Detailed information for compound 876329

Basic information

Technical information
  • TDR Targets ID: 876329
  • Name: 4-acetyl-N-(4-piperidin-1-ylphenyl)benzenesul fonamide
  • MW: 358.455 | Formula: C19H22N2O3S
  • H donors: 1 H acceptors: 3 LogP: 3.1 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)c1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)N1CCCCC1
  • InChi: 1S/C19H22N2O3S/c1-15(22)16-5-11-19(12-6-16)25(23,24)20-17-7-9-18(10-8-17)21-13-3-2-4-14-21/h5-12,20H,2-4,13-14H2,1H3
  • InChiKey: UZEGPHDKTTXDCL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-acetyl-N-[4-(1-piperidyl)phenyl]benzenesulfonamide
  • 4-acetyl-N-(4-piperidinophenyl)benzenesulfonamide
  • 4-ethanoyl-N-(4-piperidin-1-ylphenyl)benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii ABC1 family protein 0.0036 0.0197 0.071
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0386 0.2771 0.2625
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0197 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0197 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0054 0.0326 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0197 0.5
Onchocerca volvulus 0.0036 0.0197 0.5
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0386 0.2771 0.3695
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0326 1
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0984 0.7162 1
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0009 0 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0326 1
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.137 1 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0326 1
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0386 0.2771 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0197 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0197 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0326 1
Onchocerca volvulus 0.0036 0.0197 0.5
Leishmania major hypothetical protein, conserved 0.0036 0.0197 0.5
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0197 0.5
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0009 0 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0054 0.0326 1
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0984 0.7162 1
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0197 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0326 1
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0009 0 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0197 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0009 0 0.0016
Onchocerca volvulus 0.0036 0.0197 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0326 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0326 1
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0009 0 0.5
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0009 0 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0197 0.5
Trichomonas vaginalis MYB, putative 0.0009 0 0.0016
Trichomonas vaginalis esterase, putative 0.0036 0.0197 1
Giardia lamblia Myb 1-like protein 0.0009 0 0.5
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.137 1 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.1623 0.2048
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0009 0 0.5
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.137 1 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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