Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0021 | 0.0039 | 0.0171 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0039 | 0.0182 |
Schistosoma mansoni | peroxidasin | 0.0026 | 0.0073 | 0.0597 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0073 | 0.0339 |
Onchocerca volvulus | 0.0026 | 0.0073 | 0.016 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0242 | 0.1124 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0021 | 0.0039 | 0.0182 |
Onchocerca volvulus | 0.0026 | 0.0073 | 0.016 | |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0073 | 0.0339 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0073 | 0.0339 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0021 | 0.0039 | 0.0182 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0021 | 0.0039 | 0.0182 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0021 | 0.0039 | 0.0171 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1407 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.0039 | 0.0171 |
Onchocerca volvulus | Dual oxidase homolog | 0.0026 | 0.0073 | 0.016 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0021 | 0.0039 | 0.0182 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0021 | 0.0039 | 0.0182 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0242 | 0.1124 |
Echinococcus granulosus | FTZ F1 alpha | 0.0021 | 0.0039 | 0.0171 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0073 | 0.0339 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0205 | 0.168 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.0039 | 0.0171 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0205 | 0.168 |
Schistosoma mansoni | coup transcription factor | 0.0021 | 0.0039 | 0.0321 |
Echinococcus granulosus | geminin | 0.0186 | 0.1223 | 0.5346 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0021 | 0.0039 | 0.0171 |
Echinococcus granulosus | peroxidasin | 0.0026 | 0.0073 | 0.0319 |
Entamoeba histolytica | myb-like DNA-binding domain containing protein | 0.002 | 0.0028 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0021 | 0.0039 | 0.0171 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.0039 | 0.0182 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0021 | 0.0039 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0039 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0073 | 0.0339 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.0205 | 0.0955 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0073 | 0.0339 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0021 | 0.0039 | 0.0171 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0021 | 0.0039 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0239 | 0.1111 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0039 | 0.0182 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0021 | 0.0039 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0073 | 0.0339 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0021 | 0.0039 | 0.0171 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0073 | 0.0339 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0205 | 0.0955 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.0039 | 0.0171 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0021 | 0.0039 | 0.0321 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0021 | 0.0039 | 0.0171 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0039 | 0.0182 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0021 | 0.0039 | 0.0182 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0021 | 0.0039 | 0.0321 |
Echinococcus multilocularis | tumor protein p63 | 0.0334 | 0.2288 | 1 |
Brugia malayi | steroid hormone receptor | 0.0021 | 0.0039 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0073 | 0.0339 |
Toxoplasma gondii | Myb family DNA-binding domain-containing protein | 0.002 | 0.0029 | 0.0106 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0205 | 0.0898 |
Brugia malayi | ecdysteroid receptor | 0.0021 | 0.0039 | 0.0182 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0021 | 0.0039 | 0.0182 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0021 | 0.0039 | 0.0171 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0021 | 0.0039 | 0.0171 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0021 | 0.0039 | 0.0321 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0039 | 0.0182 |
Schistosoma mansoni | thyroid hormone receptor | 0.0021 | 0.0039 | 0.0321 |
Entamoeba histolytica | myb-like DNA-binding domain containing protein | 0.002 | 0.0028 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.0039 | 0.0182 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0021 | 0.0039 | 0.0171 |
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1407 | 1 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0021 | 0.0039 | 0.0182 |
Brugia malayi | Animal haem peroxidase family protein | 0.0026 | 0.0073 | 0.0339 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0021 | 0.0039 | 0.0321 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0205 | 0.0898 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0021 | 0.0039 | 0.0171 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0039 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0073 | 0.0339 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.1223 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0026 | 0.0073 | 0.0339 |
Echinococcus multilocularis | geminin | 0.0186 | 0.1223 | 0.5346 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0026 | 0.0073 | 0.0319 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.002 | 0.0029 | 1 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1407 | 1 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0242 | 0.1124 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0021 | 0.0039 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.0315 | 0.2152 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0205 | 0.0898 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0073 | 0.0339 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0021 | 0.0039 | 0.0182 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.0039 | 0.0182 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.1223 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.0039 | 0.0182 |
Brugia malayi | Animal haem peroxidase family protein | 0.0026 | 0.0073 | 0.0339 |
Onchocerca volvulus | 0.0238 | 0.1597 | 0.7375 | |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0021 | 0.0039 | 0.0182 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.0039 | 0.0182 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0238 | 0.1597 | 0.7423 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0073 | 0.0339 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.013 | 0.0603 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0026 | 0.0073 | 0.0339 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA | 0.101 | 0.7149 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0026 | 0.0073 | 0.0339 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0021 | 0.0039 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0073 | 0.0339 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0026 | 0.0073 | 0.0339 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0026 | 0.0073 | 0.0339 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.002 | 0.0029 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.0039 | 0.0171 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0026 | 0.0073 | 0.0597 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0021 | 0.0039 | 0.0321 |
Brugia malayi | Pax transcription factor protein 2 | 0.0238 | 0.1597 | 0.7423 |
Entamoeba histolytica | myb-like DNA-binding domain containing protein | 0.002 | 0.0028 | 0.5 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0073 | 0.0339 |
Entamoeba histolytica | myb-like DNA-binding domain containing protein | 0.002 | 0.0028 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.013 | 0.0603 |
Onchocerca volvulus | 0.0049 | 0.0239 | 0.0946 | |
Onchocerca volvulus | Peroxidase homolog | 0.0026 | 0.0073 | 0.016 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0026 | 0.0073 | 0.0339 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.0757 | 0.3518 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0021 | 0.0039 | 0.0182 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0205 | 0.168 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0039 | 0.0182 |
Brugia malayi | Blistered cuticle protein 3 | 0.0026 | 0.0073 | 0.0339 |
Onchocerca volvulus | Peroxidasin homolog | 0.0026 | 0.0073 | 0.016 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0073 | 0.0339 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0026 | 0.0073 | 0.016 |
Onchocerca volvulus | Peroxidasin homolog | 0.0026 | 0.0073 | 0.016 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0021 | 0.0039 | 0.0182 |
Brugia malayi | Peroxidasin | 0.0026 | 0.0073 | 0.0339 |
Trichomonas vaginalis | MYB, putative | 0.002 | 0.0029 | 1 |
Onchocerca volvulus | 0.0315 | 0.2152 | 1 | |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0021 | 0.0039 | 0.0171 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Onchocerca volvulus | 0.0026 | 0.0073 | 0.016 | |
Brugia malayi | hypothetical protein | 0.0315 | 0.2152 | 1 |
Mycobacterium leprae | PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA | 0.101 | 0.7149 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0334 | 0.2288 | 1 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.0397 | 0.2739 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0021 | 0.0039 | 0.0321 |
Onchocerca volvulus | Peroxidase homolog | 0.0026 | 0.0073 | 0.016 |
Brugia malayi | nuclear receptor NHR-88 | 0.0021 | 0.0039 | 0.0182 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.0039 | 0.0182 |
Schistosoma mansoni | thyroid hormone receptor | 0.0021 | 0.0039 | 0.0321 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0021 | 0.0039 | 0.0321 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.0757 | 0.3518 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0039 | 0.0182 |
Entamoeba histolytica | myb-like DNA-binding domain containing protein | 0.002 | 0.0028 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0021 | 0.0039 | 0.0321 |
Brugia malayi | Animal haem peroxidase family protein | 0.0026 | 0.0073 | 0.0339 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0021 | 0.0039 | 0.0171 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0049 | 0.0239 | 0.1955 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0205 | 0.0898 |
Brugia malayi | nuclear hormone receptor | 0.0021 | 0.0039 | 0.0182 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.0757 | 0.3518 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0021 | 0.0039 | 0.0182 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.013 | 0.1062 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0242 | 0.1124 |
Brugia malayi | Animal haem peroxidase family protein | 0.0026 | 0.0073 | 0.0339 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0021 | 0.0039 | 0.0321 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0021 | 0.0039 | 0.0321 |
Giardia lamblia | Myb 1-like protein | 0.002 | 0.0029 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.