Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.1064 | 0.1064 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.1064 | 0.1064 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.1064 | 0.1064 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.1064 | 0.1064 |
Loa Loa (eye worm) | TAR-binding protein | 0.0075 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.4503 | 0.4503 |
Brugia malayi | TAR-binding protein | 0.0075 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.1064 | 0.1064 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.1064 | 0.1064 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.4503 | 0.4503 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0075 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0059 | 0.7465 | 0.7465 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0059 | 0.7465 | 0.7465 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.1064 | 0.1064 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0075 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 1 | 1 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0059 | 0.7465 | 0.7465 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.1064 | 0.1064 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0075 | 1 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.1064 | 0.1064 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.1064 | 0.1064 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0075 | 1 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.1064 | 0.1064 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1064 | 0.1064 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.1064 | 0.1064 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.4503 | 0.4503 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.7465 | 0.7465 |
Loa Loa (eye worm) | RNA binding protein | 0.0075 | 1 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.1064 | 0.1064 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 1.62 uM | Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye | Saint Jude. | 20485428 |
EC50 (functional) | = 1.75 uM | Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye | Saint Jude. | 20485428 |
Percent growth inhibition (functional) | = 99.3 % | Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by YOYO-3 red dye | Saint Jude. | 20485428 |
Percent growth inhibition (functional) | = 104.3 % | Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by SYBR green dye | Saint Jude. | 20485428 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.