TDR Targets

Basic information

Technical information

TDR Targets ID: 875544
Name: N-[3-(2-methylphenyl)-[1,2,4]triazolo[4,5-d][ 1,3,4]thiadiazol-6-yl]acetamide
MW: 273.314 | Formula: C12H11N5OS
H donors: 1 H acceptors: 4 LogP: 1.8 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)Nc1nn2c(s1)nnc2c1ccccc1C
InChi: 1S/C12H11N5OS/c1-7-5-3-4-6-9(7)10-14-15-12-17(10)16-11(19-12)13-8(2)18/h3-6H,1-2H3,(H,13,16,18)
InChiKey: QNCXWZLUAACEJG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[3-(2-methylphenyl)-[1,2,4]triazolo[4,5-d][1,3,4]thiadiazol-6-yl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0067	0.0244	0.0213
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.0067	0.0244	0.2466
Schistosoma mansoni	hypothetical protein	0.0165	0.1053	0.1025
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0218	0.0187
Toxoplasma gondii	histone deacetylase HDAC1	0.0041	0.0035	0.0543
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.1256	1	1
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0117	0.0654	0.65
Echinococcus granulosus	histone deacetylase 6	0.0041	0.0035	0.0031
Loa Loa (eye worm)	histone deacetylase	0.0041	0.0035	0.0035
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.0434	0.043
Echinococcus granulosus	histone deacetylase 6	0.0041	0.0035	0.0031
Onchocerca volvulus		0.0067	0.0244	1
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.0041	0.0032	0.0319
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0032	0.1293
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0244	0.0244
Brugia malayi	Peptidase family M1 containing protein	0.0067	0.0244	0.055
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0218	0.0187
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0158	0.0989	1
Onchocerca volvulus		0.0067	0.0244	1
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0041	0.0032	0.0602
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0067	0.0244	0.2218
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0067	0.0244	0.2466
Trypanosoma brucei	histone deacetylase 3	0.0041	0.0035	0.0677
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.009	0.0434	0.0978
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0158	0.0989	0.096
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0158	0.0989	0.223
Echinococcus multilocularis	histone deacetylase 6	0.0041	0.0035	0.0031
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.1256	1	1
Toxoplasma gondii	hypothetical protein	0.0117	0.0654	1
Trypanosoma brucei	RNA helicase, putative	0.0101	0.0524	1
Trypanosoma brucei	histone deacetylase, putative	0.0041	0.0035	0.0677
Echinococcus multilocularis	histone deacetylase 6	0.0041	0.0035	0.0031
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0067	0.0244	0.024
Plasmodium falciparum	histone deacetylase 2	0.0041	0.0035	0.0359
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0244	0.0244
Onchocerca volvulus		0.0067	0.0244	1
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0084	0.0389	0.8342
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0067	0.0244	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0067	0.0244	0.024
Loa Loa (eye worm)	hypothetical protein	0.0158	0.0989	0.0989
Brugia malayi	TAR-binding protein	0.0064	0.0218	0.0491
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.0218	0.0218
Brugia malayi	Histone deacetylase family protein	0.0041	0.0035	0.008
Trypanosoma cruzi	aminopeptidase, putative	0.0067	0.0244	1
Trypanosoma brucei	histone deacetylase 4	0.0041	0.0035	0.0677
Brugia malayi	hypothetical protein	0.0067	0.0244	0.055
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0158	0.0989	1
Schistosoma mansoni	hypothetical protein	0.0101	0.0524	0.0494
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0067	0.0244	1
Trypanosoma cruzi	histone deacetylase, putative	0.0041	0.0035	0.1455
Trypanosoma brucei	Aminopeptidase M1, putative	0.0067	0.0244	0.4654
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0067	0.0244	0.024
Loa Loa (eye worm)	RNA binding protein	0.0064	0.0218	0.0218
Mycobacterium ulcerans	aminopeptidase N PepN	0.0067	0.0244	0.5
Schistosoma mansoni	hypothetical protein	0.0165	0.1053	0.1025
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0041	0.0032	0.0071
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0067	0.0244	0.024
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0041	0.0032	0.1293
Trypanosoma cruzi	histone deacetylase, putative	0.0041	0.0035	0.1455
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0158	0.0989	1
Toxoplasma gondii	aminopeptidase n, putative	0.0067	0.0244	0.373
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0067	0.0244	1
Echinococcus multilocularis	histone deacetylase 7	0.0041	0.0035	0.0031
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.0434	0.0403
Brugia malayi	Histone deacetylase family protein	0.0041	0.0035	0.008
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0158	0.0989	0.0985
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0158	0.0989	0.0985
Trypanosoma cruzi	histone deacetylase, putative	0.0041	0.0035	0.1455
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0067	0.0244	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0067	0.0244	0.024
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0084	0.0389	0.8342
Loa Loa (eye worm)	TATA binding protein associated factor	0.0067	0.0244	0.0244
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0041	0.0032	0.0032
Leishmania major	histone deacetylase, putative	0.0041	0.0035	0.1455
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0067	0.0244	0.2218
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0067	0.0244	0.2218
Toxoplasma gondii	aminopeptidase N protein	0.0067	0.0244	0.373
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.0041	0.0032	0.0319
Echinococcus granulosus	histone deacetylase 6	0.0041	0.0035	0.0031
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.0434	0.043
Echinococcus granulosus	geminin	0.0165	0.1053	0.1049
Loa Loa (eye worm)	aminopeptidase N	0.0067	0.0244	0.0244
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.0218	0.0214
Brugia malayi	TATA binding protein associated factor	0.0067	0.0244	0.055
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.0041	0.0032	0.0028
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0067	0.0244	0.024
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.0041	0.0032	0.1293
Mycobacterium tuberculosis	Probable dehydrogenase	0.0084	0.0389	0.8342
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0158	0.0989	1
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0067	0.0244	1
Plasmodium falciparum	histone deacetylase, putative	0.0041	0.0035	0.0359
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0067	0.0244	0.0213
Mycobacterium ulcerans	aminopeptidase N PepN	0.0067	0.0244	0.5
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0094	0.0466	1
Brugia malayi	hypothetical protein	0.0578	0.4434	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.009	0.0434	0.0434
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.0041	0.0032	0.0028
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.0041	0.0032	0.1293
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0067	0.0244	0.0244
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0067	0.0244	0.0213
Brugia malayi	Peptidase family M1 containing protein	0.0067	0.0244	0.055
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0067	0.0244	0.024
Toxoplasma gondii	aminopeptidase N, putative	0.0067	0.0244	0.373
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0067	0.0244	0.024
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0158	0.0989	1
Trypanosoma brucei	aminopeptidase, putative	0.0067	0.0244	0.4654
Echinococcus granulosus	tar DNA binding protein	0.0064	0.0218	0.0214
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0067	0.0244	0.0213
Plasmodium falciparum	M1-family alanyl aminopeptidase, putative	0.0067	0.0244	0.2466
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0067	0.0244	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0094	0.0466	1
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0041	0.0032	0.0602
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0084	0.0389	0.8342
Echinococcus multilocularis	histone deacetylase	0.0041	0.0035	0.0031
Entamoeba histolytica	aminopeptidase, putative	0.0067	0.0244	0.2218
Schistosoma mansoni	histone deacetylase hda2	0.0041	0.0035	0.0004
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.0041	0.0032	0.0602
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.0218	0.0491
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.0434	0.043
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.0041	0.0032	0.0028
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0158	0.0989	0.0989
Echinococcus granulosus	histone deacetylase	0.0041	0.0035	0.0031
Trypanosoma brucei	hypothetical protein, conserved	0.0041	0.0032	0.0602
Plasmodium vivax	histone deacetylase 2, putative	0.0041	0.0035	0.0359
Echinococcus granulosus	aminopeptidase N	0.0067	0.0244	0.024
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0067	0.0244	0.024
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.0041	0.0032	0.0028
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0067	0.0244	0.024
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.0434	0.0403
Trypanosoma brucei	Aminopeptidase M1, putative	0.0067	0.0244	0.4654
Toxoplasma gondii	hypothetical protein	0.0041	0.0032	0.0483
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0067	0.0244	0.2466
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0035	0.0035
Giardia lamblia	Rab geranylgeranyltransferase	0.0158	0.0989	1
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0067	0.0244	1
Mycobacterium tuberculosis	Probable reductase	0.0084	0.0389	0.8342
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0032	0.1293
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0067	0.0244	0.024
Leishmania major	puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0067	0.0244	1
Plasmodium vivax	histone deacetylase, putative	0.0041	0.0035	0.0359
Loa Loa (eye worm)	histone deacetylase 7A	0.0041	0.0035	0.0035
Trypanosoma cruzi	aminopeptidase, putative	0.0067	0.0244	1
Echinococcus granulosus	histone deacetylase 7	0.0041	0.0035	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0035	0.0035
Brugia malayi	hypothetical protein	0.0067	0.0244	0.055
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.0434	0.0403
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0244	0.0244
Echinococcus multilocularis	geminin	0.0165	0.1053	0.1049
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0094	0.0466	1
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0067	0.0244	1
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.1256	1	1
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0158	0.0989	1
Echinococcus multilocularis	aminopeptidase N	0.0067	0.0244	0.024
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0094	0.0466	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0084	0.0389	0.8342
Brugia malayi	Peptidase family M1 containing protein	0.0067	0.0244	0.055
Leishmania major	histone deacetylase, putative	0.0041	0.0035	0.1455
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.0434	0.043
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0067	0.0244	0.4654
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0218	0.0187
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0218	0.0187
Schistosoma mansoni	histone deacetylase 4 5	0.0041	0.0035	0.0004
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0067	0.0244	1
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.0218	0.0218
Echinococcus multilocularis	histone deacetylase 6	0.0041	0.0035	0.0031
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0067	0.0244	0.024
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0041	0.0032	0.1293
Schistosoma mansoni	histone deacetylase 4 5	0.0041	0.0035	0.0004
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0218	0.0187
Brugia malayi	RNA binding protein	0.0064	0.0218	0.0491

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 875544