Detailed information for compound 874374

Basic information

Technical information
  • TDR Targets ID: 874374
  • Name: N-(4-bromophenyl)-2-[[4-oxo-3-(phenylmethyl)- 6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfan yl]acetamide
  • MW: 488.421 | Formula: C21H18BrN3O2S2
  • H donors: 1 H acceptors: 2 LogP: 4.25 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)Br)CSc1nc2CCSc2c(=O)n1Cc1ccccc1
  • InChi: 1S/C21H18BrN3O2S2/c22-15-6-8-16(9-7-15)23-18(26)13-29-21-24-17-10-11-28-19(17)20(27)25(21)12-14-4-2-1-3-5-14/h1-9H,10-13H2,(H,23,26)
  • InChiKey: HWSYVBXYIVIDJP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-bromophenyl)-2-[[4-oxo-3-(phenylmethyl)-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]thio]acetamide
  • 2-[[3-(benzyl)-4-keto-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]thio]-N-(4-bromophenyl)acetamide
  • N-(4-bromophenyl)-2-[[4-oxo-3-(phenylmethyl)-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi heat shock protein 90, putative 0.0018 0.0052 0.0779
Echinococcus granulosus heat shock protein 90 0.0037 0.0186 0.0771
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0053 0.0793
Plasmodium vivax heat shock protein 90, putative 0.0028 0.0127 0.0903
Echinococcus granulosus thioredoxin glutathione reductase 0.0044 0.024 0.0994
Onchocerca volvulus Protein ultraspiracle homolog 0.0073 0.0447 0.0323
Leishmania major heat shock protein 83-1 0.0043 0.023 0.4042
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.003 0.0123
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0018 0.0053 0.0221
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0035 0.0171 0.0709
Loa Loa (eye worm) hypothetical protein 0.0047 0.0257 0.0234
Brugia malayi PXA domain containing protein 0.0018 0.0052 0.0049
Plasmodium vivax glutathione reductase, putative 0.0044 0.024 0.1973
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0073 0.0447 0.0455
Echinococcus multilocularis endoplasmin 0.004 0.0211 0.0876
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0073 0.0447 0.0455
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0073 0.0447 0.043
Trypanosoma brucei heat shock protein 84, putative 0.0028 0.0127 0.2158
Loa Loa (eye worm) RecQ helicase 0.0022 0.0085 0.0057
Schistosoma mansoni nuclear receptor nhr-48 0.0035 0.0171 0.1622
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0186 0.3231
Loa Loa (eye worm) hypothetical protein 0.0073 0.0447 0.043
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0053 0.0793
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.003 0.0026
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0085 0.0351
Entamoeba histolytica hypothetical protein 0.0034 0.0164 0.2836
Schistosoma mansoni tar DNA-binding protein 0.0059 0.0347 0.3291
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0039 0.02 0.1903
Brugia malayi nuclear receptor NHR-88 0.0073 0.0447 0.0455
Echinococcus multilocularis ecdysone induced protein 78C 0.0073 0.0447 0.1852
Trypanosoma cruzi DNA polymerase eta, putative 0.0018 0.0053 0.0793
Echinococcus granulosus regulator of G protein signaling 7 0.0018 0.0052 0.0217
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0085 0.0082
Trichomonas vaginalis endoplasmin, putative 0.0031 0.0146 0.2503
Brugia malayi RNA recognition motif domain containing protein 0.0059 0.0347 0.0352
Trypanosoma cruzi polo-like protein kinase, putative 0.0088 0.0554 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0013 0.0059
Echinococcus multilocularis axis inhibition protein axin 0.0018 0.0052 0.0217
Brugia malayi ImpB/MucB/SamB family protein 0.0018 0.0053 0.005
Loa Loa (eye worm) hypothetical protein 0.0039 0.02 0.0176
Echinococcus granulosus heat shock protein 0.0043 0.023 0.0954
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0088 0.0554 0.2297
Trypanosoma brucei heat shock protein, putative 0.0043 0.023 0.4042
Trypanosoma cruzi heat shock protein, putative 0.0028 0.0127 0.2158
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0039 0.02 0.0831
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0028 0.0127 0.0529
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0035 0.0171 0.0709
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0013 0.0059
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0034 0.0436
Echinococcus multilocularis nuclear receptor nhr 48 0.0035 0.0171 0.0709
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0018 0.0054 0.0051
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0035 0.0171 0.0709
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0035 0.0171 0.0044
Trypanosoma brucei heat shock protein, putative 0.0043 0.023 0.4042
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.003 0.0123
Trypanosoma cruzi heat shock protein 90, putative 0.0043 0.023 0.4042
Echinococcus multilocularis regulator of G protein signaling 7 0.0018 0.0052 0.0217
Trypanosoma cruzi heat shock protein 85, putative 0.0043 0.023 0.4042
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0554 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0052 0.0777
Leishmania major heat shock protein 83-1 0.0043 0.023 0.4042
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0101 0.0643 0.8837
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0053 0.0793
Loa Loa (eye worm) hypothetical protein 0.0024 0.0093 0.0065
Giardia lamblia Heat shock protein HSP 90-alpha 0.0037 0.0186 0.2922
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0073 0.0447 0.1852
Schistosoma mansoni hypothetical protein 0.0032 0.0152 0.144
Brugia malayi hypothetical protein 0.0018 0.0052 0.0049
Trypanosoma brucei trypanothione reductase 0.0044 0.024 0.4221
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0073 0.0447 0.0455
Giardia lamblia Grp94/Hsp90 0.004 0.0211 0.341
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0073 0.0447 0.0455
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0052 0.0777
Onchocerca volvulus 0.0035 0.0171 0.0044
Echinococcus multilocularis regulator of G protein signaling 0.0018 0.0052 0.0217
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0554 0.5258
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0052 0.0777
Brugia malayi tailless protein 0.0035 0.0171 0.0171
Trypanosoma brucei heat shock protein, putative 0.0043 0.023 0.4042
Mycobacterium tuberculosis Probable oxidoreductase 0.0112 0.0724 1
Schistosoma mansoni nuclear hormone receptor 0.0035 0.0171 0.1622
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0073 0.0447 0.043
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0018 0.0052 0.0497
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0053 0.0793
Loa Loa (eye worm) hypothetical protein 0.0073 0.0447 0.043
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0073 0.0447 0.0455
Loa Loa (eye worm) hypothetical protein 0.0035 0.0171 0.0146
Schistosoma mansoni hypothetical protein 0.0034 0.0164 0.156
Trichomonas vaginalis heat shock protein, putative 0.0043 0.023 0.4042
Brugia malayi heat shock protein 90 0.0043 0.023 0.0232
Schistosoma mansoni hypothetical protein 0.0158 0.1054 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0088 0.0554 0.2297
Leishmania major heat shock protein 83-1 0.0043 0.023 0.4042
Leishmania major heat shock protein 83-1 0.0043 0.023 0.4042
Echinococcus granulosus expressed protein 0.0349 0.2412 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0112 0.072 0.0712
Loa Loa (eye worm) hypothetical protein 0.0039 0.02 0.0176
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0053 0.0793
Echinococcus multilocularis axis inhibition protein axin 0.0018 0.0052 0.0217
Brugia malayi PXA domain containing protein 0.0018 0.0052 0.0049
Brugia malayi latrophilin 2 splice variant baaae 0.0032 0.0152 0.0151
Echinococcus granulosus thyroid hormone receptor alpha 0.0035 0.0171 0.0709
Schistosoma mansoni thyroid hormone receptor 0.0073 0.0447 0.424
Leishmania major trypanothione reductase 0.0044 0.024 0.4221
Loa Loa (eye worm) RNA binding protein 0.0059 0.0347 0.0327
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0023
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0034 0.0436
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0093 0.0561
Entamoeba histolytica heat shock protein 90, putative 0.0043 0.023 0.4042
Schistosoma mansoni endoplasmin 0.0043 0.023 0.2183
Loa Loa (eye worm) PXA domain-containing protein 0.0018 0.0052 0.0023
Plasmodium vivax heat shock protein, putative 0.0162 0.1082 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0447 0.043
Brugia malayi hypothetical protein 0.0015 0.0033 0.0029
Schistosoma mansoni axis inhibition protein axin 0.0018 0.0052 0.0497
Brugia malayi Hsp90 protein 0.0028 0.0127 0.0126
Leishmania major heat shock protein 83-1 0.0043 0.023 0.4042
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0035 0.0171 0.1622
Brugia malayi regulator of G-protein signaling egl-10 0.0018 0.0052 0.0049
Echinococcus granulosus regulator of G protein signaling 3 0.0018 0.0052 0.0217
Plasmodium falciparum endoplasmin, putative 0.0031 0.0146 0.1073
Leishmania major heat shock protein 83-1 0.0043 0.023 0.4042
Plasmodium falciparum heat shock protein 90 0.0043 0.023 0.1872
Brugia malayi hypothetical protein 0.0035 0.0171 0.0171
Trichomonas vaginalis CAMK family protein kinase 0.0044 0.0236 0.4157
Echinococcus multilocularis beta adrenergic receptor kinase 0.0018 0.0054 0.0226
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0053 0.0793
Loa Loa (eye worm) hypothetical protein 0.0039 0.02 0.0176
Trypanosoma brucei polo-like protein kinase 0.0088 0.0554 1
Schistosoma mansoni coup transcription factor 0.0073 0.0447 0.424
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0073 0.0447 0.043
Schistosoma mansoni steroid hormone receptor ad4bp 0.0073 0.0447 0.424
Echinococcus multilocularis dna polymerase eta 0.0018 0.0053 0.0221
Loa Loa (eye worm) hypothetical protein 0.0039 0.02 0.0176
Echinococcus granulosus nuclear receptor nhr 48 0.0035 0.0171 0.0709
Brugia malayi nuclear receptor RXR 0.0035 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0035 0.0171 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0052 0.0777
Entamoeba histolytica serine/threonine protein kinase, putative 0.0088 0.0554 1
Echinococcus granulosus geminin 0.0158 0.1054 0.4369
Brugia malayi Regulator of G protein signaling domain containing protein 0.0018 0.0052 0.0049
Schistosoma mansoni zinc finger protein 0.0035 0.0171 0.1622
Schistosoma mansoni thyroid hormone receptor 0.0073 0.0447 0.424
Schistosoma mansoni axis inhibition protein axin 0.0018 0.0052 0.0497
Brugia malayi RNA binding protein 0.0059 0.0347 0.0352
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0034 0.014
Echinococcus granulosus dna polymerase eta 0.0018 0.0053 0.0221
Entamoeba histolytica heat shock protein 90, putative 0.0043 0.023 0.4042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0073 0.0447 0.043
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0073 0.0447 0.0455
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0073 0.0447 0.0455
Echinococcus multilocularis regulator of G protein signaling 3 0.0018 0.0052 0.0217
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.004 0.0211 0.3697
Schistosoma mansoni tar DNA-binding protein 0.0059 0.0347 0.3291
Brugia malayi hypothetical protein 0.0039 0.02 0.0201
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0073 0.0447 0.1852
Brugia malayi hypothetical protein 0.0024 0.0093 0.009
Plasmodium falciparum glutathione reductase 0.0044 0.024 0.1965
Echinococcus granulosus axis inhibition protein axin 0.0018 0.0052 0.0217
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0035 0.0171 0.0709
Onchocerca volvulus Bile acid receptor homolog 0.0073 0.0447 0.0323
Echinococcus multilocularis Regulator of G protein signaling 20 0.0018 0.0052 0.0217
Loa Loa (eye worm) steroid hormone receptor 0.0073 0.0447 0.043
Brugia malayi orphan nuclear receptor NR2E1 0.0035 0.0171 0.0171
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0054 0.0517
Schistosoma mansoni hypothetical protein 0.0015 0.003 0.0283
Trypanosoma cruzi heat shock protein 85, putative 0.0043 0.023 0.4042
Loa Loa (eye worm) thioredoxin reductase 0.0044 0.024 0.0217
Trypanosoma cruzi heat shock protein 85, putative 0.0043 0.023 0.4042
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0073 0.0447 0.1852
Mycobacterium ulcerans DNA polymerase IV 0.0018 0.0053 0.1094
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0052 0.0497
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0073 0.0447 0.0455
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0112 0.0724 1
Trypanosoma brucei DNA polymerase IV, putative 0.0018 0.0053 0.0793
Trichomonas vaginalis heat shock protein, putative 0.0037 0.0186 0.3231
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0073 0.0447 0.424
Brugia malayi A-kinase anchor protein 10, precursor 0.0018 0.0052 0.0049
Loa Loa (eye worm) hypothetical protein 0.0032 0.0152 0.0126
Mycobacterium tuberculosis Conserved hypothetical protein 0.0018 0.0053 0.0281
Entamoeba histolytica hypothetical protein 0.0018 0.0052 0.0777
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0034 0.0436
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0053 0.0793
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0034 0.0022
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0018 0.0053 0.0221
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0018 0.0052 0.0497
Loa Loa (eye worm) nuclear receptor nhr-7B 0.1374 0.9724 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0447 0.043
Brugia malayi nuclear receptor RXR 0.0039 0.02 0.0201
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.0034 0.001
Brugia malayi steroid hormone receptor 0.0073 0.0447 0.0455
Leishmania major heat shock protein 83-1 0.0043 0.023 0.4042
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0073 0.0447 0.1852
Schistosoma mansoni nuclear hormone receptor 0.0035 0.0171 0.1622
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0059 0.0347 0.0327
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.003 0.0123
Mycobacterium tuberculosis Probable dehydrogenase 0.0101 0.0643 0.8837
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0018 0.0052 0.0023
Plasmodium vivax thioredoxin reductase, putative 0.0044 0.024 0.1973
Echinococcus granulosus axis inhibition protein axin 0.0018 0.0052 0.0217
Loa Loa (eye worm) hypothetical protein 0.0113 0.073 0.0722
Toxoplasma gondii heat shock protein 90, putative 0.0043 0.023 0.1889
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0093 0.1517
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0073 0.0447 0.424
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0088 0.0554 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0034 0.0436
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0034 0.0164 0.0682
Entamoeba histolytica deoxycytidyl transferase, putative 0.0018 0.0053 0.0793
Entamoeba histolytica hypothetical protein 0.0034 0.0164 0.2836
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.0053 0.0793
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0065 0.0299
Trypanosoma brucei unspecified product 0.0012 0.0013 0.0059
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0101 0.0643 0.8837
Schistosoma mansoni DNA polymerase eta 0.0018 0.0053 0.0505
Trypanosoma cruzi heat shock protein 90, putative 0.0037 0.0186 0.3231
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0018 0.0054 0.0025
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0018 0.0052 0.0497
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0093 0.1517
Loa Loa (eye worm) hypothetical protein 0.0039 0.02 0.0176
Trypanosoma brucei heat shock protein, putative 0.0043 0.023 0.4042
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0035 0.0171 0.1622
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0052 0.0497
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0035 0.0171 0.0709
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0146 0.2503
Echinococcus granulosus endoplasmin 0.004 0.0211 0.0876
Trypanosoma brucei unspecified product 0.0018 0.0053 0.0793
Loa Loa (eye worm) hypothetical protein 0.0035 0.0171 0.0146
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0073 0.0447 0.043
Entamoeba histolytica hypothetical protein 0.0034 0.0164 0.2836
Trypanosoma brucei Heat shock protein 83, putative 0.0043 0.023 0.4042
Brugia malayi regulator of G-protein signaling rgs-7 0.0018 0.0052 0.0049
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0023
Schistosoma mansoni kinase 0.0045 0.0245 0.2321
Echinococcus granulosus ecdysone induced protein 78C 0.0073 0.0447 0.1852
Echinococcus multilocularis regulator of G protein signaling 3 0.0018 0.0052 0.0217
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0073 0.0447 0.1852
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0018 0.0053 0.0281
Brugia malayi hypothetical protein 0.0034 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0035 0.0171 0.0146
Brugia malayi hypothetical protein 0.0039 0.02 0.0201
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0028 0.0127 0.2158
Trypanosoma cruzi Heat shock protein 83, putative 0.0043 0.023 0.4042
Loa Loa (eye worm) nuclear hormone receptor 0.0035 0.0171 0.0146
Mycobacterium tuberculosis Probable reductase 0.0101 0.0643 0.8837
Leishmania major DNA polymerase kappa, putative 0.0018 0.0053 0.0793
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0034 0.0436
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0034 0.0436
Giardia lamblia Heat shock protein HSP 90-alpha 0.0043 0.023 0.377
Brugia malayi Latrophilin receptor protein 2 0.0015 0.003 0.0026
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0073 0.0447 0.1852
Trypanosoma brucei heat shock protein, putative 0.0043 0.023 0.4042
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0554 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0034 0.0321
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0034 0.0436
Brugia malayi Calcitonin receptor-like protein seb-1 0.0047 0.0257 0.0259
Schistosoma mansoni nuclear receptor 0.0035 0.0171 0.1622
Echinococcus multilocularis heat shock protein 0.0043 0.023 0.0954
Echinococcus multilocularis FTZ F1 alpha 0.0073 0.0447 0.1852
Toxoplasma gondii heat shock protein 75, putative 0.0028 0.0127 0.0914
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0034 0.0436
Onchocerca volvulus 0.0035 0.0171 0.0044
Brugia malayi Nuclear hormone receptor E75 0.0035 0.0171 0.0171
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0015 0.0034 0.5
Echinococcus multilocularis thioredoxin glutathione reductase 0.0044 0.024 0.0994
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0018 0.0053 0.0793
Schistosoma mansoni terminal deoxycytidyl transferase 0.0018 0.0053 0.0505
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0073 0.0447 0.1852
Toxoplasma gondii heat shock protein HSP90 0.0043 0.023 0.1889
Brugia malayi nuclear hormone receptor 0.1374 0.9724 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0171 0.0146
Loa Loa (eye worm) nuclear receptor NHR-67 0.0035 0.0171 0.0146
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0093 0.0561
Loa Loa (eye worm) heat shock protein 75 0.0028 0.0127 0.0101
Loa Loa (eye worm) hypothetical protein 0.0035 0.0171 0.0146
Loa Loa (eye worm) transcription factor SMAD2 0.0112 0.072 0.0712
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0034 0.0436
Brugia malayi Regulator of G protein signaling domain containing protein 0.0018 0.0052 0.0049
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0047 0.0257 0.0234
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0554 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0034 0.0436
Onchocerca volvulus 0.0073 0.0447 0.0323
Loa Loa (eye worm) TAR-binding protein 0.0059 0.0347 0.0327
Brugia malayi MH2 domain containing protein 0.0112 0.072 0.0736
Loa Loa (eye worm) heat shock protein 90 0.0043 0.023 0.0207
Schistosoma mansoni transcription factor LCR-F1 0.0034 0.0164 0.156
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0018 0.0053 0.0793
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0052 0.0777
Trichomonas vaginalis DNA polymerase eta, putative 0.0018 0.0053 0.0793
Schistosoma mansoni hypothetical protein 0.0015 0.003 0.0283
Trichomonas vaginalis heat shock protein, putative 0.004 0.0211 0.3697
Loa Loa (eye worm) hypothetical protein 0.0035 0.0171 0.0146
Brugia malayi hypothetical protein 0.0018 0.0052 0.0049
Brugia malayi nuclear hormone receptor family member nhr-6 0.0035 0.0171 0.0171
Plasmodium falciparum heat shock protein 90, putative 0.0025 0.0102 0.0652
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0073 0.0447 0.1852
Loa Loa (eye worm) hypothetical protein 0.0073 0.0447 0.043
Schistosoma mansoni retinoic acid receptor RXR 0.0073 0.0447 0.424
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0018 0.0052 0.0777
Brugia malayi nuclear receptor NHR-88 0.0035 0.0171 0.0171
Echinococcus granulosus regulator of G protein signaling 3 0.0018 0.0052 0.0217
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0034 0.014
Echinococcus granulosus Nuclear hormone receptor HR96 0.0035 0.0171 0.0709
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0023
Loa Loa (eye worm) glutathione reductase 0.0044 0.024 0.0217
Trypanosoma brucei heat shock protein, putative 0.0043 0.023 0.4042
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0052 0.0497
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.003 0.0123
Echinococcus granulosus beta-adrenergic receptor kinase 0.0018 0.0054 0.0226
Trypanosoma brucei unspecified product 0.0012 0.0013 0.0059
Leishmania major heat shock protein 83-1 0.0043 0.023 0.4042
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.02 0.0201
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0101 0.0643 0.8837
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0018 0.0053 0.0024
Echinococcus multilocularis geminin 0.0158 0.1054 0.4369
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0554 1
Leishmania major heat shock protein 83-1 0.0043 0.023 0.4042
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0073 0.0447 0.1852
Leishmania major heat shock protein 83-1 0.0043 0.023 0.4042
Schistosoma mansoni heat shock protein 0.0028 0.0127 0.121
Echinococcus granulosus dna polymerase kappa 0.0018 0.0053 0.0221
Echinococcus multilocularis heat shock protein 90 0.0043 0.023 0.0954
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0028 0.0127 0.0529
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0112 0.0724 1
Leishmania major heat shock protein 83-1 0.0043 0.023 0.4042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0073 0.0447 0.043
Leishmania major heat shock protein 83-1 0.0043 0.023 0.4042
Toxoplasma gondii thioredoxin reductase 0.0044 0.024 0.1982
Plasmodium falciparum heat shock protein 90, putative 0.0162 0.1082 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0073 0.0447 0.424
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.02 0.0201
Loa Loa (eye worm) endoplasmin 0.0043 0.023 0.0207
Schistosoma mansoni heat shock protein 0.0043 0.023 0.2183
Giardia lamblia DINP protein human, muc B family 0.0018 0.0053 0.0373
Plasmodium vivax heat shock protein 86, putative 0.0043 0.023 0.188
Schistosoma mansoni endoplasmin 0.0043 0.023 0.2183
Brugia malayi nuclear hormone receptor family member odr-7 0.0035 0.0171 0.0171
Trypanosoma brucei DNA polymerase IV, putative 0.0018 0.0053 0.0793
Brugia malayi Nuclear hormone receptor-like 1 0.0073 0.0447 0.0455
Entamoeba histolytica hypothetical protein 0.0018 0.0052 0.0777
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0034 0.0022
Loa Loa (eye worm) hypothetical protein 0.1339 0.9478 0.9746
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0047 0.0257 0.0259
Leishmania major heat shock protein 83-1 0.0043 0.023 0.4042
Schistosoma mansoni hypothetical protein 0.0015 0.003 0.0283
Leishmania major hypothetical protein, conserved 0.0024 0.0093 0.1517
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0034 0.0436
Schistosoma mansoni heat shock protein 0.0043 0.023 0.2183
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0053 0.0793
Echinococcus granulosus heat shock protein 90 0.0043 0.023 0.0954
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0073 0.0447 0.0455
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0034 0.0436
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0018 0.0052 0.0217
Echinococcus multilocularis heat shock protein 90 0.0037 0.0186 0.0771
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0039 0.02 0.0176
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0073 0.0447 0.1852
Schistosoma mansoni tar DNA-binding protein 0.0059 0.0347 0.3291
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0554 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0088 0.0554 0.0541
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0023
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0035 0.0171 0.0171
Echinococcus granulosus bloom syndrome protein 0.0022 0.0085 0.0351
Schistosoma mansoni RAR-like nuclear receptor 0.0073 0.0447 0.424
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0073 0.0447 0.424
Echinococcus granulosus FTZ F1 alpha 0.0073 0.0447 0.1852
Brugia malayi Nuclear hormone receptor E75 0.0035 0.0171 0.0171
Schistosoma mansoni nuclear hormone receptor 0.0073 0.0447 0.424
Brugia malayi ecdysone receptor 0.0035 0.0171 0.0171
Echinococcus granulosus tar DNA binding protein 0.0059 0.0347 0.1438
Brugia malayi TAR-binding protein 0.0059 0.0347 0.0352
Schistosoma mansoni tar DNA-binding protein 0.0059 0.0347 0.3291
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0554 1
Entamoeba histolytica hypothetical protein 0.0034 0.0164 0.2836
Trypanosoma brucei DNA polymerase IV, putative 0.0018 0.0053 0.0793
Brugia malayi serine/threonine-protein kinase plk-2 0.0088 0.0554 0.0565
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0023
Schistosoma mansoni tar DNA-binding protein 0.0059 0.0347 0.3291
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0093 0.057
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0053 0.0793
Loa Loa (eye worm) hypothetical protein 0.0073 0.0447 0.043
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0102 0.1692
Schistosoma mansoni hypothetical protein 0.0015 0.003 0.0283
Brugia malayi nuclear receptor NHR-67 0.0035 0.0171 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0052 0.0777
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0035 0.0171 0.0709
Brugia malayi ImpB/MucB/SamB family protein 0.0018 0.0053 0.005
Brugia malayi Steroid receptor seven-up type 2 0.0073 0.0447 0.0455
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0035 0.0171 0.0709
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0073 0.0447 0.0455
Onchocerca volvulus Serine\/threonine kinase homolog 0.0088 0.0554 0.0432
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.0024
Loa Loa (eye worm) hypothetical protein 0.0035 0.0171 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0073 0.0447 0.0455
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0054 0.0517
Echinococcus granulosus regulator of G protein signaling 7 0.0018 0.0052 0.0217
Leishmania major heat shock protein, putative 0.0028 0.0127 0.2158
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0073 0.0447 0.1852
Mycobacterium ulcerans DNA polymerase IV 0.0018 0.0053 0.1094
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0037 0.0186 0.0771
Echinococcus multilocularis expressed protein 0.0349 0.2412 1
Trichomonas vaginalis heat shock protein, putative 0.004 0.0211 0.3697
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0053 0.0793
Brugia malayi Thioredoxin reductase 0.0044 0.024 0.0242
Trypanosoma cruzi polo-like protein kinase, putative 0.0088 0.0554 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0171 0.0146
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.02 0.1903
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0052 0.0497
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0554 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0013 0.0059
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0034 0.0164 0.0682
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0073 0.0447 0.0455
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0073 0.0447 0.043
Echinococcus multilocularis thyroid hormone receptor alpha 0.0073 0.0447 0.1852
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0093 0.0582
Schistosoma mansoni z-protein (S1r protein) 0.0018 0.0052 0.0497
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.024 0.4221
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0034 0.0436
Loa Loa (eye worm) hypothetical protein 0.0035 0.0171 0.0146
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0018 0.0053 0.0505
Brugia malayi Endoplasmin precursor 0.0043 0.023 0.0232
Leishmania major heat shock protein 83-1 0.0043 0.023 0.4042
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0073 0.0447 0.1852
Trichomonas vaginalis CAMK family protein kinase 0.0044 0.0236 0.4157
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.0053 0.0793
Loa Loa (eye worm) hypothetical protein 0.0035 0.0171 0.0146
Echinococcus multilocularis dna polymerase kappa 0.0018 0.0053 0.0221
Leishmania major heat shock protein 83-1 0.0043 0.023 0.4042
Schistosoma mansoni nuclear receptor 0.0035 0.0171 0.1622
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0034 0.0436
Trypanosoma brucei heat shock protein 90, putative 0.0043 0.023 0.4042
Echinococcus granulosus GPCR family 2 0.0015 0.003 0.0123
Echinococcus multilocularis GPCR, family 2 0.0015 0.003 0.0123
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0073 0.0447 0.1852
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0093 0.1517
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.0053 0.0793
Loa Loa (eye worm) hypothetical protein 0.0035 0.0171 0.0146
Leishmania major DNA polymerase eta, putative 0.0018 0.0053 0.0793
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0044 0.024 0.2985
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0034 0.0436
Brugia malayi glutathione reductase 0.0044 0.024 0.0242
Leishmania major heat shock protein 83-1 0.0043 0.023 0.4042
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0112 0.0724 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0034 0.0436
Brugia malayi ecdysteroid receptor 0.0073 0.0447 0.0455
Mycobacterium ulcerans heat shock protein 90 0.004 0.0211 1
Trypanosoma brucei heat shock protein, putative 0.0043 0.023 0.4042
Echinococcus granulosus Regulator of G protein signaling 20 0.0018 0.0052 0.0217
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0023
Brugia malayi conserved hypotetical protein 0.0035 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0073 0.0447 0.043
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0054 0.0517
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0034 0.0436
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0073 0.0447 0.424
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.0034 0.001
Echinococcus granulosus Nuclear hormone receptor HR96 0.0035 0.0171 0.0709
Echinococcus multilocularis regulator of G protein signaling 7 0.0018 0.0052 0.0217
Toxoplasma gondii Hsp90 domain-containing protein 0.0162 0.1082 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0051 0.0484
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0034 0.0436
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0101 0.0643 0.8435
Treponema pallidum heat shock protein 90 0.004 0.0211 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0085 0.137
Loa Loa (eye worm) DR-78 0.0035 0.0171 0.0146
Trypanosoma brucei heat shock protein 90, putative 0.0043 0.023 0.4042
Plasmodium falciparum thioredoxin reductase 0.0044 0.024 0.1965
Brugia malayi nuclear hormone receptor 0.0073 0.0447 0.0455
Loa Loa (eye worm) hypothetical protein 0.0035 0.0171 0.0146
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0085 0.137
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0073 0.0447 0.424
Trypanosoma brucei heat shock protein, putative 0.0043 0.023 0.4042
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0034 0.0436
Entamoeba histolytica hypothetical protein 0.0018 0.0052 0.0777
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.004 0.0211 1
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0052 0.0497
Brugia malayi photoreceptor-specific nuclear receptor 0.0073 0.0447 0.0455
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0018 0.0052 0.0217
Schistosoma mansoni hypothetical protein 0.0158 0.1054 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0447 0.043
Plasmodium vivax endoplasmin, putative 0.0043 0.023 0.188
Leishmania major heat shock protein 83-1 0.0043 0.023 0.4042
Loa Loa (eye worm) RGS-3 protein 0.0018 0.0052 0.0023
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.0053 0.0793
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0101 0.0643 0.8837
Brugia malayi hypothetical protein 0.0035 0.0171 0.0171
Trypanosoma brucei DNA polymerase eta, putative 0.0018 0.0053 0.0793
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0039 0.02 0.0831
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0073 0.0447 0.0455
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0034 0.003
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.004 0.0211 0.2572
Echinococcus multilocularis tar DNA binding protein 0.0059 0.0347 0.1438
Giardia lamblia Kinase, PLK 0.0088 0.0554 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0035 0.0171 0.0044
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0018 0.0054 0.0025

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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