Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.052 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0275 | 0.4972 | 0.4922 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.437 | 0.437 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.052 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.052 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0245 | 0.437 | 0.4313 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.052 | 1 | 1 |
Loa Loa (eye worm) | DR-78 | 0.0245 | 0.437 | 0.437 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.052 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.052 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.052 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.437 | 0.437 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.052 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.052 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.052 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.052 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.052 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.052 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.052 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.4972 | 0.4972 |
Brugia malayi | hypothetical protein | 0.0245 | 0.437 | 0.4313 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0275 | 0.4972 | 0.4886 |
Schistosoma mansoni | nuclear receptor | 0.0245 | 0.437 | 0.4272 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.052 | 1 | 1 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0245 | 0.437 | 0.4313 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.052 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.052 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.052 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.0245 | 0.437 | 0.4313 |
Loa Loa (eye worm) | hypothetical protein | 0.052 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.052 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.052 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.437 | 0.437 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.052 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.437 | 0.437 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.052 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0245 | 0.437 | 0.437 |
Loa Loa (eye worm) | hypothetical protein | 0.052 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.052 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.052 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.052 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.052 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0275 | 0.4972 | 0.4922 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.4972 | 0.4972 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0245 | 0.437 | 0.4313 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.052 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.052 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.437 | 0.437 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.437 | 0.437 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0275 | 0.4972 | 0.4886 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.052 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.052 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0275 | 0.4972 | 0.4922 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0245 | 0.437 | 0.437 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.052 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.052 | 1 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0245 | 0.437 | 0.437 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0245 | 0.437 | 0.4313 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0245 | 0.437 | 0.4313 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.052 | 1 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0245 | 0.437 | 0.4272 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0245 | 0.437 | 0.4272 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.437 | 0.437 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.4972 | 0.4972 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0037 | 0.01 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.052 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0245 | 0.437 | 0.4313 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0245 | 0.437 | 0.4313 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.437 | 0.437 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.052 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.052 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.052 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0035 | 0.005 | 0.5 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0245 | 0.437 | 0.4313 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.052 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.4972 | 0.4972 |
Loa Loa (eye worm) | hypothetical protein | 0.052 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.052 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.052 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.052 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0275 | 0.4972 | 0.4922 |
Schistosoma mansoni | nuclear hormone receptor | 0.0245 | 0.437 | 0.4272 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.052 | 1 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0245 | 0.437 | 0.4313 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0245 | 0.437 | 0.4272 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.052 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0245 | 0.437 | 0.4313 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.052 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.052 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.052 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.052 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0275 | 0.4972 | 0.4922 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.4972 | 0.4972 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.052 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.437 | 0.437 |
Brugia malayi | steroid hormone receptor | 0.052 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0245 | 0.437 | 0.4272 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.437 | 0.437 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0245 | 0.437 | 0.4313 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.052 | 1 | 1 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0245 | 0.437 | 0.4313 |
Onchocerca volvulus | 0.052 | 1 | 1 | |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.052 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.437 | 0.437 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.052 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.052 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.052 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.052 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0275 | 0.4972 | 0.4922 |
Schistosoma mansoni | nuclear hormone receptor | 0.0245 | 0.437 | 0.4272 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0245 | 0.437 | 0.4313 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0245 | 0.437 | 0.4313 |
Brugia malayi | hypothetical protein | 0.0275 | 0.4972 | 0.4922 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.052 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.052 | 1 | 1 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0245 | 0.437 | 0.4313 |
Brugia malayi | conserved hypotetical protein | 0.0245 | 0.437 | 0.4313 |
Brugia malayi | nuclear receptor RXR | 0.0245 | 0.437 | 0.4313 |
Loa Loa (eye worm) | hypothetical protein | 0.052 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.437 | 0.437 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0275 | 0.4972 | 0.4972 |
Loa Loa (eye worm) | steroid hormone receptor | 0.052 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0245 | 0.437 | 0.4313 |
Schistosoma mansoni | nuclear hormone receptor | 0.052 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.437 | 0.437 |
Brugia malayi | ecdysone receptor | 0.0245 | 0.437 | 0.4313 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.052 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.052 | 1 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0245 | 0.437 | 0.4272 |
Brugia malayi | nuclear receptor NHR-88 | 0.0245 | 0.437 | 0.4313 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.052 | 1 | 1 |
Brugia malayi | tailless protein | 0.0245 | 0.437 | 0.4313 |
Brugia malayi | nuclear hormone receptor | 0.0245 | 0.437 | 0.4313 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0035 | 0.005 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.052 | 1 | 1 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0245 | 0.437 | 0.4313 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.052 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0245 | 0.437 | 0.4313 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0245 | 0.437 | 0.4313 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.052 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.