Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0172 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0326 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0326 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0326 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0326 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0326 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0326 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0326 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0326 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0326 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0172 | 0.1071 | 0.1071 |
Brugia malayi | hypothetical protein | 0.0172 | 0.1071 | 0.1071 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0326 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0326 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0326 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0326 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0326 | 1 | 1 |
Onchocerca volvulus | 0.0326 | 1 | 1 | |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0326 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0326 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0326 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0326 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0326 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0172 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.1071 | 0.1071 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0326 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0326 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0326 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0326 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0326 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0326 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0326 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0172 | 0.1071 | 0.1071 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0172 | 0.1071 | 0.1071 |
Schistosoma mansoni | nuclear hormone receptor | 0.0326 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0326 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0326 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0326 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0326 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0326 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0326 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0326 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0326 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0326 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0326 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0326 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0172 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.1071 | 0.1071 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0326 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0326 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0326 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0326 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0326 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0326 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0326 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0326 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0326 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0326 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0326 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0326 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0326 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0326 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0326 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0326 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0326 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0326 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0172 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0326 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0172 | 0.1071 | 0.1071 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0326 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0326 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0326 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0326 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0326 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0326 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0326 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0172 | 0.1071 | 0.1071 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0326 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0326 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0326 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0326 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0326 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (binding) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.