Detailed information for compound 876553

Basic information

Technical information
  • TDR Targets ID: 876553
  • Name: 3-[2-[[5-(dimethylaminomethyl)furan-2-yl]meth ylsulfanyl]ethyl]-2-(4-ethylphenyl)-1,3-thiaz olidin-4-one
  • MW: 404.589 | Formula: C21H28N2O2S2
  • H donors: 0 H acceptors: 1 LogP: 3.72 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)C1SCC(=O)N1CCSCc1ccc(o1)CN(C)C
  • InChi: 1S/C21H28N2O2S2/c1-4-16-5-7-17(8-6-16)21-23(20(24)15-27-21)11-12-26-14-19-10-9-18(25-19)13-22(2)3/h5-10,21H,4,11-15H2,1-3H3
  • InChiKey: FBBREPUWEQFTOO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[2-[[5-(dimethylaminomethyl)-2-furyl]methylsulfanyl]ethyl]-2-(4-ethylphenyl)thiazolidin-4-one
  • 3-[2-[[5-(dimethylaminomethyl)-2-furyl]methylthio]ethyl]-2-(4-ethylphenyl)-4-thiazolidinone
  • 3-[2-[[5-(dimethylaminomethyl)-2-furyl]methylthio]ethyl]-2-(4-ethylphenyl)thiazolidin-4-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum thioredoxin reductase 0.0046 0.0486 1
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0078 0.0061
Trichomonas vaginalis set domain proteins, putative 0.023 0.3099 0.9116
Loa Loa (eye worm) hypothetical protein 0.0027 0.022 0.0204
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0027 0.022 0.0204
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0078 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.022 0.022
Loa Loa (eye worm) hypothetical protein 0.0014 0.0038 0.0022
Brugia malayi nuclear receptor RXR 0.0014 0.0038 0.0038
Brugia malayi intermediate filament protein 0.0053 0.0589 0.0589
Echinococcus granulosus bloom syndrome protein 0.0021 0.0128 0.0112
Brugia malayi beta-lactamase family protein 0.0035 0.033 0.033
Onchocerca volvulus 0.023 0.3099 1
Loa Loa (eye worm) hypothetical protein 0.0165 0.2171 0.2158
Mycobacterium leprae Probable lipase LipE 0.0035 0.033 0.0315
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0346 0.3654
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0246 0.023
Echinococcus granulosus ecdysone induced protein 78C 0.0027 0.022 0.0204
Loa Loa (eye worm) hypothetical protein 0.0027 0.022 0.0204
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0716 1 1
Schistosoma mansoni thyroid hormone receptor 0.015 0.1955 0.1942
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0078 0.0062
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.033 0.0918
Onchocerca volvulus 0.0029 0.0246 0.0744
Mycobacterium tuberculosis Probable reductase 0.0105 0.1321 0.4282
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0772 0.0757
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.006 0.0015
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.033 0.0315
Schistosoma mansoni hypothetical protein 0.0122 0.1569 0.1555
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0469 0.0453
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0329 0.0314
Brugia malayi Thioredoxin reductase 0.0046 0.0486 0.0486
Plasmodium vivax SET domain protein, putative 0.0029 0.0246 0.4694
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.3393 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0038 0.0022
Brugia malayi follicle stimulating hormone receptor 0.023 0.3093 0.3093
Leishmania major 0.0716 1 1
Echinococcus granulosus zinc finger protein 0.0019 0.0104 0.0088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0027 0.022 0.0204
Schistosoma mansoni RAR-like nuclear receptor 0.0027 0.022 0.0204
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.3393 1
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0486 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0145 0.0129
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0589 0.0574
Brugia malayi steroid hormone receptor 0.0027 0.022 0.022
Brugia malayi beta-lactamase 0.0035 0.033 0.033
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.033 0.0315
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.006 0.0015
Brugia malayi tailless protein 0.0013 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0017 0.0069 0.0052
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.1569 0.1555
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0069 0.0053
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.1321 0.4282
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0027 0.022 0.0204
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.3393 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.1487 0.4845
Echinococcus multilocularis geminin 0.0334 0.4577 0.4568
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.3004 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0657 0.0642
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0101 0.0085
Onchocerca volvulus 0.0053 0.0589 0.1858
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.033 0.0811
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0246 0.0216
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.033 0.0315
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2702 0.2691
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0078 0.0034
Toxoplasma gondii fructose-bisphospatase II 0.0716 1 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.006 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0027 0.022 0.0204
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0027 0.022 0.0662
Loa Loa (eye worm) hypothetical protein 0.0026 0.0198 0.0182
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0118 0.0102
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0069 0.0053
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.2169 0.6328
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0078 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0027 0.022 0.022
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0078 0.0034
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.006 0.0015
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.006 0.006
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0101 0.0124
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0101 0.0972
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0346 0.0303
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.006 0.0044
Loa Loa (eye worm) hypothetical protein 0.0069 0.0809 0.0794
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0716 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.022 0.0204
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0027 0.022 0.0204
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.033 0.0811
Trypanosoma brucei trypanothione reductase 0.0046 0.0486 0.0443
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.033 0.0918
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0377 0.0361
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0266 0.3615 0.3586
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0092 0.0764
Brugia malayi nuclear hormone receptor family member odr-7 0.0013 0.0016 0.0016
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0486 0.047
Schistosoma mansoni lamin 0.0053 0.0589 0.0574
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0346 0.0859
Loa Loa (eye worm) hypothetical protein 0.0035 0.033 0.0315
Brugia malayi PHD-finger family protein 0.0024 0.0177 0.0177
Leishmania major trypanothione reductase 0.0046 0.0486 0.0443
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0027 0.022 0.0204
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.006 0.0015
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0101 0.0085
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0772 0.0757
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0772 0.0757
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0014 0.0038 0.0022
Brugia malayi isocitrate dehydrogenase 0.0017 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0053 0.0589 0.0574
Echinococcus granulosus intermediate filament protein 0.0053 0.0589 0.0574
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.006 0.0015
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0716 1 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0772 0.073
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0016 0.0016
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0013 0.0016 0.0016
Echinococcus multilocularis musashi 0.0053 0.0589 0.0574
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0251 0.3393 0.3383
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0027 0.022 0.0204
Loa Loa (eye worm) follicle stimulating hormone receptor 0.023 0.3093 0.3081
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0101 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0078 0.0062
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0238 0.0238
Toxoplasma gondii fructose-bisphospatase I 0.0266 0.3615 0.3595
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0246 0.023
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0101 0.0124
Brugia malayi glutathione reductase 0.0046 0.0486 0.0486
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.1321 0.4282
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.006 0.0029
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0078 0.0048
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0238 0.0223
Loa Loa (eye worm) hypothetical protein 0.0014 0.0038 0.0022
Schistosoma mansoni inositol monophosphatase 0.0036 0.0346 0.0331
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0027 0.022 0.022
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.3393 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0101 0.0057
Loa Loa (eye worm) hypothetical protein 0.0027 0.022 0.0204
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0078 0.0062
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0346 0.0859
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0027 0.022 0.0204
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0101 0.0141
Echinococcus multilocularis lamin dm0 0.0053 0.0589 0.0574
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0128 0.0128
Toxoplasma gondii ABC1 family protein 0.0035 0.033 0.0301
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0027 0.022 0.0204
Loa Loa (eye worm) hypothetical protein 0.0014 0.0038 0.0022
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0078 0.0034
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.006 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0481 0.0465
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0027 0.022 0.0204
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0469 0.0469
Schistosoma mansoni lamin 0.0053 0.0589 0.0574
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0128 0.0112
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0481 0.0465
Brugia malayi nuclear hormone receptor 0.0013 0.0016 0.0016
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0346 0.0303
Loa Loa (eye worm) hypothetical protein 0.0046 0.0481 0.0465
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0027 0.022 0.022
Loa Loa (eye worm) hypothetical protein 0.0035 0.033 0.0315
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.006 0.0015
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0014 0.0038 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.033 0.0287
Schistosoma mansoni hypothetical protein 0.0334 0.4577 0.4568
Brugia malayi ecdysone receptor 0.0013 0.0016 0.0016
Plasmodium vivax glutathione reductase, putative 0.0046 0.0486 1
Brugia malayi Pre-SET motif family protein 0.0029 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0027 0.022 0.0204
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0589 0.0589
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0198 0.0182
Loa Loa (eye worm) inositol-1 0.0036 0.0346 0.0331
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0772 0.073
Schistosoma mansoni hypothetical protein 0.0334 0.4577 0.4568
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.1487 1
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0266 0.3615 0.3586
Schistosoma mansoni hypothetical protein 0.0015 0.0045 0.0029
Brugia malayi Steroid receptor seven-up type 2 0.0027 0.022 0.022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0027 0.022 0.0204
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0716 1 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0078 0.0063
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0469 0.0453
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0469 0.0453
Brugia malayi hypothetical protein 0.0014 0.0038 0.0038
Brugia malayi nuclear receptor RXR 0.0013 0.0016 0.0016
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.2169 0.6328
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0772 0.0772
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0251 0.3393 0.3393
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0027 0.022 0.0204
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0469 0.0453
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.033 0.9438
Loa Loa (eye worm) hypothetical protein 0.0025 0.0185 0.0169
Echinococcus granulosus lamin dm0 0.0053 0.0589 0.0574
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.3393 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0246 0.023
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0066 0.005
Echinococcus multilocularis ecdysone induced protein 78C 0.0027 0.022 0.0204
Loa Loa (eye worm) hypothetical protein 0.0014 0.0038 0.0022
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0078 0.0034
Onchocerca volvulus Protein ultraspiracle homolog 0.0027 0.022 0.0662
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.022 0.022
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.006 0.0015
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.022 0.022
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0078 0.1004
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.2169 0.6328
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.033 0.0315
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.1321 0.4282
Mycobacterium tuberculosis Conserved protein 0.0035 0.033 0.0918
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.033 0.9438
Trichomonas vaginalis esterase, putative 0.0035 0.033 0.0811
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.033 0.0918
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.006 0.0044
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.022 0.022
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0101 0.0057
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0772 0.0757
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0027 0.022 0.022
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.006 0.0015
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0014 0.0038 0.0022
Schistosoma mansoni ap endonuclease 0.0019 0.0101 0.0085
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.022 0.0204
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0056 0.0634 0.0619
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0078 0.0034
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.033 0.0918
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0481 0.0465
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.022 0.0204
Loa Loa (eye worm) steroid hormone receptor 0.0027 0.022 0.0204
Echinococcus multilocularis thyroid hormone receptor alpha 0.015 0.1955 0.1942
Brugia malayi orphan nuclear receptor NR2E1 0.0013 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0025 0.0185 0.0169
Mycobacterium tuberculosis Conserved protein 0.0035 0.033 0.0918
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0128 0.0205
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.2295 0.6706
Brugia malayi nuclear hormone receptor 0.0027 0.022 0.022
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0772 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0101 0.1445
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0716 1 1
Echinococcus granulosus lamin 0.0053 0.0589 0.0574
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.022 0.0204
Brugia malayi conserved hypotetical protein 0.0013 0.0016 0.0016
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0027 0.022 0.0204
Echinococcus multilocularis zinc finger protein 0.0019 0.0104 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0027 0.022 0.022
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0128 0.0205
Mycobacterium ulcerans lipase LipD 0.0035 0.033 0.9438
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.022 0.022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0469 0.0453
Mycobacterium ulcerans beta-lactamase 0.0035 0.033 0.9438
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0346 0.0331
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0469 0.0453
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0078 0.0062
Onchocerca volvulus 0.0035 0.033 0.1019
Schistosoma mansoni zinc finger protein 0.0019 0.0104 0.0088
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0486 0.047
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0027 0.022 0.0204
Schistosoma mansoni retinoic acid receptor RXR 0.0027 0.022 0.0204
Echinococcus granulosus geminin 0.0334 0.4577 0.4568
Brugia malayi beta-lactamase family protein 0.0035 0.033 0.033
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.006 0.0015
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.033 0.0918
Loa Loa (eye worm) hypothetical protein 0.0035 0.033 0.0315
Loa Loa (eye worm) hypothetical protein 0.0027 0.022 0.0204
Loa Loa (eye worm) hypothetical protein 0.0035 0.033 0.0315
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0346 0.0331
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0101 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0145 0.0129
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0027 0.022 0.0204
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.2169 0.6328
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0027 0.022 0.0204
Plasmodium falciparum glutathione reductase 0.0046 0.0486 1
Schistosoma mansoni coup transcription factor 0.0027 0.022 0.0204
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.2169 0.6328
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0078 0.0434
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.033 0.0811
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0486 0.047
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.1487 0.4845
Onchocerca volvulus Bile acid receptor homolog 0.0027 0.022 0.0662
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.033 0.0811
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.006 0.0015
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0716 1 1
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0716 1 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.006 0.0015
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.006 0.0044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.022 0.0204
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0078 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0027 0.022 0.022
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0772 0.073
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0346 0.0859
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0481 0.0465
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.006 0.0015
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.006 0.0029
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.033 0.0811
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.033 0.0918
Brugia malayi hypothetical protein 0.0013 0.0016 0.0016
Loa Loa (eye worm) beta-lactamase 0.0035 0.033 0.0315
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0101 0.151
Onchocerca volvulus 0.0035 0.033 0.1019
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.2169 0.6328
Onchocerca volvulus 0.0165 0.2171 0.6989
Schistosoma mansoni inositol monophosphatase 0.0036 0.0346 0.0331
Mycobacterium leprae conserved hypothetical protein 0.0035 0.033 0.0315
Loa Loa (eye worm) hypothetical protein 0.0027 0.022 0.0204
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0772 0.073
Brugia malayi hypothetical protein 0.0014 0.0038 0.0038
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0589 0.0574
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0078 0.0062
Loa Loa (eye worm) hypothetical protein 0.0041 0.0422 0.0406
Schistosoma mansoni intermediate filament proteins 0.0053 0.0589 0.0574
Brugia malayi nuclear hormone receptor family member nhr-6 0.0013 0.0016 0.0016
Loa Loa (eye worm) glutathione reductase 0.0046 0.0486 0.047
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0346 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0293 0.0791
Loa Loa (eye worm) hypothetical protein 0.0035 0.033 0.0315
Onchocerca volvulus 0.0053 0.0589 0.1858
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0101 0.0057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0078 0.0062
Brugia malayi nuclear receptor NHR-88 0.0027 0.022 0.022
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.2295 0.6706
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0027 0.022 0.0204
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0266 0.3615 0.3595
Toxoplasma gondii exonuclease III APE 0.0019 0.0101 0.0071
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0657 0.0642
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.2169 0.6328
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.022 0.0204
Loa Loa (eye worm) hypothetical protein 0.0027 0.022 0.0204
Schistosoma mansoni thyroid hormone receptor 0.015 0.1955 0.1942
Brugia malayi nuclear receptor NHR-88 0.0013 0.0016 0.0016
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.1487 0.4845
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0101 0.0085
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0069 0.0053
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.006 0.0015
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0027 0.022 0.0204
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0198 0.0182
Loa Loa (eye worm) hypothetical protein 0.0037 0.0363 0.0347
Schistosoma mansoni hypothetical protein 0.002 0.0118 0.0102
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.1321 0.4282
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0027 0.022 0.0204
Mycobacterium tuberculosis Conserved protein 0.0035 0.033 0.0918
Echinococcus multilocularis lamin 0.0053 0.0589 0.0574
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0078 0.0062
Brugia malayi Pre-SET motif family protein 0.0202 0.2702 0.2702
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0469 0.0453
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.1569 0.1555
Toxoplasma gondii thioredoxin reductase 0.0046 0.0486 0.0457
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.033 0.0287
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0346 0.0303
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.033 0.0918
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0101 0.0057
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0027 0.022 0.0204
Echinococcus multilocularis FTZ F1 alpha 0.0027 0.022 0.0204
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0346 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0346 0.0303
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0052 0.0575 0.056
Brugia malayi ecdysteroid receptor 0.0027 0.022 0.022
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.022 0.022
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0101 0.1445
Leishmania major hypothetical protein, conserved 0.0035 0.033 0.0287
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0486 0.1446
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.033 0.0287
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0027 0.022 0.0204
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0014 0.0038 0.0022
Brugia malayi Inositol-1 0.0036 0.0346 0.0346
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0346 0.0317
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.0038 0.0022
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0101 0.0101
Brugia malayi photoreceptor-specific nuclear receptor 0.0027 0.022 0.022
Schistosoma mansoni steroid hormone receptor ad4bp 0.0027 0.022 0.0204
Schistosoma mansoni nuclear hormone receptor 0.0027 0.022 0.0204
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.033 0.0315
Onchocerca volvulus 0.0035 0.033 0.1019
Brugia malayi hypothetical protein 0.0013 0.0016 0.0016
Schistosoma mansoni bromodomain containing protein 0.0061 0.0706 0.0691
Plasmodium vivax hypothetical protein, conserved 0.0035 0.033 0.6567
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.022 0.022
Echinococcus granulosus FTZ F1 alpha 0.0027 0.022 0.0204
Brugia malayi hypothetical protein 0.0165 0.2171 0.2171
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.006 0.0015
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.023 0.0214
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.006 0.0015
Brugia malayi Bromodomain containing protein 0.0037 0.0362 0.0362
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0069 0.0053
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0038 0.0038
Loa Loa (eye worm) RecQ helicase 0.0021 0.0128 0.0112
Loa Loa (eye worm) hypothetical protein 0.0035 0.033 0.0315
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.2169 0.6985
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0329 0.0314
Schistosoma mansoni ap endonuclease 0.0019 0.0101 0.0085
Loa Loa (eye worm) hypothetical protein 0.004 0.0396 0.038
Brugia malayi Bromodomain containing protein 0.0073 0.0868 0.0868
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0377 0.0361
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0469 0.0453
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0266 0.3615 0.3586
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.006 0.0015
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.006 0.0596
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.033 0.033
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.3393 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0145 0.0129
Onchocerca volvulus 0.0027 0.022 0.0662
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.1321 0.861
Brugia malayi nuclear receptor NHR-67 0.0013 0.0016 0.0016
Mycobacterium ulcerans hypothetical protein 0.0035 0.033 0.9438
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0027 0.022 0.022
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.006 0.0596
Schistosoma mansoni zinc finger protein 0.0015 0.0045 0.0029
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.1321 0.4282
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0486 0.0443

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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