Detailed information for compound 875496

Basic information

Technical information
  • TDR Targets ID: 875496
  • Name: 3-chloro-N-[2-methyl-5-([1,3]thiazolo[5,4-b]p yridin-2-yl)phenyl]benzamide
  • MW: 379.863 | Formula: C20H14ClN3OS
  • H donors: 1 H acceptors: 3 LogP: 5.13 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)C(=O)Nc1cc(ccc1C)c1nc2c(s1)nccc2
  • InChi: 1S/C20H14ClN3OS/c1-12-7-8-14(19-24-16-6-3-9-22-20(16)26-19)11-17(12)23-18(25)13-4-2-5-15(21)10-13/h2-11H,1H3,(H,23,25)
  • InChiKey: JVZFGTLHGHDNOA-UHFFFAOYSA-N  

Network

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Synonyms

  • 3-chloro-N-(2-methyl-5-thiazolo[5,4-b]pyridin-2-yl-phenyl)benzamide
  • 3-chloro-N-[2-methyl-5-(2-thiazolo[5,4-b]pyridinyl)phenyl]benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0053 0.0356 0.2162
Brugia malayi GCC2 and GCC3 family protein 0.0017 0.0071 0.0376
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0015 0.0024
Echinococcus granulosus notch 0.0017 0.0071 0.1985
Loa Loa (eye worm) hypothetical protein 0.0053 0.0356 0.2162
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.0039 0.0037
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0234 0.0324
Brugia malayi EGF-like domain containing protein 0.0017 0.0071 0.0376
Schistosoma mansoni hypothetical protein 0.0017 0.0071 0.0786
Echinococcus granulosus protein jagged 1 0.0017 0.0071 0.1985
Onchocerca volvulus 0.0038 0.0234 0.121
Onchocerca volvulus 0.003 0.0177 0.0896
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0135 0.4894
Onchocerca volvulus Peroxidasin homolog 0.0053 0.0356 0.1884
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0359
Echinococcus multilocularis protein jagged 1 0.0017 0.0071 0.1985
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0015 0.0419
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0015 0.0166
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0006
Schistosoma mansoni hypothetical protein 0.0017 0.0071 0.0786
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0234 0.0324
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0015 0.0024
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.0039 0.0051
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0039 0.01
Onchocerca volvulus 0.0017 0.0071 0.0308
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0015 0.0024
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0015 0.0166
Mycobacterium ulcerans lipase LipD 0.0038 0.0234 0.0232
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0429 0.4763
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0.0011 0.5
Onchocerca volvulus 0.0038 0.0234 0.121
Schistosoma mansoni septate junction protein 0.0017 0.0071 0.0786
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0356 0.2772 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0359
Onchocerca volvulus 0.0038 0.0234 0.121
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0039 0.0037
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0.0011 0.5
Brugia malayi Cadherin domain containing protein 0.0017 0.0071 0.0376
Schistosoma mansoni ferritin 0.0009 0.0002 0.0026
Loa Loa (eye worm) notch protein 0.0017 0.0071 0.0359
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.0622 0.0865
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0908 0.7162 1
Onchocerca volvulus 0.0053 0.0356 0.1884
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0096 0.0699 0.0973
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0236 0.1401
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0.0011 0.5
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0234 0.0324
Echinococcus multilocularis neurogenic locus notch protein 0.0017 0.0071 0.1985
Trichomonas vaginalis esterase, putative 0.0038 0.0234 0.127
Brugia malayi nuclear hormone receptor 0.001 0.0015 0.0024
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0015 0.0166
Loa Loa (eye worm) glutathione reductase 0.0038 0.0236 0.1401
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0006
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0359
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.0356 0.2162
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.0356 0.2162
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0015 0.0006
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0234 0.2602
Loa Loa (eye worm) hypothetical protein 0.0053 0.0356 0.2162
Echinococcus multilocularis neurogenic locus protein delta 0.0017 0.0071 0.1985
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0234 0.657
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0177 0.197
Plasmodium falciparum thioredoxin reductase 0.0038 0.0236 1
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0015 0.0024
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0234 0.1406
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0234 0.127
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0164 0.4588
Onchocerca volvulus 0.0053 0.0356 0.1884
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0015 0.0419
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0039 0.109
Loa Loa (eye worm) hypothetical protein 0.0053 0.0356 0.2162
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0.0011 0.0047
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1264 1 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.0039 0.0037
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0006
Loa Loa (eye worm) hypothetical protein 0.0038 0.0234 0.139
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0096 0.0699 0.0973
Echinococcus multilocularis neurogenic locus notch protein 0.0017 0.0071 0.1985
Brugia malayi beta-lactamase family protein 0.0038 0.0234 0.1406
Echinococcus granulosus protein jagged 1 0.0017 0.0071 0.1985
Brugia malayi Animal haem peroxidase family protein 0.0053 0.0356 0.2176
Brugia malayi EGF-like domain containing protein 0.0017 0.0071 0.0376
Brugia malayi EGF-like domain containing protein 0.0017 0.0071 0.0376
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0039 0.01
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0015 0.0006
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1264 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0234 0.9914
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0015 0.0024
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0015 0.0419
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0006
Brugia malayi Peroxidasin 0.0053 0.0356 0.2176
Loa Loa (eye worm) hypothetical protein 0.0038 0.0234 0.139
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.0622 0.0865
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0039 0.0432
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0015 0.0024
Loa Loa (eye worm) hypothetical protein 0.0053 0.0356 0.2162
Echinococcus multilocularis slit 2 protein 0.0017 0.0071 0.1985
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0015 0.0419
Loa Loa (eye worm) beta-lactamase 0.0038 0.0234 0.139
Schistosoma mansoni slit 0.0017 0.0071 0.0786
Treponema pallidum NADH oxidase 0.0013 0.0039 0.0037
Echinococcus multilocularis expressed protein 0.0009 0.0002 0.0066
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0234 0.2602
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0015 0.0166
Brugia malayi steroid hormone receptor 0.001 0.0015 0.0024
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0015 0.0419
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0177 0.197
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0015 0.0006
Brugia malayi CXXC zinc finger family protein 0.0029 0.0163 0.0959
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0039 0.02
Echinococcus granulosus ferritin 0.0009 0.0002 0.0066
Echinococcus granulosus neurogenic locus protein delta 0.0017 0.0071 0.1985
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0.0011 0.5
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0015 0.0024
Schistosoma mansoni peroxidasin 0.0053 0.0356 0.3961
Echinococcus multilocularis neural cadherin 0.0017 0.0071 0.1985
Brugia malayi hypothetical protein 0.0016 0.0064 0.0334
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0177 0.0601
Echinococcus multilocularis protein jagged 2 0.0017 0.0071 0.1985
Brugia malayi Cadherin domain containing protein 0.0017 0.0071 0.0376
Schistosoma mansoni notch 0.0017 0.0071 0.0786
Trichomonas vaginalis C-MYB, putative 0.001 0.0011 0.0047
Schistosoma mansoni ferritin 0.0009 0.0002 0.0026
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0071 0.0376
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0017 0.0071 0.0308
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0015 0.0166
Leishmania major hypothetical protein, conserved 0.0025 0.0135 0.4894
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0015 0.0419
Brugia malayi Blistered cuticle protein 3 0.0053 0.0356 0.2176
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0015 0.0419
Echinococcus multilocularis fibropellin Ia 0.0017 0.0071 0.1985
Echinococcus granulosus slit 2 protein 0.0017 0.0071 0.1985
Mycobacterium leprae Probable lipase LipE 0.0038 0.0234 0.0324
Onchocerca volvulus Dual oxidase homolog 0.0053 0.0356 0.1884
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0017 0.0071 0.0376
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0234 0.657
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0015 0.0419
Onchocerca volvulus Slit protein homolog 0.0017 0.0071 0.0308
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0.0011 0.0047
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.0622 0.0865
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0.0011 0.0049
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0377 0.1324
Onchocerca volvulus 0.0017 0.0071 0.0308
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0015 0.0024
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0015 0.0419
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0015 0.0419
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0015 0.0419
Brugia malayi beta-lactamase family protein 0.0038 0.0234 0.1406
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0234 0.127
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0096 0.0699 0.0973
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0006
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0234 0.0324
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0234 0.9914
Mycobacterium tuberculosis Possible penicillin-binding protein 0.024 0.1849 0.258
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0359
Brugia malayi EGF-like domain containing protein 0.0017 0.0071 0.0376
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0234 0.0324
Schistosoma mansoni hypothetical protein 0.0017 0.0071 0.0786
Echinococcus multilocularis notch 0.0017 0.0071 0.1985
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0015 0.0006
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.0039 0.0037
Brugia malayi Pre-SET motif family protein 0.003 0.0177 0.1047
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0015 0.0166
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0015 0.0006
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0015 0.0024
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0024 0.0687
Schistosoma mansoni peroxidasin 0.0053 0.0356 0.3961
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0015 0.0024
Echinococcus multilocularis fat cadherin tumor suppressor 0.0017 0.0071 0.1985
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0015 0.0024
Brugia malayi hypothetical protein 0.0053 0.0356 0.2176
Plasmodium vivax SET domain protein, putative 0.003 0.0177 0.7027
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0.0011 0.0047
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0014 0.0391
Brugia malayi Muscle positioning protein 4 0.0017 0.0071 0.0376
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0234 0.127
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0006
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0.0011 0.5
Schistosoma mansoni notch 0.0017 0.0071 0.0786
Loa Loa (eye worm) hypothetical protein 0.0053 0.0356 0.2162
Schistosoma mansoni hypothetical protein 0.0017 0.0071 0.0786
Loa Loa (eye worm) hypothetical protein 0.0038 0.0234 0.139
Mycobacterium ulcerans beta-lactamase 0.0038 0.0234 0.0232
Schistosoma mansoni apoferritin-2 0.0009 0.0002 0.0026
Onchocerca volvulus Chorion peroxidase homolog 0.0053 0.0356 0.1884
Echinococcus granulosus peroxidasin 0.0053 0.0356 1
Echinococcus granulosus delta-like protein 1 0.0017 0.0071 0.1985
Schistosoma mansoni ferritin light chain 0.0009 0.0002 0.0026
Schistosoma mansoni notch 0.0017 0.0071 0.0786
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0359
Brugia malayi Delta serrate ligand family protein 0.0017 0.0071 0.0376
Schistosoma mansoni laminin gamma-3 chain 0.0017 0.0071 0.0786
Brugia malayi Animal haem peroxidase family protein 0.0053 0.0356 0.2176
Toxoplasma gondii ABC1 family protein 0.0038 0.0234 0.0807
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0177 0.197
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0015 0.0024
Onchocerca volvulus 0.0017 0.0071 0.0308
Brugia malayi EGF-like domain containing protein 0.0017 0.0071 0.0376
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0015 0.0419
Onchocerca volvulus 0.0029 0.0163 0.0819
Loa Loa (eye worm) hypothetical protein 0.0053 0.0356 0.2162
Trypanosoma brucei trypanothione reductase 0.0038 0.0236 1
Trichomonas vaginalis MYB72, putative 0.001 0.0011 0.0047
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0359
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0.0011 0.0049
Brugia malayi EGF-like domain containing protein 0.0017 0.0071 0.0376
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0908 0.7162 1
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0356 0.2772 0.3868
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0234 0.9914
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0039 0.109
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0015 0.0006
Brugia malayi hypothetical protein 0.0025 0.0135 0.0782
Echinococcus granulosus protein jagged 2 0.0017 0.0071 0.1985
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0.0011 0.0047
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0234 0.0232
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.0356 0.2162
Brugia malayi nuclear receptor NHR-88 0.001 0.0015 0.0024
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0024 0.0687
Brugia malayi Animal haem peroxidase family protein 0.0053 0.0356 0.2176
Echinococcus granulosus neural cadherin 0.0017 0.0071 0.1985
Loa Loa (eye worm) hypothetical protein 0.0053 0.0356 0.2162
Schistosoma mansoni hypothetical protein 0.0017 0.0071 0.0786
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0135 0.4894
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0015 0.0419
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0359
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0014 0.0391
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.1598 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0356 0.2162
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0135 0.0449
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0234 0.139
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0135 0.4894
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0015 0.0166
Onchocerca volvulus Peroxidase homolog 0.0053 0.0356 0.1884
Schistosoma mansoni coup transcription factor 0.001 0.0015 0.0166
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0.0011 0.0047
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0039 0.02
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0236 0.0326
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0015 0.0419
Schistosoma mansoni cpg binding protein 0.003 0.0176 0.1959
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0234 0.9914
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0177 0.4974
Onchocerca volvulus Neurogenic locus notch homolog 0.0017 0.0071 0.0308
Trichomonas vaginalis pc-MYB2, putative 0.001 0.0011 0.0047
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0359
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0039 0.0037
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0015 0.0419
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.024 0.673
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0006
Loa Loa (eye worm) hypothetical protein 0.0053 0.0356 0.2162
Echinococcus granulosus FTZ F1 alpha 0.001 0.0015 0.0419
Trichomonas vaginalis MYB3r3, putative 0.001 0.0011 0.0047
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0234 0.127
Schistosoma mansoni ferritin light chain 0.0009 0.0002 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0359
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0177 0.4974
Brugia malayi Thioredoxin reductase 0.0038 0.0236 0.1416
Echinococcus granulosus cpg binding protein 0.003 0.0176 0.4947
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0015 0.0024
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0359
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0039 0.4637
Echinococcus multilocularis protein jagged 1 0.0017 0.0071 0.1985
Loa Loa (eye worm) blistered cuticle protein 3 0.0053 0.0356 0.2162
Toxoplasma gondii EGF family domain-containing protein 0.0017 0.0071 0.0215
Trichomonas vaginalis pc-MYB2, putative 0.001 0.0011 0.0047
Mycobacterium ulcerans hypothetical protein 0.0038 0.0234 0.0232
Schistosoma mansoni nuclear hormone receptor 0.001 0.0015 0.0166
Mycobacterium tuberculosis Conserved protein 0.0038 0.0234 0.0324
Echinococcus multilocularis cpg binding protein 0.003 0.0176 0.4947
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0163 0.0943
Brugia malayi Animal haem peroxidase family protein 0.0053 0.0356 0.2176
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0015 0.0024
Onchocerca volvulus Putative cubilin 0.0017 0.0071 0.0308
Echinococcus granulosus neurogenic locus notch protein 4 0.0017 0.0071 0.1985
Mycobacterium tuberculosis Conserved protein 0.0038 0.0234 0.0324
Leishmania major trypanothione reductase 0.0038 0.0236 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0177 0.1031
Echinococcus multilocularis neurogenic locus protein delta 0.0017 0.0071 0.1985
Schistosoma mansoni cpg binding protein 0.0029 0.0163 0.1814
Schistosoma mansoni ferritin 0.0009 0.0002 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0015 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0015 0.0006
Schistosoma mansoni cell polarity protein 0.0017 0.0071 0.0786
Onchocerca volvulus 0.0053 0.0356 0.1884
Leishmania major hypothetical protein, conserved 0.0038 0.0234 0.9914
Schistosoma mansoni thyroid hormone receptor 0.001 0.0015 0.0166
Trichomonas vaginalis set domain proteins, putative 0.0238 0.1827 1
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0356 0.2772 0.277
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0359
Echinococcus granulosus expressed protein 0.0009 0.0002 0.0066
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0359
Echinococcus granulosus fibropellin Ia 0.0017 0.0071 0.1985
Mycobacterium tuberculosis Conserved protein 0.0038 0.0234 0.0324
Schistosoma mansoni hypothetical protein 0.0017 0.0071 0.0786
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.0622 0.0865
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0356 0.2772 0.2744
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0359
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0359
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0359
Trichomonas vaginalis C-MYB, putative 0.001 0.0011 0.0047
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0359
Onchocerca volvulus 0.0017 0.0071 0.0308
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0236 1
Echinococcus multilocularis neurogenic locus notch protein 4 0.0017 0.0071 0.1985
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.0356 0.2162
Schistosoma mansoni cpg binding protein 0.003 0.0176 0.1959
Schistosoma mansoni notch 0.0017 0.0071 0.0786
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0135 0.4894
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.024 0.673
Trichomonas vaginalis MYB, putative 0.001 0.0011 0.0049
Brugia malayi ecdysteroid receptor 0.001 0.0015 0.0024
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0236 1
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0015 0.0166
Mycobacterium tuberculosis Probable oxidoreductase 0.0096 0.0699 0.0973
Brugia malayi beta-lactamase 0.0038 0.0234 0.1406
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0177 0.4974
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0015 0.0166
Loa Loa (eye worm) hypothetical protein 0.0038 0.0234 0.139
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0135 0.4894
Loa Loa (eye worm) hypothetical protein 0.0053 0.0356 0.2162
Brugia malayi notch-like transmembrane receptor 0.0017 0.0071 0.0376
Giardia lamblia High cysteine protein 0.0017 0.0071 1
Schistosoma mansoni notch 0.0017 0.0071 0.0786
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0006
Loa Loa (eye worm) Notch2 0.0017 0.0071 0.0359
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0015 0.0419
Plasmodium falciparum glutathione reductase 0.0038 0.0236 1
Schistosoma mansoni notch 0.0017 0.0071 0.0786
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0017 0.0071 0.0786
Brugia malayi EGF-like domain containing protein 0.0017 0.0071 0.0376
Loa Loa (eye worm) hypothetical protein 0.0053 0.0356 0.2162
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0359
Brugia malayi Pre-SET motif family protein 0.0209 0.1598 1
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0071 0.0376
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0135 0.4894
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.0622 0.0865
Loa Loa (eye worm) hypothetical protein 0.0025 0.0135 0.0766
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0086 0.0622 0.0865
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0359
Onchocerca volvulus Peroxidasin homolog 0.0053 0.0356 0.1884
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0071 0.0376
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0359
Schistosoma mansoni thyroid hormone receptor 0.001 0.0015 0.0166
Loa Loa (eye worm) hypothetical protein 0.0038 0.0234 0.139
Loa Loa (eye worm) hypothetical protein 0.0038 0.0234 0.139
Plasmodium vivax glutathione reductase, putative 0.0038 0.0236 1
Schistosoma mansoni ferritin 0.0009 0.0002 0.0026
Onchocerca volvulus Peroxidase homolog 0.0053 0.0356 0.1884
Echinococcus granulosus protein jagged 2 0.0017 0.0071 0.1985
Brugia malayi glutathione reductase 0.0038 0.0236 0.1416
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0015 0.0024
Schistosoma mansoni hypothetical protein 0.0011 0.0024 0.0272
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0359
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0234 0.0232
Loa Loa (eye worm) hypothetical protein 0.0053 0.0356 0.2162
Loa Loa (eye worm) hypothetical protein 0.0053 0.0356 0.2162
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0234 0.127
Echinococcus granulosus neurogenic locus notch protein 0.0017 0.0071 0.1985
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0.0011 0.0047
Echinococcus multilocularis peroxidasin 0.0053 0.0356 1
Toxoplasma gondii thioredoxin reductase 0.0038 0.0236 0.0813
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0359
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0177 0.197
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0359
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0013 0.0012
Onchocerca volvulus 0.0238 0.1827 1
Echinococcus granulosus neurogenic locus notch protein 0.0017 0.0071 0.1985
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0234 0.0324
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0234 0.0324
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0039 0.0175
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1264 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0015 0.0006
Brugia malayi Animal haem peroxidase family protein 0.0053 0.0356 0.2176
Schistosoma mansoni apoferritin-2 0.0009 0.0002 0.0026
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0234 0.0324
Schistosoma mansoni hypothetical protein 0.0017 0.0071 0.0786
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0015 0.0419
Echinococcus multilocularis ferritin 0.0009 0.0002 0.0066
Onchocerca volvulus 0.0017 0.0071 0.0308
Mycobacterium tuberculosis Probable reductase 0.0086 0.0622 0.0865

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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