TDR Targets

Basic information

Technical information

TDR Targets ID: 874932
Name: N-(4-chlorophenyl)-2-[1-(3-methoxyphenyl)-2,5 -dioxo-3-(pyridin-3-ylmethyl)imidazolidin-4-y l]acetamide
MW: 464.901 | Formula: C24H21ClN4O4
H donors: 1 H acceptors: 4 LogP: 2.74 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)N1C(=O)N(C(C1=O)CC(=O)Nc1ccc(cc1)Cl)Cc1cccnc1
InChi: 1S/C24H21ClN4O4/c1-33-20-6-2-5-19(12-20)29-23(31)21(13-22(30)27-18-9-7-17(25)8-10-18)28(24(29)32)15-16-4-3-11-26-14-16/h2-12,14,21H,13,15H2,1H3,(H,27,30)
InChiKey: PHVBXVYPLYDLFB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-chlorophenyl)-2-[1-(3-methoxyphenyl)-2,5-dioxo-3-(3-pyridylmethyl)imidazolidin-4-yl]acetamide
N-(4-chlorophenyl)-2-[1-(3-methoxyphenyl)-2,5-dioxo-3-(3-pyridylmethyl)-4-imidazolidinyl]acetamide
N-(4-chlorophenyl)-2-[2,5-diketo-1-(3-methoxyphenyl)-3-(3-pyridylmethyl)imidazolidin-4-yl]acetamide
N-(4-chlorophenyl)-2-[1-(3-methoxyphenyl)-2,5-dioxo-3-(pyridin-3-ylmethyl)imidazolidin-4-yl]ethanamide
STK196348

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	neuroligin	0.0944	0.1653	0.1653
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0207	0.0328	0.0328
Onchocerca volvulus		0.0944	0.1653	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0342	0.057	1
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0037	0.0023	0.0023
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0069	0.008	0.008
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.0011	0.0011
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.5586	1	1
Echinococcus granulosus	lamin dm0	0.0031	0.0011	0.0011
Loa Loa (eye worm)	carboxylesterase	0.0944	0.1653	0.1653
Echinococcus multilocularis	glutamate receptor 2	0.0037	0.0023	0.0023
Loa Loa (eye worm)	cytochrome P450 family protein	0.0056	0.0056	0.0056
Echinococcus multilocularis	lamin	0.0031	0.0011	0.0011
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0069	0.008	0.0071
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0037	0.0023	0.0023
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0944	0.1653	0.1653
Echinococcus multilocularis	lamin dm0	0.0031	0.0011	0.0011
Brugia malayi	Carboxylesterase family protein	0.0944	0.1653	0.1653
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.0063	0.0069	0.5
Echinococcus multilocularis	geminin	0.0192	0.0301	0.0301
Schistosoma mansoni	lamin	0.0031	0.0011	0.0011
Toxoplasma gondii	aldehyde dehydrogenase	0.0069	0.008	1
Echinococcus granulosus	neuroligin	0.0944	0.1653	0.1653
Entamoeba histolytica	acetyltransferase, GNAT family	0.0044	0.0036	0.5
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0944	0.1653	0.1653
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0037	0.0023	0.0023
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0944	0.1653	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0031	0.0011	0.0011
Brugia malayi	intermediate filament protein	0.0031	0.0011	0.0011
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0037	0.0023	0.0023
Schistosoma mansoni	hypothetical protein	0.0192	0.0301	0.0301
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0162	0.0247	0.3398
Mycobacterium tuberculosis	Conserved hypothetical protein	0.018	0.028	0.133
Echinococcus granulosus	lamin	0.0031	0.0011	0.0011
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0944	0.1653	1
Schistosoma mansoni	intermediate filament proteins	0.0031	0.0011	0.0011
Mycobacterium ulcerans	carboxylesterase, LipT	0.0944	0.1653	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0059	0.0061	0.0358
Echinococcus granulosus	glutamate receptor 2	0.0037	0.0023	0.0023
Echinococcus granulosus	carboxylesterase 5A	0.5586	1	1
Loa Loa (eye worm)	hypothetical protein	0.0944	0.1653	0.1653
Chlamydia trachomatis	glutamine binding protein	0.0063	0.0069	0.5
Echinococcus multilocularis	acetylcholinesterase	0.5586	1	1
Loa Loa (eye worm)	acetylcholinesterase 1	0.5586	1	1
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0944	0.1653	0.1653
Schistosoma mansoni	lamin	0.0031	0.0011	0.0011
Brugia malayi	Carboxylesterase family protein	0.0944	0.1653	0.1653
Mycobacterium ulcerans	hypothetical protein	0.018	0.028	0.133
Onchocerca volvulus		0.0944	0.1653	1
Toxoplasma gondii	hypothetical protein	0.0055	0.0055	0.321
Plasmodium falciparum	histone acetyltransferase GCN5	0.0044	0.0036	0.5
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0162	0.0247	0.3871
Brugia malayi	Carboxylesterase family protein	0.0944	0.1653	0.1653
Brugia malayi	acetyltransferase, GNAT family protein	0.0165	0.0253	0.0253
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.0063	0.0069	0.5
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0049	0.0043	0.5
Echinococcus multilocularis	nmda type glutamate receptor	0.0087	0.0113	0.0113
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0069	0.008	0.008
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0165	0.0253	0.0253
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0087	0.0113	0.0113
Brugia malayi	Carboxylesterase family protein	0.5586	1	1
Echinococcus granulosus	acetylcholinesterase	0.5586	1	1
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0165	0.0253	0.0253
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0037	0.0023	0.0023
Brugia malayi	Cytochrome P450 family protein	0.0056	0.0056	0.0056
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0162	0.0247	0.3871
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0342	0.057	1
Loa Loa (eye worm)	hypothetical protein	0.0944	0.1653	0.1653
Echinococcus granulosus	geminin	0.0192	0.0301	0.0301
Echinococcus granulosus	para nitrobenzyl esterase	0.0944	0.1653	0.1653
Loa Loa (eye worm)	carboxylesterase	0.0944	0.1653	0.1653
Schistosoma mansoni	acetylcholinesterase	0.0944	0.1653	0.1653
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0037	0.0023	0.0023
Onchocerca volvulus		0.0944	0.1653	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0069	0.008	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0011	0.0011
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.0011	0.0011
Echinococcus multilocularis	musashi	0.0031	0.0011	0.0011
Onchocerca volvulus		0.0944	0.1653	1
Brugia malayi	Carboxylesterase family protein	0.0944	0.1653	0.1653
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0069	0.008	0.0071
Schistosoma mansoni	hypothetical protein	0.0192	0.0301	0.0301
Schistosoma mansoni	aldehyde dehydrogenase	0.0069	0.008	0.008
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0944	0.1653	0.1653
Loa Loa (eye worm)	hypothetical protein	0.003	0.001	0.001
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0207	0.0328	0.0328
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0944	0.1653	0.1653
Loa Loa (eye worm)	hypothetical protein	0.0944	0.1653	0.1653
Schistosoma mansoni	aldehyde dehydrogenase	0.0069	0.008	0.008
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0037	0.0023	0.0023
Loa Loa (eye worm)	carboxylesterase	0.5586	1	1
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0944	0.1653	0.1653
Echinococcus granulosus	BC026374 protein S09 family	0.0944	0.1653	0.1653
Loa Loa (eye worm)	hypothetical protein	0.0944	0.1653	0.1653
Echinococcus granulosus	intermediate filament protein	0.0031	0.0011	0.0011
Echinococcus multilocularis	acetylcholinesterase	0.5586	1	1
Schistosoma mansoni	gliotactin	0.0944	0.1653	0.1653
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0069	0.008	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0944	0.1653	0.1653
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0063	0.0069	0.0069
Onchocerca volvulus		0.0944	0.1653	1
Giardia lamblia	Histone acetyltransferase GCN5	0.0044	0.0036	0.5
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0944	0.1653	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0049	0.0043	0.0043
Brugia malayi	hypothetical protein	0.0944	0.1653	0.1653
Loa Loa (eye worm)	acetyltransferase	0.0165	0.0253	0.0253
Schistosoma mansoni	glutamate receptor NMDA	0.0037	0.0023	0.0023
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0063	0.0069	0.0069
Schistosoma mansoni	BC026374 protein (S09 family)	0.0944	0.1653	0.1653
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0342	0.057	1
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.0063	0.0069	0.5
Echinococcus granulosus	histone acetyltransferase KAT2B	0.016	0.0244	0.0244
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0944	0.1653	1
Loa Loa (eye worm)	hypothetical protein	0.5586	1	1
Schistosoma mansoni	lipoxygenase	0.0063	0.0069	0.0069
Trichomonas vaginalis	spcc417.12 protein, putative	0.0944	0.1653	1
Loa Loa (eye worm)	hypothetical protein	0.5586	1	1
Schistosoma mansoni	glutamate receptor NMDA	0.0207	0.0328	0.0328
Echinococcus multilocularis	para nitrobenzyl esterase	0.0944	0.1653	0.1653
Echinococcus multilocularis	carboxylesterase 5A	0.5586	1	1
Loa Loa (eye worm)	hypothetical protein	0.0944	0.1653	0.1653
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0037	0.0023	0.0023
Echinococcus granulosus	nmda type glutamate receptor	0.0087	0.0113	0.0113
Echinococcus granulosus	acetylcholinesterase	0.5586	1	1
Leishmania major	mitochondrial DNA polymerase beta	0.0342	0.057	1
Loa Loa (eye worm)	hypothetical protein	0.0944	0.1653	0.1653
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0944	0.1653	0.1653

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 874932