TDR Targets

Basic information

Technical information

TDR Targets ID: 873620
Name: 1-[(6-ethyl-2-pyrrol-1-yl-5,7-dihydro-4H-thie no[5,4-c]pyridin-3-yl)methyl]-3-(4-methoxyphe nyl)urea
MW: 410.532 | Formula: C22H26N4O2S
H donors: 2 H acceptors: 1 LogP: 3.08 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCN1CCc2c(C1)sc(c2CNC(=O)Nc1ccc(cc1)OC)n1cccc1
InChi: 1S/C22H26N4O2S/c1-3-25-13-10-18-19(21(29-20(18)15-25)26-11-4-5-12-26)14-23-22(27)24-16-6-8-17(28-2)9-7-16/h4-9,11-12H,3,10,13-15H2,1-2H3,(H2,23,24,27)
InChiKey: CHGIGZCILCCERS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[[6-ethyl-2-(1-pyrrolyl)-5,7-dihydro-4H-thieno[5,4-c]pyridin-3-yl]methyl]-3-(4-methoxyphenyl)urea

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0005	0.0104	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0063	0.0046
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.084	0.2803
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0016	0.084	0.2827
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.1065	0.4053
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0004	0.0019	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0063	0.0046
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0444	0.0443
Plasmodium falciparum	glutathione reductase	0.0016	0.084	0.2803
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0357	0.0352
Schistosoma mansoni	nuclear receptor	0.0005	0.0063	0.0046
Schistosoma mansoni	sulfide quinone reductase	0.0004	0.0019	0.0002
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.1065	0.3573
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0187	0.0713
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0444	0.0443
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.0063	0.0046
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0444	0.0457
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0444	0.0443
Toxoplasma gondii	thioredoxin reductase	0.0046	0.2946	0.7644
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0444	0.0443
Schistosoma mansoni	hypothetical protein	0.0004	0.0019	0.0002
Brugia malayi	hypothetical protein	0.0005	0.0063	0.0046
Trichomonas vaginalis	dihydrolipoamide dehydrogenase, putative	0.0004	0.0019	0.0074
Brugia malayi	PHD-finger family protein	0.0005	0.0082	0.0065
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.084	0.2803
Treponema pallidum	NADH oxidase	0.0016	0.084	0.7845
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0082	0.0065
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.2628	1
Plasmodium vivax	glutathione reductase, putative	0.0046	0.2946	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0005	0.0104	0.0087
Trichomonas vaginalis	apoptosis inducing factor, putative	0.0004	0.0019	0.0074
Loa Loa (eye worm)	hypothetical protein	0.001	0.0444	0.0443
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0004	0.0019	0.0074
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.084	0.2803
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0104	0.0088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.2987	0.2975
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0349	0.0344
Schistosoma mansoni	cpg binding protein	0.0031	0.1889	0.1875
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0232	0.0229
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0016	0.084	0.7845
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.0104	0.0088
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0004	0.0019	0.0074
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0444	0.0443
Brugia malayi	conserved hypotetical protein	0.0005	0.0063	0.0046
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0005	0.0063	0.0046
Onchocerca volvulus		0.001	0.0444	0.2423
Brugia malayi	nuclear hormone receptor family member odr-7	0.0005	0.0063	0.0046
Loa Loa (eye worm)	glutathione reductase	0.0046	0.2946	0.3054
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0444	0.0443
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0444	0.0443
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0187	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0063	0.0046
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0187	0.0713
Brugia malayi	nuclear receptor NHR-88	0.001	0.0444	0.0443
Plasmodium falciparum	glutathione reductase	0.0046	0.2946	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0357	0.0352
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0105	0.7074	0.8958
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0138	0.9324	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0059	0.3848	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0444	0.0457
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0444	0.0443
Brugia malayi	CXXC zinc finger family protein	0.0029	0.1772	0.183
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0005	0.0063	0.0046
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0444	0.0443
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0063	0.0046
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0105	0.7074	0.8958
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0005	0.0063	0.0046
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0046	0.2946	0.3716
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.1065	1
Brugia malayi	tailless protein	0.0005	0.0063	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0063	0.0046
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0444	0.0443
Schistosoma mansoni	cpg binding protein	0.0029	0.1772	0.1758
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0016	0.084	0.2803
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0005	0.0063	0.0046
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0005	0.0104	0.0088
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0005	0.0082	0.0065
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.2628	0.2803
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.1065	0.1091
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.1065	0.3573
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.084	0.7845
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.2628	0.6814
Mycobacterium tuberculosis	Probable reductase	0.0105	0.7074	0.8958
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0005	0.0104	0.0091
Brugia malayi	nuclear receptor RXR	0.0005	0.0104	0.0088
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.0004	0.0019	0.0074
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0187	0.0713
Brugia malayi	steroid hormone receptor	0.001	0.0444	0.0443
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0444	0.0443
Mycobacterium tuberculosis	Probable oxidoreductase	0.0117	0.7894	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0016	0.084	0.2803
Echinococcus granulosus	nuclear receptor nhr 48	0.0005	0.0063	0.0047
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0444	0.0443
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0444	0.0443
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0005	0.0063	0.0046
Loa Loa (eye worm)	hypothetical protein	0.001	0.0444	0.0443
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0004	0.0019	0.0074
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.084	0.2803
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0187	0.0713
Plasmodium vivax	type II NADH:ubiquinone oxidoreductase, putative	0.0004	0.0019	0.0033
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0444	0.0457
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0016	0.084	0.1042
Trichomonas vaginalis	helicase, putative	0.0007	0.0187	0.0713
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0012	0.0543	0.0547
Trichomonas vaginalis	mercuric reductase, putative	0.0016	0.084	0.3195
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0005	0.0063	0.0047
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0005	0.0063	0.025
Plasmodium falciparum	thioredoxin reductase	0.0016	0.084	0.2803
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.1065	1
Echinococcus granulosus	thyroid hormone receptor alpha	0.0005	0.0063	0.0047
Loa Loa (eye worm)	hypothetical protein	0.001	0.0444	0.0443
Loa Loa (eye worm)	hypothetical protein	0.001	0.0444	0.0443
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.1772	0.183
Echinococcus granulosus	cpg binding protein	0.0031	0.1889	0.201
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0187	0.0713
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0016	0.084	0.2803
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0187	0.0713
Brugia malayi	acetyltransferase, GNAT family protein	0.0142	0.9601	1
Onchocerca volvulus		0.0029	0.1772	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0444	0.0457
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0187	0.0713
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0444	0.0428
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.1065	0.1091
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.2628	1
Toxoplasma gondii	exonuclease III APE	0.0019	0.1065	0.2731
Loa Loa (eye worm)	nuclear hormone receptor	0.0005	0.0063	0.0046
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.407	0.406
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0063	0.0046
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.2987	0.3097
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0104	0.0088
Trichomonas vaginalis	glutamate synthase, putative	0.0004	0.0019	0.0074
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0187	0.0713
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.0104	0.0088
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0005	0.0082	0.0067
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0444	0.0443
Brugia malayi	ecdysone receptor	0.0005	0.0063	0.0046
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0444	0.0443
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0232	0.0222
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0105	0.7074	0.8958
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0016	0.084	0.2803
Schistosoma mansoni	bromodomain containing protein	0.0005	0.0082	0.0065
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.084	0.0856
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.2987	0.3097
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0063	0.0046
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0005	0.0063	0.0046
Schistosoma mansoni	glutamate synthase	0.0004	0.0019	0.0002
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.1065	0.4419
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.2946	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0444	0.0428
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.2987	0.2975
Brugia malayi	hypothetical protein	0.0005	0.0104	0.0088
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0444	0.0428
Brugia malayi	nuclear receptor RXR	0.0005	0.0063	0.0046
Schistosoma mansoni	zinc finger protein	0.0005	0.0082	0.0065
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0004	0.0019	0.0074
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0444	0.0428
Plasmodium falciparum	thioredoxin reductase	0.0046	0.2946	1
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0016	0.084	1
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0104	0.0088
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0444	0.0443
Onchocerca volvulus		0.0005	0.0063	0.025
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.084	0.7845
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.1065	0.4419
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.1065	0.3573
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0104	0.0088
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0444	0.0428
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0444	0.0443
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.2987	0.319
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.0063	0.0046
Loa Loa (eye worm)	hypothetical protein	0.001	0.0444	0.0443
Trypanosoma brucei	trypanothione reductase	0.0046	0.2946	1
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0016	0.084	0.2803
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0016	0.084	0.0882
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0063	0.0046
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0232	0.0229
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0005	0.0104	0.0087
Brugia malayi	nuclear receptor NHR-67	0.0005	0.0063	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0063	0.0046
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0444	0.0457
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0444	0.0428
Schistosoma mansoni	bromodomain containing protein	0.0005	0.0082	0.0065
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0444	0.0457
Schistosoma mansoni	glutamate synthase	0.0004	0.0019	0.0002
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0016	0.084	0.2803
Schistosoma mansoni	glutamate synthase	0.0004	0.0019	0.0002
Brugia malayi	hypothetical protein	0.0005	0.0063	0.0046
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.2987	0.319
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0187	0.0713
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0016	0.084	0.0824
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0142	0.9601	1
Brugia malayi	nuclear receptor NHR-88	0.0005	0.0063	0.0046
Schistosoma mansoni	nuclear receptor nhr-48	0.0005	0.0063	0.0046
Schistosoma mansoni	sulfide quinone reductase	0.0004	0.0019	0.0002
Mycobacterium tuberculosis	Probable dehydrogenase	0.0105	0.7074	0.8958
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.2946	1
Schistosoma mansoni	ap endonuclease	0.0019	0.1065	0.105
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0357	0.0363
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0444	0.0443
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.2987	0.3097
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0444	0.0443
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0005	0.0063	0.0046
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0187	0.0713
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.2386	0.8087
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0444	0.0457
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0444	0.0428
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0117	0.7894	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0005	0.0063	0.0046
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.1065	0.3594
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0004	0.0019	0.0074
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0444	0.0443
Trichomonas vaginalis	glutamate synthase, putative	0.0004	0.0019	0.0074
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0105	0.7074	0.8958
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0063	0.0046
Plasmodium vivax	ferrodoxin reductase, putative	0.0004	0.0019	0.0033
Trichomonas vaginalis	glutathione reductase, putative	0.0016	0.084	0.3195
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.084	0.2803
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.084	0.2803
Brugia malayi	Nuclear hormone receptor E75	0.0005	0.0063	0.0046
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0444	0.0443
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0444	0.0443
Echinococcus granulosus	zinc finger protein	0.0005	0.0082	0.0067
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.1065	0.1328
Schistosoma mansoni	nuclear receptor	0.0005	0.0063	0.0046
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.084	0.2803
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0187	0.0713
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0444	0.0428
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.2946	0.3145
Brugia malayi	Thioredoxin reductase	0.0046	0.2946	0.3054
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0012	0.0543	0.0547
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0444	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0063	0.0046
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.2946	0.3054
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0016	0.084	0.0856
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0016	0.084	0.2827
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0063	0.0046
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.1065	0.3573
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0082	0.0065
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0444	0.0457
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0444	0.0428
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0005	0.0063	0.0047
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0444	0.0428
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0444	0.2423
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0444	0.0443
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0444	0.0443
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0444	0.0457
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0142	0.9601	0.96
Brugia malayi	nuclear hormone receptor	0.001	0.0444	0.0443
Loa Loa (eye worm)	hypothetical protein	0.001	0.0444	0.0443
Schistosoma mansoni	ap endonuclease	0.0019	0.1065	0.105
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.084	0.2803
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.1065	0.1091
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.2628	0.6814
Brugia malayi	nuclear hormone receptor	0.0005	0.0063	0.0046
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.084	0.2803
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0016	0.084	0.7845
Brugia malayi	orphan nuclear receptor NR2E1	0.0005	0.0063	0.0046
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0016	0.084	0.2143
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0004	0.0019	0.0074
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0005	0.0063	0.0046
Loa Loa (eye worm)	acetyltransferase	0.0142	0.9601	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0232	0.0216
Plasmodium vivax	NAD(P)H-dependent glutamate synthase, putative	0.0004	0.0019	0.0033
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.2386	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0005	0.0063	0.0047
Leishmania major	trypanothione reductase	0.0046	0.2946	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0444	0.0443
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0004	0.0019	0.0074
Echinococcus multilocularis	zinc finger protein	0.0005	0.0082	0.0065
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.1065	0.4053
Schistosoma mansoni	coup transcription factor	0.001	0.0444	0.0428
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0444	0.0428
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0444	0.0443
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.1065	0.3573
Schistosoma mansoni	disulfide oxidoreductase	0.0004	0.0019	0.0002
Brugia malayi	Nuclear hormone receptor E75	0.0005	0.0063	0.0046
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0444	0.2423
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0005	0.0063	0.0046
Echinococcus multilocularis	nuclear receptor nhr 48	0.0005	0.0063	0.0046
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.2946	0.3054
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.084	0.2803
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0104	0.0088
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0444	0.0443
Brugia malayi	glutathione reductase	0.0046	0.2946	0.3054
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0005	0.0063	0.025
Brugia malayi	hypothetical protein	0.0005	0.0104	0.0088
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0187	0.0713
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0016	0.084	0.7845
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0016	0.084	0.2803
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0444	0.0443
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0117	0.7894	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.2987	0.2975
Schistosoma mansoni	cpg binding protein	0.0031	0.1889	0.1875
Onchocerca volvulus		0.0005	0.0063	0.025
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0005	0.0063	0.0047
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0444	0.2423
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0444	0.0443
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.2386	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0187	0.0713
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0444	0.0443
Loa Loa (eye worm)	hypothetical protein	0.001	0.0444	0.0443
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0105	0.7074	0.8958
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.084	0.2803
Loa Loa (eye worm)	DR-78	0.0005	0.0063	0.0046
Brugia malayi	ecdysteroid receptor	0.001	0.0444	0.0443
Schistosoma mansoni	zinc finger protein	0.0005	0.0063	0.0046
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.084	0.2803
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0444	0.0443
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0232	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0063	0.0046
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.2987	0.3097
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0444	0.0443
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0187	0.0713
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.2628	0.8918
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0016	0.084	0.3466
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0005	0.0063	0.0046
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0187	0.0713
Echinococcus multilocularis	cpg binding protein	0.0031	0.1889	0.1951
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0444	0.0443
Brugia malayi	Bromodomain containing protein	0.0005	0.0082	0.0065
Toxoplasma gondii	NADPH-glutathione reductase	0.0016	0.084	0.2143
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0117	0.7894	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.1065	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0444	0.0443
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0187	0.0713
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.1065	0.1124

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

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Detailed information for compound 873620