TDR Targets

Basic information

Technical information

TDR Targets ID: 875123
Name: N-(4-chlorophenyl)-2-[3-cyclopentyl-1-(3-meth oxyphenyl)-2,5-dioxoimidazolidin-4-yl]acetami de
MW: 441.907 | Formula: C23H24ClN3O4
H donors: 1 H acceptors: 3 LogP: 3.59 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)N1C(=O)N(C(C1=O)CC(=O)Nc1ccc(cc1)Cl)C1CCCC1
InChi: 1S/C23H24ClN3O4/c1-31-19-8-4-7-18(13-19)27-22(29)20(26(23(27)30)17-5-2-3-6-17)14-21(28)25-16-11-9-15(24)10-12-16/h4,7-13,17,20H,2-3,5-6,14H2,1H3,(H,25,28)
InChiKey: ZOUMVSGHVRVUNZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-chlorophenyl)-2-[3-cyclopentyl-1-(3-methoxyphenyl)-2,5-dioxo-imidazolidin-4-yl]acetamide
N-(4-chlorophenyl)-2-[3-cyclopentyl-1-(3-methoxyphenyl)-2,5-dioxo-4-imidazolidinyl]acetamide
N-(4-chlorophenyl)-2-[3-cyclopentyl-2,5-diketo-1-(3-methoxyphenyl)imidazolidin-4-yl]acetamide
N-(4-chlorophenyl)-2-[3-cyclopentyl-1-(3-methoxyphenyl)-2,5-dioxo-imidazolidin-4-yl]ethanamide
STK196366

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0152	0.0502	0.0502
Echinococcus multilocularis	abhydrolase domain containing protein	0.0009	0.0002	0.0002
Mycobacterium ulcerans	hydrolase	0.0009	0.0002	0.0016
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0004	0.0009
Brugia malayi	UPF0017 protein CG3488	0.0009	0.0002	0.0004
Loa Loa (eye worm)	ab-hydrolase associated lipase region family protein	0.0009	0.0002	0.0002
Entamoeba histolytica	hypothetical protein	0.0009	0.0002	0.0037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0009	0.0002	0.0037
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0051	0.0981
Mycobacterium tuberculosis	Possible peroxidase BpoB (non-haem peroxidase)	0.0009	0.0002	0.0016
Plasmodium falciparum	M1-family alanyl aminopeptidase, putative	0.0152	0.0502	1
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0004	0.0004
Echinococcus granulosus	lysosomal acid lipase:cholesteryl ester	0.0009	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0017	0.003	0.003
Mycobacterium ulcerans	aminopeptidase N PepN	0.0152	0.0502	0.4323
Mycobacterium ulcerans	peroxidase BpoB	0.0009	0.0002	0.0016
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0004	0.0009
Schistosoma mansoni	family S33 non-peptidase homologue (S33 family)	0.0009	0.0002	0.0002
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0152	0.0502	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.003	0.003
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0152	0.0502	1
Mycobacterium leprae	Possible short-chain dehydrogenase EphD	0.0009	0.0002	0.0369
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0152	0.0502	0.0502
Mycobacterium ulcerans	homoserine O-acetyltransferase	0.0009	0.0002	0.0016
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0004	0.0004
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0152	0.0502	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0004	0.0004
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0004	0.0004
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0152	0.0502	1
Mycobacterium leprae	Probable exported protease	0.0009	0.0002	0.0369
Plasmodium falciparum	epoxide hydrolase 1	0.0009	0.0002	0.0037
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0796	0.2767	0.2767
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0152	0.0502	0.0502
Mycobacterium ulcerans	hypothetical protein	0.0009	0.0002	0.0016
Echinococcus granulosus	aminopeptidase N	0.0152	0.0502	0.0502
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0152	0.0502	1
Brugia malayi	nuclear hormone receptor	0.001	0.0004	0.0009
Echinococcus multilocularis	lysosomal acid lipase:cholesteryl ester	0.0009	0.0002	0.0002
Mycobacterium tuberculosis	Probable homoserine O-acetyltransferase MetA (homoserine O-trans-acetylase) (homoserine transacetylase) (HTA)	0.0009	0.0002	0.0016
Trypanosoma cruzi	aminopeptidase, putative	0.0152	0.0502	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0004	0.0004
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0004	0.008
Echinococcus granulosus	abhydrolase domain containing protein	0.0009	0.0002	0.0002
Mycobacterium ulcerans	exported protease	0.0009	0.0002	0.0016
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0027	0.0232
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0004	0.008
Trypanosoma brucei	hydrolase, alpha/beta fold family, putative	0.0009	0.0002	0.0037
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0051	0.0439
Trypanosoma brucei	hydrolase, alpha/beta fold family, putative	0.0009	0.0002	0.0037
Mycobacterium ulcerans	haloalkane dehalogenase	0.0009	0.0002	0.0016
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0128	0.0128
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0051	0.0439
Trypanosoma cruzi	hypothetical protein, conserved	0.0009	0.0002	0.0037
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0152	0.0502	0.0502
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0004	0.0004
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.003	1
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0152	0.0502	0.0502
Trypanosoma cruzi	hydrolase-like protein	0.0009	0.0002	0.0037
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0004	0.0004
Mycobacterium ulcerans	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD	0.0009	0.0002	0.0016
Trypanosoma cruzi	hypothetical protein, conserved	0.0009	0.0002	0.0037
Schistosoma mansoni	coup transcription factor	0.001	0.0004	0.0004
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0004	0.0009
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.0152	0.0502	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0051	0.0051
Echinococcus granulosus	abhydrolase domain containing protein 11	0.0009	0.0002	0.0002
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0152	0.0502	1
Loa Loa (eye worm)	TATA binding protein associated factor	0.0152	0.0502	0.0502
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0152	0.0502	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0004	0.0004
Echinococcus multilocularis	abhydrolase domain containing protein 3	0.0009	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.001	0.0004	0.0004
Onchocerca volvulus		0.0023	0.0051	0.1015
Mycobacterium tuberculosis	Possible haloalkane dehalogenase	0.0009	0.0002	0.0016
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.2852	1	1
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0152	0.0502	1
Mycobacterium tuberculosis	Probable haloalkane dehalogenase	0.0009	0.0002	0.0016
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0152	0.0502	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0128	0.0279
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0152	0.0502	1
Mycobacterium ulcerans	oxidoreductase	0.0009	0.0002	0.0016
Mycobacterium ulcerans	acyl-CoA synthetase	0.001	0.0005	0.0045
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0152	0.0502	0.0502
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0004	0.0004
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.003	0.0261
Onchocerca volvulus	Lipase homolog	0.0009	0.0002	0.0037
Mycobacterium ulcerans	haloalkane dehalogenase	0.0009	0.0002	0.0016
Entamoeba histolytica	alpha/beta hydrolase fold protein, putative	0.0009	0.0002	0.0037
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0004	0.0004
Trypanosoma cruzi	hydrolase, alpha/beta fold family, putative	0.0009	0.0002	0.0037
Trypanosoma cruzi	hypothetical protein, conserved	0.0009	0.0002	0.0037
Brugia malayi	Peptidase family M1 containing protein	0.0152	0.0502	0.1096
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0004	0.0004
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0004	0.0009
Mycobacterium leprae	POSSIBLE EPOXIDE HYDROLASE EPHE (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE)	0.0009	0.0002	0.0369
Loa Loa (eye worm)	hypothetical protein	0.001	0.0004	0.0004
Mycobacterium ulcerans	lignin peroxidase LipJ	0.0009	0.0002	0.0016
Echinococcus multilocularis	abhydrolase domain containing 3	0.0009	0.0002	0.0002
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0051	0.1015
Brugia malayi	Peptidase family M1 containing protein	0.0152	0.0502	0.1096
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0004	0.0004
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0004	0.0004
Brugia malayi	TATA binding protein associated factor	0.0152	0.0502	0.1096
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0152	0.0502	0.0502
Mycobacterium ulcerans	lipase/esterase	0.0009	0.0002	0.0016
Mycobacterium ulcerans	hypothetical protein	0.0009	0.0002	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0002
Echinococcus multilocularis	abhydrolase domain containing protein 11	0.0009	0.0002	0.0002
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0051	0.0111
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0128	0.0128
Trypanosoma cruzi	hydrolase-like protein, putative	0.0009	0.0002	0.0037
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0152	0.0502	0.0502
Entamoeba histolytica	aminopeptidase, putative	0.0152	0.0502	1
Onchocerca volvulus		0.0152	0.0502	1
Trypanosoma brucei	aminopeptidase, putative	0.0152	0.0502	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0004	0.0004
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0004	0.0004
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0128	0.0128
Brugia malayi	hydrolase, alpha/beta fold family protein	0.0009	0.0002	0.0004
Mycobacterium ulcerans	hypothetical protein	0.0009	0.0002	0.0016
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0051	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0017	0.003	0.003
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0009	0.0002	0.0037
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0004	0.0004
Mycobacterium tuberculosis	Probable carboxylesterase CaeA	0.0009	0.0002	0.0016
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0051	0.0439
Loa Loa (eye worm)	hypothetical protein	0.001	0.0004	0.0004
Mycobacterium tuberculosis	Possible epoxide hydrolase EphE (epoxide hydratase) (arene-oxide hydratase)	0.0009	0.0002	0.0016
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0051	0.1015
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0004	0.0004
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0004	0.0004
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0009	0.0002	0.0037
Mycobacterium leprae	Probable exported protease	0.0009	0.0002	0.0369
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0051	0.0439
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0017	0.003	0.0261
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0051	0.0981
Mycobacterium ulcerans	epoxide hydrolase EphA	0.0339	0.1161	1
Echinococcus multilocularis	lysosomal acid lipase:cholesteryl ester	0.0009	0.0002	0.0002
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0128	0.0128
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0004	0.0004
Mycobacterium ulcerans	non-heme haloperoxidase Hpx	0.0009	0.0002	0.0016
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0152	0.0502	0.0502
Mycobacterium ulcerans	epoxide hydrolase EphE	0.0009	0.0002	0.0016
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0152	0.0502	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0004	0.0004
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0004	0.0004
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0128	0.0128
Echinococcus multilocularis	abhydrolase domain containing protein 16A	0.0009	0.0002	0.0002
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0152	0.0502	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0152	0.0502	0.0502
Trypanosoma cruzi	hydrolase-like protein, putative	0.0009	0.0002	0.0037
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0004	0.0009
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0152	0.0502	0.0502
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0004	0.0009
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0152	0.0502	0.0502
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0004	0.0004
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.2852	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0004	0.0009
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0004	0.0004
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0051	0.0439
Brugia malayi	ecdysteroid receptor	0.001	0.0004	0.0009
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0004	0.0009
Brugia malayi	alpha/beta hydrolase	0.0009	0.0002	0.0004
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0004	0.0004
Brugia malayi	steroid hormone receptor	0.001	0.0004	0.0009
Brugia malayi	hypothetical protein	0.0152	0.0502	0.1096
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.001	0.0004	0.0004
Mycobacterium ulcerans	epoxide hydrolase EphB	0.0009	0.0002	0.0016
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0004	0.0004
Mycobacterium ulcerans	lipase/esterase	0.0009	0.0002	0.0016
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0152	0.0502	0.0502
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0051	0.0981
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0051	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0051	1
Mycobacterium ulcerans	bromoperoxidase BpoC	0.0009	0.0002	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0152	0.0502	0.0502
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0004	0.0004
Toxoplasma gondii	aminopeptidase N protein	0.0152	0.0502	1
Plasmodium vivax	acyl-CoA synthetase, putative	0.0017	0.003	0.0603
Mycobacterium tuberculosis	Probable exported protease	0.0009	0.0002	0.0016
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.0009	0.0002	0.0037
Trypanosoma cruzi	aminopeptidase, putative	0.0152	0.0502	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0128	0.0128
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0004	0.008
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0004	0.0004
Plasmodium falciparum	acyl-CoA synthetase	0.0017	0.003	0.0603
Echinococcus granulosus	abhydrolase domain containing protein 3	0.0009	0.0002	0.0002
Toxoplasma gondii	aminopeptidase N, putative	0.0152	0.0502	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0004	0.0009
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0027	0.0232
Brugia malayi	nuclear receptor NHR-88	0.001	0.0004	0.0009
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0004	0.0009
Brugia malayi	Peptidase family M1 containing protein	0.0152	0.0502	0.1096
Giardia lamblia	ENC6 protein	0.0009	0.0002	1
Wolbachia endosymbiont of Brugia malayi	phosphatase	0.0009	0	0.5
Mycobacterium ulcerans	exported protease	0.0009	0.0002	0.0016
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0152	0.0502	1
Schistosoma mansoni	hydrolase	0.0009	0.0002	0.0002
Loa Loa (eye worm)	hydrolase	0.0009	0.0002	0.0002
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.2852	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0.0002	0.0016
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0027	0.0232
Treponema pallidum	phosphoglycolate phosphatase	0.0009	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0004	0.0004
Plasmodium vivax	hypothetical protein, conserved	0.0009	0.0002	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0017	0.003	0.003
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0004	0.0004
Loa Loa (eye worm)	abhydrolase domain-containing protein 2	0.0009	0.0002	0.0002
Onchocerca volvulus		0.001	0.0004	0.008
Mycobacterium leprae	POSSIBLE SECRETED PROTEASE	0.0009	0.0002	0.0369
Plasmodium vivax	hypothetical protein, conserved	0.0009	0.0002	0.0037
Mycobacterium tuberculosis	Possible short-chain dehydrogenase EphD	0.0009	0.0002	0.0016
Mycobacterium ulcerans	hypothetical protein	0.0009	0.0002	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0152	0.0502	0.0502
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0017	0.003	0.003
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0004	0.0004
Mycobacterium ulcerans	aminopeptidase N PepN	0.0152	0.0502	0.4323
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0051	0.0439
Brugia malayi	Alpha/beta hydrolase	0.0009	0.0002	0.0004
Mycobacterium tuberculosis	Possible epoxide hydrolase EphF (epoxide hydratase) (arene-oxide hydratase)	0.0009	0.0002	0.0016
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0004	0.0009
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0152	0.0502	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0051	0.0439
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0004	0.0004
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0004	0.0004
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0004	0.0004
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0009	0.0002	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0152	0.0502	0.0502
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0004	0.0009
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0004	0.0009
Brugia malayi	hydrolase, alpha/beta fold family protein	0.0009	0.0002	0.0004
Mycobacterium tuberculosis	Conserved protein	0.0009	0.0002	0.0016
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0152	0.0502	0.0502
Mycobacterium tuberculosis	Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase)	0.0339	0.1161	1
Mycobacterium ulcerans	epoxide hydrolase EphF	0.0009	0.0002	0.0016
Trypanosoma brucei	Aminopeptidase M1, putative	0.0152	0.0502	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0004	0.0004
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0128	0.0128
Echinococcus multilocularis	aminopeptidase N	0.0152	0.0502	0.0502
Leishmania major	puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0152	0.0502	1
Onchocerca volvulus	Epoxide hydrolase 1 homolog	0.0009	0.0002	0.0037
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0051	0.0051
Plasmodium vivax	hypothetical protein, conserved	0.0009	0.0002	0.0037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0009	0.0002	0.0037
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0027	0.0232
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0152	0.0502	0.0502
Mycobacterium tuberculosis	Probable oxidoreductase	0.0009	0.0002	0.0016
Plasmodium falciparum	acid cluster protein 33 homologue, putative	0.0009	0.0002	0.0037
Loa Loa (eye worm)	aminopeptidase N	0.0152	0.0502	0.0502
Mycobacterium ulcerans	hydrolase	0.0009	0.0002	0.0016
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0152	0.0502	1
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0004	0.0009
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0009	0.0002	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0002
Onchocerca volvulus		0.0152	0.0502	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0004	0.0004
Brugia malayi	hypothetical protein	0.0152	0.0502	0.1096
Mycobacterium tuberculosis	Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase)	0.0009	0.0002	0.0016
Brugia malayi	hypothetical protein	0.1311	0.4581	1
Onchocerca volvulus	Lipase homolog	0.0009	0.0002	0.0037
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0051	0.1015
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0051	0.0439
Plasmodium vivax	alpha/beta hydrolase, putative	0.0009	0.0002	0.0037
Onchocerca volvulus		0.0152	0.0502	1
Trypanosoma brucei	Aminopeptidase M1, putative	0.0152	0.0502	1
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0009	0.0002	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0051	0.0051
Mycobacterium ulcerans	proline iminopeptidase PIP	0.0009	0.0002	0.0016
Treponema pallidum	phosphoglycolate phosphatase	0.0009	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0004	0.0009
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0051	0.0111
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0051	0.0111
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0051	0.0439
Toxoplasma gondii	aminopeptidase n, putative	0.0152	0.0502	1
Brugia malayi	Hypothetical 54.7 kDa protein F37A4.1 in chromosome III	0.0009	0.0002	0.0004
Loa Loa (eye worm)	hypothetical protein	0.001	0.0004	0.0004
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0152	0.0502	0.0502
Trichomonas vaginalis	hydrolase, putative	0.0009	0.0002	0.0037
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0152	0.0502	0.0502
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0004	0.0004
Mycobacterium leprae	Probable homoserine o-acetyltransferase MetA	0.0009	0.0002	0.0369
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0004	0.0009
Entamoeba histolytica	alpha/beta hydrolase domain protein, putative	0.0009	0.0002	0.0037
Loa Loa (eye worm)	hypothetical protein	0.001	0.0004	0.0004
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0128	0.0128
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0004	0.0004

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 875123