Detailed information for compound 874170

Basic information

Technical information
  • TDR Targets ID: 874170
  • Name: N-(3-dimethylaminopropyl)-3,4-dimethyl-N-(4-m ethyl-1,3-benzothiazol-2-yl)benzamide
  • MW: 381.534 | Formula: C22H27N3OS
  • H donors: 0 H acceptors: 2 LogP: 5.22 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCCN(C(=O)c1ccc(c(c1)C)C)c1nc2c(s1)cccc2C)C
  • InChi: 1S/C22H27N3OS/c1-15-10-11-18(14-17(15)3)21(26)25(13-7-12-24(4)5)22-23-20-16(2)8-6-9-19(20)27-22/h6,8-11,14H,7,12-13H2,1-5H3
  • InChiKey: PYHMXXJMMQVWJI-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0351 0.0535
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0011 0.0012
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.4579 0.6988
Trypanosoma brucei heat shock protein, putative 0.0093 0.1945 0.4042
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0091 0.1881 1
Echinococcus granulosus heat shock protein 0.0093 0.1945 0.1945
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0318 0.0485
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.4579 0.6988
Trypanosoma cruzi heat shock protein, putative 0.0062 0.1112 0.2158
Schistosoma mansoni hypothetical protein 0.0344 0.864 1
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0091 0.1881 0.3897
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0004 0.0004
Plasmodium falciparum heat shock protein 90, putative 0.0054 0.0906 0.1021
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0508 0.0365
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0448 0.0657
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0508 0.1102
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0508 0.0793
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0011 0.0016
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0351 0.0202
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0351 0.0436
Trypanosoma cruzi heat shock protein 85, putative 0.008 0.1586 0.3231
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0011 0.0011
Trichomonas vaginalis DNA helicase recq, putative 0.0049 0.0763 0.1159
Schistosoma mansoni regulator of G protein signaling 0.002 0.0004 0.0005
Trypanosoma cruzi polo-like protein kinase, putative 0.0192 0.4579 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0184 0.0059
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0508 0.0793
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0016
Echinococcus granulosus geminin 0.0344 0.864 0.864
Trichomonas vaginalis heat shock protein, putative 0.0093 0.1945 0.2964
Brugia malayi steroid hormone receptor 0.002 0.0011 0.0016
Plasmodium falciparum glutathione reductase 0.0096 0.2024 0.2282
Echinococcus multilocularis heat shock protein 0.0093 0.1945 0.1945
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0508 0.077
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0033 0.0351 0.0086
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1252 0.1449
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0004 0.0004
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0099 0.2096 0.3195
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0508 0.0508
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0318 0.0318
Plasmodium falciparum thioredoxin reductase 0.0033 0.0351 0.0395
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0175 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0011 0.0016
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.1309 0.1998
Schistosoma mansoni heat shock protein 0.0093 0.1945 0.2251
Entamoeba histolytica serine/threonine protein kinase, putative 0.0192 0.4579 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0243 0.5956 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0351 0.0436
Trypanosoma brucei heat shock protein, putative 0.0093 0.1945 0.4042
Schistosoma mansoni thyroid hormone receptor 0.002 0.0011 0.0012
Entamoeba histolytica hypothetical protein 0.0073 0.1412 0.3076
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0011 0.0012
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0508 0.0793
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0099 0.2096 0.3195
Schistosoma mansoni thyroid hormone receptor 0.002 0.0011 0.0012
Trypanosoma brucei polo-like protein kinase 0.0192 0.4579 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0351 0.0436
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0508 0.0793
Schistosoma mansoni hypothetical protein 0.0032 0.0318 0.0368
Echinococcus granulosus axis inhibition protein axin 0.002 0.0004 0.0004
Echinococcus granulosus thioredoxin glutathione reductase 0.0096 0.2024 0.2024
Echinococcus granulosus axis inhibition protein axin 0.002 0.0004 0.0004
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0087 0.1792 1
Echinococcus multilocularis dna polymerase eta 0.0064 0.1169 0.1169
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0004 0.0004
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0175 0.0039
Schistosoma mansoni hypothetical protein 0.0344 0.864 1
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0004 0.0004
Plasmodium vivax glutathione reductase, putative 0.0096 0.2024 0.2127
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1252 0.1449
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0175 0.0197
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0011 0.0011
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0219 0.5304 0.8847
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0011 0.0016
Loa Loa (eye worm) thioredoxin reductase 0.0096 0.2024 0.309
Trichomonas vaginalis heat shock protein, putative 0.0067 0.1264 0.1925
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0192 0.4579 1
Trichomonas vaginalis heat shock protein, putative 0.0087 0.1792 0.2731
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0351 0.0395
Leishmania major heat shock protein 83-1 0.0093 0.1945 0.4042
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0011 0.0011
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0004 0.0007
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.2163 0.3302
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0351 0.0436
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0043 0.0605 0.0683
Schistosoma mansoni hypothetical protein 0.0032 0.0318 0.0368
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0016
Schistosoma mansoni glutaminase 0.0265 0.655 0.7582
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0091 0.1881 1
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0508 0.0508
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0011 0.0011
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0011 0.0011
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0219 0.5304 0.8847
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0351 0.0436
Echinococcus granulosus heat shock protein 90 0.008 0.1586 0.1586
Echinococcus multilocularis thioredoxin glutathione reductase 0.0096 0.2024 0.2024
Schistosoma mansoni endoplasmin 0.0093 0.1945 0.2251
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0351 0.0436
Plasmodium vivax heat shock protein 86, putative 0.0093 0.1945 0.2036
Echinococcus granulosus tar DNA binding protein 0.0067 0.1252 0.1252
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0351 0.0436
Trypanosoma brucei heat shock protein, putative 0.0093 0.1945 0.4042
Leishmania major DNA polymerase eta, putative 0.0037 0.0448 0.0657
Schistosoma mansoni axis inhibition protein axin 0.002 0.0004 0.0005
Trypanosoma cruzi trypanothione reductase, putative 0.0096 0.2024 0.4221
Schistosoma mansoni regulator of G protein signaling 0.002 0.0004 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1252 0.1449
Plasmodium falciparum heat shock protein 90 0.0093 0.1945 0.2193
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.4579 0.6988
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0351 0.0395
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0508 0.0793
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.1169 0.1784
Schistosoma mansoni hypothetical protein 0.0073 0.1412 0.1634
Schistosoma mansoni heat shock protein 0.0093 0.1945 0.2251
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0175 0.0039
Leishmania major heat shock protein 83-1 0.0093 0.1945 0.4042
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0062 0.1112 0.1112
Trypanosoma brucei heat shock protein 84, putative 0.0062 0.1112 0.2158
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0004 0.0005
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0351 0.0395
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0508 0.0793
Treponema pallidum heat shock protein 90 0.0087 0.1792 0.9421
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0007
Loa Loa (eye worm) MH2 domain-containing protein 0.0242 0.5928 0.9051
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0115 0.0176
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0004 0.0004
Brugia malayi ecdysteroid receptor 0.002 0.0011 0.0016
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0318 0.0318
Brugia malayi hypothetical protein 0.002 0.0004 0.0007
Schistosoma mansoni blooms syndrome DNA helicase 0.0038 0.049 0.0567
Leishmania major heat shock protein 83-1 0.0093 0.1945 0.4042
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0011 0.0016
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0508 0.0254
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0351 0.0436
Echinococcus multilocularis expressed protein 0.0395 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0508 0.0793
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0004 0.0004
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0091 0.1881 0.1881
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0021 0.0024
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0318 0.0485
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0099 0.2096 0.2364
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.0032 0.0318 0.0485
Brugia malayi PXA domain containing protein 0.002 0.0004 0.0007
Brugia malayi glutathione reductase 0.0096 0.2024 0.309
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0064 0.1169 0.1784
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0508 0.0793
Echinococcus granulosus endoplasmin 0.0087 0.1792 0.1792
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0016
Trypanosoma brucei heat shock protein, putative 0.0093 0.1945 0.4042
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0351 0.0529
Loa Loa (eye worm) transcription factor SMAD2 0.0242 0.5928 0.9051
Trypanosoma brucei unspecified product 0.0027 0.0184 0.0059
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0011 0.0016
Schistosoma mansoni endoplasmin 0.0093 0.1945 0.2251
Trichomonas vaginalis endoplasmin, putative 0.0067 0.1264 0.1925
Entamoeba histolytica hypothetical protein 0.0073 0.1412 0.3076
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0508 0.0776
Echinococcus granulosus dna polymerase kappa 0.0039 0.0508 0.0508
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0011 0.0016
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0099 0.2096 0.3195
Loa Loa (eye worm) hypothetical protein 0.0069 0.1309 0.1998
Trichomonas vaginalis DNA helicase recq1, putative 0.0049 0.0763 0.1159
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0011 0.0016
Trypanosoma brucei unspecified product 0.0027 0.0184 0.0059
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.4579 0.6988
Giardia lamblia Grp94/Hsp90 0.0087 0.1792 0.3914
Plasmodium falciparum endoplasmin, putative 0.0067 0.1264 0.1426
Plasmodium vivax heat shock protein 90, putative 0.0062 0.1112 0.1078
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0011 0.0011
Leishmania major heat shock protein 83-1 0.0093 0.1945 0.4042
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0318 0.0485
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0021 0.0032
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0219 0.5304 0.8847
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0351 0.0436
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0016
Trypanosoma brucei heat shock protein, putative 0.0093 0.1945 0.4042
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0096 0.2024 0.3046
Trypanosoma cruzi polo-like protein kinase, putative 0.0192 0.4579 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0011 0.0016
Toxoplasma gondii thioredoxin reductase 0.0096 0.2024 0.2282
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0004 0.0004
Schistosoma mansoni serine/threonine protein kinase 0.0192 0.4579 0.53
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0175 0.0039
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0508 0.0793
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0351 0.0436
Schistosoma mansoni hypothetical protein 0.0032 0.0318 0.0368
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0011 0.0011
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0021 0.0032
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0091 0.1881 0.3897
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1996 0.3042
Mycobacterium tuberculosis Probable oxidoreductase 0.0243 0.5956 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1252 0.1449
Leishmania major DNA polymerase eta, putative 0.0064 0.1169 0.2287
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0351 0.0395
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0004 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1996 0.3042
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0351 0.0202
Trypanosoma brucei heat shock protein 90, putative 0.0093 0.1945 0.4042
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0004 0.0007
Echinococcus multilocularis GPCR, family 2 0.0032 0.0318 0.0318
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0091 0.1881 0.3897
Brugia malayi PXA domain containing protein 0.002 0.0004 0.0007
Toxoplasma gondii heat shock protein HSP90 0.0093 0.1945 0.2193
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.1412 0.1412
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0351 0.0406
Brugia malayi serine/threonine-protein kinase plk-2 0.0192 0.4579 0.699
Schistosoma mansoni kinase 0.0097 0.2063 0.2388
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1252 0.1449
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0011 0.0012
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0351 0.0351
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0011 0.0016
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0004 0.0004
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0004 0.0007
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0508 0.0254
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0175 0.0197
Brugia malayi nuclear hormone receptor 0.002 0.0011 0.0016
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0318 0.0318
Giardia lamblia DINP protein human, muc B family 0.0039 0.0508 0.111
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0011 0.0016
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0508 0.0589
Leishmania major DNA polymerase kappa, putative 0.0039 0.0508 0.0793
Brugia malayi glutaminase DH11.1 0.0265 0.655 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.2163 0.3302
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0011 0.0011
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0011 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0508 0.0793
Leishmania major heat shock protein 83-1 0.0093 0.1945 0.4042
Leishmania major heat shock protein 83-1 0.0093 0.1945 0.4042
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0004 0.0007
Leishmania major heat shock protein 83-1 0.0093 0.1945 0.4042
Entamoeba histolytica recQ family helicase, putative 0.0026 0.0158 0.0335
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.00000000024439 0.0000000002756
Trypanosoma cruzi Heat shock protein 83, putative 0.0093 0.1945 0.4042
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0091 0.1881 0.1881
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.1412 0.1412
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0508 0.0793
Onchocerca volvulus Serine\/threonine kinase homolog 0.0192 0.4579 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.1252 0.1911
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0004 0.0007
Loa Loa (eye worm) RecQ helicase 0.0049 0.0763 0.1165
Brugia malayi Bloom's syndrome protein homolog 0.0049 0.0763 0.1165
Trypanosoma brucei heat shock protein, putative 0.0093 0.1945 0.4042
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0011 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0021 0.0024
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0508 0.0776
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0508 0.0508
Trypanosoma brucei heat shock protein, putative 0.0093 0.1945 0.4042
Plasmodium vivax thioredoxin reductase, putative 0.0096 0.2024 0.2127
Brugia malayi hypothetical protein 0.0073 0.1412 0.2155
Leishmania major heat shock protein 83-1 0.0093 0.1945 0.4042
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0219 0.5304 0.8847
Loa Loa (eye worm) hypothetical protein 0.0101 0.2163 0.3302
Leishmania major heat shock protein 83-1 0.0093 0.1945 0.4042
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.4579 0.6988
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0508 0.0589
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0219 0.5304 0.8435
Trypanosoma brucei unspecified product 0.0039 0.0508 0.0793
Giardia lamblia Heat shock protein HSP 90-alpha 0.0093 0.1945 0.4247
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0243 0.5956 1
Plasmodium vivax endoplasmin, putative 0.0093 0.1945 0.2036
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0091 0.1881 0.2177
Trypanosoma brucei DNA polymerase eta, putative 0.0064 0.1169 0.2287
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0004 0.0005
Entamoeba histolytica hypothetical protein 0.0073 0.1412 0.3076
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0011 0.0011
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0448 0.0505
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0087 0.1792 0.2636
Leishmania major heat shock protein 83-1 0.0093 0.1945 0.4042
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.4579 0.6988
Trypanosoma cruzi DNA polymerase eta, putative 0.0064 0.1169 0.2287
Mycobacterium ulcerans heat shock protein 90 0.0087 0.1792 0.2325
Mycobacterium ulcerans glutaminase 0.0265 0.655 1
Leishmania major heat shock protein 83-1 0.0093 0.1945 0.4042
Brugia malayi hypothetical protein 0.0027 0.0175 0.0267
Loa Loa (eye worm) glutathione reductase 0.0096 0.2024 0.309
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0007
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0021 0.0021
Echinococcus multilocularis endoplasmin 0.0087 0.1792 0.1792
Schistosoma mansoni axis inhibition protein axin 0.002 0.0004 0.0005
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0004 0.0004
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.2163 0.3302
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0062 0.1112 0.2421
Entamoeba histolytica hypothetical protein 0.0073 0.1412 0.3076
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0351 0.0436
Brugia malayi Thioredoxin reductase 0.0096 0.2024 0.309
Plasmodium falciparum thioredoxin reductase 0.0096 0.2024 0.2282
Trypanosoma cruzi heat shock protein 90, putative 0.008 0.1586 0.3231
Plasmodium falciparum heat shock protein 90, putative 0.0352 0.8867 1
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0011 0.0016
Brugia malayi nuclear receptor NHR-88 0.002 0.0011 0.0016
Echinococcus multilocularis heat shock protein 90 0.008 0.1586 0.1586
Echinococcus granulosus dna polymerase eta 0.0064 0.1169 0.1169
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0508 0.0793
Loa Loa (eye worm) RNA binding protein 0.0067 0.1252 0.1911
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0011 0.0016
Schistosoma mansoni regulator of G protein signaling 0.002 0.0004 0.0005
Schistosoma mansoni hypothetical protein 0.0032 0.0318 0.0368
Giardia lamblia Kinase, PLK 0.0192 0.4579 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0351 0.0436
Trypanosoma cruzi heat shock protein 90, putative 0.0093 0.1945 0.4042
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0011 0.0016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0351 0.0436
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0007
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0011 0.0012
Brugia malayi glucose-6-phosphate dehydrogenase 0.0091 0.1881 0.2871
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0062 0.1112 0.2411
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0011 0.0016
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0351 0.0529
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0011 0.0012
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0004 0.0007
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0351 0.0436
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0011 0.0012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0351 0.0436
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0508 0.0793
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0011 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0184 0.0059
Loa Loa (eye worm) heat shock protein 90 0.0093 0.1945 0.2969
Trypanosoma brucei heat shock protein, putative 0.0093 0.1945 0.4042
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.4579 0.6988
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0192 0.4579 0.699
Leishmania major heat shock protein 83-1 0.0093 0.1945 0.4042
Loa Loa (eye worm) endoplasmin 0.0093 0.1945 0.2969
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0011 0.0016
Mycobacterium tuberculosis Probable reductase 0.0219 0.5304 0.8847
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0099 0.2096 0.221
Loa Loa (eye worm) hypothetical protein 0.0027 0.0175 0.0267
Brugia malayi Endoplasmin precursor 0.0093 0.1945 0.2969
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0011 0.0011
Schistosoma mansoni regulator of G protein signaling 0.002 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0245 0.6007 0.9171
Loa Loa (eye worm) glutaminase 2 0.0265 0.655 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0033 0.0342 0.0193
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0021 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0011 0.0016
Trypanosoma brucei Heat shock protein 83, putative 0.0093 0.1945 0.4042
Trypanosoma brucei trypanothione reductase 0.0096 0.2024 0.4221
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0021 0.0032
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0016
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0099 0.2096 0.2364
Leishmania major heat shock protein 83-1 0.0093 0.1945 0.4042
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0021 0.0024
Entamoeba histolytica heat shock protein 90, putative 0.0093 0.1945 0.4242
Schistosoma mansoni coup transcription factor 0.002 0.0011 0.0012
Brugia malayi RNA binding protein 0.0067 0.1252 0.1911
Trypanosoma cruzi heat shock protein 85, putative 0.0093 0.1945 0.4042
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0011 0.0011
Plasmodium vivax heat shock protein, putative 0.0352 0.8867 1
Leishmania major heat shock protein 83-1 0.0093 0.1945 0.4042
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0062 0.1112 0.1112
Echinococcus granulosus heat shock protein 90 0.0093 0.1945 0.1945
Toxoplasma gondii Hsp90 domain-containing protein 0.0352 0.8867 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0011 0.0016
Trypanosoma brucei heat shock protein 90, putative 0.0093 0.1945 0.4042
Echinococcus multilocularis heat shock protein 90 0.0093 0.1945 0.1945
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0004 0.0004
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0004 0.0004
Plasmodium falciparum glutathione reductase 0.0033 0.0351 0.0395
Brugia malayi MH2 domain containing protein 0.0242 0.5928 0.9051
Echinococcus multilocularis tar DNA binding protein 0.0067 0.1252 0.1252
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0059 0.1042 0.1175
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0091 0.1881 0.2468
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0091 0.1881 0.2871
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0502 0.0779
Trichomonas vaginalis heat shock protein, putative 0.0054 0.0906 0.1377
Entamoeba histolytica heat shock protein 90, putative 0.0093 0.1945 0.4242
Trichomonas vaginalis heat shock protein, putative 0.0087 0.1792 0.2731
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0011 0.0016
Echinococcus granulosus bloom syndrome protein 0.0049 0.0763 0.0763
Leishmania major heat shock protein, putative 0.0062 0.1112 0.2158
Brugia malayi Hsp90 protein 0.0062 0.1112 0.1697
Toxoplasma gondii heat shock protein 75, putative 0.0062 0.1112 0.1254
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0004 0.0004
Loa Loa (eye worm) glutaminase 0.0265 0.655 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0007
Mycobacterium tuberculosis Probable dehydrogenase 0.0219 0.5304 0.8847
Trypanosoma cruzi heat shock protein 85, putative 0.0093 0.1945 0.4042
Schistosoma mansoni DNA polymerase eta 0.0064 0.1169 0.1353
Trypanosoma cruzi heat shock protein 85, putative 0.0093 0.1945 0.4042
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.008 0.1586 0.1586
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0508 0.0365
Echinococcus multilocularis bloom syndrome protein 0.0049 0.0763 0.0763
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0011 0.0016
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0508 0.0793
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0007
Trichomonas vaginalis glutaminase, putative 0.0265 0.655 1
Leishmania major hypothetical protein, conserved 0.0027 0.0175 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0011 0.0016
Loa Loa (eye worm) RGS-3 protein 0.002 0.0004 0.0007
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0243 0.5956 1
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0059 0.1042 0.1115
Leishmania major trypanothione reductase 0.0096 0.2024 0.4221
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.1252 0.1911
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0011 0.0012
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0351 0.0436
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.003 0.0264 0.0241
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0087 0.1792 0.3697
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0099 0.2096 0.4578
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.1412 0.1634
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0508 0.077
Schistosoma mansoni nuclear hormone receptor 0.002 0.0011 0.0012
Echinococcus granulosus FTZ F1 alpha 0.002 0.0011 0.0011
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0115 0.0176
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0004 0.0004
Leishmania major heat shock protein 83-1 0.0093 0.1945 0.4042
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0007
Leishmania major heat shock protein 83-1 0.0093 0.1945 0.4042
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0011 0.0011
Schistosoma mansoni regulator of G protein signaling 0.002 0.0004 0.0005
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0351 0.0766
Brugia malayi TAR-binding protein 0.0067 0.1252 0.1911
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0011 0.0016
Giardia lamblia Heat shock protein HSP 90-alpha 0.008 0.1586 0.3464
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0029 0.0241 0.0188
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0011 0.0011
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0508 0.0793
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0004 0.0007
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0004 0.0005
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0192 0.4579 0.4579
Toxoplasma gondii heat shock protein 90, putative 0.0093 0.1945 0.2193
Trichomonas vaginalis heat shock protein, putative 0.008 0.1586 0.2416
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0011 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0508 0.0793
Loa Loa (eye worm) heat shock protein 75 0.0062 0.1112 0.1697
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0033 0.0332 0.0374
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0004 0.0004
Echinococcus multilocularis geminin 0.0344 0.864 0.864
Loa Loa (eye worm) TAR-binding protein 0.0067 0.1252 0.1911
Schistosoma mansoni heat shock protein 0.0062 0.1112 0.1287
Leishmania major heat shock protein 83-1 0.0093 0.1945 0.4042
Schistosoma mansoni hypothetical protein 0.0069 0.1309 0.1515
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0508 0.0793
Echinococcus granulosus GPCR family 2 0.0032 0.0318 0.0318
Brugia malayi heat shock protein 90 0.0093 0.1945 0.2969
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0184 0.0059
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0508 0.0793
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0158 0.0234
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0351 0.0436
Brugia malayi hypothetical protein 0.002 0.0004 0.0007
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0011 0.0011
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0192 0.4579 0.4579

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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