
Brugia malayi hypothetical protein 0.011 0.0232 0.0331
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0084 0.0604
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0015 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0038 0.0247
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0144 0.1182
Loa Loa (eye worm) hypothetical protein 0.0032 0.0044 0.0062
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0028 0.0034 0.1257
Echinococcus granulosus Niemann Pick C1 protein 0.0301 0.0696 0.5641
Loa Loa (eye worm) hypothetical protein 0.0105 0.0221 0.0314
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0034 0.0087
Echinococcus granulosus expressed conserved protein 0.0283 0.0651 0.5276
Loa Loa (eye worm) hypothetical protein 0.003 0.0038 0.0054
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0084 0.0119
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0015 0.005
Echinococcus granulosus Niemann Pick C1 protein 0.0431 0.1009 0.822
Schistosoma mansoni hypothetical protein 0.0049 0.0084 0.0604
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0015 0.0042
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0015 0.0042
Brugia malayi AMP-binding enzyme family protein 0.0096 0.0199 0.0283
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0015 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0036 0.023
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0027 0.0063
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0028 0.0034 0.1257
Echinococcus granulosus GPCR family 2 0.0049 0.0084 0.0604
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0092 0.0677
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Echinococcus granulosus geminin 0.052 0.1225 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0096 0.0199 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0028 0.0034 0.0087
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0015 0.0005
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.0032 0.04
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0034 0.1257
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0015 0.0042
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0091 0.0186 0.0265
Onchocerca volvulus 0.0088 0.0178 0.1492
Entamoeba histolytica hypothetical protein 0.011 0.0232 0.3239
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.0521 0.0511
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0027 0.118
Brugia malayi Carboxylesterase family protein 0.0067 0.0127 0.0181
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.003 0.0038 0.1478
Echinococcus granulosus tumor protein p63 0.0328 0.0759 0.6166
Echinococcus multilocularis geminin 0.052 0.1225 0.1216
Loa Loa (eye worm) hypothetical protein 0.0096 0.0199 0.0282
Schistosoma mansoni patched 1 0.0129 0.0279 0.221
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0028 0.0034 0.1621
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0015 0.0042
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0073 0.0556
Schistosoma mansoni hypothetical protein 0.0125 0.0267 0.2117
Brugia malayi Carboxylesterase family protein 0.0067 0.0127 0.0181
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0034 0.0087
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Brugia malayi AMP-binding enzyme family protein 0.0096 0.0199 0.0283
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.003 0.0038 0.074
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.001 0.0015
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0092 0.4361
Loa Loa (eye worm) patched family protein 0.0018 0.001 0.0013
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0034 0.1257
Brugia malayi chromobox protein homolog 3 0.0041 0.0065 0.0093
Echinococcus multilocularis musashi 0.0027 0.0031 0.0021
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0079 0.0112
Giardia lamblia Replication factor C, subunit 1 0.003 0.0038 0.1582
Plasmodium falciparum acyl-CoA synthetase 0.0072 0.014 0.8699
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0028 0.0034 0.0346
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0015 0.005
Plasmodium falciparum replication factor C subunit 1, putative 0.003 0.0038 0.19
Echinococcus multilocularis protein dispatched 1 0.0148 0.0323 0.0313
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0084 0.0073
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0113 0.0103
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0015 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0015 0.0021
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0015 0.0005
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.003 0.0038 0.0247
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0021
Brugia malayi putative malonyl-CoA decarboxylase 0.2914 0.7023 1
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.003 0.0038 0.0247
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0015 0.0005
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0021
Loa Loa (eye worm) patched family protein 0.0018 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.0159 0.1227
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0028 0.0034 0.1257
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0028 0.0034 0.1257
Loa Loa (eye worm) hypothetical protein 0.003 0.0038 0.0054
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0186 0.0646
Brugia malayi hypothetical protein 0.0017 0.0005 0.0008
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0034 0.0087
Entamoeba histolytica hypothetical protein 0.003 0.0038 0.0407
Brugia malayi Patched related family protein 4 0.0018 0.001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Onchocerca volvulus 0.0048 0.0082 0.0637
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.028 0.0644 0.5216
Brugia malayi protein C24B5.3 0.0018 0.001 0.0014
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0028 0.0034 0.0195
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0028 0.0034 0.1257
Echinococcus multilocularis acetylcholinesterase 0.0067 0.0127 0.0117
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0084 0.0118
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.003 0.0038 0.0054
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0015 0.0042
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0113 0.0849
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0091 0.0186 0.145
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0034 0.0048
Echinococcus granulosus acetylcholinesterase 0.0067 0.0127 0.0964
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.011 0.5297
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0113 0.0849
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0015 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.028 0.0644 0.5216
Onchocerca volvulus 0.0047 0.0079 0.0611
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0031 0.0043
Brugia malayi Patched family protein 0.0018 0.001 0.0014
Plasmodium vivax acetyl-CoA synthetase, putative 0.0028 0.0034 0.1621
Chlamydia trachomatis DNA ligase 0.003 0.0038 0.0959
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0015 0.0042
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0028 0.0034 0.1257
Entamoeba histolytica hypothetical protein 0.011 0.0232 0.3239
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0015 0.0042
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0015 0.0022
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0 0.0001
Echinococcus multilocularis Niemann Pick C1 protein 0.0431 0.1009 0.1
Mycobacterium ulcerans acetyl-CoA synthetase 0.0028 0.0034 0.1257
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.028 0.0644 0.5216
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.003 0.0038 0.0102
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0034 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0065 0.0488
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.0521 0.4204
Brugia malayi AMP-binding enzyme family protein 0.0096 0.0199 0.0283
Toxoplasma gondii propionate-CoA ligase 0.0028 0.0034 0.1621
Echinococcus multilocularis protein patched 0.0129 0.0279 0.0269
Loa Loa (eye worm) oxidoreductase 0.0028 0.0034 0.0048
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0025 0.1041
Trichomonas vaginalis conserved hypothetical protein 0.0129 0.0279 0.2378
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.0159 0.0149
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0038 0.0247
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0034 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0015 0.0022
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0144 0.1182
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0034 0.1257
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.003 0.0038 0.19
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0015 0.0005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0015 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0065 0.0488
Schistosoma mansoni hypothetical protein 0.0125 0.0267 0.2117
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.028 0.0644 0.0634
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Leishmania major 4-coumarate:coa ligase-like protein 0.0096 0.0199 0.0691
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0072 0.014 0.8548
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0015 0.0021
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.011 0.0822
Trypanosoma brucei polo-like protein kinase 0.0091 0.0186 0.0646
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.011 0.6715
Brugia malayi hypothetical protein 0.0018 0.001 0.0014
Echinococcus granulosus Protein patched homolog 1 0.0129 0.0279 0.221
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0024 0.0752
Echinococcus granulosus carboxylesterase 5A 0.0067 0.0127 0.0964
Leishmania major 4-coumarate:coa ligase-like protein 0.0096 0.0199 0.0691
Onchocerca volvulus 0.0032 0.0044 0.0302
Plasmodium vivax SET domain protein, putative 0.0061 0.0113 0.693
Brugia malayi Patched family protein 0.0018 0.001 0.0014
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0113 0.0103
Onchocerca volvulus 0.0027 0.0031 0.0188
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0113 0.0849
Echinococcus multilocularis GPCR, family 2 0.0049 0.0084 0.0073
Echinococcus multilocularis chromobox protein 1 0.0074 0.0144 0.0134
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0027 0.118
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0034 0.0087
Onchocerca volvulus 0.0028 0.0034 0.0215
Toxoplasma gondii hypothetical protein 0.0028 0.0032 0.1505
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0088 0.0178 0.1383
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.0159 0.0213
Brugia malayi hypothetical protein 0.003 0.0038 0.0054
Loa Loa (eye worm) hypothetical protein 0.0301 0.0696 0.099
Echinococcus multilocularis lamin dm0 0.0027 0.0031 0.0021
Toxoplasma gondii ATPase, AAA family protein 0.003 0.0038 0.19
Plasmodium vivax acyl-CoA synthetase, putative 0.0072 0.014 0.8699
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0025 0.0797
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0186 0.0646
Echinococcus multilocularis lamin 0.0027 0.0031 0.0021
Echinococcus granulosus sterol regulatory element binding protein 0.0129 0.0279 0.221
Echinococcus granulosus lamin 0.0027 0.0031 0.017
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0084 0.0073
Brugia malayi Patched family protein 0.0018 0.001 0.0014
Brugia malayi hypothetical protein 0.0026 0.0027 0.0039
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0034 0.1257
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0028 0.0034 0.1257
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0159 0.7903
Loa Loa (eye worm) hypothetical protein 0.0072 0.014 0.0198
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0067 0.0127 0.0964
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0073 0.0556
Brugia malayi Patched family protein 0.0018 0.001 0.0014
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0159 1
Schistosoma mansoni transcription factor LCR-F1 0.011 0.0232 0.1827
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0154 0.0339 0.0482
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0028 0.0034 0.1621
Loa Loa (eye worm) hypothetical protein 0.0129 0.0279 0.0396
Schistosoma mansoni lamin 0.0027 0.0031 0.017
Schistosoma mansoni hypothetical protein 0.0105 0.0221 0.1733
Brugia malayi nuclear receptor NHR-88 0.0021 0.0015 0.0022
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0015 0.0042
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0091 0.0186 0.0176
Onchocerca volvulus 0.0028 0.0034 0.0215
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.003 0.0038 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0038 0.0247
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0021
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0301 0.0696 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.001 0.0037
Brugia malayi protein C24B5.3 0.0018 0.001 0.0014
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.011 0.0822
Loa Loa (eye worm) hypothetical protein 0.003 0.0038 0.0054
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0096 0.0199 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Schistosoma mansoni kinase 0.0046 0.0078 0.0556
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0113 0.0849
Schistosoma mansoni chromosome transmission fidelity factor 0.003 0.0038 0.0229
Entamoeba histolytica hypothetical protein 0.0025 0.0025 0.0219
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0092 0.3873
Brugia malayi steroid hormone receptor 0.0021 0.0015 0.0022
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0028 0.0034 0.1257
Loa Loa (eye worm) hypothetical protein 0.0041 0.0065 0.0092
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0015 0.0042
Echinococcus multilocularis expressed conserved protein 0.0283 0.0651 0.0642
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0028 0.0034 0.05
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0015 0.0042
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0028 0.0034 0.1257
Schistosoma mansoni acetyl-CoA synthetase 0.0028 0.0034 0.0195
Brugia malayi nuclear hormone receptor 0.0021 0.0015 0.0022
Brugia malayi Patched family protein 0.0018 0.001 0.0014
Brugia malayi hypothetical protein 0.0018 0.001 0.0014
Brugia malayi Pax transcription activation domain interacting protein 0.003 0.0038 0.0054
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0034 0.1257
Loa Loa (eye worm) hypothetical protein 0.0096 0.0199 0.0282
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.028 0.0644 0.5216
Echinococcus multilocularis sterol regulatory element binding protein 0.0129 0.0279 0.0269
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0034 0.1257
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0065 0.0493
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0015 0.0042
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.013 0.6366
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0084 0.0604
Echinococcus multilocularis replication factor c subunit 1 0.003 0.0038 0.0028
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0084 0.0119
Brugia malayi intermediate filament protein 0.0027 0.0031 0.0044
Entamoeba histolytica serine/threonine protein kinase, putative 0.0091 0.0186 0.2571
Echinococcus granulosus chromobox protein 1 0.0074 0.0144 0.1099
Schistosoma mansoni lamin 0.0027 0.0031 0.017
Trypanosoma cruzi FHA domain containing protein, putative 0.003 0.0038 0.0102
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0096 0.0199 1
Wolbachia endosymbiont of Brugia malayi malonyl-CoA decarboxylase 0.2914 0.7023 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0015 0.0022
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0096 0.0199 1
Mycobacterium ulcerans hypothetical protein 0.0096 0.0199 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Schistosoma mansoni hypothetical protein 0.011 0.0232 0.1827
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0015 0.0005
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.003 0.0038 0.0407
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0096 0.0199 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0091 0.0186 0.1565
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0034 0.1257
Echinococcus granulosus lamin dm0 0.0027 0.0031 0.017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0015 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0015 0.0022
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0027 0.118
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0034 0.05
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0034 0.1257
Brugia malayi Pre-SET motif family protein 0.0426 0.0997 0.1419
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.0159 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Schistosoma mansoni hypothetical protein 0.0049 0.0084 0.0604
Mycobacterium ulcerans acyl-CoA synthetase 0.0096 0.0199 1
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0025 0.0021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0015 0.0005
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0034 0.0048
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0034 0.0048
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0186 0.1561
Loa Loa (eye worm) hypothetical protein 0.0088 0.0178 0.0253
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0186 0.1561
Echinococcus multilocularis chromobox protein 1 0.0074 0.0144 0.0134
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0015 0.005
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0186 0.1561
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0021
Brugia malayi Pre-SET motif family protein 0.0061 0.0113 0.0161
Loa Loa (eye worm) hypothetical protein 0.0067 0.0127 0.0181
Brugia malayi Patched family protein 0.0018 0.001 0.0014
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0091 0.0186 0.0646
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0025 0.1041
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0027 0.0063
Loa Loa (eye worm) hypothetical protein 0.0049 0.0084 0.0118
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0113 0.693
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0034 0.0087
Loa Loa (eye worm) hypothetical protein 0.0048 0.0082 0.0116
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0028 0.0034 0.1621
Echinococcus granulosus L aminoadipate semialdehyde 0.0088 0.0178 0.1383
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0025 0.0055
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0159 1
Onchocerca volvulus 0.004 0.0063 0.047
Brugia malayi Patched family protein 0.0018 0.001 0.0014
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0159 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0096 0.0199 0.2752
Schistosoma mansoni topbp1 0.003 0.0038 0.0229
Onchocerca volvulus 0.0485 0.1139 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Brugia malayi Patched related family protein 10 0.0018 0.001 0.0014
Schistosoma mansoni hypothetical protein 0.0049 0.0084 0.0604
Leishmania major malonyl-coa decarboxylase-like protein 0.1145 0.2738 1
Echinococcus granulosus nibrin 0.003 0.0038 0.0229
Onchocerca volvulus 0.0027 0.0031 0.0188
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.028 0.0644 0.0634
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.014 0.6871
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.011 0.5297
Loa Loa (eye worm) acetylcholinesterase 1 0.0067 0.0127 0.0181
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0075 0.0572
Entamoeba histolytica hypothetical protein 0.011 0.0232 0.3239
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0032 0.1505
Schistosoma mansoni hypothetical protein 0.0047 0.0079 0.0564
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0034 0.021
Loa Loa (eye worm) hypothetical protein 0.0067 0.0127 0.0181
Brugia malayi Niemann-Pick C1 protein precursor 0.0301 0.0696 0.099
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0028 0.0034 0.1257
Brugia malayi Myosin head containing protein 0.0018 0.001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0021
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.0034 0.1257
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0073 0.056
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0186 0.145
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.003 0.0038 0.004
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.028 0.0644 0.0917
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0034 0.0087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0015 0.0021
Onchocerca volvulus 0.0096 0.0199 0.1674
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0034 0.0048
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.0232 0.0222
Leishmania major hypothetical protein, conserved 0.0026 0.0027 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0028 0.0034 0.1257
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0027 0.118
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0096 0.0199 0.0282
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0159 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0073 0.0143 0.1089
Loa Loa (eye worm) hypothetical protein 0.0072 0.014 0.0198
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0088 0.0178 0.0254
Schistosoma mansoni hypothetical protein 0.052 0.1225 1
Onchocerca volvulus 0.003 0.0038 0.0252
Brugia malayi Patched related family protein 12 0.0018 0.001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0061 0.0113 0.0161
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0015 0.0005
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0025 0.0055
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0034 0.1257
Loa Loa (eye worm) hypothetical protein 0.003 0.0038 0.0054
Loa Loa (eye worm) hypothetical protein 0.0072 0.014 0.0198
Brugia malayi hypothetical protein 0.003 0.0038 0.0054
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0015 0.0042
Brugia malayi DKFZp564C0469 protein 0.003 0.0038 0.0054
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.003 0.0038 0.0102
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0154 0.0339 0.0483
Giardia lamblia Kinase, PLK 0.0091 0.0186 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.013 0.6366
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.011 0.0366
Brugia malayi Heterochromatin protein 1 0.0074 0.0144 0.0205
Echinococcus multilocularis carboxylesterase 5A 0.0067 0.0127 0.0117
Loa Loa (eye worm) hypothetical protein 0.0028 0.0034 0.0048
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0034 0.1257
Loa Loa (eye worm) hypothetical protein 0.0027 0.003 0.0042
Onchocerca volvulus 0.0073 0.0143 0.1176
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0025 0.1041
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.0159 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.0349 0.0497
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0025 0.1041
Entamoeba histolytica hypothetical protein 0.011 0.0232 0.3239
Loa Loa (eye worm) hypothetical protein 0.2914 0.7023 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.013 0.6366
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0129 0.0279 0.0396
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0075 0.0572
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0186 0.1561
Schistosoma mansoni intermediate filament proteins 0.0027 0.0031 0.017
Trypanosoma brucei malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.1145 0.2738 1
Schistosoma mansoni survival motor neuron protein 0.0047 0.0079 0.0564
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0015 0.0042
Schistosoma mansoni chromobox protein 0.0074 0.0144 0.1099
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.003 0.0038 0.0247
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0082 0.0588
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Onchocerca volvulus 0.0021 0.0015 0.005
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0028 0.0034 0.1257
Loa Loa (eye worm) hypothetical protein 0.003 0.0038 0.0054
Loa Loa (eye worm) patched family protein 0.0018 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Mycobacterium ulcerans acyl-CoA synthetase 0.0096 0.0199 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0096 0.0199 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0096 0.0199 1
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0025 0.1008
Loa Loa (eye worm) hypothetical protein 0.008 0.0159 0.0226
Echinococcus granulosus acetylcholinesterase 0.0067 0.0127 0.0964
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0108 0.0804
Leishmania major 4-coumarate:coa ligase-like protein 0.0096 0.0199 0.0691
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0028 0.0034 0.1257
Plasmodium vivax replication factor C subunit 1, putative 0.003 0.0038 0.19
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0025 0.0797
Brugia malayi Probable ClpP-like protease 0.008 0.0159 0.0227
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0015 0.0042
Echinococcus granulosus chromobox protein 1 0.0074 0.0144 0.1099
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0028 0.0034 0.0048
Treponema pallidum DNA ligase (lig) 0.003 0.0038 0.187
Echinococcus multilocularis nibrin 0.003 0.0038 0.0028
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0096 0.0199 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0028 0.0034 0.0024
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0034 0.0048
Echinococcus multilocularis L aminoadipate semialdehyde 0.0088 0.0178 0.0168
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0015 0.0005
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0159 0.7903
Brugia malayi Patched family protein 0.0018 0.001 0.0014
Toxoplasma gondii exonuclease III APE 0.0019 0.001 0.0037
Schistosoma mansoni DNA ligase IV 0.003 0.0038 0.0229
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0072 0.014 0.6871
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0229 0.0521 0.0741
Trichomonas vaginalis replication factor C large subunit, putative 0.003 0.0038 0.0247
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0186 0.1561
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0015 0.0021
Echinococcus granulosus replication factor c subunit 1 0.003 0.0038 0.0229
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0038 0.0247
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.0159 0.1227
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.011 0.5297
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0015 0.0022
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.0232 0.1827
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0426 0.0997 0.1419
Brugia malayi ecdysteroid receptor 0.0021 0.0015 0.0022
Schistosoma mansoni hypothetical protein 0.0049 0.0084 0.0604
Schistosoma mansoni hypothetical protein 0.0125 0.0267 0.2117
Loa Loa (eye worm) patched family protein 0.0018 0.001 0.0013
Brugia malayi Patched family protein 0.0018 0.001 0.0014
Loa Loa (eye worm) patched family protein 0.0018 0.001 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0015 0.0022
Echinococcus granulosus intermediate filament protein 0.0027 0.0031 0.017
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0036 0.023
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.0159 0.7721
Loa Loa (eye worm) hypothetical protein 0.0154 0.0339 0.0482
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0015 0.0022

Activities

Activity type Activity value Assay description Source Reference
CD50 (functional) > 100 uM Cytotoxic dose required to reduce the proliferation of normal uninfected MT-4 cells by 50% ChEMBL. 9457243
CD50 (functional) > 100 uM Cytotoxic dose required to reduce the proliferation of normal uninfected MT-4 cells by 50% ChEMBL. 9457243
ED50 (functional) = 21 uM Effective dose required for 50% inhibition of HIV-1 antigen production in MT-4 cultures ChEMBL. 9457243
SI (functional) > 5 Selectivity index is the ratio between CD50 and IC50 values of the compound ChEMBL. 9457243

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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