TDR Targets

Basic information

Technical information

TDR Targets ID: 875865
Name: N-(3-methoxypropyl)-2-pyridin-3-ylquinazolin- 4-amine
MW: 294.351 | Formula: C17H18N4O
H donors: 1 H acceptors: 3 LogP: 2.66 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COCCCNc1nc(nc2c1cccc2)c1cccnc1
InChi: 1S/C17H18N4O/c1-22-11-5-10-19-17-14-7-2-3-8-15(14)20-16(21-17)13-6-4-9-18-12-13/h2-4,6-9,12H,5,10-11H2,1H3,(H,19,20,21)
InChiKey: FJNJYNKYSSFUBQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(3-methoxypropyl)-2-(3-pyridyl)quinazolin-4-amine
N-(3-methoxypropyl)-2-(3-pyridyl)-4-quinazolinamine
3-methoxypropyl-[2-(3-pyridyl)quinazolin-4-yl]amine
N-(3-methoxypropyl)-2-pyridin-3-yl-quinazolin-4-amine
T5893075
ZINC01771827

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	microtubule associated protein 2	0.1546	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0039	0.0304
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.021	0.1288	0.1254
Onchocerca volvulus		0.0018	0.0039	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0069	0.0372	0.0984
Onchocerca volvulus		0.0018	0.0039	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0018	0.0039	0.0304
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0039	0.0304
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0039	0.0114
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0039	0.0114
Trypanosoma cruzi	cysteine peptidase, putative	0.0069	0.0372	0.0984
Loa Loa (eye worm)	fibroinase	0.0018	0.0039	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0039	0.0304
Leishmania major	cathepsin L-like protease	0.0069	0.0372	0.0984
Trypanosoma cruzi	major cysteine proteinase, putative	0.0054	0.0276	0.0699
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0039	0.0114
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.021	0.1288	0.1288
Onchocerca volvulus		0.0018	0.0039	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0039	0.0304
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.0039	0.0039
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0039	0.0304
Mycobacterium leprae	Probable dihydroorotate dehydrogenase PyrD	0.0537	0.3422	0.5
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.021	0.1288	1
Loa Loa (eye worm)	cysteine protease	0.0018	0.0039	1
Wolbachia endosymbiont of Brugia malayi	dihydroorotate dehydrogenase 2	0.0537	0.3422	0.5
Plasmodium vivax	dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0537	0.3422	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0039	0.0304
Trypanosoma cruzi	cruzipain precursor, putative	0.0069	0.0372	0.0984
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0039	0.0304
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0018	0.0039	0.0304
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0039	0.0114
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0039	0.0304
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0018	0.0039	0.0039
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0039	0.0304
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0039	0.0304
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0039	0.0304
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.021	0.1288	0.3691
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0039	0.0304
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0063	0.0333	0.0869
Onchocerca volvulus		0.0018	0.0039	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0018	0.0039	0.0039
Echinococcus granulosus	cathepsin l1	0.0018	0.0039	0.0039
Onchocerca volvulus		0.0018	0.0039	1
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0039	0.0304
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0039	0.0114
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0039	0.0304
Toxoplasma gondii	dihydroorotate dehydrogenase reveal, putative	0.0537	0.3422	1
Mycobacterium ulcerans	dihydroorotate dehydrogenase 2	0.0537	0.3422	0.5
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.021	0.1288	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0039	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0039	1
Leishmania major	dihydroorotate dehydrogenase	0.0537	0.3422	1
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0537	0.3422	1
Onchocerca volvulus		0.0018	0.0039	1
Onchocerca volvulus	Cathepsin F homolog	0.0018	0.0039	1
Loa Loa (eye worm)	ctsf protein	0.0018	0.0039	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0039	0.0304
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0039	0.0304
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.021	0.1288	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0039	0.0304
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0537	0.3422	1
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.021	0.1288	1
Leishmania major	cathepsin L-like protease	0.0069	0.0372	0.0984
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0039	0.0304
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0537	0.3422	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0069	0.0372	0.0984
Brugia malayi	Zinc finger, C2H2 type family protein	0.021	0.1288	0.3763
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0039	0.0304
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.021	0.1288	1
Mycobacterium tuberculosis	Probable dihydroorotate dehydrogenase PyrD	0.0537	0.3422	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0039	0.0304
Leishmania major	cathepsin L-like protease	0.0069	0.0372	0.0984
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0039	0.0114
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0039	0.0304
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0039	0.0304
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0039	0.0304
Trypanosoma brucei	dihydroorotate dehydrogenase (fumarate)	0.0537	0.3422	1
Plasmodium falciparum	dihydroorotate dehydrogenase	0.0537	0.3422	1
Onchocerca volvulus		0.0018	0.0039	1
Schistosoma mansoni	microtubule-associated protein tau	0.1546	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0018	0.0039	1
Schistosoma mansoni	dihydroorotate dehydrogenase	0.0537	0.3422	0.3422
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.0039	0.0039
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0039	0.0304
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0039	0.0304
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0018	0.0039	1
Onchocerca volvulus	Cathepsin L homolog	0.0018	0.0039	1
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.021	0.1288	0.1288
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.021	0.1288	0.1254
Onchocerca volvulus	Cathepsin L homolog	0.0018	0.0039	1
Entamoeba histolytica	dihydropyrimidine dehydrogenase, putative	0.021	0.1288	1
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0537	0.3422	1
Brugia malayi	Papain family cysteine protease containing protein	0.0018	0.0039	0.0114
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.021	0.1288	1
Trypanosoma cruzi	dihydroorotate dehydrogenase (fumarate), putative	0.0537	0.3422	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 875865