Detailed information for compound 873948

Basic information

Technical information
  • TDR Targets ID: 873948
  • Name: 3-[[2-(3,5-dimethylphenyl)-1,1,3-trioxobenzo[ e][1,2,4]thiadiazin-4-yl]methyl]benzonitrile
  • MW: 417.48 | Formula: C23H19N3O3S
  • H donors: 0 H acceptors: 4 LogP: 4 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cccc(c1)CN1C(=O)N(c2cc(C)cc(c2)C)S(=O)(=O)c2c1cccc2
  • InChi: 1S/C23H19N3O3S/c1-16-10-17(2)12-20(11-16)26-23(27)25(15-19-7-5-6-18(13-19)14-24)21-8-3-4-9-22(21)30(26,28)29/h3-13H,15H2,1-2H3
  • InChiKey: ZABOBLWYDYSWBJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[[2-(3,5-dimethylphenyl)-1,1,3-trioxo-benzo[e][1,2,4]thiadiazin-4-yl]methyl]benzonitrile
  • 3-[[2-(3,5-dimethylphenyl)-1,1,3-trioxo-4-benzo[e][1,2,4]thiadiazinyl]methyl]benzonitrile
  • 3-[[2-(3,5-dimethylphenyl)-1,1,3-triketo-benzo[e][1,2,4]thiadiazin-4-yl]methyl]benzonitrile

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0038 0.0164 0.0219
Schistosoma mansoni importin beta-1 0.0029 0.0101 0.0091
Brugia malayi Latrophilin receptor protein 2 0.0015 0.001 0.0013
Brugia malayi intermediate filament protein 0.0028 0.0097 0.013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0333 0.0324
Onchocerca volvulus 0.0028 0.0097 0.03
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0206 0.2293
Schistosoma mansoni hypothetical protein 0.0705 0.4685 0.4679
Brugia malayi Glycosyl hydrolases family 31 protein 0.0167 0.1039 0.1391
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0008 0.0011
Schistosoma mansoni hypothetical protein 0.009 0.0516 0.0507
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0189 0.1185 0.3663
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.0206 0.2293
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0097 0.013
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0158 0.1758
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.005 0.0555
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0101 0.1128
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0089 0.0986
Echinococcus multilocularis aryl hydrocarbon receptor 0.0026 0.0085 0.0076
Echinococcus multilocularis microtubule associated protein 2 0.149 1 1
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.009 0.0516 0.0507
Mycobacterium tuberculosis Carboxylesterase LipT 0.0189 0.1185 0.1623
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0034 0.0381
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0291 0.1878 0.2771
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0158 0.0488
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0232 0.1476 0.1468
Echinococcus granulosus dnaJ subfamily B 0.0825 0.5494 0.549
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0158 0.0488
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0164 0.5898
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0189 0.1185 0.1176
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.1039 0.103
Mycobacterium ulcerans putative regulatory protein 0.0075 0.0416 0.2173
Schistosoma mansoni BC026374 protein (S09 family) 0.0189 0.1185 0.1176
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0338 0.0452
Schistosoma mansoni aldehyde dehydrogenase 0.0185 0.1162 0.1153
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0026 0.0085 0.0952
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0243 0.075
Echinococcus multilocularis neuroligin 0.0189 0.1185 0.1176
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0015 0.0005
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0146 0.0897 0.1201
Trichomonas vaginalis mercuric reductase, putative 0.0044 0.0206 0.0636
Echinococcus multilocularis BC026374 protein (S09 family) 0.0189 0.1185 0.1176
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0015 0.0005
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0026 0.0085 0.0076
Loa Loa (eye worm) glutaminase 0.0279 0.1793 0.2401
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.0892 0.1193
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0232 0.1476 0.1468
Trypanosoma brucei glucosidase, putative 0.0037 0.0158 0.1758
Entamoeba histolytica hypothetical protein 0.0035 0.0142 0.825
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0097 0.013
Loa Loa (eye worm) hypothetical protein 0.1117 0.7471 1
Loa Loa (eye worm) apoptosis regulator protein 0.009 0.0516 0.0691
Leishmania major importin beta-1 subunit, putative 0.0023 0.0064 0.0554
Trichomonas vaginalis adenylate cyclase, putative 0.0026 0.0085 0.0264
Giardia lamblia NADH oxidase lateral transfer candidate 0.0044 0.0206 0.809
Plasmodium vivax glutathione reductase, putative 0.0128 0.077 0.8561
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0234 0.0313
Schistosoma mansoni hypothetical protein 0.0825 0.5494 0.549
Brugia malayi Carboxylesterase family protein 0.1117 0.7471 1
Schistosoma mansoni hypothetical protein 0.009 0.0516 0.0507
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0164 0.0506
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0085 0.0264
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0085 0.0264
Trichomonas vaginalis D-aminoacylase, putative 0.0146 0.0897 0.2775
Plasmodium falciparum importin beta, putative 0.0029 0.0101 0.1137
Echinococcus multilocularis snurportin 1 0.0307 0.1987 0.1979
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0935 0.6238 1
Mycobacterium tuberculosis Conserved protein 0.0146 0.0897 0.1146
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0015 0.0172
Onchocerca volvulus 0.0189 0.1185 0.3663
Leishmania major protein kinase, putative 0.0027 0.0089 0.0762
Loa Loa (eye worm) beta-lactamase 0.0146 0.0897 0.1201
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0315 0.0306
Echinococcus granulosus para nitrobenzyl esterase 0.0189 0.1185 0.1176
Schistosoma mansoni cpg binding protein 0.0061 0.0321 0.0311
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0044 0.0206 0.0975
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0164 0.0154
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0044 0.0206 0.2293
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0189 0.1185 0.1176
Echinococcus granulosus lamin 0.0028 0.0097 0.0087
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0267 0.2979
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0267 0.3337
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0243 0.1982
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0158 0.0488
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0013
Brugia malayi Pre-SET motif family protein 0.0063 0.0333 0.0446
Brugia malayi hypoxia-induced factor 1 0.0315 0.2039 0.273
Trypanosoma brucei trypanothione reductase 0.0128 0.077 0.8586
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0044 0.0206 0.2293
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0043 0.0033
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0021
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0167 0.1039 0.1391
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0172 0.6334
Entamoeba histolytica hypothetical protein 0.0035 0.0142 0.825
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0044 0.0206 0.2521
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0021
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0164 0.0154
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0158 0.0211
Mycobacterium tuberculosis Probable oxidoreductase 0.0323 0.2097 0.3136
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0164 0.1408
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0015 0.0005
Loa Loa (eye worm) hypothetical protein 0.0189 0.1185 0.1585
Loa Loa (eye worm) hypothetical protein 0.0189 0.1185 0.1585
Brugia malayi jmjC domain containing protein 0.0016 0.0015 0.0021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0206 0.2293
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.005 0.0067
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0164 0.1822
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0015 0.0005
Schistosoma mansoni single-minded 0.0102 0.0596 0.0586
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0185 0.1162 0.1584
Trichomonas vaginalis esterase, putative 0.0146 0.0897 0.2775
Entamoeba histolytica hypothetical protein 0.0035 0.0142 0.825
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0315 0.0306
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.005 0.0555
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.009 0.0516 0.0507
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0232 0.1476 0.1468
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0164 0.0154
Echinococcus multilocularis neuropeptide receptor A26 0.0479 0.3152 0.3145
Brugia malayi jmjC domain containing protein 0.0064 0.0338 0.0452
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0243 0.2089
Mycobacterium tuberculosis Probable dehydrogenase 0.0291 0.1878 0.2771
Mycobacterium ulcerans aldehyde dehydrogenase 0.0185 0.1162 0.6408
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.009 0.0516 0.0507
Schistosoma mansoni ran 0.0021 0.005 0.004
Loa Loa (eye worm) hypothetical protein 0.0189 0.1185 0.1585
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0164 0.0506
Trichomonas vaginalis penicillin-binding protein, putative 0.0146 0.0897 0.2775
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.013 0.0174
Loa Loa (eye worm) hypothetical protein 0.009 0.0516 0.0691
Plasmodium falciparum thioredoxin reductase 0.0128 0.077 1
Onchocerca volvulus 0.0189 0.1185 0.3663
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0243 0.2704
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0085 0.0264
Loa Loa (eye worm) carboxylesterase 0.1117 0.7471 1
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.009 0.0516 0.0507
Mycobacterium tuberculosis Probable reductase 0.0291 0.1878 0.2771
Leishmania major hypothetical protein, conserved 0.0146 0.0897 0.7726
Trypanosoma brucei hypothetical protein, conserved 0.0146 0.0897 1
Brugia malayi Cytochrome P450 family protein 0.0047 0.0228 0.0305
Brugia malayi Cytochrome P450 family protein 0.0019 0.0034 0.0046
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0158 0.1242
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.005 0.004
Echinococcus multilocularis acetylcholinesterase 0.1117 0.7471 0.7468
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0189 0.1185 0.1176
Loa Loa (eye worm) hypothetical protein 0.0146 0.0897 0.1201
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.009 0.0516 0.0507
Loa Loa (eye worm) hypothetical protein 0.0028 0.0097 0.013
Loa Loa (eye worm) carboxylesterase 0.0189 0.1185 0.1585
Trypanosoma brucei protein kinase, putative 0.005 0.0243 0.2704
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0085 0.0264
Schistosoma mansoni hypothetical protein 0.0035 0.0142 0.0132
Brugia malayi Carboxylesterase family protein 0.0189 0.1185 0.1585
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0234 0.0313
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0044 0.0206 0.0196
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0232 0.1476 0.1976
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0189 0.1185 0.1585
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0044 0.0206 0.2293
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0015 0.0021
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0015 0.0005
Loa Loa (eye worm) hypothetical protein 0.0028 0.0093 0.0125
Echinococcus granulosus lysine specific demethylase 5A 0.0064 0.0338 0.0328
Loa Loa (eye worm) hypothetical protein 0.0146 0.0897 0.1201
Brugia malayi hypothetical protein 0.0189 0.1185 0.1585
Onchocerca volvulus 0.0097 0.0562 0.1737
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0243 0.0325
Echinococcus multilocularis para nitrobenzyl esterase 0.0189 0.1185 0.1176
Loa Loa (eye worm) carboxylesterase 0.0189 0.1185 0.1585
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0243 0.075
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0158 0.0488
Schistosoma mansoni hypothetical protein 0.0307 0.1987 0.1979
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0232 0.1476 0.1976
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0089 0.0986
Onchocerca volvulus 0.0028 0.0097 0.03
Onchocerca volvulus 0.0075 0.0416 0.1288
Echinococcus granulosus cpg binding protein 0.0061 0.0321 0.0311
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0189 0.1185 0.1176
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0044 0.0206 0.2293
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0196 0.1576
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0158 0.0488
Echinococcus granulosus beta LACTamase domain containing family member 0.0146 0.0897 0.0888
Echinococcus multilocularis lamin 0.0028 0.0097 0.0087
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0044 0.0206 0.2159
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0015 0.0005
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0026 0.0085 0.0736
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0267 0.3337
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0338 0.0328
Echinococcus granulosus intermediate filament protein 0.0028 0.0097 0.0087
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0146 0.0897 0.1201
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0243 0.0233
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0232 0.1476 0.1468
Loa Loa (eye worm) hypothetical protein 0.0189 0.1185 0.1585
Brugia malayi Carboxylesterase family protein 0.0189 0.1185 0.1585
Echinococcus granulosus thioredoxin glutathione reductase 0.0129 0.0778 0.0768
Plasmodium falciparum thioredoxin reductase 0.0044 0.0206 0.2521
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0101 0.0749
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0101 0.1128
Schistosoma mansoni acetylcholinesterase 0.0189 0.1185 0.1176
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0034 0.0046
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0019 0.0009
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0146 0.0897 0.1146
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0019 0.0009
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0196 0.2048
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.0892 0.0882
Echinococcus granulosus carboxylesterase 5A 0.1117 0.7471 0.7468
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0015 0.0005
Echinococcus granulosus geminin 0.0705 0.4685 0.4679
Loa Loa (eye worm) hypothetical protein 0.0146 0.0897 0.1201
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0038 0.0028
Mycobacterium tuberculosis Conserved protein 0.0146 0.0897 0.1146
Brugia malayi Carboxylesterase family protein 0.0189 0.1185 0.1585
Echinococcus multilocularis acetylcholinesterase 0.1117 0.7471 0.7468
Schistosoma mansoni hypothetical protein 0.0024 0.0068 0.0058
Brugia malayi Carboxylesterase family protein 0.1117 0.7471 1
Plasmodium vivax thioredoxin reductase, putative 0.0128 0.077 0.8561
Echinococcus granulosus acetylcholinesterase 0.1117 0.7471 0.7468
Schistosoma mansoni neuroligin 3 (S09 family) 0.0189 0.1185 0.1176
Leishmania major trypanothione reductase 0.0128 0.077 0.6633
Brugia malayi glutaminase DH11.1 0.0279 0.1793 0.2401
Mycobacterium ulcerans carboxylesterase, LipT 0.0189 0.1185 0.6539
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0085 0.0264
Brugia malayi beta-lactamase 0.0146 0.0897 0.1201
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0068 0.0058
Echinococcus granulosus lysosomal alpha glucosidase 0.0167 0.1039 0.103
Mycobacterium ulcerans aldehyde dehydrogenase 0.0185 0.1162 0.6408
Brugia malayi Pre-SET motif family protein 0.0432 0.2831 0.3789
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0043 0.0033
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0085 0.0264
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0044 0.0206 0.2521
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0315 0.0306
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0164 0.0154
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0044 0.0206 0.1772
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0128 0.077 0.0936
Treponema pallidum NADH oxidase 0.0044 0.0206 0.5
Loa Loa (eye worm) hypothetical protein 0.0146 0.0897 0.1201
Plasmodium falciparum glutathione reductase 0.0044 0.0206 0.2521
Onchocerca volvulus 0.0058 0.0299 0.0924
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0196 0.0606
Brugia malayi jmjC domain containing protein 0.006 0.0315 0.0422
Toxoplasma gondii aldehyde dehydrogenase 0.0185 0.1162 1
Schistosoma mansoni microtubule-associated protein tau 0.149 1 1
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.009 0.0516 0.0691
Schistosoma mansoni lamin 0.0028 0.0097 0.0087
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0309 0.03
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0044 0.0206 0.0975
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0333 0.2772
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0243 0.075
Echinococcus multilocularis thioredoxin glutathione reductase 0.0129 0.0778 0.0768
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0038 0.0028
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0034 0.0381
Echinococcus granulosus neuropeptide s receptor 0.0479 0.3152 0.3145
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0267 0.2857
Schistosoma mansoni hypothetical protein 0.0033 0.013 0.012
Mycobacterium ulcerans aldehyde dehydrogenase 0.0185 0.1162 0.6408
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.005 0.039
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0323 0.2097 1
Loa Loa (eye worm) acetyltransferase 0.0145 0.0892 0.1193
Schistosoma mansoni aldehyde dehydrogenase 0.0185 0.1162 0.1153
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0085 0.0264
Mycobacterium ulcerans lipase LipD 0.0146 0.0897 0.4906
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0158 0.0211
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0032 0.0126 0.0169
Brugia malayi Carboxylesterase family protein 0.0189 0.1185 0.1585
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0164 0.0154
Brugia malayi hypothetical protein 0.0035 0.0142 0.019
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0333 0.0324
Trichomonas vaginalis set domain proteins, putative 0.0491 0.3234 1
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0015 0.0172
Trichomonas vaginalis D-aminoacylase, putative 0.0146 0.0897 0.2775
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0243 0.0233
Brugia malayi hypothetical protein 0.0053 0.0267 0.0358
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0196 0.0606
Brugia malayi RNA, U transporter 1 0.0082 0.0461 0.0616
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0064 0.0199
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0034 0.0381
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0044 0.0206 0.0196
Schistosoma mansoni gliotactin 0.0189 0.1185 0.1176
Echinococcus granulosus acetylcholinesterase 0.1117 0.7471 0.7468
Mycobacterium ulcerans esterase/lipase LipP 0.0146 0.0897 0.4906
Echinococcus multilocularis musashi 0.0028 0.0097 0.0087
Loa Loa (eye worm) hypoxia-induced factor 1 0.0315 0.2039 0.273
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.005 0.0555
Toxoplasma gondii NADPH-glutathione reductase 0.0044 0.0206 0.1661
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0206 0.2293
Leishmania major GTP-binding protein, putative 0.0021 0.005 0.0429
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0158 0.0488
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0242 0.1543 0.2066
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0338 0.0328
Schistosoma mansoni intermediate filament proteins 0.0028 0.0097 0.0087
Loa Loa (eye worm) thioredoxin reductase 0.0128 0.077 0.1031
Schistosoma mansoni apoptosis regulator bax 0.009 0.0516 0.0507
Mycobacterium tuberculosis Conserved protein 0.0146 0.0897 0.1146
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0019 0.0009
Echinococcus multilocularis cpg binding protein 0.0061 0.0321 0.0311
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0206 0.2293
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0142 0.0132
Mycobacterium leprae conserved hypothetical protein 0.0146 0.0897 0.4035
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0044 0.0206 0.0975
Trichomonas vaginalis spcc417.12 protein, putative 0.0189 0.1185 0.3663
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0267 0.2198
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0026 0.0085 0.0952
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0158 0.0488
Leishmania major protein kinase, putative 0.0027 0.0089 0.0762
Leishmania major cytochrome p450-like protein 0.0019 0.0034 0.0294
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0015 0.0005
Brugia malayi follicle stimulating hormone receptor 0.0242 0.1543 0.2066
Onchocerca volvulus 0.0026 0.0085 0.0264
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0189 0.1185 0.1176
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0189 0.1185 0.1623
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0291 0.1878 0.2771
Plasmodium vivax SET domain protein, putative 0.0063 0.0333 0.3603
Schistosoma mansoni alpha glucosidase 0.0037 0.0158 0.0148
Schistosoma mansoni cpg binding protein 0.0058 0.0299 0.0289
Loa Loa (eye worm) hypothetical protein 0.0063 0.0333 0.0446
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0243 0.2704
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0243 0.2704
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0291 0.1878 0.2771
Loa Loa (eye worm) hypothetical protein 0.0189 0.1185 0.1585
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0164 0.0154
Echinococcus multilocularis carboxylesterase 5A 0.1117 0.7471 0.7468
Trichomonas vaginalis D-aminoacylase, putative 0.0146 0.0897 0.2775
Echinococcus multilocularis beta LACTamase domain containing family member 0.0146 0.0897 0.0888
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0196 0.1576
Brugia malayi jmjC domain containing protein 0.0016 0.0015 0.0021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0206 0.2293
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.005 0.03
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0044 0.0206 0.2293
Plasmodium falciparum glutathione reductase 0.0128 0.077 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0089 0.0986
Mycobacterium tuberculosis Probable esterase LipL 0.0146 0.0897 0.1146
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1117 0.7471 0.7468
Echinococcus granulosus snurportin 1 0.0307 0.1987 0.1979
Brugia malayi PAS domain containing protein 0.0102 0.0596 0.0797
Trichomonas vaginalis penicillin-binding protein, putative 0.0146 0.0897 0.2775
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0015 0.0005
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0044 0.0206 0.5
Brugia malayi hypothetical protein 0.0034 0.0139 0.0187
Echinococcus multilocularis transfer RNA-Lys 0.0075 0.0416 0.0407
Brugia malayi MAP kinase sur-1 0.005 0.0243 0.0325
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0232 0.1476 0.1468
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0019 0.0009
Loa Loa (eye worm) hypothetical protein 0.0146 0.0897 0.1201
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0243 0.2089
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0243 0.075
Trichomonas vaginalis glutaminase, putative 0.0279 0.1793 0.5546
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0158 0.1358
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0044 0.0206 0.0275
Schistosoma mansoni aryl hydrocarbon receptor 0.0102 0.0596 0.0586
Onchocerca volvulus 0.0491 0.3234 1
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0026 0.0085 0.0114
Onchocerca volvulus 0.0189 0.1185 0.3663
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0164 0.1822
Mycobacterium tuberculosis Probable hydrolase 0.0146 0.0897 0.1146
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0158 0.0148
Brugia malayi bHLH-PAS transcription factor 0.0075 0.0416 0.0557
Mycobacterium ulcerans glutaminase 0.0279 0.1793 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0164 0.1822
Trypanosoma cruzi hypothetical protein, conserved 0.0146 0.0897 1
Schistosoma mansoni ran 0.0021 0.005 0.004
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0243 1
Loa Loa (eye worm) glutathione reductase 0.0128 0.077 0.1031
Toxoplasma gondii thioredoxin reductase 0.0128 0.077 0.6588
Brugia malayi hypothetical protein 0.0341 0.2218 0.2969
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0044 0.0206 0.0196
Mycobacterium tuberculosis Probable lipase LipD 0.0146 0.0897 0.1146
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0243 0.2704
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0291 0.1878 0.8907
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0333 0.0324
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0097 0.013
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0185 0.1162 0.1153
Brugia malayi beta-lactamase family protein 0.0146 0.0897 0.1201
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0333 0.0324
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0044 0.0206 0.1772
Loa Loa (eye worm) hypothetical protein 0.0189 0.1185 0.1585
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0333 0.0324
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0044 0.0206 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0164 0.0506
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0044 0.0206 0.2159
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0158 0.0488
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0333 0.0324
Entamoeba histolytica hypothetical protein 0.0035 0.0142 0.825
Mycobacterium leprae Probable lipase LipE 0.0146 0.0897 0.4035
Echinococcus granulosus aryl hydrocarbon receptor 0.0026 0.0085 0.0076
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0146 0.0897 0.0888
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.001 0.0013
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.001 0.0013
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0146 0.0897 0.1146
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0243 0.0233
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0164 0.0154
Loa Loa (eye worm) glutaminase 2 0.0279 0.1793 0.2401
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0158 0.1758
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0164 0.0154
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0299 0.04
Brugia malayi Importin beta-1 subunit 0.0029 0.0101 0.0136
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0015 0.0021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0232 0.1476 0.1468
Echinococcus multilocularis lamin dm0 0.0028 0.0097 0.0087
Loa Loa (eye worm) hypothetical protein 0.1117 0.7471 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0034 0.0046
Schistosoma mansoni glutaminase 0.0279 0.1793 0.1785
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0015 0.0005
Loa Loa (eye worm) histone methyltransferase 0.002 0.0043 0.0058
Echinococcus multilocularis geminin 0.0705 0.4685 0.4679
Brugia malayi Cytochrome P450 family protein 0.0019 0.0034 0.0046
Loa Loa (eye worm) hypothetical protein 0.0033 0.013 0.0174
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0172 0.2073
Plasmodium vivax hypothetical protein, conserved 0.0146 0.0897 1
Schistosoma mansoni jumonji domain containing protein 0.006 0.0315 0.0306
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0158 0.0148
Brugia malayi Thioredoxin reductase 0.0128 0.077 0.1031
Echinococcus granulosus importin subunit beta 1 0.0029 0.0101 0.0091
Mycobacterium tuberculosis Probable lipase LipE 0.0146 0.0897 0.1146
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0015 0.0005
Schistosoma mansoni alpha-glucosidase 0.0144 0.0882 0.0873
Onchocerca volvulus 0.0146 0.0897 0.2775
Echinococcus granulosus phd:f box containing protein 0.0016 0.0015 0.0005
Loa Loa (eye worm) hypothetical protein 0.0146 0.0897 0.1201
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0042 0.0056
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0142 0.0132
Leishmania major hypothetical protein, conserved 0.0053 0.0267 0.2302
Entamoeba histolytica Ran family GTPase 0.0021 0.005 0.2896
Entamoeba histolytica hypothetical protein 0.0023 0.0064 0.3745
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.0892 0.0882
Brugia malayi CXXC zinc finger family protein 0.0058 0.0299 0.04
Trypanosoma cruzi hypothetical protein, conserved 0.0146 0.0897 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0307 0.1987 0.2659
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0158 0.9177
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0323 0.2097 0.3136
Echinococcus granulosus lamin dm0 0.0028 0.0097 0.0087
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0196 0.0186
Onchocerca volvulus 0.0189 0.1185 0.3663
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0015 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0085 0.0264
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0267 0.2979
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0034 0.0046
Brugia malayi jmjC domain containing protein 0.0016 0.0015 0.0021
Loa Loa (eye worm) acetylcholinesterase 1 0.1117 0.7471 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0142 0.0132
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0032 0.0126 0.0169
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0432 0.2831 0.3789
Loa Loa (eye worm) hypothetical protein 0.0048 0.0234 0.0313
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.005 0.0455
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0291 0.1878 0.2771
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0008 0.0011
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0323 0.2097 0.3136
Loa Loa (eye worm) hypothetical protein 0.0341 0.2218 0.2969
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0146 0.0897 0.4906
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0185 0.1162 0.1153
Schistosoma mansoni cpg binding protein 0.0061 0.0321 0.0311
Echinococcus granulosus BC026374 protein S09 family 0.0189 0.1185 0.1176
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0172 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0243 0.2704
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0164 0.0219
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0243 0.0233
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0164 0.9511
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0206 0.2293
Echinococcus granulosus neuropeptide receptor A26 0.0479 0.3152 0.3145
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0146 0.0897 0.0888
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.1039 0.103
Trypanosoma cruzi trypanothione reductase, putative 0.0128 0.077 0.8586
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0146 0.0897 0.1146
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.0864 0.0855
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.005 0.004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0085 0.0114
Schistosoma mansoni alpha-glucosidase 0.0144 0.0882 0.0873
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0189 0.1185 0.1623
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0158 0.9177
Brugia malayi beta-lactamase family protein 0.0146 0.0897 0.1201
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0333 0.0324
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0089 0.0986
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0101 0.0091
Toxoplasma gondii histone lysine methyltransferase SET1 0.0116 0.0689 0.5879
Echinococcus multilocularis neuropeptide s receptor 0.0479 0.3152 0.3145
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0044 0.0206 0.1661
Plasmodium vivax importin-beta 2, putative 0.0029 0.0101 0.0973
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0044 0.0206 0.1772
Onchocerca volvulus 0.0063 0.0333 0.103
Mycobacterium ulcerans hypothetical protein 0.0146 0.0897 0.4906
Schistosoma mansoni hypothetical protein 0.009 0.0516 0.0507
Onchocerca volvulus 0.0189 0.1185 0.3663
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0185 0.1162 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0044 0.0206 0.1772
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0064 0.0718
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0026 0.0085 0.0264
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0228 0.0305
Onchocerca volvulus 0.0146 0.0897 0.2775
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0243 0.0233
Leishmania major hypothetical protein, conserved 0.0016 0.0015 0.0133
Mycobacterium ulcerans beta-lactamase 0.0146 0.0897 0.4906
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0068 0.0058
Loa Loa (eye worm) hypothetical protein 0.0029 0.0101 0.0136
Schistosoma mansoni lamin 0.0028 0.0097 0.0087
Trichomonas vaginalis ran, putative 0.0021 0.005 0.0154
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0125 0.0754 0.0745
Schistosoma mansoni hypothetical protein 0.0705 0.4685 0.4679
Echinococcus granulosus single minded 2 0.0075 0.0416 0.0407
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0234 0.0313
Echinococcus granulosus neuroligin 0.0189 0.1185 0.1176
Toxoplasma gondii ABC1 family protein 0.0146 0.0897 0.7695
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.005 0.0067
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0019 0.0009
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0064 0.0199
Loa Loa (eye worm) hypothetical protein 0.0053 0.0267 0.0358
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0158 0.0488
Echinococcus multilocularis dnaJ subfamily B 0.0825 0.5494 0.549
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0015 0.0005
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0044 0.0206 0.2293
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0064 0.0199
Brugia malayi glutathione reductase 0.0128 0.077 0.1031
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0267 0.2979
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0026 0.0085 0.0076
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0026 0.0085 0.0264
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0015 0.0172
Onchocerca volvulus 0.0146 0.0897 0.2775
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0044 0.0206 0.5
Brugia malayi jmjC domain containing protein 0.0016 0.0015 0.0021
Trichomonas vaginalis glutathione reductase, putative 0.0044 0.0206 0.0636
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0232 0.1476 0.1468

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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