Detailed information for compound 875949

Basic information

Technical information
  • TDR Targets ID: 875949
  • Name: N-(2-ethylphenyl)-2-[2-[(4-fluorophenyl)amino ]-2-oxoethyl]sulfanylacetamide
  • MW: 346.419 | Formula: C18H19FN2O2S
  • H donors: 2 H acceptors: 2 LogP: 3.58 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccccc1NC(=O)CSCC(=O)Nc1ccc(cc1)F
  • InChi: 1S/C18H19FN2O2S/c1-2-13-5-3-4-6-16(13)21-18(23)12-24-11-17(22)20-15-9-7-14(19)8-10-15/h3-10H,2,11-12H2,1H3,(H,20,22)(H,21,23)
  • InChiKey: ICWJRPJKIYYFRI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-ethylphenyl)-2-[2-[(4-fluorophenyl)amino]-2-oxo-ethyl]sulfanyl-acetamide
  • N-(2-ethylphenyl)-2-[[2-[(4-fluorophenyl)amino]-2-oxoethyl]thio]acetamide
  • N-(2-ethylphenyl)-2-[[2-[(4-fluorophenyl)amino]-2-keto-ethyl]thio]acetamide
  • N-(2-ethylphenyl)-2-[2-[(4-fluorophenyl)amino]-2-oxo-ethyl]sulfanyl-ethanamide
  • ZINC00148694

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0009 0.0004 0.0004
Brugia malayi Melatonin receptor type 1A 0.0042 0.0118 0.039
Brugia malayi SRC-1 0.0009 0.0004 0.0012
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.0141 0.086
Echinococcus granulosus dro:myosuppressin receptor 0.0042 0.0118 0.0117
Schistosoma mansoni biogenic amine receptor 0.0042 0.0118 0.0719
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0031 0.0079 0.0294
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0042 0.0118 0.0719
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0031 0.0079 0.0185
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0031 0.0079 0.0294
Brugia malayi G-protein coupled receptor 0.0042 0.0118 0.039
Echinococcus multilocularis neuropeptide Y receptor 0.0042 0.0118 0.0117
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.0118 0.039
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0881 0.3001 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0118 0.0117
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0009 0.0004 0.0004
Echinococcus granulosus sex peptide receptor 0.0042 0.0118 0.0117
Schistosoma mansoni neuropeptide receptor 0.0042 0.0118 0.0719
Loa Loa (eye worm) hypothetical protein 0.0017 0.0033 0.011
Schistosoma mansoni adenoreceptor 0.0042 0.0118 0.0719
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0007 0.0042
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0238 0.0791 0.079
Mycobacterium leprae putative cytochrome p450 0.0031 0.0079 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0033 0.5
Brugia malayi hypothetical protein 0.0042 0.0118 0.039
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0042 0.0118 0.0117
Echinococcus multilocularis neuropeptide Y receptor 0.0042 0.0118 0.0117
Echinococcus granulosus c src tyrosine kinase 0.0009 0.0004 0.0004
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0042 0.0118 0.039
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0031 0.0079 0.0294
Echinococcus multilocularis orexin receptor type 2 0.0042 0.0118 0.0117
Echinococcus multilocularis expressed conserved protein 0.001 0.0007 0.0007
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0031 0.0079 0.0185
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0118 0.0117
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0009 0.0004 0.0004
Schistosoma mansoni alpha-1 adrenergic receptor 0.0042 0.0118 0.0719
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0013 0.0019 0.0018
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0033 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0031 0.0079 0.0185
Loa Loa (eye worm) hypothetical protein 0.0017 0.0033 0.011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0118 0.0117
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0042 0.0118 0.039
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0031 0.0079 0.0294
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.0118 0.039
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0031 0.0079 0.0185
Mycobacterium ulcerans haloalkane dehalogenase 0.0792 0.2697 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0042 0.0118 0.0117
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Schistosoma mansoni amine GPCR 0.0042 0.0118 0.0719
Echinococcus multilocularis voltage gated potassium channel 0.0013 0.0019 0.0018
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0042 0.0118 0.039
Schistosoma mansoni hypothetical protein 0.0042 0.0118 0.0719
Echinococcus granulosus tyrosine protein kinase Fyn 0.0009 0.0004 0.0004
Echinococcus granulosus tyrosine protein kinase Src64B 0.0009 0.0004 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0118 0.0719
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0031 0.0079 0.0294
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0881 0.3001 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0176
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0118 0.0117
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0118 0.0117
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Onchocerca volvulus 0.0042 0.0118 1
Loa Loa (eye worm) hypothetical protein 0.0388 0.1306 0.4351
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0053 0.0087
Echinococcus multilocularis mitogen activated protein kinase 14 0.0881 0.3001 0.3001
Schistosoma mansoni neuropeptide receptor 0.0042 0.0118 0.0719
Echinococcus granulosus tyrosine protein kinase Src42A 0.0009 0.0004 0.0004
Schistosoma mansoni neuropeptide receptor 0.0042 0.0118 0.0719
Brugia malayi hypothetical protein 0.0042 0.0118 0.039
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0118 0.0719
Onchocerca volvulus 0.0042 0.0118 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0053 0.0198
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Onchocerca volvulus 0.0042 0.0118 1
Brugia malayi ORL1-like opioid receptor 0.0042 0.0118 0.039
Onchocerca volvulus 0.0042 0.0118 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0118 0.0719
Brugia malayi G protein-coupled receptor 0.0042 0.0118 0.039
Brugia malayi hypothetical protein 0.0042 0.0118 0.039
Echinococcus granulosus biogenic amine 5HT receptor 0.0482 0.163 0.163
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0118 0.0117
Echinococcus multilocularis mitogen activated protein kinase 11 0.0881 0.3001 0.3001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0015
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0118 0.0117
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0118 0.0117
Leishmania major cytochrome p450-like protein 0.0031 0.0079 0.0241
Echinococcus multilocularis tyrosine protein kinase Abl 0.0009 0.0004 0.0004
Echinococcus granulosus mitogen activated protein kinase 14 0.0881 0.3001 0.3001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0118 0.0117
Schistosoma mansoni biogenic amine receptor 0.0042 0.0118 0.0719
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0042 0.0118 0.0117
Loa Loa (eye worm) hypothetical protein 0.0017 0.0033 0.011
Schistosoma mansoni tyrosine kinase 0.0009 0.0004 0.0023
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0053 0.0198
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0118 0.0117
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Loa Loa (eye worm) cytochrome P450 0.0031 0.0079 0.0263
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.011 0.0365
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0009 0.0005 0.0004
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.0118 0.039
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0009 0.0004 0.0004
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0042 0.0118 0.0117
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0031 0.0079 0.0185
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0042 0.0118 0.0117
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0005 0.0025
Echinococcus multilocularis conserved hypothetical protein 0.0807 0.2748 0.2747
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0019 0.0111
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0881 0.3001 1
Echinococcus granulosus g protein coupled receptor 0.0042 0.0118 0.0117
Schistosoma mansoni cytochrome P450 0.0031 0.0079 0.0485
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0031 0.0079 0.0294
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0388 0.1306 0.8011
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0042 0.0118 0.039
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0118 0.0117
Echinococcus granulosus tyrosine protein kinase Fyn 0.0009 0.0004 0.0004
Brugia malayi Cytochrome P450 family protein 0.0031 0.0079 0.0263
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.0141 0.086
Echinococcus multilocularis neuropeptides capa receptor 0.0042 0.0118 0.0117
Echinococcus granulosus neuropeptide Y receptor 0.0042 0.0118 0.0117
Echinococcus multilocularis amiloride sensitive amine oxidase 0.0096 0.0303 0.0302
Echinococcus granulosus g protein coupled receptor 0.0042 0.0118 0.0117
Schistosoma mansoni amine GPCR 0.0042 0.0118 0.0719
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0031 0.0079 0.0185
Echinococcus granulosus cGMP dependent protein kinase 0.001 0.0007 0.0007
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0053 0.0154
Brugia malayi follicle stimulating hormone receptor 0.0042 0.0118 0.039
Brugia malayi Egg laying defective protein 4 0.001 0.0007 0.0023
Onchocerca volvulus 0.0023 0.0053 0.4544
Onchocerca volvulus 0.0042 0.0118 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0042 0.0118 0.0719
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0019 0.0111
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0009 0.0004 0.0004
Brugia malayi larval opioid receptor 0.0042 0.0118 0.039
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.0117 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0053 0.0176
Trypanosoma cruzi cytochrome P450, putative 0.0039 0.011 0.0105
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0009 0.0004 0.0004
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0118 0.0117
Echinococcus granulosus tyrosine protein kinase Fyn 0.0009 0.0004 0.0004
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0009 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.006
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0031 0.0079 0.0294
Echinococcus multilocularis serotonin receptor 0.0184 0.0607 0.0607
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0009 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0042 0.0118 0.0719
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Echinococcus multilocularis somatostatin receptor 0.0042 0.0118 0.0117
Echinococcus granulosus g protein coupled receptor 0.0042 0.0118 0.0117
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0042 0.0118 0.039
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0053 0.0176
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0881 0.3001 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0042 0.0118 0.0719
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Brugia malayi Dopamine receptor protein 2 0.0042 0.0118 0.039
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Loa Loa (eye worm) hypothetical protein 0.0017 0.0033 0.011
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0044 0.0127 0.0126
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0031 0.0079 0.0294
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0031 0.0079 0.0185
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0031 0.0079 0.0185
Onchocerca volvulus 0.0042 0.0118 1
Echinococcus multilocularis cGMP dependent protein kinase 1 0.001 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0184 0.0607 0.2021
Onchocerca volvulus 0.0042 0.0118 1
Brugia malayi P38 map kinase family protein 2 0.0881 0.3001 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0042 0.0118 0.0719
Echinococcus multilocularis neuropeptide receptor A26 0.0042 0.0118 0.0117
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0053 1
Onchocerca volvulus 0.0042 0.0118 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0042 0.0118 0.0117
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0042 0.0118 0.0117
Brugia malayi G-protein coupled receptor 0.0042 0.0118 0.039
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0013 0.0019 0.006
Echinococcus granulosus neuropeptide receptor 0.0042 0.0118 0.0117
Onchocerca volvulus 0.0042 0.0118 1
Loa Loa (eye worm) hypothetical protein 0.0587 0.1992 0.6637
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Echinococcus granulosus g-protein coupled receptor 0.0042 0.0118 0.0117
Loa Loa (eye worm) hypothetical protein 0.0388 0.1306 0.4351
Schistosoma mansoni amine GPCR 0.0042 0.0118 0.0719
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0044 0.0127 0.0126
Echinococcus multilocularis neuropeptide FF receptor 2 0.0042 0.0118 0.0117
Echinococcus granulosus amiloride sensitive amine oxidase 0.0096 0.0303 0.0302
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0042 0.0118 0.0117
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0388 0.1306 0.4351
Echinococcus granulosus peptide allatostatin:somatostatin 0.0042 0.0118 0.0117
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.0118 0.0719
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0013 0.0019 0.0018
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0118 0.0719
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0031 0.0079 0.0261
Schistosoma mansoni hypothetical protein 0.0042 0.0118 0.0719
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0042 0.0118 0.0719
Echinococcus granulosus neuropeptide receptor A26 0.0042 0.0118 0.0117
Echinococcus granulosus neuropeptide s receptor 0.0042 0.0118 0.0117
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Loa Loa (eye worm) cytochrome P450 family protein 0.0069 0.0213 0.0708
Schistosoma mansoni tyrosine kinase 0.0009 0.0004 0.0023
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0042 0.0118 0.0117
Echinococcus granulosus cytochrome P450 2K1 0.0031 0.0079 0.0079
Echinococcus granulosus neuropeptide Y receptor 0.0042 0.0118 0.0117
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0053 0.0198
Echinococcus multilocularis neuropeptide receptor 0.0042 0.0118 0.0117
Echinococcus granulosus tachykinin peptides receptor 99D 0.0042 0.0118 0.0117
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0031 0.0079 0.0185
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0118 0.0719
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0118 0.0117
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0053 0.0198
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0042 0.0118 0.0117
Echinococcus multilocularis mitogen activated protein kinase 14 0.0881 0.3001 0.3001
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0044 0.0127 0.042
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0031 0.0079 0.0241
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0053 0.0198
Brugia malayi hypothetical protein 0.0042 0.0118 0.039
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.0118 0.0719
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0009 0.0004 0.0004
Trypanosoma brucei cytochrome P450, putative 0.0039 0.011 0.0363
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0031 0.0079 0.0185
Schistosoma mansoni hypothetical protein 0.0042 0.0118 0.0719
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.0118 0.0719
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0033 0.0124
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0031 0.0079 0.0294
Echinococcus multilocularis neuropeptide receptor 0.0042 0.0118 0.0117
Echinococcus granulosus voltage gated potassium channel 0.0013 0.0019 0.0018
Brugia malayi Cytochrome P450 family protein 0.0039 0.011 0.0365
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.0005 0.0004
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0053 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0176
Onchocerca volvulus 0.0042 0.0118 1
Echinococcus granulosus neuropeptides capa receptor 0.0042 0.0118 0.0117
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Schistosoma mansoni biogenic amine (5HT) receptor 0.0184 0.0607 0.3721
Trypanosoma cruzi cytochrome P450, putative 0.0039 0.011 0.0105
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0118 0.0117
Leishmania major cytochrome p450-like protein 0.0039 0.011 0.0343
Echinococcus granulosus neuropeptide FF receptor 2 0.0042 0.0118 0.0117
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0009 0.0004 0.0004
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0009 0.0004 0.0023
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0031 0.0079 0.0185
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0118 0.0117
Echinococcus granulosus neuropeptide receptor 0.0042 0.0118 0.0117
Schistosoma mansoni amine GPCR 0.0042 0.0118 0.0719
Brugia malayi hypothetical protein 0.0042 0.0118 0.039
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0053 0.0198
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0031 0.0079 0.0185
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0014
Onchocerca volvulus 0.0042 0.0118 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0042 0.0118 0.0117
Echinococcus multilocularis dro:myosuppressin receptor 0.0042 0.0118 0.0117
Brugia malayi small heat shock protein 0.0587 0.1992 0.6637
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0039 0.011 0.0408
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0042 0.0118 0.039
Echinococcus granulosus neuropeptides capa receptor 0.0042 0.0118 0.0117
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0031 0.0079 0.0294
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Toxoplasma gondii hypothetical protein 0.0048 0.014 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0009 0.0005 0.0004
Loa Loa (eye worm) melatonin receptor type 1A 0.0042 0.0118 0.039
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0031 0.0079 0.0185
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Echinococcus granulosus c-Jun N-terminal kinases 0.0238 0.0791 0.079
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0053 1
Schistosoma mansoni hypothetical protein 0.0031 0.0079 0.0485
Brugia malayi Stress-activated protein kinase jnk-1 0.0238 0.0791 0.2633
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.0117 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0033 0.011
Echinococcus multilocularis neuropeptide s receptor 0.0042 0.0118 0.0117
Schistosoma mansoni copper/topaquinone oxidase 0.0096 0.0303 0.1855
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0042 0.0118 0.0117
Echinococcus granulosus hyperpolarization activated cyclic 0.0009 0.0005 0.0004
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0042 0.0118 0.039
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0031 0.0079 0.0294
Echinococcus granulosus alpha 1A adrenergic receptor 0.0042 0.0118 0.0117
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0005 0.0025
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0031 0.0079 0.0294
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0118 0.0719
Mycobacterium leprae Conserved hypothetical protein 0.0031 0.0079 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0042 0.0118 0.0719
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Echinococcus multilocularis neuropeptides capa receptor 0.0042 0.0118 0.0117
Schistosoma mansoni myosin xvIII 0.0042 0.0118 0.0719
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0482 0.163 0.163
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0031 0.0079 0.0294
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0005 0.0025
Onchocerca volvulus 0.0042 0.0118 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0009 0.0004 0.0004
Echinococcus granulosus orexin receptor type 2 0.0042 0.0118 0.0117
Brugia malayi hypothetical protein 0.0042 0.0118 0.039
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Echinococcus granulosus cGMP dependent protein kinase 1 0.001 0.0007 0.0007
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0005 0.0025
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0118 0.0719
Schistosoma mansoni neuropeptide f receptor 76f 0.0042 0.0118 0.0719
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.0118 0.039
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0031 0.0079 0.0185
Echinococcus granulosus hyperpolarization activated cyclic 0.0009 0.0005 0.0004
Echinococcus multilocularis 0.0031 0.0079 0.0079
Schistosoma mansoni tyrosine kinase 0.0009 0.0004 0.0023
Brugia malayi hypothetical protein 0.0042 0.0118 0.039
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0031 0.0079 0.0185
Onchocerca volvulus 0.0042 0.0118 1
Brugia malayi Cytochrome P450 family protein 0.0039 0.011 0.0365
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0118 0.0719
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.2918 1 1
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0031 0.0079 0.0294
Brugia malayi G protein-coupled receptor F59B2.13 0.0042 0.0118 0.039
Echinococcus multilocularis hyperpolarization activated cyclic 0.0009 0.0005 0.0004
Echinococcus multilocularis sex peptide receptor 0.0042 0.0118 0.0117
Brugia malayi Tyrosine-protein kinase abl-1 0.0009 0.0004 0.0012
Schistosoma mansoni biogenic amine receptor 0.0042 0.0118 0.0719
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0009 0.0005 0.0014
Leishmania major cytochrome p450-like protein 0.0031 0.0079 0.0241
Brugia malayi Serotonin receptor 0.058 0.1966 0.6551
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.0005 0.0004
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.0005 0.0025
Toxoplasma gondii cytochrome p450 superfamily protein 0.0031 0.0079 0.5428
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0031 0.0079 0.0294
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0118 0.0719
Echinococcus multilocularis G-protein coupled receptor, putative 0.0042 0.0118 0.0117
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0118 0.0719
Brugia malayi Cyclic-nucleotide gated cation channel 0.0009 0.0005 0.0014
Onchocerca volvulus 0.0042 0.0118 1
Loa Loa (eye worm) CYP4Cod1 0.0039 0.011 0.0365
Brugia malayi RE15519p 0.0042 0.0118 0.039
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0053 0.0154
Brugia malayi AKH receptor 0.0042 0.0118 0.039
Brugia malayi putative neuropeptide receptor NPR1 0.0042 0.0118 0.039
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0118 0.0117
Loa Loa (eye worm) hypothetical protein 0.0184 0.0607 0.2021
Brugia malayi hypothetical protein 0.0042 0.0118 0.039
Brugia malayi Dopamine receptor 0.0042 0.0118 0.039
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0007 0.0042
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0118 0.0117
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0042 0.0118 0.0117
Brugia malayi neuropeptide F receptor 0.0042 0.0118 0.039
Echinococcus granulosus G protein coupled receptor 139 0.0042 0.0118 0.0117
Brugia malayi neuropeptide F receptor 0.0042 0.0118 0.039
Echinococcus multilocularis cGMP dependent protein kinase 1 0.001 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0344 0.1158 0.3856
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Echinococcus granulosus somatostatin receptor 0.0042 0.0118 0.0117
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0118 0.0117
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Schistosoma mansoni opsin-like receptor 0.0042 0.0118 0.0719
Echinococcus granulosus serotonin receptor 0.0042 0.0118 0.0117
Loa Loa (eye worm) SRC-1 0.0009 0.0004 0.0012
Onchocerca volvulus 0.0042 0.0118 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0053 0.0087
Schistosoma mansoni opsin-like receptor 0.0042 0.0118 0.0719
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0053 0.0176
Echinococcus multilocularis c src tyrosine kinase 0.0009 0.0004 0.0004
Mycobacterium ulcerans hypothetical protein 0.0023 0.0053 0.0198
Echinococcus granulosus hypothetical protein 0.0849 0.2891 0.289
Schistosoma mansoni neuropeptide receptor 0.0042 0.0118 0.0719
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0118 0.0117
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0031 0.0079 0.0294
Onchocerca volvulus 0.0042 0.0118 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0033 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0118 0.0117
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0009 0.0004 0.0004
Echinococcus granulosus fmrfamide receptor 0.0042 0.0118 0.0117
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0044 0.0127 0.042
Schistosoma mansoni biogenic amine (5HT) receptor 0.0482 0.163 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0031 0.0079 0.0185
Schistosoma mansoni tyrosine kinase 0.0009 0.0004 0.0023
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0238 0.0791 0.2633
Echinococcus multilocularis fmrfamide receptor 0.0042 0.0118 0.0117
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0031 0.0079 0.0185
Echinococcus multilocularis fmrfamide receptor 0.0042 0.0118 0.0117
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0031 0.0079 0.0294
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0009 0.0005 0.0004
Echinococcus multilocularis G protein coupled receptor 139 0.0042 0.0118 0.0117
Echinococcus multilocularis allatostatin A receptor 0.0042 0.0118 0.0117
Echinococcus granulosus mitogen activated protein kinase 11 0.0881 0.3001 0.3001
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0053 0.0154
Brugia malayi cytochrome P450 0.0031 0.0079 0.0263
Echinococcus granulosus allatostatin A receptor 0.0042 0.0118 0.0117
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0009 0.0005 0.0004
Echinococcus granulosus tyrosine protein kinase Lyn 0.0012 0.0017 0.0016
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0042 0.0118 0.0719
Brugia malayi Cytochrome P450 family protein 0.0069 0.0213 0.0708
Brugia malayi Serotonin receptor 0.0042 0.0118 0.039
Loa Loa (eye worm) hypothetical protein 0.0038 0.0107 0.0353
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0053 0.0198
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.0005 0.0025
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0007 0.0042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Schistosoma mansoni amine GPCR 0.0042 0.0118 0.0719
Brugia malayi GnHR receptor homolog 0.0042 0.0118 0.039
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0042 0.0118 0.039
Loa Loa (eye worm) AGC/PKG protein kinase 0.001 0.0007 0.0023
Loa Loa (eye worm) TYRA-2 protein 0.0042 0.0118 0.039
Echinococcus granulosus biogenic amine 5HT receptor 0.0184 0.0607 0.0607
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0009 0.0005 0.0014
Mycobacterium tuberculosis Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) 0.0792 0.2697 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0042 0.0118 0.039
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0031 0.0079 0.0185
Schistosoma mansoni histamine h1 receptor 0.0042 0.0118 0.0719
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0042 0.0118 0.0117
Echinococcus granulosus 7tm_1 domain containing protein 0.0042 0.0118 0.0117
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.011 0.0365
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0118 0.0719
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0031 0.0079 0.0294
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0176
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0118 0.0117
Onchocerca volvulus Neuropeptide F receptor homolog 0.0042 0.0118 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0118 0.0719
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0009 0.0004 0.0004
Brugia malayi hypothetical protein 0.0042 0.0118 0.039
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0009 0.0005 0.0004
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0881 0.3001 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0118 0.0117
Schistosoma mansoni opsin-like receptor 0.0042 0.0118 0.0719
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0033 1
Schistosoma mansoni serine/threonine protein kinase 0.0238 0.0791 0.4849
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0031 0.0079 0.0294
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.039
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0031 0.0079 0.0185
Brugia malayi sulfakinin receptor protein 0.0042 0.0118 0.039
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0042 0.0118 0.0117
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0009 0.0005 0.0004
Brugia malayi hypothetical protein 0.0042 0.0118 0.039
Brugia malayi Tachykinin-like peptides receptor 99D 0.0042 0.0118 0.039
Echinococcus granulosus 7TM GPCR rhodopsin 0.0042 0.0118 0.0117
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0031 0.0079 0.0185
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.0118 0.0719
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0042 0.0118 1
Brugia malayi putative neuropeptide receptor 0.0042 0.0118 0.039
Echinococcus multilocularis mitogen activated protein kinase 11 0.0881 0.3001 0.3001
Brugia malayi Dopamine receptor protein 1 0.0042 0.0118 0.039
Echinococcus multilocularis serotonin receptor 0.0184 0.0607 0.0607
Echinococcus multilocularis g-protein coupled receptor 0.0042 0.0118 0.0117
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0031 0.0079 0.0294
Echinococcus granulosus cGMP dependent protein kinase 1 0.001 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0096 0.0303 0.1855
Schistosoma mansoni hypothetical protein 0.0042 0.0118 0.0719
Onchocerca volvulus 0.0042 0.0118 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0042 0.0118 0.0117

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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