Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0094 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.0403 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.119 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.119 | 0.2319 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.119 | 0.2319 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0094 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0094 | 1 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0046 | 0.3795 | 0.3534 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0046 | 0.3795 | 0.3795 |
Leishmania major | DNA polymerase eta, putative | 0.0032 | 0.2023 | 0.4775 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.0403 | 0.0403 |
Echinococcus multilocularis | dna polymerase eta | 0.0046 | 0.3795 | 0.3534 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0046 | 0.3795 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.119 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.0403 | 0.5 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0032 | 0.2023 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.119 | 0.2319 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.119 | 0.082 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.002 | 0.0403 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0046 | 0.3795 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0094 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.119 | 0.2319 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0094 | 1 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.002 | 0.0403 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.119 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0094 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0094 | 1 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.002 | 0.0403 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0046 | 0.3795 | 0.3534 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0032 | 0.2023 | 0.4775 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.3795 | 0.3534 |
Brugia malayi | hypothetical protein | 0.0026 | 0.119 | 0.119 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0094 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0046 | 0.3795 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.002 | 0.0403 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.002 | 0.0403 | 0.5 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.002 | 0.0403 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.