Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0043 | 0.1946 | 0.1946 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0081 | 0.4494 | 0.3654 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0103 | 0.592 | 0.592 |
Brugia malayi | glutathione reductase | 0.0036 | 0.1469 | 0.1469 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0034 | 0.1325 | 0.1325 |
Loa Loa (eye worm) | TAR-binding protein | 0.0056 | 0.2789 | 0.2789 |
Schistosoma mansoni | hypothetical protein | 0.0146 | 0.8781 | 0.8781 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0091 | 0.5112 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0035 | 0.1392 | 0.1392 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0036 | 0.1469 | 0.1469 |
Toxoplasma gondii | thioredoxin reductase | 0.0036 | 0.1469 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0056 | 0.2789 | 0.2789 |
Schistosoma mansoni | tar DNA-binding protein | 0.0056 | 0.2789 | 0.2789 |
Echinococcus granulosus | tar DNA binding protein | 0.0056 | 0.2789 | 0.2789 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0034 | 0.1325 | 0.1325 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0036 | 0.1469 | 0.2874 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0031 | 0.1153 | 0.1153 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0164 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0056 | 0.2789 | 0.2789 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0082 | 0.4508 | 0.8819 |
Echinococcus multilocularis | dna polymerase eta | 0.0056 | 0.2809 | 0.2809 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0164 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0056 | 0.2789 | 0.2789 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0034 | 0.1325 | 0.1325 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0056 | 0.2809 | 0.2809 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0164 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0035 | 0.1392 | 0.1392 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0091 | 0.5112 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0164 | 1 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0082 | 0.4508 | 0.8819 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0056 | 0.2789 | 0.2789 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0035 | 0.1392 | 0.1392 |
Giardia lamblia | Kinase, PLK | 0.0164 | 1 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0033 | 0.1273 | 0.8665 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0036 | 0.1469 | 0.1469 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0164 | 1 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0034 | 0.1325 | 0.1325 |
Leishmania major | DNA polymerase eta, putative | 0.0033 | 0.1273 | 0.1273 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0164 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0034 | 0.1325 | 0.1325 |
Trypanosoma brucei | unspecified product | 0.0034 | 0.1325 | 0.1325 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0081 | 0.4494 | 0.3654 |
Schistosoma mansoni | hypothetical protein | 0.0146 | 0.8781 | 0.8781 |
Echinococcus multilocularis | geminin | 0.0146 | 0.8781 | 0.8781 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0043 | 0.1946 | 0.1946 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0034 | 0.1325 | 0.1325 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0035 | 0.1392 | 0.1392 |
Leishmania major | DNA polymerase kappa, putative | 0.0034 | 0.1325 | 0.1325 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0036 | 0.1469 | 0.1469 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.7903 | 0.7903 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0633 | 0.0633 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0091 | 0.5112 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0164 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0164 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0164 | 1 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0164 | 1 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0034 | 0.1325 | 0.1325 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0036 | 0.1469 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0034 | 0.1325 | 0.1325 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1045 | 0.1045 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1153 | 0.1153 |
Echinococcus granulosus | geminin | 0.0146 | 0.8781 | 0.8781 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0034 | 0.1325 | 0.1325 |
Plasmodium vivax | glutathione reductase, putative | 0.0036 | 0.1469 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0036 | 0.1469 | 1 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0034 | 0.1325 | 0.1325 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1946 | 0.1946 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0164 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0034 | 0.1325 | 0.1325 |
Leishmania major | trypanothione reductase | 0.0036 | 0.1469 | 0.1469 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0056 | 0.2789 | 0.2789 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.0633 | 0.0633 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.0633 | 0.0633 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0034 | 0.1325 | 0.1325 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.1045 | 0.1045 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0035 | 0.1392 | 0.1392 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0056 | 0.2809 | 0.2809 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0082 | 0.4508 | 0.8819 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0056 | 0.2809 | 0.2809 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0034 | 0.1325 | 0.1325 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0034 | 0.1325 | 0.1325 |
Brugia malayi | MH2 domain containing protein | 0.0103 | 0.592 | 0.592 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0033 | 0.1273 | 0.1273 |
Brugia malayi | hypothetical protein | 0.0133 | 0.7903 | 0.7903 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.2809 | 0.2809 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0082 | 0.4508 | 0.8819 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0091 | 0.5112 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0056 | 0.2809 | 0.2809 |
Schistosoma mansoni | tar DNA-binding protein | 0.0056 | 0.2789 | 0.2789 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0034 | 0.1325 | 0.1325 |
Brugia malayi | hypothetical protein | 0.0031 | 0.1153 | 0.1153 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0034 | 0.1325 | 0.1325 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0164 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0035 | 0.1392 | 0.1392 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0036 | 0.1469 | 0.1469 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0034 | 0.1325 | 0.1325 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0034 | 0.1325 | 0.5 |
Echinococcus multilocularis | dna polymerase kappa | 0.0034 | 0.1325 | 0.1325 |
Echinococcus granulosus | dna polymerase eta | 0.0056 | 0.2809 | 0.2809 |
Schistosoma mansoni | tar DNA-binding protein | 0.0056 | 0.2789 | 0.2789 |
Plasmodium falciparum | glutathione reductase | 0.0036 | 0.1469 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0103 | 0.592 | 0.592 |
Brugia malayi | Thioredoxin reductase | 0.0036 | 0.1469 | 0.1469 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0633 | 0.0633 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0035 | 0.1392 | 0.1392 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0031 | 0.1153 | 0.1153 |
Trypanosoma brucei | trypanothione reductase | 0.0036 | 0.1469 | 0.1469 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0082 | 0.4508 | 0.8819 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0029 | 0.1045 | 0.1045 |
Schistosoma mansoni | tar DNA-binding protein | 0.0056 | 0.2789 | 0.2789 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0164 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0043 | 0.1946 | 0.1946 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0036 | 0.1469 | 0.1469 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0034 | 0.1325 | 0.1325 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0034 | 0.1325 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0034 | 0.1325 | 0.1325 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0034 | 0.1325 | 0.0194 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0034 | 0.1325 | 0.1325 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0035 | 0.1392 | 0.1392 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0034 | 0.1325 | 0.1325 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0034 | 0.1325 | 0.2591 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0031 | 0.1153 | 0.1153 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0164 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0034 | 0.1325 | 0.1325 |
Brugia malayi | RNA binding protein | 0.0056 | 0.2789 | 0.2789 |
Mycobacterium tuberculosis | Probable reductase | 0.0082 | 0.4508 | 0.8819 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0035 | 0.1392 | 0.1392 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0034 | 0.1325 | 0.1325 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0056 | 0.2789 | 0.2789 |
Schistosoma mansoni | DNA polymerase eta | 0.0056 | 0.2809 | 0.2809 |
Schistosoma mansoni | kinase | 0.0084 | 0.4638 | 0.4638 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0034 | 0.1325 | 0.1325 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0034 | 0.1325 | 0.2591 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0633 | 0.0633 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0034 | 0.1325 | 0.1325 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.