TDR Targets

Basic information

Technical information

TDR Targets ID: 874137
Name: 1-(2-dimethylaminoethyl)-1-ethyl-3-(2-methyl- 1-oxoisoquinolin-4-yl)urea
MW: 316.398 | Formula: C17H24N4O2
H donors: 1 H acceptors: 2 LogP: 0.83 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCN(C(=O)Nc1cn(C)c(=O)c2c1cccc2)CCN(C)C
InChi: 1S/C17H24N4O2/c1-5-21(11-10-19(2)3)17(23)18-15-12-20(4)16(22)14-9-7-6-8-13(14)15/h6-9,12H,5,10-11H2,1-4H3,(H,18,23)
InChiKey: NUGDKXOFCYGSMI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(2-dimethylaminoethyl)-1-ethyl-3-(2-methyl-1-oxo-4-isoquinolyl)urea
1-(2-dimethylaminoethyl)-1-ethyl-3-(1-keto-2-methyl-4-isoquinolyl)urea
1-(2-dimethylaminoethyl)-1-ethyl-3-(2-methyl-1-oxo-isoquinolin-4-yl)urea

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	Tubulin alpha 1 chain	0.0052	0.0053	0.0031
Loa Loa (eye worm)	tubulin beta-2A chain	0.0042	0.0036	0.0027
Leishmania major	beta tubulin	0.0042	0.0036	0.0027
Schistosoma mansoni	tubulin subunit beta	0.0042	0.0036	0.0015
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.2653	0.4671	1
Echinococcus granulosus	peroxisome assembly protein 26	0.0052	0.0053	0.0031
Schistosoma mansoni	tubulin subunit gamma	0.0042	0.0036	0.0015
Mycobacterium ulcerans	DNA gyrase subunit A	0.0117	0.0169	0.0099
Echinococcus multilocularis	protein patched	0.2329	0.4094	0.4081
Loa Loa (eye worm)	TOPoisomerase family member	0.0034	0.0022	0.0012
Echinococcus multilocularis	tubulin subunit beta	0.0042	0.0036	0.0015
Echinococcus granulosus	tubulin alpha chain	0.0052	0.0053	0.0031
Leishmania major	epsilon tubulin, putative	0.0042	0.0036	0.0027
Entamoeba histolytica	tubulin gamma chain	0.0042	0.0036	0.4771
Echinococcus granulosus	beta tubulin	0.0042	0.0036	0.0015
Echinococcus granulosus	Tubulin beta 2C chain	0.0042	0.0036	0.0015
Entamoeba histolytica	tubulin family protein	0.0042	0.0036	0.4771
Echinococcus multilocularis	sterol regulatory element binding protein	0.2329	0.4094	0.4081
Echinococcus multilocularis	beta tubulin	0.0042	0.0036	0.0015
Echinococcus granulosus	tubulin gamma 1 chain	0.0042	0.0036	0.0015
Echinococcus granulosus	tubulin epsilon chain	0.0042	0.0036	0.0015
Leishmania major	alpha tubulin	0.0052	0.0053	0.0043
Schistosoma mansoni	tubulin subunit beta	0.0042	0.0036	0.0015
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0042	0.0036	0.007
Echinococcus multilocularis	tubulin alpha 3 chain	0.0052	0.0053	0.0031
Trypanosoma brucei	epsilon tubulin	0.0042	0.0036	0.0033
Leishmania major	beta tubulin	0.0042	0.0036	0.0027
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0034	0.0022	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0052	0.0053	0.0105
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.5656	1	1
Trypanosoma brucei	alpha tubulin	0.0052	0.0053	0.0049
Echinococcus granulosus	Tubulin beta 2C chain	0.0042	0.0036	0.0015
Brugia malayi	tubulin alpha chain - mouse	0.0052	0.0053	0.0049
Trypanosoma brucei	DNA topoisomerase II beta, putative	0.0027	0.001	0.0006
Leishmania major	alpha tubulin	0.0052	0.0053	0.0043
Trichomonas vaginalis	tubulin alpha chain, putative	0.0042	0.0036	0.007
Echinococcus multilocularis	protein dispatched 1	0.2329	0.4094	0.4081
Leishmania major	gamma-tubulin	0.0042	0.0036	0.0027
Trichomonas vaginalis	tubulin, putative	0.0042	0.0036	0.007
Trypanosoma brucei	DNA topoisomerase ii	0.0034	0.0022	0.0018
Echinococcus multilocularis	Tubulin beta 2C chain	0.0042	0.0036	0.0015
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase	0.5656	1	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.0052	0.0053	0.0031
Toxoplasma gondii	alpha tubulin TUBA1	0.0052	0.0053	0.3105
Trypanosoma brucei	epsilon tubulin	0.0042	0.0036	0.0033
Echinococcus multilocularis	tubulin alpha chain	0.0052	0.0053	0.0031
Giardia lamblia	Alpha-tubulin	0.0052	0.0053	0.0078
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0052	0.0053	0.0031
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.0034	0.0022	0.0018
Trypanosoma brucei	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.5656	1	1
Leishmania major	beta tubulin	0.0042	0.0036	0.0027
Loa Loa (eye worm)	beta-tubulin	0.0042	0.0036	0.0027
Echinococcus granulosus	tubulin subunit beta	0.0042	0.0036	0.0015
Echinococcus granulosus	tubulin beta 1 chain	0.0042	0.0036	0.0015
Trichomonas vaginalis	tubulin beta chain, putative	0.0052	0.0053	0.0105
Trichomonas vaginalis	tubulin beta chain, putative	0.0042	0.0036	0.007
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0033	0.002	0.001
Loa Loa (eye worm)	tubulin alpha chain	0.0052	0.0053	0.0043
Echinococcus granulosus	Protein patched homolog 1	0.2329	0.4094	0.4081
Trichomonas vaginalis	tubulin beta chain, putative	0.0052	0.0053	0.0105
Plasmodium falciparum	alpha tubulin 1	0.0052	0.0053	0.2095
Brugia malayi	CHE-14 protein	0.2329	0.4094	0.4092
Echinococcus multilocularis	hydroxymethylglutaryl coenzyme A reductase	0.5656	1	1
Brugia malayi	Probable DNA topoisomerase II	0.0034	0.0022	0.0018
Toxoplasma gondii	beta-1 tubulin, putative	0.0042	0.0036	0.215
Loa Loa (eye worm)	BEN-1 protein	0.0042	0.0036	0.0027
Leishmania major	beta tubulin	0.0042	0.0036	0.0027
Schistosoma mansoni	tubulin subunit alpha	0.0052	0.0053	0.0031
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0052	0.0053	0.0031
Giardia lamblia	3-hydroxy-3-methylglutaryl-coenzyme A reductase	0.2653	0.4671	1
Echinococcus multilocularis	tubulin alpha chain	0.0052	0.0053	0.0031
Loa Loa (eye worm)	alpha-tubulin	0.0052	0.0053	0.0043
Toxoplasma gondii	DNA topoisomerase 2, putative	0.0034	0.0022	0.1278
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0034	0.0022	1
Toxoplasma gondii	alpha-tubulin I, putative	0.0052	0.0053	0.3105
Toxoplasma gondii	beta tubulin	0.0042	0.0036	0.215
Leishmania major	alpha tubulin	0.0052	0.0053	0.0043
Leishmania major	alpha tubulin	0.0052	0.0053	0.0043
Loa Loa (eye worm)	hypothetical protein	0.5656	1	1
Plasmodium falciparum	tubulin beta chain	0.0042	0.0036	0.1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.002	0.001
Giardia lamblia	Beta tubulin	0.0042	0.0036	0.0043
Leishmania major	alpha tubulin	0.0052	0.0053	0.0043
Trichomonas vaginalis	DNA topoisomerase II, putative	0.0034	0.0022	0.0039
Brugia malayi	Tubulin beta-1 chain	0.0042	0.0036	0.0033
Trypanosoma brucei	beta tubulin	0.0042	0.0036	0.0033
Toxoplasma gondii	DNA gyrase/topoisomerase IV, A subunit domain-containing protein	0.0117	0.0169	1
Leishmania major	beta tubulin	0.0042	0.0036	0.0027
Brugia malayi	Tubulin alpha chain	0.0052	0.0053	0.0049
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.0034	0.0022	0.0018
Schistosoma mansoni	tubulin subunit beta	0.0042	0.0036	0.0015
Trypanosoma brucei	beta tubulin	0.0042	0.0036	0.0033
Echinococcus multilocularis	tubulin beta 1 chain	0.0042	0.0036	0.0015
Echinococcus multilocularis	tubulin gamma 1 chain	0.0042	0.0036	0.0015
Giardia lamblia	Alpha-tubulin	0.0052	0.0053	0.0078
Trypanosoma cruzi	beta tubulin, putative	0.0042	0.0036	0.0027
Plasmodium vivax	DNA gyrase subunit B, putative	0.0062	0.007	0.3308
Loa Loa (eye worm)	tubulin alpha 2	0.0033	0.002	0.001
Schistosoma mansoni	alpha tubulin	0.0052	0.0053	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0053	0.0043
Echinococcus multilocularis	tubulin alpha chain	0.0052	0.0053	0.0031
Entamoeba histolytica	tubulin alpha-1 chain	0.0052	0.0053	1
Echinococcus multilocularis	peroxisome assembly protein 26	0.0052	0.0053	0.0031
Loa Loa (eye worm)	tubulin beta chain	0.0042	0.0036	0.0027
Echinococcus multilocularis	Tubulin beta 2C chain	0.0042	0.0036	0.0015
Leishmania major	alpha tubulin	0.0052	0.0053	0.0043
Trichomonas vaginalis	tubulin beta chain, putative	0.0052	0.0053	0.0105
Trypanosoma brucei	beta tubulin	0.0042	0.0036	0.0033
Leishmania major	beta tubulin	0.0042	0.0036	0.0027
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.2329	0.4094	0.4088
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0034	0.0022	0.0012
Echinococcus granulosus	Tubulin beta 2C chain	0.0042	0.0036	0.0015
Schistosoma mansoni	tubulin subunit beta	0.0042	0.0036	0.0015
Plasmodium vivax	tubulin epsilon chain, putative	0.0042	0.0036	0.1
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.2653	0.4671	1
Trichomonas vaginalis	conserved hypothetical protein	0.2329	0.4094	0.8764
Loa Loa (eye worm)	alpha-tubulin	0.0052	0.0053	0.0043
Leishmania major	beta tubulin	0.0042	0.0036	0.0027
Echinococcus granulosus	Tubulin beta 2C chain	0.0042	0.0036	0.0015
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0052	0.0053	0.0031
Leishmania major	alpha tubulin	0.0052	0.0053	0.0043
Echinococcus granulosus	Tubulin alpha 1 chain	0.0052	0.0053	0.0031
Plasmodium vivax	DNA gyrase subunit A, putative	0.0117	0.0169	1
Leishmania major	beta tubulin	0.0042	0.0036	0.0027
Giardia lamblia	Gamma tubulin	0.0042	0.0036	0.0043
Leishmania major	beta tubulin	0.0042	0.0036	0.0027
Plasmodium vivax	tubulin alpha chain, putative	0.0052	0.0053	0.2095
Echinococcus granulosus	tubulin alpha 1C chain	0.0052	0.0053	0.0031
Leishmania major	beta tubulin	0.0042	0.0036	0.0027
Treponema pallidum	DNA gyrase, subunit A (gyrA)	0.0117	0.0169	1
Leishmania major	beta tubulin	0.0042	0.0036	0.0027
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0042	0.0036	0.007
Echinococcus multilocularis	tubulin subunit TubB	0.0052	0.0053	0.0031
Echinococcus granulosus	Niemann Pick C1 protein	0.2329	0.4094	0.4081
Leishmania major	mitochondrial DNA topoisomerase II	0.0034	0.0022	0.0012
Leishmania major	alpha tubulin	0.0052	0.0053	0.0043
Schistosoma mansoni	patched 1	0.2329	0.4094	0.4081
Echinococcus granulosus	tubulin alpha 1C chain	0.0052	0.0053	0.0031
Plasmodium falciparum	tubulin epsilon chain, putative	0.0042	0.0036	0.1
Trichomonas vaginalis	tubulin beta chain, putative	0.0052	0.0053	0.0105
Brugia malayi	beta-tubulin, identical	0.0042	0.0036	0.0033
Echinococcus multilocularis	tubulin alpha	0.0042	0.0036	0.0015
Echinococcus multilocularis	tubulin alpha 3 chain	0.0052	0.0053	0.0031
Loa Loa (eye worm)	hypothetical protein	0.2329	0.4094	0.4088
Loa Loa (eye worm)	tubulin alpha chain	0.0052	0.0053	0.0043
Brugia malayi	tubulin alpha-2 chain	0.0052	0.0053	0.0049
Trypanosoma cruzi	epsilon tubulin, putative	0.0042	0.0036	0.0027
Echinococcus granulosus	tubulin alpha	0.0042	0.0036	0.0015
Echinococcus granulosus	tubulin subunit TubB	0.0052	0.0053	0.0031
Giardia lamblia	Beta tubulin	0.0042	0.0036	0.0043
Chlamydia trachomatis	DNA gyrase subunit A	0.0117	0.0169	1
Plasmodium falciparum	DNA gyrase subunit A	0.0117	0.0169	1
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0034	0.0022	0.0012
Schistosoma mansoni	alpha tubulin	0.0052	0.0053	0.0031
Schistosoma mansoni	hydroxymethylglutaryl-CoA reductase (NADPH)	0.5656	1	1
Trypanosoma brucei	alpha tubulin	0.0052	0.0053	0.0049
Echinococcus granulosus	alpha tubulin	0.0052	0.0053	0.0031
Echinococcus multilocularis	tubulin epsilon chain	0.0042	0.0036	0.0015
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0028	0.001	0.0013
Entamoeba histolytica	tubulin alpha chain, putative	0.0052	0.0053	1
Leishmania major	beta tubulin	0.0042	0.0036	0.0027
Leishmania major	3-hydroxy-3-methylglutaryl-CoA reductase	0.5656	1	1
Plasmodium vivax	tubulin beta chain, putative	0.0042	0.0036	0.1
Schistosoma mansoni	tubulin subunit epsilon	0.0042	0.0036	0.0015
Loa Loa (eye worm)	tubulin beta-4 chain	0.0042	0.0036	0.0027
Echinococcus granulosus	Tubulin beta 2C chain	0.0042	0.0036	0.0015
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0033	0.002	0.0035
Echinococcus granulosus	tubulin alpha chain	0.0052	0.0053	0.0031
Leishmania major	alpha tubulin	0.0052	0.0053	0.0043
Trypanosoma cruzi	epsilon tubulin, putative	0.0042	0.0036	0.0027
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0052	0.0053	0.0043
Trypanosoma brucei	tubulin gamma chain	0.0042	0.0036	0.0033
Schistosoma mansoni	tubulin subunit beta	0.0042	0.0036	0.0015
Plasmodium vivax	tubulin gamma chain, putative	0.0042	0.0036	0.1
Entamoeba histolytica	tubulin family protein	0.0042	0.0036	0.4771
Echinococcus multilocularis	tubulin alpha 1C chain	0.0052	0.0053	0.0031
Echinococcus granulosus	tubulin alpha chain	0.0052	0.0053	0.0031
Echinococcus granulosus	tubulin alpha 3 chain	0.0052	0.0053	0.0031
Trypanosoma brucei	alpha tubulin	0.0052	0.0053	0.0049
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0042	0.0036	0.0015
Echinococcus granulosus	tubulin alpha chain	0.0052	0.0053	0.0031
Echinococcus multilocularis	Tubulin beta 2C chain	0.0042	0.0036	0.0015
Leishmania major	beta tubulin	0.0042	0.0036	0.0027
Echinococcus granulosus	sterol regulatory element binding protein	0.2329	0.4094	0.4081
Leishmania major	alpha tubulin	0.0052	0.0053	0.0043
Schistosoma mansoni	tubulin subunit alpha	0.0052	0.0053	0.0031
Brugia malayi	Tubulin alpha-2 chain	0.0052	0.0053	0.0049
Trypanosoma brucei	epsilon tubulin	0.0042	0.0036	0.0033
Leishmania major	alpha tubulin	0.0052	0.0053	0.0043
Echinococcus multilocularis	Tubulin beta 2C chain	0.0042	0.0036	0.0015
Trichomonas vaginalis	tubulin beta chain, putative	0.0052	0.0053	0.0105
Echinococcus multilocularis	hypothetical protein	0.0052	0.0053	0.0031
Trichomonas vaginalis	tubulin gamma chain, putative	0.0042	0.0036	0.007
Echinococcus granulosus	tubulin alpha 3 chain	0.0052	0.0053	0.0031
Schistosoma mansoni	tubulin subunit beta	0.0042	0.0036	0.0015
Trichomonas vaginalis	tubulin gamma chain, putative	0.0042	0.0036	0.007
Trypanosoma cruzi	alpha tubulin, putative	0.0052	0.0053	0.0043
Mycobacterium tuberculosis	DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.0117	0.0169	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0042	0.0036	0.0015
Echinococcus multilocularis	tubulin alpha chain	0.0052	0.0053	0.0031
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0052	0.0053	0.0105
Trypanosoma brucei	alpha tubulin	0.0052	0.0053	0.0049
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.2329	0.4094	0.4081
Trypanosoma brucei	DNA topoisomerase II alpha, putative	0.0027	0.001	0.0006
Trichomonas vaginalis	tubulin gamma chain, putative	0.0042	0.0036	0.007
Leishmania major	alpha tubulin	0.0052	0.0053	0.0043
Brugia malayi	Tubulin alpha-2 chain	0.0052	0.0053	0.0049
Loa Loa (eye worm)	tubulin beta-1 chain	0.0042	0.0036	0.0027
Echinococcus granulosus	tubulin beta 4A class IVa	0.0042	0.0036	0.0015
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0042	0.0036	0.215
Echinococcus granulosus	tubulin alpha chain	0.0052	0.0053	0.0031
Leishmania major	beta tubulin	0.0042	0.0036	0.0027
Mycobacterium leprae	Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase)	0.0056	0.006	0.5
Echinococcus multilocularis	Niemann Pick C1 protein	0.2329	0.4094	0.4081
Trichomonas vaginalis	tubulin alpha chain, putative	0.0042	0.0036	0.007
Brugia malayi	alpha-tubulin	0.0052	0.0053	0.0049
Wolbachia endosymbiont of Brugia malayi	DNA gyrase subunit A	0.0117	0.0169	1
Brugia malayi	Tubulin gamma chain	0.0042	0.0036	0.0033
Echinococcus multilocularis	tubulin alpha chain	0.0052	0.0053	0.0031
Plasmodium falciparum	alpha tubulin 2	0.0052	0.0053	0.2095
Leishmania major	beta tubulin	0.0042	0.0036	0.0027
Mycobacterium ulcerans	hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase	0.5656	1	1
Loa Loa (eye worm)	BEN-1 protein	0.0042	0.0036	0.0027
Onchocerca volvulus	Putative DNA topoisomerase 2, mitochondrial	0.0034	0.0022	1
Trypanosoma cruzi	tubulin gamma chain	0.0042	0.0036	0.0027
Plasmodium falciparum	tubulin gamma chain	0.0042	0.0036	0.1
Leishmania major	beta tubulin	0.0042	0.0036	0.0027
Echinococcus granulosus	hydroxymethylglutaryl coenzyme A reductase	0.5656	1	1
Trypanosoma brucei	beta tubulin	0.0042	0.0036	0.0033
Echinococcus granulosus	Tubulin alpha 1 chain	0.0052	0.0053	0.0031
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0052	0.0053	0.0105
Loa Loa (eye worm)	tubulin alpha 2	0.0033	0.002	0.001
Echinococcus granulosus	beta tubulin	0.0042	0.0036	0.0015
Schistosoma mansoni	alpha tubulin	0.0052	0.0053	0.0031
Leishmania major	beta tubulin	0.0042	0.0036	0.0027
Plasmodium falciparum	DNA gyrase subunit B	0.0062	0.007	0.3308
Loa Loa (eye worm)	tubulin gamma chain	0.0042	0.0036	0.0027
Giardia lamblia	Beta tubulin	0.0042	0.0036	0.0043
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.2653	0.4671	1
Echinococcus multilocularis	beta tubulin	0.0042	0.0036	0.0015
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0052	0.0053	0.0105
Leishmania major	beta tubulin	0.0042	0.0036	0.0027
Schistosoma mansoni	tubulin subunit alpha	0.0052	0.0053	0.0031
Plasmodium vivax	tubulin alpha chain, putative	0.0052	0.0053	0.2095
Toxoplasma gondii	beta-tubulin, putative	0.0042	0.0036	0.215
Trypanosoma brucei	beta tubulin	0.0042	0.0036	0.0033

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

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Detailed information for compound 874137