Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | flavodoxin family protein | 0.0089 | 0.3033 | 0.3033 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0144 | 0.5684 | 0.5684 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0089 | 0.3033 | 0.5 |
Onchocerca volvulus | 0.0026 | 0 | 0.5 | |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0233 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0206 | 0.8717 | 0.8717 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0206 | 0.8717 | 1 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0089 | 0.3033 | 0.3033 |
Chlamydia trachomatis | sulfite reductase | 0.0144 | 0.5684 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0233 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0144 | 0.5684 | 0.5684 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0089 | 0.3033 | 0.3033 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0233 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0115 | 0.4316 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0233 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0233 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0233 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0115 | 0.4316 | 1 |
Mycobacterium tuberculosis | Possible oxygenase | 0.0026 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0089 | 0.3033 | 0.3033 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0233 | 1 | 1 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0026 | 0 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0233 | 1 | 1 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0089 | 0.3033 | 0.3033 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0115 | 0.4316 | 0.4316 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0233 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0233 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0089 | 0.3033 | 0.3033 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0233 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0089 | 0.3033 | 0.5 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0089 | 0.3033 | 0.3033 |
Mycobacterium tuberculosis | Probable monooxygenase | 0.0026 | 0 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0089 | 0.3033 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0117 | 0.4402 | 0.4402 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0089 | 0.3033 | 0.3033 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0233 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0233 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0089 | 0.3033 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0233 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical oxidoreductase | 0.0026 | 0 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0233 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0233 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0233 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0206 | 0.8717 | 0.8159 |
Echinococcus multilocularis | methionine synthase reductase | 0.0144 | 0.5684 | 0.5684 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0089 | 0.3033 | 0.3033 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0233 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0206 | 0.8717 | 1 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0089 | 0.3033 | 0.3033 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0026 | 0 | 0.5 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0206 | 0.8717 | 0.8717 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0144 | 0.5684 | 0.5684 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0233 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0089 | 0.3033 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0233 | 1 | 1 |
Echinococcus granulosus | methionine synthase reductase | 0.0144 | 0.5684 | 0.5684 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0233 | 1 | 1 |
Treponema pallidum | flavodoxin | 0.0089 | 0.3033 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.