Detailed information for compound 876329

Basic information

Technical information
  • TDR Targets ID: 876329
  • Name: 4-acetyl-N-(4-piperidin-1-ylphenyl)benzenesul fonamide
  • MW: 358.455 | Formula: C19H22N2O3S
  • H donors: 1 H acceptors: 3 LogP: 3.1 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)c1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)N1CCCCC1
  • InChi: 1S/C19H22N2O3S/c1-15(22)16-5-11-19(12-6-16)25(23,24)20-17-7-9-18(10-8-17)21-13-3-2-4-14-21/h5-12,20H,2-4,13-14H2,1H3
  • InChiKey: UZEGPHDKTTXDCL-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • 4-acetyl-N-[4-(1-piperidyl)phenyl]benzenesulfonamide
  • 4-acetyl-N-(4-piperidinophenyl)benzenesulfonamide
  • 4-ethanoyl-N-(4-piperidin-1-ylphenyl)benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis esterase, putative 0.0036 0.0197 1
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0386 0.2771 0.3695
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0197 1
Leishmania major hypothetical protein, conserved 0.0036 0.0197 0.5
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0009 0 0.0016
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0197 1
Toxoplasma gondii ABC1 family protein 0.0036 0.0197 0.071
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0197 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0009 0 0.0016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0326 1
Onchocerca volvulus 0.0036 0.0197 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0054 0.0326 1
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0009 0 0.5
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0009 0 0.5
Onchocerca volvulus 0.0036 0.0197 0.5
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0009 0 0.5
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.137 1 0.5
Trichomonas vaginalis MYB, putative 0.0009 0 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0326 1
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0984 0.7162 1
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0386 0.2771 0.2625
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0386 0.2771 1
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0197 0.5
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0009 0 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0326 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0326 1
Onchocerca volvulus 0.0036 0.0197 0.5
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0197 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0197 1
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.137 1 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0197 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0326 1
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0984 0.7162 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0326 1
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0009 0 0.5
Giardia lamblia Myb 1-like protein 0.0009 0 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0197 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0326 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0197 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.1623 0.2048
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.137 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0054 0.0326 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.