Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0137 | 0.0405 | 0.0411 |
Loa Loa (eye worm) | carboxylesterase | 0.0137 | 0.0405 | 0.0405 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0137 | 0.0405 | 0.0405 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0356 | 0.13 | 1 |
Loa Loa (eye worm) | SRC-1 | 0.008 | 0.0172 | 0.0172 |
Onchocerca volvulus | 0.0046 | 0.003 | 0.0739 | |
Brugia malayi | Carboxylesterase family protein | 0.0811 | 0.3165 | 0.5274 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.008 | 0.0172 | 0.0172 |
Brugia malayi | Protein kinase domain containing protein | 0.0046 | 0.003 | 0.005 |
Schistosoma mansoni | tyrosine kinase | 0.0046 | 0.003 | 0.003 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0046 | 0.003 | 0.003 |
Onchocerca volvulus | 0.0046 | 0.003 | 0.0739 | |
Loa Loa (eye worm) | TK protein kinase | 0.0046 | 0.003 | 0.003 |
Schistosoma mansoni | acetylcholinesterase | 0.0137 | 0.0405 | 0.0411 |
Loa Loa (eye worm) | inositol-1 | 0.0039 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.0405 | 0.0405 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0046 | 0.003 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0588 | 0.0588 |
Echinococcus granulosus | tyrosine kinase | 0.0046 | 0.003 | 0.003 |
Onchocerca volvulus | 0.0137 | 0.0405 | 1 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0046 | 0.003 | 0.003 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0004 | 0.0031 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0046 | 0.003 | 0.003 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0733 | 0.2843 | 0.2843 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.008 | 0.0172 | 0.0172 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0137 | 0.0405 | 0.0411 |
Echinococcus multilocularis | NCK adaptor protein | 0.007 | 0.0131 | 0.0131 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0004 | 0.0004 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.248 | 1 | 1 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.008 | 0.0172 | 0.0172 |
Brugia malayi | Variant SH3 domain containing protein | 0.007 | 0.0131 | 0.0218 |
Brugia malayi | protein-tyrosine kinase | 0.0046 | 0.003 | 0.005 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.0405 | 0.0405 |
Brugia malayi | Carboxylesterase family protein | 0.0137 | 0.0405 | 0.0674 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0039 | 0.0004 | 0.01 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.008 | 0.0172 | 0.0172 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.008 | 0.0172 | 0.0172 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0046 | 0.003 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0356 | 0.13 | 0.13 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.007 | 0.0131 | 0.0131 |
Loa Loa (eye worm) | carboxylesterase | 0.0137 | 0.0405 | 0.0405 |
Onchocerca volvulus | 0.0137 | 0.0405 | 1 | |
Brugia malayi | Variant SH3 domain containing protein | 0.007 | 0.0131 | 0.0218 |
Schistosoma mansoni | gliotactin | 0.0137 | 0.0405 | 0.0411 |
Echinococcus granulosus | acetylcholinesterase | 0.0811 | 0.3165 | 0.3165 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0039 | 0.0004 | 0.0004 |
Brugia malayi | Carboxylesterase family protein | 0.0137 | 0.0405 | 0.0674 |
Mycobacterium leprae | Probable lipase LipE | 0.0038 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0811 | 0.3165 | 0.3165 |
Echinococcus granulosus | c src tyrosine kinase | 0.008 | 0.0172 | 0.0172 |
Brugia malayi | hypothetical protein | 0.0046 | 0.003 | 0.005 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.008 | 0.0172 | 0.0172 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.248 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0137 | 0.0405 | 0.0405 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0046 | 0.003 | 0.003 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0046 | 0.003 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.0405 | 0.0405 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0046 | 0.003 | 0.003 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0046 | 0.003 | 0.003 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.007 | 0.0131 | 0.0131 |
Mycobacterium leprae | conserved hypothetical protein | 0.0038 | 0 | 0.5 |
Brugia malayi | SRC-1 | 0.008 | 0.0172 | 0.0286 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0131 | 0.0131 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.007 | 0.0131 | 0.0131 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.008 | 0.0172 | 0.0172 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.007 | 0.0131 | 0.0133 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.008 | 0.0172 | 0.0172 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.0172 | 0.0174 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.0405 | 0.0405 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0039 | 0.0004 | 0.01 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0046 | 0.003 | 0.003 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0004 | 0.0031 |
Onchocerca volvulus | 0.0046 | 0.003 | 0.0739 | |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0861 | 0.3368 | 0.3368 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0046 | 0.003 | 0.003 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.0004 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.0405 | 0.0405 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.0004 | 0.01 |
Schistosoma mansoni | adapter molecule crk | 0.007 | 0.0131 | 0.0133 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0046 | 0.003 | 0.003 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.007 | 0.0131 | 0.0133 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.008 | 0.0172 | 0.0172 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0046 | 0.003 | 0.003 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0137 | 0.0405 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.008 | 0.0172 | 0.0172 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.008 | 0.0172 | 0.0172 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0137 | 0.0405 | 0.0405 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0046 | 0.003 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0137 | 0.0405 | 1 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0356 | 0.13 | 0.2166 |
Onchocerca volvulus | 0.0046 | 0.003 | 0.0739 | |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.008 | 0.0172 | 0.0172 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0811 | 0.3165 | 0.3165 |
Onchocerca volvulus | 0.0137 | 0.0405 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.0405 | 0.0405 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0137 | 0.0405 | 0.0411 |
Brugia malayi | hypothetical protein | 0.0137 | 0.0405 | 0.0674 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.008 | 0.0172 | 0.0172 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0046 | 0.003 | 0.003 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0137 | 0.0405 | 0.48 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0039 | 0.0004 | 0.0004 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0356 | 0.13 | 1 |
Onchocerca volvulus | 0.0137 | 0.0405 | 1 | |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0046 | 0.003 | 0.003 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.0172 | 0.0174 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.008 | 0.0172 | 0.0174 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.003 | 0.003 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0045 | 0.0026 | 0.0027 |
Onchocerca volvulus | 0.0137 | 0.0405 | 1 | |
Brugia malayi | Protein kinase domain containing protein | 0.0046 | 0.003 | 0.005 |
Echinococcus granulosus | acetylcholinesterase | 0.0811 | 0.3165 | 0.3165 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0039 | 0.0004 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0137 | 0.0405 | 0.0405 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.1011 | 0.3984 | 0.6638 |
Echinococcus multilocularis | neuroligin | 0.0137 | 0.0405 | 0.0405 |
Onchocerca volvulus | 0.0046 | 0.003 | 0.0739 | |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0137 | 0.0405 | 0.0405 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0137 | 0.0405 | 0.0405 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0137 | 0.0405 | 0.48 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.0405 | 0.0405 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0004 | 0.0031 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0137 | 0.0405 | 0.0411 |
Brugia malayi | Protein kinase domain containing protein | 0.0046 | 0.003 | 0.005 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0811 | 0.3165 | 0.3212 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0046 | 0.003 | 0.003 |
Echinococcus granulosus | carboxylesterase 5A | 0.0811 | 0.3165 | 0.3165 |
Onchocerca volvulus | 0.0046 | 0.003 | 0.0739 | |
Echinococcus multilocularis | tyrosine kinase | 0.0046 | 0.003 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0811 | 0.3165 | 0.3165 |
Echinococcus multilocularis | acetylcholinesterase | 0.0811 | 0.3165 | 0.3165 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0356 | 0.13 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.008 | 0.0172 | 0.0172 |
Schistosoma mansoni | tyrosine kinase | 0.2445 | 0.9854 | 1 |
Brugia malayi | SH2 domain containing protein | 0.0046 | 0.003 | 0.005 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.008 | 0.0172 | 0.0172 |
Brugia malayi | Carboxylesterase family protein | 0.0137 | 0.0405 | 0.0674 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0137 | 0.0405 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0733 | 0.2843 | 0.2843 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0046 | 0.003 | 0.003 |
Echinococcus granulosus | tyrosine kinase | 0.0046 | 0.003 | 0.003 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.007 | 0.0131 | 0.0133 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0137 | 0.0405 | 0.0411 |
Echinococcus granulosus | neuroligin | 0.0137 | 0.0405 | 0.0405 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0046 | 0.003 | 0.003 |
Loa Loa (eye worm) | carboxylesterase | 0.0811 | 0.3165 | 0.3165 |
Brugia malayi | Protein kinase domain containing protein | 0.0046 | 0.003 | 0.005 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0039 | 0.0004 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0137 | 0.0405 | 0.0674 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0244 | 0.0843 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0046 | 0.003 | 0.003 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0733 | 0.2843 | 0.2885 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0004 | 0.0031 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.008 | 0.0172 | 0.0172 |
Schistosoma mansoni | nck2/grb4 | 0.007 | 0.0131 | 0.0133 |
Schistosoma mansoni | tyrosine kinase | 0.0046 | 0.003 | 0.003 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.0172 | 0.0174 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.008 | 0.0172 | 0.0172 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.007 | 0.0131 | 0.0131 |
Echinococcus granulosus | NCK adaptor protein | 0.007 | 0.0131 | 0.0131 |
Loa Loa (eye worm) | hypothetical protein | 0.0811 | 0.3165 | 0.3165 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0046 | 0.003 | 0.003 |
Brugia malayi | SH2 domain containing protein | 0.0046 | 0.003 | 0.005 |
Loa Loa (eye worm) | hypothetical protein | 0.0941 | 0.3696 | 0.3696 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.1011 | 0.3984 | 0.3984 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.1504 | 0.6001 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0811 | 0.3165 | 0.3165 |
Echinococcus multilocularis | c src tyrosine kinase | 0.008 | 0.0172 | 0.0172 |
Plasmodium vivax | hypothetical protein, conserved | 0.0038 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.008 | 0.0172 | 0.0172 |
Brugia malayi | Inositol-1 | 0.0039 | 0.0004 | 0.0007 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.007 | 0.0131 | 0.0218 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.008 | 0.0172 | 0.0172 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.0172 | 0.0174 |
Brugia malayi | Carboxylesterase family protein | 0.0811 | 0.3165 | 0.5274 |
Brugia malayi | Protein kinase domain containing protein | 0.0046 | 0.003 | 0.005 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0137 | 0.0405 | 0.48 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.