Detailed information for compound 875149

Basic information

Technical information
  • TDR Targets ID: 875149
  • Name: N-(2,5-diethoxyphenyl)-1-(4-fluorophenyl)-3-m ethyl-5-pyrrol-1-ylpyrazole-4-carboxamide
  • MW: 448.489 | Formula: C25H25FN4O3
  • H donors: 1 H acceptors: 2 LogP: 4.64 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1NC(=O)c1c(C)nn(c1n1cccc1)c1ccc(cc1)F)OCC
  • InChi: 1S/C25H25FN4O3/c1-4-32-20-12-13-22(33-5-2)21(16-20)27-24(31)23-17(3)28-30(19-10-8-18(26)9-11-19)25(23)29-14-6-7-15-29/h6-16H,4-5H2,1-3H3,(H,27,31)
  • InChiKey: MSOJRXCCPVGUKQ-UHFFFAOYSA-N  

Network

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Synonyms

  • N-(2,5-diethoxyphenyl)-1-(4-fluorophenyl)-3-methyl-5-pyrrol-1-yl-pyrazole-4-carboxamide
  • N-(2,5-diethoxyphenyl)-1-(4-fluorophenyl)-3-methyl-5-(1-pyrrolyl)-4-pyrazolecarboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus RNA directed DNA polymerase 0.0039 0.015 0.0437
Onchocerca volvulus 0.0015 0.0026 0.0065
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0109 0.0436
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0013 0.0013 0.0024
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0205 0.0697
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0015 0.0025 0.0045
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0015 0.0026 0.0021
Trichomonas vaginalis AGC family protein kinase 0.0014 0.002 0.0193
Schistosoma mansoni tyrosine kinase 0.0013 0.0013 0.0029
Giardia lamblia DINP protein human, muc B family 0.0057 0.0247 0.1029
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0247 0.2952
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0241 0.0691
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0013 0.0013 0.0038
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0241 0.5505
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0428 0.5269
Schistosoma mansoni ankyrin 23/unc44 0.0059 0.0258 0.074
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0241 0.5505
Plasmodium falciparum DNA repair protein REV1, putative 0.0018 0.0039 0.0443
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0057 0.0244 0.0233
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0241 0.5505
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0017 0.003
Leishmania major DNA polymerase eta, putative 0.0083 0.038 0.462
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0056 0.0241 0.0438
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.0247 0.2952
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0057 0.0244 0.2995
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1374 0.7165 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0015 0.0025 0.0307
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0241 0.5505
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0056 0.0241 0.0982
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0074 0.0333 0.0959
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0057 0.0244 0.0239
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0037 0.0141 0.2778
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0241 0.2949
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0039 0.015 0.0273
Entamoeba histolytica hypothetical protein 0.0106 0.05 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0014 0.0017 0.005
Echinococcus multilocularis smad 0.0032 0.0113 0.0205
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0406 0.2078 0.8622
Brugia malayi Calcitonin receptor-like protein seb-1 0.0132 0.064 0.2642
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0015 0.0025 0.0307
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0057 0.0244 0.0997
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0056 0.0241 0.0438
Brugia malayi Latrophilin receptor protein 2 0.0042 0.0165 0.0667
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0539 0.278 0.2776
Trichomonas vaginalis pc-MYB2, putative 0.0037 0.0141 0.3111
Brugia malayi hypothetical protein 0.0106 0.05 0.206
Brugia malayi hypothetical protein 0.0032 0.0113 0.045
Echinococcus multilocularis dna polymerase kappa 0.0057 0.0247 0.0449
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0056 0.0241 0.2949
Toxoplasma gondii thioredoxin reductase 0.0164 0.0809 0.288
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0205 0.2503
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0057 0.0244 0.0702
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0037 0.0141 0.2778
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0241 0.0982
Brugia malayi Protein kinase domain containing protein 0.006 0.0261 0.1065
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.0428 0.2774
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0056 0.0241 0.2872
Trichomonas vaginalis AGC family protein kinase 0.0015 0.0025 0.0325
Mycobacterium ulcerans DNA polymerase IV 0.0057 0.0247 0.0241
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0056 0.0241 0.2949
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.005
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0056 0.0241 0.0699
Schistosoma mansoni tumor necrosis factor receptor related 0.0091 0.0422 0.1218
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0056 0.0241 0.2949
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0241 0.5505
Echinococcus multilocularis ecdysone induced protein 78C 0.0014 0.0017 0.003
Brugia malayi MH1 domain containing protein 0.0018 0.0038 0.0139
Loa Loa (eye worm) MH1 domain-containing protein 0.0032 0.0113 0.0451
Trichomonas vaginalis MYB, putative 0.0037 0.0142 0.3134
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0241 0.2949
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.0428 0.5217
Leishmania major DNA polymerase kappa, putative 0.0018 0.0039 0.034
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0015 0.0025 0.0071
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0042 0.0165 0.0479
Schistosoma mansoni kinase 0.0047 0.0191 0.0547
Plasmodium falciparum thioredoxin reductase 0.0057 0.0244 0.2995
Entamoeba histolytica PH domain containing protein kinase, putative 0.0012 0.0009 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0014 0.0017 0.005
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0241 0.5505
Echinococcus multilocularis Protein kinase C, brain isozyme 0.006 0.0263 0.0478
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0057 0.0244 0.2919
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0247 0.2952
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0241 0.5505
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0241 0.0827
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0013 0.0012 0.0034
Schistosoma mansoni transcription factor LCR-F1 0.0106 0.05 0.1445
Loa Loa (eye worm) hypothetical protein 0.0056 0.0241 0.0982
Loa Loa (eye worm) hypothetical protein 0.0083 0.038 0.1561
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0059 0.0258 0.0468
Brugia malayi MH1 domain containing protein 0.0018 0.0038 0.0139
Echinococcus multilocularis netrin receptor unc 5 0.0059 0.0258 0.0468
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0241 0.2949
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0247 0.2952
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0375 0.1916 0.2648
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0015 0.0025 0.0031
Trichomonas vaginalis glutamate synthase, putative 0.0015 0.0025 0.0307
Brugia malayi latrophilin 2 splice variant baaae 0.009 0.042 0.1728
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0015 0.0025 0.0307
Brugia malayi nuclear receptor NHR-88 0.0014 0.0017 0.005
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0039 0.0443
Echinococcus granulosus netrin receptor unc 5 0.0059 0.0258 0.0748
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0059 0.0258 0.074
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0014 0.0017 0.004
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0205 0.2503
Loa Loa (eye worm) PDE1B protein 0.0056 0.0241 0.0982
Brugia malayi hypothetical protein 0.0049 0.0205 0.0832
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0056 0.0241 0.5505
Echinococcus granulosus tyrosine protein kinase Fyn 0.0013 0.0013 0.0038
Trypanosoma brucei DNA polymerase eta, putative 0.0083 0.038 0.462
Trichomonas vaginalis AGC family protein kinase 0.0026 0.008 0.1644
Schistosoma mansoni hypothetical protein 0.0666 0.3443 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0015 0.0025 0.0083
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0015 0.0025 0.016
Mycobacterium ulcerans glutamate synthase subunit beta 0.0015 0.0025 0.0019
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0057 0.0244 0.2919
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0241 0.5505
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0013 0.0013 0.0024
Trypanosoma brucei NADH dehydrogenase 0.0015 0.0025 0.016
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0462 0.2374 0.4316
Brugia malayi isocitrate dehydrogenase 0.0031 0.0109 0.0436
Echinococcus multilocularis N chimaerin 0.0012 0.0007 0.0012
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0026 0.0021
Schistosoma mansoni terminal deoxycytidyl transferase 0.0057 0.0247 0.0709
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0026 0.0033
Echinococcus granulosus ecdysone induced protein 78C 0.0014 0.0017 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0247 0.2952
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0014 0.002 0.0036
Entamoeba histolytica thioredoxin reductase, putative 0.0015 0.0025 0.0431
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0015 0.0025 0.0071
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0018 0.0039 0.0098
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0013 0.0013 0.0029
Loa Loa (eye worm) hypothetical protein 0.0132 0.064 0.2642
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0013 0.0013 0.0024
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0015 0.0025 0.016
Giardia lamblia Myb 1-like protein 0.0037 0.0142 0.0586
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0057 0.0244 0.0841
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0241 0.5505
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0139
Mycobacterium ulcerans hypothetical protein 0.0018 0.0039 0.0033
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0012 0.0009 0.0068
Brugia malayi mothers against decapentaplegic homolog 3 0.0014 0.002 0.0065
Brugia malayi MH2 domain containing protein 0.0469 0.241 1
Brugia malayi ImpB/MucB/SamB family protein 0.0083 0.038 0.1561
Brugia malayi Tyrosine-protein kinase abl-1 0.0013 0.0013 0.0035
Trypanosoma brucei unspecified product 0.0057 0.0247 0.2952
Loa Loa (eye worm) hypothetical protein 0.0159 0.0783 0.3238
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0241 0.5505
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0241 0.0982
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0241 0.5505
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0037 0.0141 0.3111
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0241 0.0691
Echinococcus granulosus c src tyrosine kinase 0.0013 0.0013 0.0038
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0539 0.278 0.3858
Loa Loa (eye worm) AGC/PKN protein kinase 0.0014 0.002 0.0063
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0025 0.0075 0.0291
Trypanosoma brucei rac serine-threonine kinase, putative 0.0026 0.008 0.0858
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0462 0.2374 0.8534
Brugia malayi ImpB/MucB/SamB family protein 0.0057 0.0247 0.1008
Schistosoma mansoni steroid hormone receptor ad4bp 0.0014 0.0017 0.004
Schistosoma mansoni tyrosine kinase 0.0013 0.0013 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0039 0.034
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0015 0.0025 0.0266
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.0428 0.1242
Echinococcus granulosus serine threonine protein kinase nrc 0.0011 0.0003 0.0009
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0013 0.0013 0.0024
Echinococcus granulosus Smad4 0.0032 0.0113 0.0328
Schistosoma mansoni smad1 5 8 and 0.0032 0.0113 0.032
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0185 0.416
Toxoplasma gondii selenide, water dikinase 0.0015 0.0025 0.0046
Echinococcus granulosus Protein kinase C brain isozyme 0.006 0.0263 0.0764
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0109 0.0309
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0406 0.2078 0.6036
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.005
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0056 0.0241 0.5505
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0241 0.5505
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0014 0.0017 0.005
Trichomonas vaginalis glutathione reductase, putative 0.0057 0.0244 0.5594
Brugia malayi SRC-1 0.0013 0.0013 0.0035
Plasmodium vivax thioredoxin reductase, putative 0.0164 0.0809 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0172 0.2093
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0015 0.0025 0.0045
Mycobacterium tuberculosis Probable reductase 0.0375 0.1916 0.2671
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0428 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0014 0.0017 0.005
Trypanosoma brucei hypothetical protein, conserved 0.0056 0.0241 0.2872
Schistosoma mansoni tar DNA-binding protein 0.0062 0.027 0.0775
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0057 0.0244 0.2919
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0037 0.0142 0.3134
Trypanosoma cruzi NADH dehydrogenase, putative 0.0015 0.0025 0.0266
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0042 0.0165 0.0667
Giardia lamblia DNA damage repair protein 0.0018 0.0039 0.0151
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0015 0.0025 0.0431
Loa Loa (eye worm) hypothetical protein 0.0056 0.0241 0.0982
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0539 0.278 0.2776
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0014 0.0017 0.0117
Schistosoma mansoni DNA polymerase eta 0.0083 0.038 0.1096
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0244 0.2995
Echinococcus granulosus tar DNA binding protein 0.0062 0.027 0.0783
Echinococcus granulosus N chimaerin 0.0012 0.0007 0.002
Echinococcus granulosus protein kinase c epsilon type 0.0021 0.0058 0.0168
Echinococcus multilocularis thioredoxin glutathione reductase 0.0165 0.0811 0.1474
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0015 0.0025 0.0045
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0205 0.2503
Leishmania major hypothetical protein, conserved 0.0049 0.0205 0.2422
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0015 0.0025 0.0046
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0462 0.2374 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0165 0.0811 0.2355
Toxoplasma gondii AGC kinase 0.0025 0.0075 0.0227
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0017 0.0049
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0013 0.0013 0.0024
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0241 0.5505
Entamoeba histolytica acyl-CoA synthetase, putative 0.0015 0.0026 0.0467
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0014 0.0017 0.005
Echinococcus multilocularis growth factor receptor bound protein 2 0.0011 0.0005 0.0008
Brugia malayi glutathione reductase 0.0164 0.0809 0.3344
Schistosoma mansoni adapter molecule crk 0.0011 0.0005 0.0005
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0247 0.3028
Schistosoma mansoni Smad4 0.0014 0.002 0.005
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0015 0.0025 0.0046
Leishmania major 4-coumarate:coa ligase-like protein 0.0015 0.0026 0.0183
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0013 0.0013 0.0038
Schistosoma mansoni serine/threonine-protein kinase 0.0012 0.001 0.0021
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0263 0.0756
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0057 0.0247 0.0709
Entamoeba histolytica protein kinase, putative 0.0014 0.002 0.0335
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0014 0.0017 0.005
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0247 0.2952
Echinococcus granulosus smad 0.0032 0.0113 0.0328
Echinococcus multilocularis NCK adaptor protein 0.0011 0.0005 0.0008
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0109 0.0199
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0014 0.0017 0.004
Leishmania major DNA damage repair protein, putative 0.0018 0.0039 0.034
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0014 0.002 0.0063
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0056 0.0241 0.0699
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0056 0.0241 0.0699
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0056 0.0241 0.0699
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0056 0.0241 0.0438
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0056 0.0241 0.2949
Brugia malayi steroid hormone receptor 0.0014 0.0017 0.005
Loa Loa (eye worm) RNA binding protein 0.0062 0.027 0.1101
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0057 0.0244 0.2919
Echinococcus multilocularis geminin 0.0666 0.3443 0.6259
Schistosoma mansoni smad 0.0032 0.0113 0.032
Mycobacterium ulcerans DNA polymerase IV 0.0057 0.0247 0.0241
Brugia malayi TAR-binding protein 0.0062 0.027 0.1101
Schistosoma mansoni ap endonuclease 0.0013 0.0012 0.0025
Schistosoma mansoni hypothetical protein 0.0042 0.0165 0.0471
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0241 0.0827
Mycobacterium ulcerans hypothetical protein 0.0015 0.0026 0.0021
Schistosoma mansoni hypothetical protein 0.0042 0.0165 0.0471
Trichomonas vaginalis AGC family protein kinase 0.0026 0.008 0.1644
Treponema pallidum oxidoreductase 0.0015 0.0025 0.0013
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0057 0.0244 0.0239
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0012 0.0007 0.002
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0026 0.009
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0462 0.2374 0.6895
Schistosoma mansoni sulfide quinone reductase 0.0015 0.0025 0.0062
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0132 0.064 0.2642
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0428 0.5269
Loa Loa (eye worm) transcription factor SMAD2 0.0469 0.241 1
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0015 0.0025 0.0266
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0109 0.0199
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0014 0.0017 0.005
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0241 0.2949
Toxoplasma gondii NADPH-glutathione reductase 0.0057 0.0244 0.0841
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0015 0.0025 0.0307
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0241 0.0827
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.009
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0241 0.2949
Leishmania major NADH dehydrogenase, putative 0.0015 0.0025 0.016
Trypanosoma brucei polo-like protein kinase 0.0092 0.0428 0.5217
Brugia malayi Variant SH3 domain containing protein 0.0012 0.0007 0.0009
Trypanosoma cruzi trypanothione reductase, putative 0.0164 0.0809 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.0428 0.0777
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0014 0.0017 0.005
Trypanosoma brucei chrX additional, unordered contigs 0.0018 0.0039 0.034
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0025 0.0266
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0014 0.0017 0.005
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0057 0.0247 0.1008
Trypanosoma cruzi DNA polymerase eta, putative 0.0083 0.038 0.4678
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.027 0.1101
Giardia lamblia hypothetical protein 0.0056 0.0241 0.1002
Echinococcus granulosus tyrosine protein kinase Src42A 0.0013 0.0013 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0153 0.1776
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0005
Schistosoma mansoni RAR-like nuclear receptor 0.0014 0.0017 0.004
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0026 0.009
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0428 0.1234
Plasmodium falciparum glutathione reductase 0.0164 0.0809 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0013 0.0012 0.0107
Echinococcus granulosus protein kinase C gamma type 0.0055 0.0232 0.0673
Schistosoma mansoni hypothetical protein 0.0015 0.0025 0.0062
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0037 0.0141 0.3111
Brugia malayi protein kinase C II. 0.0021 0.0058 0.0221
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0014 0.0017 0.005
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0109 0.1318
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0015 0.0026 0.0021
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0015 0.0025 0.016
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0056 0.0241 0.2872
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0241 0.5505
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0015 0.0025 0.0431
Echinococcus granulosus tyrosine protein kinase Fyn 0.0013 0.0013 0.0038
Schistosoma mansoni smad1 5 8 and 0.0032 0.0113 0.032
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0065
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0057 0.0244 0.2919
Echinococcus multilocularis tar DNA binding protein 0.0062 0.027 0.049
Echinococcus multilocularis GPCR, family 2 0.0042 0.0165 0.03
Brugia malayi Protein kinase domain containing protein 0.0014 0.002 0.0063
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0057 0.0244 0.2995
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0406 0.2078 0.3778
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0015 0.0025 0.0071
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0017 0.004
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0014 0.0017 0.0049
Echinococcus granulosus TGF beta signal transducer SmadC 0.0032 0.0113 0.0328
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0057 0.0244 0.2995
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0241 0.5505
Brugia malayi MH2 domain containing protein 0.0032 0.0113 0.0451
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0056 0.0241 0.0438
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0037 0.0141 0.3111
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1913 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0014 0.0017 0.005
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0109 0.0149
Loa Loa (eye worm) hypothetical protein 0.0086 0.0395 0.1625
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0039 0.034
Echinococcus granulosus protein kinase c iota type 0.002 0.0051 0.0149
Echinococcus multilocularis Smad4 0.0032 0.0113 0.0205
Leishmania major cAMP-specific phosphodiesterase, putative 0.0056 0.0241 0.2872
Leishmania major hypothetical protein, conserved 0.0056 0.0241 0.2872
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0241 0.2949
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0375 0.1916 0.2671
Schistosoma mansoni thyroid hormone receptor 0.0014 0.0017 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0039 0.034
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0241 0.5505
Brugia malayi MH2 domain containing protein 0.0032 0.0113 0.0451
Schistosoma mansoni hypothetical protein 0.0042 0.0165 0.0471
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0043 0.0172 0.0578
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0056 0.0241 0.0691
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0014 0.002 0.0058
Schistosoma mansoni DNA polymerase IV / kappa 0.0018 0.0039 0.0104
Entamoeba histolytica PH domain containing protein kinase, putative 0.0012 0.0009 0.0111
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0015 0.0025 0.0266
Loa Loa (eye worm) AGC/NDR protein kinase 0.0014 0.002 0.0063
Echinococcus multilocularis serine threonine protein kinase 0.0055 0.0232 0.0421
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0012 0.0007 0.0011
Entamoeba histolytica protein kinase, putative 0.0026 0.008 0.155
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0013 0.0013 0.0024
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0241 0.0827
Schistosoma mansoni hypothetical protein 0.0059 0.0258 0.074
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0241 0.5505
Trichomonas vaginalis DNA polymerase eta, putative 0.0057 0.0247 0.5659
Schistosoma mansoni sulfide quinone reductase 0.0015 0.0025 0.0062
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0015 0.0025 0.0071
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0241 0.0827
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.005
Echinococcus granulosus glutamate synthase 0.0015 0.0025 0.0071
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0375 0.1916 0.2671
Trichomonas vaginalis glutamate synthase, putative 0.0015 0.0025 0.0307
Echinococcus granulosus FTZ F1 alpha 0.0014 0.0017 0.0049
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0015 0.0025 0.0266
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0037 0.0142 0.0471
Giardia lamblia NADH oxidase lateral transfer candidate 0.0057 0.0244 0.1018
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0015 0.0025 0.0045
Brugia malayi nuclear hormone receptor 0.0014 0.0017 0.005
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0037 0.0141 0.3111
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0109 0.0353
Schistosoma mansoni Smad4 0.0032 0.0113 0.032
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0015 0.0026 0.0033
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0014 0.0017 0.0049
Schistosoma mansoni coup transcription factor 0.0014 0.0017 0.004
Loa Loa (eye worm) hypothetical protein 0.0049 0.0205 0.0832
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0015 0.0025 0.0431
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0014 0.0017 0.005
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0057 0.0247 0.0342
Brugia malayi polk-prov protein 0.0018 0.0039 0.0142
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0015 0.0025 0.0071
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0056 0.0241 0.0982
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0015 0.0026 0.0021
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.0017 0.004
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0202 0.1009 0.4175
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.005
Echinococcus multilocularis Glutaredoxin protein 5 0.0011 0.0002 0.0003
Trichomonas vaginalis MYB3r3, putative 0.0037 0.0141 0.3111
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0109 0.1318
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0241 0.2949
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0057 0.0247 0.0449
Echinococcus granulosus Glutaredoxin protein 5 0.0011 0.0002 0.0005
Brugia malayi p70 ribosomal S6 kinase beta 0.0025 0.0075 0.0291
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0014 0.002 0.0036
Schistosoma mansoni tar DNA-binding protein 0.0062 0.027 0.0775
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0011 0.0005 0.0005
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0015 0.0025 0.0019
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0241 0.0827
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0462 0.2374 0.6895
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0056 0.0241 0.0438
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0417 0.2135 0.2956
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0017 0.0049
Trichomonas vaginalis pc-MYB2, putative 0.0037 0.0141 0.3111
Giardia lamblia Hypothetical protein 0.0056 0.0241 0.1002
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0037 0.0141 0.2778
Loa Loa (eye worm) hypothetical protein 0.0056 0.0241 0.0982
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0205 0.2422
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0109 0.1224
Schistosoma mansoni tar DNA-binding protein 0.0062 0.027 0.0775
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0428 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0013 0.0012 0.0107
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0241 0.0691
Leishmania major DNA polymerase kappa, putative 0.0057 0.0247 0.2952
Schistosoma mansoni tar DNA-binding protein 0.0062 0.027 0.0775
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0013 0.0012 0.0021
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0014 0.0017 0.0049
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0056 0.0241 0.5505
Echinococcus granulosus NCK adaptor protein 0.0011 0.0005 0.0013
Trichomonas vaginalis C-MYB, putative 0.0037 0.0141 0.3111
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0014 0.0017 0.0049
Schistosoma mansoni hypothetical protein 0.0042 0.0165 0.0471
Echinococcus granulosus Ankyrin 0.0059 0.0258 0.0748
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0241 0.2949
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.005
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0109 0.0318
Entamoeba histolytica acyl-coA synthetase, putative 0.0015 0.0026 0.0467
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0241 0.0827
Loa Loa (eye worm) nuclear factor I 0.0018 0.0038 0.0139
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0109 0.1224
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0014 0.0017 0.0049
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0109 0.1318
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0057 0.0244 0.2919
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0015 0.0025 0.0431
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0013 0.0012 0.0036
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0015 0.0025 0.0019
Entamoeba histolytica hypothetical protein 0.0106 0.05 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0013 0.0013 0.0024
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0014 0.0017 0.003
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0015 0.0026 0.0021
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0015 0.0025 0.0266
Onchocerca volvulus 0.0015 0.0025 0.0053
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0241 0.2949
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0109 0.0199
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0013 0.0013 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0005
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0241 0.2872
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0039 0.0443
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0056 0.0241 0.0691
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0241 0.0827
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0039 0.0443
Loa Loa (eye worm) glutathione reductase 0.0164 0.0809 0.3344
Mycobacterium tuberculosis Conserved hypothetical protein 0.0057 0.0247 0.0342
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0241 0.5505
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0015 0.0025 0.0019
Trypanosoma cruzi NADH dehydrogenase, putative 0.0015 0.0025 0.0266
Plasmodium falciparum ferrodoxin reductase-like protein 0.0015 0.0025 0.0266
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0106 0.05 0.0909
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.0091 0.0422 0.0767
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0406 0.2078 0.8622
Schistosoma mansoni smad 0.0014 0.002 0.005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0005
Trypanosoma brucei trypanothione reductase 0.0164 0.0809 1
Mycobacterium ulcerans monoxygenase 0.0015 0.0025 0.0019
Trichomonas vaginalis AGC family protein kinase 0.0026 0.008 0.1644
Loa Loa (eye worm) hypothetical protein 0.0045 0.0182 0.0737
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0241 0.5505
Entamoeba histolytica acyl-CoA synthetase, putative 0.0015 0.0026 0.0467
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0687
Mycobacterium tuberculosis Probable oxidoreductase 0.0417 0.2135 0.2978
Echinococcus granulosus GPCR family 2 0.0042 0.0165 0.0479
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0012 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.005
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0042 0.0165 0.0667
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0247 0.2952
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0041 0.016 0.0646
Loa Loa (eye worm) hypothetical protein 0.0059 0.0258 0.1052
Brugia malayi hypothetical protein 0.0295 0.1498 0.621
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0241 0.2949
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0015 0.0026 0.0002
Schistosoma mansoni hypothetical protein 0.0666 0.3443 1
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0241 0.5505
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.0091 0.0422 0.1226
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0032 0.0113 0.032
Trichomonas vaginalis AGC family protein kinase 0.0026 0.008 0.1644
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0241 0.0827
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0241 0.5505
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0241 0.0691
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0015 0.0025 0.0266
Entamoeba histolytica protein kinase, putative 0.0025 0.0075 0.144
Loa Loa (eye worm) AGC/AKT protein kinase 0.0026 0.008 0.0314
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0013 0.0012 0.0174
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0039 0.034
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0241 0.5505
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0015 0.0025 0.0013
Schistosoma mansoni tyrosine kinase 0.0013 0.0013 0.0029
Schistosoma mansoni glutamate synthase 0.0015 0.0025 0.0062
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0057 0.0244 0.2919
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0241 0.0982
Loa Loa (eye worm) MH1 domain-containing protein 0.0014 0.002 0.0065
Schistosoma mansoni glutamate synthase 0.0015 0.0025 0.0062
Echinococcus multilocularis thyroid hormone receptor alpha 0.0014 0.0017 0.003
Trypanosoma brucei hypothetical protein, conserved 0.0015 0.0025 0.016
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0015 0.0025 0.0019
Echinococcus multilocularis serine:threonine protein kinase N2 0.0014 0.002 0.0036
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.0091 0.0422 0.0767
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0241 0.5505
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0059 0.0258 0.0748
Brugia malayi Death domain containing protein 0.0059 0.0258 0.1052
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0012 0.0007 0.0011
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0057 0.0247 0.2952
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0375 0.1916 0.2671
Loa Loa (eye worm) MH2 domain-containing protein 0.0014 0.002 0.0065
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0205 0.2503
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0015 0.0025 0.0031
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0015 0.0025 0.0307
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0039 0.0443
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0015 0.0025 0.0019
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0026 0.0021
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.009
Leishmania major 4-coumarate:coa ligase-like protein 0.0015 0.0026 0.0183
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0109 0.0353
Schistosoma mansoni netrin receptor unc5 0.0059 0.0258 0.074
Echinococcus granulosus transcription factor eb 0.007 0.0315 0.0915
Echinococcus granulosus serine:threonine protein kinase N2 0.0014 0.002 0.0058
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0039 0.034
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0015 0.0025 0.0307
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0015 0.0025 0.0019
Brugia malayi Smad1 0.0032 0.0113 0.0451
Entamoeba histolytica disulphide oxidoreductase, putative 0.0015 0.0025 0.0431
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0241 0.5505
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0015 0.0025 0.0307
Leishmania major trypanothione reductase 0.0164 0.0809 1
Schistosoma mansoni glutamate synthase 0.0015 0.0025 0.0062
Echinococcus multilocularis c src tyrosine kinase 0.0013 0.0013 0.0024
Echinococcus granulosus NDR protein kinase 0.0014 0.002 0.0058
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0015 0.0025 0.0307
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0015 0.0025 0.0071
Schistosoma mansoni nck2/grb4 0.0011 0.0005 0.0005
Mycobacterium ulcerans hypothetical protein 0.0015 0.0025 0.0019
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0014 0.0017 0.004
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0014 0.0017 0.005
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0057 0.0244 0.2995
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.002 0.0049
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0037 0.0141 0.3111
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0015 0.0025 0.0307
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0015 0.0025 0.0045
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0014 0.0017 0.003
Echinococcus multilocularis dna polymerase eta 0.0083 0.038 0.0691
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0057 0.0244 0.0444
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.005
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0417 0.2135 0.2978
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0056 0.0241 0.2949
Leishmania major hypothetical protein, conserved 0.0015 0.0025 0.016
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0539 0.278 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0042 0.0165 0.0667
Echinococcus multilocularis tyrosine protein kinase Abl 0.0013 0.0013 0.0024
Brugia malayi Protein kinase domain containing protein 0.0026 0.008 0.0314
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0015 0.0025 0.0046
Plasmodium falciparum glutathione reductase 0.0057 0.0244 0.2995
Echinococcus granulosus mothers against decapentaplegic 5 0.0032 0.0113 0.0328
Leishmania major DNA polymerase eta, putative 0.0043 0.0172 0.2007
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0241 0.5505
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.027 0.1101
Loa Loa (eye worm) MH2 domain-containing protein 0.0032 0.0113 0.0451
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0015 0.0025 0.0031
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0058 0.0159
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1057 0.5501 1
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0015 0.0025 0.0031
Loa Loa (eye worm) latrophilin receptor protein 2 0.0042 0.0165 0.0667
Schistosoma mansoni ap endonuclease 0.0013 0.0012 0.0025
Giardia lamblia Thioredoxin reductase 0.0015 0.0025 0.009
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0056 0.0241 0.0691
Entamoeba histolytica deoxycytidyl transferase, putative 0.0057 0.0247 0.491
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0057 0.0244 0.2995
Plasmodium vivax phosphodiesterase gamma, putative 0.0056 0.0241 0.2949
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0057 0.0244 0.0239
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0062 0.0112
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.007 0.0315 0.129
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0109 0.0199
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.009
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0042 0.0165 0.0479
Brugia malayi MH2 domain containing protein 0.0014 0.002 0.0065
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0014 0.002 0.0058
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0059 0.0258 0.1052
Trichomonas vaginalis AGC family protein kinase 0.0026 0.008 0.1644
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0014 0.0017 0.005
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0428 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0241 0.0827
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0241 0.5505
Echinococcus granulosus mothers against decapentaplegic 6 0.0014 0.002 0.0059
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0428 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0241 0.0827
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0014 0.0017 0.005
Mycobacterium ulcerans ferredoxin reductase 0.0015 0.0025 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0014 0.0017 0.005
Echinococcus multilocularis RNA directed DNA polymerase 0.0039 0.015 0.0273
Onchocerca volvulus Netrin receptor homolog 0.0059 0.0258 0.1626
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0428 1
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0056 0.0241 0.2872
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0015 0.0025 0.0013
Trichomonas vaginalis AGC family protein kinase 0.0014 0.002 0.0193
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0241 0.5505
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0017 0.005
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0056 0.0241 0.0982
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0241 0.5505
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0057 0.0244 0.0338
Echinococcus granulosus tyrosine protein kinase Fyn 0.0013 0.0013 0.0038
Schistosoma mansoni tar DNA-binding protein 0.0062 0.027 0.0775
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0037 0.0142 0.3134
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0241 0.5505
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0021 0.0058 0.0221
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0164 0.0809 0.1126
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0247 0.2952
Treponema pallidum NADH oxidase 0.0057 0.0244 0.0233
Leishmania major hypothetical protein, conserved 0.0015 0.0025 0.016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0014 0.0017 0.005
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0057 0.0244 0.2995
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0462 0.2374 0.4316
Echinococcus granulosus dna polymerase kappa 0.0057 0.0247 0.0718
Entamoeba histolytica protein kinase, putative 0.0026 0.008 0.155
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0012 0.0007 0.0012
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0012 0.0006 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0247 0.2952
Plasmodium falciparum thioredoxin reductase 0.0164 0.0809 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0241 0.0691
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0015 0.0026 0.0002
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.0428 0.1759
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0241 0.0827
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0013 0.0013 0.0024
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0428 1
Schistosoma mansoni thyroid hormone receptor 0.0014 0.0017 0.004
Brugia malayi ecdysteroid receptor 0.0014 0.0017 0.005
Plasmodium vivax ferrodoxin reductase, putative 0.0015 0.0025 0.0266
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0057 0.0244 0.0233
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0013 0.0012 0.003
Loa Loa (eye worm) hypothetical protein 0.0042 0.0165 0.0667
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0039 0.034
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.0428 0.8543
Trypanosoma cruzi Protein kinase B 0.0012 0.0009 0.0068
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0057 0.0244 0.2995
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0109 0.0199
Leishmania major hypothetical protein, conserved 0.0015 0.0025 0.016
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0015 0.0025 0.016
Loa Loa (eye worm) hypothetical protein 0.0295 0.1498 0.621
Mycobacterium ulcerans NADH dehydrogenase 0.0015 0.0025 0.0019
Schistosoma mansoni retinoic acid receptor RXR 0.0014 0.0017 0.004
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0015 0.0025 0.0045
Loa Loa (eye worm) steroid hormone receptor 0.0014 0.0017 0.005
Echinococcus multilocularis Ankyrin 0.0059 0.0258 0.0468
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0057 0.0244 0.2995
Schistosoma mansoni hypothetical protein 0.0022 0.0062 0.017
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0013 0.0012 0.0006
Echinococcus granulosus growth factor receptor bound protein 2 0.0011 0.0005 0.0013
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1913 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0241 0.0827
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0056 0.0241 0.0699
Trichomonas vaginalis C-MYB, putative 0.0037 0.0141 0.3111
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.005
Echinococcus granulosus tyrosine protein kinase Lyn 0.0014 0.0016 0.0047
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.002 0.0049
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0185 0.416
Brugia malayi RNA binding protein 0.0062 0.027 0.1101
Mycobacterium ulcerans dehydrogenase 0.0015 0.0025 0.0019
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0241 0.5505
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0247 0.3028
Schistosoma mansoni growth factor receptor-bound protein 0.0011 0.0005 0.0005
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0056 0.0241 0.2872
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0015 0.0025 0.0266
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0057 0.0247 0.0718
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0241 0.5505
Loa Loa (eye worm) hypothetical protein 0.007 0.0313 0.1283
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0032 0.0113 0.0205
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0057 0.0244 0.2995
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0241 0.5505
Brugia malayi Steroid receptor seven-up type 2 0.0014 0.0017 0.005
Loa Loa (eye worm) SRC-1 0.0013 0.0013 0.0035
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0015 0.0025 0.0431
Loa Loa (eye worm) TAR-binding protein 0.0062 0.027 0.1101
Brugia malayi Thioredoxin reductase 0.0164 0.0809 0.3344
Brugia malayi glutamate synthase 0.0015 0.0025 0.0083
Echinococcus granulosus serine/threonine protein kinase 0.0012 0.0009 0.0025
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.0247 0.2952
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0241 0.5505
Schistosoma mansoni serine/threonine kinase 0.0014 0.002 0.0049
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0241 0.2949
Schistosoma mansoni disulfide oxidoreductase 0.0015 0.0025 0.0062
Leishmania major hypothetical protein, conserved 0.0056 0.0241 0.2872
Loa Loa (eye worm) hypothetical protein 0.009 0.042 0.1728
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0057 0.0244 0.071
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0153 0.1776
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0015 0.0025 0.0046
Echinococcus multilocularis protein kinase c epsilon type 0.0021 0.0058 0.0105
Trichomonas vaginalis mercuric reductase, putative 0.0057 0.0244 0.5594
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0241 0.0827
Schistosoma mansoni atypical protein kinase C 0.002 0.0051 0.014
Schistosoma mansoni hypothetical protein 0.0106 0.05 0.1445
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0417 0.2135 0.2978
Trichomonas vaginalis AGC family protein kinase 0.0014 0.002 0.0193
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0015 0.0025 0.0266
Loa Loa (eye worm) hypothetical protein 0.0015 0.0025 0.0083
Brugia malayi Protein kinase domain containing protein 0.0014 0.002 0.0063
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0056 0.0241 0.0699
Plasmodium falciparum acyl-CoA synthetase 0.0012 0.0006 0.0033
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0205 0.2503
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0241 0.5505
Chlamydia trachomatis thioredoxin reductase 0.0015 0.0025 0.0019
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1374 0.7165 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0014 0.0017 0.004
Echinococcus granulosus dna polymerase eta 0.0083 0.038 0.1104
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0106 0.05 0.1452
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0014 0.0017 0.005
Echinococcus multilocularis FTZ F1 alpha 0.0014 0.0017 0.003
Trichomonas vaginalis MYB72, putative 0.0037 0.0141 0.3111
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0018 0.0039 0.0098
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0014 0.0017 0.003
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0241 0.0827
Echinococcus multilocularis rac serine:threonine kinase 0.0012 0.0009 0.0016
Echinococcus multilocularis mothers against decapentaplegic 2 0.0014 0.002 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0247 0.2952
Loa Loa (eye worm) thioredoxin reductase 0.0164 0.0809 0.3344
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0056 0.0241 0.0982
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0153 0.1776
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0014 0.002 0.0058
Brugia malayi Hr1 repeat family protein 0.0014 0.002 0.0063
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0375 0.1916 0.2671
Brugia malayi MH1 domain containing protein 0.0032 0.0113 0.0451
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0015 0.0025 0.0083
Loa Loa (eye worm) Smad1 0.0032 0.0113 0.0451
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0263 0.0756
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0015 0.0025 0.0019
Schistosoma mansoni hypothetical protein 0.009 0.042 0.1213
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0042 0.0165 0.03
Brugia malayi Uncoordinated protein 44 0.0059 0.0258 0.1052
Echinococcus multilocularis serine:threonine protein kinase N2 0.0014 0.002 0.0036
Trypanosoma brucei unspecified product 0.004 0.0153 0.1776
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.002 0.0049
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0241 0.5505
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0013 0.0012 0.0107
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0015 0.0025 0.0013
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0015 0.0025 0.009
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0132 0.064 0.2642
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0013 0.0012 0.0107
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0109 0.1318
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0015 0.0025 0.0266
Echinococcus multilocularis serine:threonine protein kinase 38 0.0014 0.002 0.0036
Plasmodium vivax DNA repair protein REV1, putative 0.0018 0.0039 0.0443
Schistosoma mansoni smad1 5 8 and 0.0032 0.0113 0.032
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0013 0.0013 0.0038
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1913 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0241 0.0827
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0428 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0469 0.241 1
Echinococcus multilocularis mothers against decapentaplegic 6 0.0014 0.002 0.0037
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0011 0.0003 0.0006
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0015 0.0025 0.0031
Loa Loa (eye worm) hypothetical protein 0.0039 0.015 0.0606
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0241 0.5505
Echinococcus multilocularis glutamate synthase 0.0015 0.0025 0.0045
Plasmodium vivax acyl-CoA synthetase, putative 0.0012 0.0006 0.0033
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0015 0.0025 0.0083
Brugia malayi RhoGAP domain containing protein 0.0012 0.0007 0.0009
Echinococcus multilocularis mothers against decapentaplegic 5 0.0032 0.0113 0.0205
Brugia malayi MH1 domain containing protein 0.0032 0.0113 0.0451
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0037 0.0141 0.2778
Trichomonas vaginalis AGC family protein kinase 0.0026 0.008 0.1644
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0037 0.0141 0.3111
Brugia malayi exodeoxyribonuclease III family protein 0.0013 0.0012 0.003
Schistosoma mansoni Smad4 0.0014 0.002 0.005
Schistosoma mansoni growth factor receptor-bound protein 0.0011 0.0005 0.0005
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.0428 0.1759
Loa Loa (eye worm) hypothetical protein 0.0462 0.2374 0.9852
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0241 0.5505
Plasmodium vivax glutathione reductase, putative 0.0164 0.0809 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0056 0.0241 0.2949
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0057 0.0244 0.2919
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.0091 0.0422 0.1226
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0056 0.0241 0.5505
Schistosoma mansoni serine/threonine-protein kinase 0.0012 0.0009 0.0016
Entamoeba histolytica hypothetical protein 0.0106 0.05 1
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0241 0.2949
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0241 0.5505
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0015 0.0025 0.016
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0062 0.0179
Brugia malayi Immunoglobulin I-set domain containing protein 0.0059 0.0258 0.1052
Echinococcus granulosus tyrosine protein kinase Src64B 0.0013 0.0013 0.0038
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0037 0.0141 0.2778
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0017 0.003
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0014 0.002 0.0023
Giardia lamblia Glutamate synthase 0.0015 0.0025 0.009
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0109 0.1224
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0013 0.0012 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0014 0.0017 0.005
Echinococcus multilocularis protein kinase c iota type 0.002 0.0051 0.0093
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0026 0.009
Brugia malayi Protein kinase c protein 2 0.0047 0.0192 0.0777
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0013 0.0013 0.0024
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0042 0.0165 0.03
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0025 0.0266
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0056 0.0241 0.0691
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0057 0.0244 0.0239
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0015 0.0025 0.0031
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0056 0.0241 0.5505
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0014 0.0017 0.004
Echinococcus granulosus mothers against decapentaplegic 2 0.0014 0.002 0.0059
Loa Loa (eye worm) hypothetical protein 0.0059 0.0258 0.1052
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0057 0.0244 0.2995
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0056 0.0241 0.2949
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0241 0.2949
Treponema pallidum thioredoxin reductase (trxB) 0.0015 0.0025 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0247 0.2952
Plasmodium falciparum phosphodiesterase gamma, putative 0.0056 0.0241 0.2949
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0057 0.0244 0.2995
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0015 0.0025 0.0046
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.002 0.0049
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0011 0.0003 0.0009
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0109 0.0436
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0142
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0057 0.0244 0.2995
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0014 0.002 0.0063
Mycobacterium tuberculosis Probable dehydrogenase 0.0375 0.1916 0.2671
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0026 0.0021
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0247 0.3028
Giardia lamblia Kinase, PLK 0.0092 0.0428 0.1791
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0056 0.0241 0.2872
Trichomonas vaginalis AGC family protein kinase 0.0026 0.008 0.1644
Leishmania major 4-coumarate:coa ligase-like protein 0.0015 0.0026 0.0183
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0014 0.0017 0.003
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.0247 0.2952
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0014 0.002 0.0036
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0247 0.3028
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0241 0.0827
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0014 0.002 0.0063
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0462 0.2374 0.6892
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0241 0.2872
Echinococcus multilocularis transcription factor eb 0.007 0.0315 0.0572
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.007 0.0313 0.1283
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0015 0.0025 0.016
Echinococcus granulosus geminin 0.0666 0.3443 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0057 0.0247 0.5659
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0241 0.5505
Schistosoma mansoni vav2 0.0013 0.0012 0.0027
Brugia malayi photoreceptor-specific nuclear receptor 0.0014 0.0017 0.005
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0056 0.0241 0.0438
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0014 0.0017 0.005
Trypanosoma brucei unspecified product 0.004 0.0153 0.1776
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0241 0.2949
Onchocerca volvulus 0.0295 0.1498 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0241 0.5505
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0063
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0241 0.5505
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0005
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0241 0.0691
Schistosoma mansoni tyrosine kinase 0.0013 0.0013 0.0029
Echinococcus granulosus death domain containing protein 0.0059 0.0258 0.0748
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0015 0.0025 0.0307
Trichomonas vaginalis apoptosis inducing factor, putative 0.0015 0.0025 0.0307
Loa Loa (eye worm) programmed cell death 8 0.0015 0.0025 0.0083
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0015 0.0025 0.0083
Entamoeba histolytica hypothetical protein 0.0106 0.05 1
Plasmodium falciparum phosphodiesterase delta, putative 0.0056 0.0241 0.2949

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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