Detailed information for compound 876594

Basic information

Technical information
  • TDR Targets ID: 876594
  • Name: 1-[4-[3-chloro-5-(trifluoromethyl)pyridin-2-y l]-1,4-diazepan-1-yl]-3-ethoxypropan-2-ol
  • MW: 381.821 | Formula: C16H23ClF3N3O2
  • H donors: 1 H acceptors: 2 LogP: 2.59 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOCC(CN1CCCN(CC1)c1ncc(cc1Cl)C(F)(F)F)O
  • InChi: 1S/C16H23ClF3N3O2/c1-2-25-11-13(24)10-22-4-3-5-23(7-6-22)15-14(17)8-12(9-21-15)16(18,19)20/h8-9,13,24H,2-7,10-11H2,1H3
  • InChiKey: KZDHKPFZZHRJFD-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 1-[4-[3-chloro-5-(trifluoromethyl)-2-pyridyl]-1,4-diazepan-1-yl]-3-ethoxy-propan-2-ol
  • 1-[4-[3-chloro-5-(trifluoromethyl)-2-pyridyl]-1,4-diazepan-1-yl]-3-ethoxypropan-2-ol
  • 1-[4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1,4-diazepan-1-yl]-3-ethoxy-propan-2-ol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cyclin 0.076 0.6562 1
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.015 0.0901 1
Entamoeba histolytica protein kinase 2, putative 0.015 0.0901 0.1296
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0075 0.0211 0.0154
Schistosoma mansoni hypothetical protein 0.0118 0.061 0.0555
Plasmodium vivax hypothetical protein, conserved 0.0118 0.061 0.6547
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0178 0.1161 0.1109
Toxoplasma gondii hypothetical protein 0.0118 0.061 0.19
Brugia malayi RhoGAP domain containing protein 0.0075 0.0211 0.0154
Echinococcus granulosus cyclin B3 1 0.049 0.4058 0.4058
Trichomonas vaginalis cyclins, putative 0.0118 0.061 0.0848
Plasmodium vivax cyclin 4, putative 0.0118 0.061 0.6547
Loa Loa (eye worm) hypothetical protein 0.0075 0.0211 0.0154
Plasmodium falciparum glycogen synthase kinase 3 0.0064 0.0109 0.0129
Brugia malayi protein kinase C II. 0.0416 0.3373 0.3334
Brugia malayi cyclin fold protein 1 variant b 0.0118 0.061 0.0555
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.019 0.1277 0.1874
Echinococcus multilocularis Diacylglycerol kinase theta 0.0075 0.0211 0.0154
Echinococcus granulosus Rac GTPase activating protein 1 0.0075 0.0211 0.0211
Schistosoma mansoni protein kinase C 0.0082 0.0276 0.022
Trichomonas vaginalis cyclin B3, putative 0.0118 0.061 0.0848
Echinococcus granulosus protein kinase c iota type 0.0346 0.2724 0.2724
Echinococcus multilocularis nervana 2 0.0139 0.0803 0.075
Trypanosoma cruzi cyclin, putative 0.076 0.6562 1
Trichomonas vaginalis cyclin B, putative 0.049 0.4058 0.615
Echinococcus multilocularis cyclin y 0.0118 0.061 0.0555
Trypanosoma cruzi mitotic cyclin, putative 0.0118 0.061 0.0848
Echinococcus granulosus serine:threonine protein kinase N2 0.0178 0.1161 0.1161
Loa Loa (eye worm) hypothetical protein 0.0075 0.0211 0.0154
Echinococcus granulosus cyclins 0.049 0.4058 0.4058
Echinococcus multilocularis protein kinase c iota type 0.0346 0.2724 0.2681
Schistosoma mansoni cyclin G2 0.0118 0.061 0.0555
Loa Loa (eye worm) AGC/NDR protein kinase 0.0178 0.1161 0.1109
Trichomonas vaginalis cyclins, putative 0.076 0.6562 1
Echinococcus granulosus cyclin G2 0.0118 0.061 0.061
Schistosoma mansoni serine/threonine protein kinase 0.0531 0.4438 0.4406
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0064 0.0109 0.0177
Loa Loa (eye worm) hypothetical protein 0.0209 0.1452 0.1402
Loa Loa (eye worm) hypothetical protein 0.0312 0.241 0.2365
Echinococcus multilocularis cyclins 0.049 0.4058 0.4023
Schistosoma mansoni cyclin G 0.0118 0.061 0.0555
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.061 0.0848
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0068 0.014 0.0126
Entamoeba histolytica hypothetical protein 0.0075 0.0211 0.0235
Brugia malayi hypothetical protein 0.0118 0.061 0.0555
Loa Loa (eye worm) hypothetical protein 0.0138 0.0791 0.0737
Echinococcus granulosus NDR protein kinase 0.0178 0.1161 0.1161
Echinococcus multilocularis nervana 2 0.0139 0.0803 0.075
Trypanosoma cruzi cyclin, putative 0.076 0.6562 1
Echinococcus multilocularis cyclins 0.049 0.4058 0.4023
Trypanosoma cruzi CYC2-like cyclin, putative 0.076 0.6562 1
Loa Loa (eye worm) hypothetical protein 0.1013 0.8903 0.8897
Trichomonas vaginalis cyclin D, putative 0.049 0.4058 0.615
Loa Loa (eye worm) hypothetical protein 0.0134 0.0754 0.0701
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.061 0.0848
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0068 0.014 0.0126
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0224 0.1585 0.1536
Loa Loa (eye worm) hypothetical protein 0.0222 0.1574 0.1525
Brugia malayi Protein kinase domain containing protein 0.0201 0.1374 0.1324
Entamoeba histolytica protein kinase, putative 0.0326 0.2538 0.3812
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0148 0.0888 0.0835
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.014 0.0126
Echinococcus multilocularis cyclin k 0.0118 0.061 0.0555
Loa Loa (eye worm) hypothetical protein 0.0075 0.0211 0.0154
Echinococcus multilocularis myotubularin protein 13 0.0085 0.0297 0.024
Echinococcus granulosus Diacylglycerol kinase theta 0.0075 0.0211 0.0211
Toxoplasma gondii diacylglycerol kinase, putative 0.0075 0.0211 0.0526
Brugia malayi Cyclin, N-terminal domain containing protein 0.0118 0.061 0.0555
Giardia lamblia Hypothetical protein 0.0118 0.061 0.0848
Echinococcus multilocularis cyclin t1 0.0118 0.061 0.0555
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0378 0.3022 0.2981
Echinococcus multilocularis protein kinase c epsilon type 0.0416 0.3373 0.3334
Trichomonas vaginalis cyclins, putative 0.0118 0.061 0.0848
Giardia lamblia Hypothetical protein 0.049 0.4058 0.615
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0075 0.0211 0.0154
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0531 0.4438 0.4406
Brugia malayi RhoGEF domain containing protein 0.0075 0.0211 0.0154
Schistosoma mansoni diacylglycerol kinase theta 0.0075 0.0211 0.0154
Echinococcus multilocularis cyclin G2 0.0118 0.061 0.0555
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.061 0.0848
Toxoplasma gondii AGC kinase 0.0317 0.2451 0.8245
Trichomonas vaginalis AGC family protein kinase 0.0326 0.2538 0.3812
Trypanosoma brucei protein kinase, putative 0.0068 0.014 0.0126
Echinococcus multilocularis protein kinase shaggy 0.0064 0.0109 0.0052
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0082 0.0276 0.022
Trypanosoma brucei rac serine-threonine kinase, putative 0.0326 0.2538 0.3812
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.061 0.0848
Echinococcus multilocularis cyclin b3 0.049 0.4058 0.4023
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0308 0.0251
Echinococcus granulosus cyclins 0.0118 0.061 0.061
Brugia malayi Stress-activated protein kinase jnk-1 0.0531 0.4438 0.4406
Trypanosoma cruzi Protein kinase B 0.0159 0.0987 0.1428
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0178 0.1161 0.1161
Schistosoma mansoni vav2 0.0085 0.0297 0.024
Echinococcus multilocularis cyclin y 0.0118 0.061 0.0555
Brugia malayi P38 map kinase family protein 2 0.0437 0.356 0.3523
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0075 0.0211 0.0211
Brugia malayi Cyclin, N-terminal domain containing protein 0.0118 0.061 0.0555
Trichomonas vaginalis cyclin B, putative 0.076 0.6562 1
Schistosoma mansoni hypothetical protein 0.0075 0.0211 0.0154
Echinococcus multilocularis Cyclin L1 0.0118 0.061 0.0555
Onchocerca volvulus 0.0213 0.1488 0.2137
Echinococcus granulosus nervana 2 0.0139 0.0803 0.0803
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0151 0.0917 0.0864
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0068 0.014 0.0126
Giardia lamblia Cyclin A 0.049 0.4058 0.615
Echinococcus granulosus cyclins 0.049 0.4058 0.4058
Giardia lamblia Kinase, CMGC GSK 0.0064 0.0109 0.0079
Loa Loa (eye worm) hypothetical protein 0.0138 0.0791 0.0737
Brugia malayi Immunoglobulin I-set domain containing protein 0.0397 0.3192 0.3153
Echinococcus multilocularis cyclin B3 1 0.049 0.4058 0.4023
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.061 0.0848
Schistosoma mansoni cyclin d 0.1131 1 1
Loa Loa (eye worm) raf kinase 0.0075 0.0211 0.0154
Brugia malayi intracellular kinase 0.0064 0.0109 0.0052
Loa Loa (eye worm) hypothetical protein 0.0075 0.0211 0.0154
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0118 0.061 0.061
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0064 0.0109 0.0052
Brugia malayi Cyclin C 0.0118 0.061 0.0555
Echinococcus granulosus raf serine:threonine protein kinase 0.0082 0.0271 0.0271
Plasmodium falciparum cyclin 0.049 0.4058 1
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0531 0.4438 0.4406
Onchocerca volvulus 0.0222 0.1574 0.2271
Echinococcus granulosus cyclin dependent kinase 5 0.0059 0.0058 0.0058
Trichomonas vaginalis cyclins, putative 0.076 0.6562 1
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0139 0.0803 0.0803
Echinococcus multilocularis serine:threonine protein kinase N2 0.0334 0.2609 0.2566
Plasmodium falciparum cyclin 1 0.0118 0.061 0.1379
Echinococcus multilocularis serine threonine protein kinase 0.0319 0.2468 0.2424
Echinococcus granulosus cyclin B 0.076 0.6562 0.6562
Entamoeba histolytica cyclin, domain containing protein 0.0118 0.061 0.0848
Loa Loa (eye worm) cyclin C 0.0118 0.061 0.0555
Trypanosoma brucei protein kinase, putative 0.0064 0.0109 0.0079
Loa Loa (eye worm) hypothetical protein 0.0118 0.061 0.0555
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0271 0.0215
Echinococcus granulosus protein kinase shaggy 0.0064 0.0109 0.0109
Echinococcus granulosus cyclin t1 0.0118 0.061 0.061
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0178 0.1161 0.1161
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0118 0.061 0.19
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0068 0.014 0.0282
Trichomonas vaginalis cyclins, putative 0.076 0.6562 1
Echinococcus multilocularis cyclin A3 4 0.0118 0.061 0.0555
Brugia malayi Ras association domain family 1 isoform A 0.0075 0.0211 0.0154
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.014 0.0126
Brugia malayi Variant SH3 domain containing protein 0.0075 0.0211 0.0154
Giardia lamblia Hypothetical protein 0.0118 0.061 0.0848
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.015 0.0901 0.0901
Loa Loa (eye worm) hypothetical protein 0.0213 0.1488 0.1439
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0118 0.061 0.1379
Echinococcus granulosus cyclin dependent kinase 1 0.0059 0.0058 0.0058
Echinococcus multilocularis rac serine:threonine kinase 0.0159 0.0987 0.0934
Trypanosoma cruzi cyclin 9, putative 0.0118 0.061 0.0848
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0308 0.0251
Echinococcus granulosus nervana 2 0.0139 0.0803 0.0803
Schistosoma mansoni unc-13 (munc13) 0.0082 0.0276 0.022
Entamoeba histolytica protein kinase, putative 0.0178 0.1161 0.1696
Brugia malayi protein kinase C3,putative 0.0179 0.1173 0.1122
Brugia malayi diacylglycerol kinase 0.0075 0.0211 0.0154
Brugia malayi Cyclin, N-terminal domain containing protein 0.0985 0.8647 0.8639
Echinococcus granulosus Protein kinase C brain isozyme 0.0394 0.3166 0.3166
Schistosoma mansoni cyclins 0.049 0.4058 0.4023
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0985 0.8647 0.8639
Echinococcus granulosus cyclin y 0.0118 0.061 0.061
Schistosoma mansoni cyclin k 0.0118 0.061 0.0555
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0064 0.0109 0.0052
Echinococcus multilocularis mitogen activated protein kinase 0.0068 0.014 0.0082
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0118 0.061 0.0555
Onchocerca volvulus Cyclin L homolog 0.0118 0.061 0.0775
Loa Loa (eye worm) hypothetical protein 0.0075 0.0211 0.0154
Schistosoma mansoni diacylglycerol kinase theta 0.0075 0.0211 0.0154
Entamoeba histolytica cyclin family protein 0.049 0.4058 0.615
Loa Loa (eye worm) cyclin domain-containing protein 0.0118 0.061 0.0555
Entamoeba histolytica cyclin, putative 0.049 0.4058 0.615
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0437 0.356 0.5385
Echinococcus granulosus fibroblast growth factor receptor 4 0.0378 0.3022 0.3022
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0178 0.1161 0.1109
Echinococcus multilocularis cyclins 0.049 0.4058 0.4023
Echinococcus granulosus cyclins 0.049 0.4058 0.4058
Echinococcus granulosus mitogen activated protein kinase 11 0.0437 0.356 0.356
Giardia lamblia Cyclin B-like protein 0.0118 0.061 0.0848
Loa Loa (eye worm) hypothetical protein 0.0312 0.241 0.2365
Loa Loa (eye worm) RasGEF domain-containing protein 0.0075 0.0211 0.0154
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0416 0.3373 0.3334
Brugia malayi Cyclin, N-terminal domain containing protein 0.0118 0.061 0.0555
Echinococcus granulosus cyclin y 0.0118 0.061 0.061
Trichomonas vaginalis AGC family protein kinase 0.0326 0.2538 0.3812
Onchocerca volvulus Protein CNPPD1 homolog 0.0118 0.061 0.0775
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0378 0.3022 0.2981
Loa Loa (eye worm) hypothetical protein 0.0082 0.0276 0.022
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0214 0.1495 0.1445
Schistosoma mansoni atypical protein kinase C 0.0353 0.2787 0.2745
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.014 0.0126
Echinococcus multilocularis cyclin 0.0118 0.061 0.0555
Brugia malayi p70 ribosomal S6 kinase beta 0.0317 0.2451 0.2407
Toxoplasma gondii cyclin dependent kinase binding protein 0.0118 0.061 0.19
Trichomonas vaginalis AGC family protein kinase 0.0201 0.1374 0.2024
Schistosoma mansoni serine/threonine protein kinase 0.0178 0.1161 0.1109
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0118 0.061 0.0848
Loa Loa (eye worm) hypothetical protein 0.0085 0.0297 0.024
Loa Loa (eye worm) AGC/AKT protein kinase 0.0326 0.2538 0.2494
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0394 0.3166 0.3126
Schistosoma mansoni tyrosine kinase 0.0378 0.3022 0.2981
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0139 0.0803 0.075
Trichomonas vaginalis conserved hypothetical protein 0.049 0.4058 0.615
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.015 0.0901 0.0848
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0214 0.1495 0.1445
Onchocerca volvulus Cyclin L homolog 0.0118 0.061 0.0775
Echinococcus granulosus mitogen activated protein kinase 14 0.0437 0.356 0.356
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0985 0.8647 0.8647
Brugia malayi Protein kinase domain containing protein 0.0086 0.0308 0.0251
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.014 0.0082
Trypanosoma cruzi rac serine-threonine kinase, putative 0.015 0.0901 0.1296
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0086 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.076 0.6562 0.6542
Trichomonas vaginalis cyclin A, putative 0.076 0.6562 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.076 0.6562 0.6542
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.015 0.0901 0.2107
Echinococcus multilocularis mitogen activated protein kinase 11 0.0437 0.356 0.3523
Brugia malayi Protein kinase domain containing protein 0.0178 0.1161 0.1109
Plasmodium vivax glycogen synthase kinase 3, putative 0.0064 0.0109 0.0611
Trichomonas vaginalis cyclin B, putative 0.076 0.6562 1
Trichomonas vaginalis cyclin D, putative 0.0118 0.061 0.0848
Brugia malayi Hr1 repeat family protein 0.0178 0.1161 0.1109
Brugia malayi Protein kinase c protein 2 0.0227 0.1615 0.1566
Echinococcus granulosus G1:S specific cyclin D1 0.1131 1 1
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0178 0.1161 0.1109
Echinococcus multilocularis unc 13 (munc13) 0.0082 0.0276 0.022
Loa Loa (eye worm) AGC/PKN protein kinase 0.0178 0.1161 0.1109
Schistosoma mansoni rac gtpase activating protein 0.0075 0.0211 0.0154
Echinococcus granulosus cyclins 0.049 0.4058 0.4058
Entamoeba histolytica PH domain containing protein kinase, putative 0.0176 0.1144 0.1671
Schistosoma mansoni serine/threonine protein kinase 0.0394 0.3166 0.3126
Giardia lamblia Kinase, CMGC GSK 0.0064 0.0109 0.0079
Entamoeba histolytica protein kinase domain containing protein 0.0064 0.0109 0.0079
Echinococcus granulosus serine:threonine protein kinase N2 0.0167 0.1058 0.1058
Schistosoma mansoni serine/threonine protein kinase 0.0178 0.1161 0.1109
Trypanosoma brucei cyclin 3 0.0118 0.061 0.0848
Entamoeba histolytica PH domain containing protein kinase, putative 0.0159 0.0987 0.1428
Echinococcus granulosus serine threonine protein kinase nrc 0.015 0.0901 0.0901
Entamoeba histolytica protein kinase, putative 0.0317 0.2451 0.368
Loa Loa (eye worm) hypothetical protein 0.027 0.2017 0.1971
Giardia lamblia G2/mitotic-specific cyclin B 0.076 0.6562 1
Leishmania major mitotic cyclin, putative 0.0118 0.061 0.0848
Entamoeba histolytica diacylglycerol kinase, putative 0.0075 0.0211 0.0235
Echinococcus multilocularis mitogen activated protein kinase 11 0.0437 0.356 0.3523
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0437 0.356 0.5385
Schistosoma mansoni Cyclin fold protein 0.0118 0.061 0.0555
Trichomonas vaginalis cyclin D, putative 0.049 0.4058 0.615
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0118 0.061 0.061
Onchocerca volvulus 0.0312 0.241 0.3565
Echinococcus multilocularis Rac GTPase activating protein 1 0.0075 0.0211 0.0154
Schistosoma mansoni g1/s-specific cyclin C 0.0118 0.061 0.0555
Echinococcus multilocularis mitogen activated protein kinase 14 0.0437 0.356 0.3523
Brugia malayi diacylglycerol kinase 0.0075 0.0211 0.0154
Echinococcus multilocularis cyclin G2 0.0118 0.061 0.0555
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0064 0.0109 0.0079
Trichomonas vaginalis cyclin B, putative 0.0118 0.061 0.0848
Trichomonas vaginalis AGC family protein kinase 0.0326 0.2538 0.3812
Onchocerca volvulus 0.076 0.6562 1
Loa Loa (eye worm) hypothetical protein 0.0312 0.241 0.2365
Trichomonas vaginalis cyclins, putative 0.076 0.6562 1
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0437 0.356 0.3523
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0068 0.014 0.0082
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0075 0.0211 0.0154
Echinococcus multilocularis cyclins 0.049 0.4058 0.4023
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0118 0.061 0.1379
Brugia malayi C1-like domain containing protein 0.0224 0.1585 0.1536
Brugia malayi Cyclin, N-terminal domain containing protein 0.0118 0.061 0.0555
Schistosoma mansoni serine/threonine protein kinase 0.0178 0.1161 0.1109
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0118 0.061 0.19
Trichomonas vaginalis AGC family protein kinase 0.0326 0.2538 0.3812
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0178 0.1161 0.1109
Trichomonas vaginalis cyclin B, putative 0.076 0.6562 1
Trichomonas vaginalis AGC family protein kinase 0.0326 0.2538 0.3812
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0068 0.014 0.0126
Echinococcus granulosus serine/threonine protein kinase 0.0159 0.0987 0.0987
Echinococcus multilocularis cyclin B 0.076 0.6562 0.6542
Brugia malayi hypothetical protein 0.0118 0.061 0.0555
Entamoeba histolytica PH domain containing protein kinase, putative 0.0159 0.0987 0.1428
Schistosoma mansoni cyclin l 0.0118 0.061 0.0555
Loa Loa (eye worm) cyclin domain-containing protein 0.0118 0.061 0.0555
Trypanosoma cruzi mitotic cyclin, putative 0.0118 0.061 0.0848
Brugia malayi Pleckstrin Homology Domain 0.0085 0.0297 0.024
Loa Loa (eye worm) cyclin domain-containing protein 0.0118 0.061 0.0555
Trypanosoma cruzi cyclin 6, putative 0.076 0.6562 1
Trichomonas vaginalis CMGC family protein kinase 0.0064 0.0109 0.0079
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0075 0.0211 0.0154
Echinococcus granulosus cyclin G2 0.0118 0.061 0.061
Echinococcus multilocularis G1:S specific cyclin D1 0.1131 1 1
Echinococcus granulosus Glutaredoxin protein 5 0.0139 0.0803 0.0803
Entamoeba histolytica protein kinase, putative 0.0326 0.2538 0.3812
Trichomonas vaginalis cyclin B3, putative 0.0118 0.061 0.0848
Echinococcus granulosus unc 13 munc13 0.0082 0.0276 0.0276
Loa Loa (eye worm) CYL-1 protein 0.0118 0.061 0.0555
Trichomonas vaginalis cyclin B, putative 0.0118 0.061 0.0848
Schistosoma mansoni serine/threonine protein kinase 0.0214 0.1495 0.1445
Giardia lamblia Cyclin fold protein 1, putative 0.0118 0.061 0.0848
Schistosoma mansoni protein kinase C mu 0.0224 0.1585 0.1536
Schistosoma mansoni serine/threonine-protein kinase 0.0159 0.0987 0.0934
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0086 0.0308 0.0251
Trichomonas vaginalis AGC family protein kinase 0.0326 0.2538 0.3812
Entamoeba histolytica diacylglycerol kinase, putative 0.0075 0.0211 0.0235
Leishmania major mitotic cyclin, putative 0.0118 0.061 0.0848
Loa Loa (eye worm) cyclin domain-containing protein 0.0118 0.061 0.0555
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0118 0.061 0.0555
Giardia lamblia Kinase, AGC PKA 0.015 0.0901 0.1296
Brugia malayi Cyclin, N-terminal domain containing protein 0.076 0.6562 0.6542
Leishmania major cyclin 9, putative 0.0118 0.061 0.0848
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0064 0.0109 0.0052
Echinococcus granulosus mitogen activated protein kinase 3 0.0068 0.014 0.014
Schistosoma mansoni cyclin B 0.076 0.6562 0.6542
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0224 0.1585 0.1536
Trichomonas vaginalis AGC family protein kinase 0.0326 0.2538 0.3812
Echinococcus granulosus protein kinase C gamma type 0.0319 0.2468 0.2468
Echinococcus granulosus cyclin A3 4 0.0118 0.061 0.061
Schistosoma mansoni serine/threonine protein kinase 0.0394 0.3166 0.3126
Entamoeba histolytica protein kinase, putative 0.0064 0.0109 0.0079
Echinococcus granulosus RNA directed DNA polymerase 0.0134 0.0754 0.0754
Schistosoma mansoni serine/threonine protein kinase 0.0178 0.1161 0.1109
Echinococcus granulosus mitogen activated protein kinase 0.0068 0.014 0.014
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0214 0.1495 0.1495
Entamoeba histolytica cyclin, putative 0.076 0.6562 1
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0378 0.3022 0.3022
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0159 0.0987 0.1428
Echinococcus granulosus N chimaerin 0.0075 0.0211 0.0211
Loa Loa (eye worm) cyclin domain-containing protein 0.0118 0.061 0.0555
Loa Loa (eye worm) hypothetical protein 0.0075 0.0211 0.0154
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0201 0.1374 0.1324
Trypanosoma brucei mitotic cyclin 0.0118 0.061 0.0848
Echinococcus multilocularis serine:threonine protein kinase N2 0.0178 0.1161 0.1109
Trichomonas vaginalis AGC family protein kinase 0.0201 0.1374 0.2024
Echinococcus granulosus cyclins 0.049 0.4058 0.4058
Onchocerca volvulus 0.0138 0.0791 0.1056
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0082 0.0276 0.0276
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0068 0.014 0.0126
Loa Loa (eye worm) cyclin domain-containing protein 0.0985 0.8647 0.8639
Trichomonas vaginalis cyclin B, putative 0.076 0.6562 1
Echinococcus multilocularis cyclins 0.049 0.4058 0.4023
Echinococcus granulosus cyclin k 0.0118 0.061 0.061
Schistosoma mansoni cyclin B3 0.0985 0.8647 0.8639
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0437 0.356 0.5385
Schistosoma mansoni serine/threonine-protein kinase 0.0159 0.0987 0.0934
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0134 0.0754 0.0701
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0059 0.0058 0.0058
Trichomonas vaginalis cyclin B3, putative 0.049 0.4058 0.615
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0068 0.014 0.0126
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0178 0.1161 0.1161
Entamoeba histolytica protein kinase domain containing protein 0.0064 0.0109 0.0079
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0118 0.061 0.0555
Echinococcus multilocularis protein kinase c eta type 0.0075 0.0211 0.0154
Echinococcus multilocularis mitogen activated protein kinase 14 0.0437 0.356 0.3523
Echinococcus multilocularis RNA directed DNA polymerase 0.0134 0.0754 0.0701
Brugia malayi Protein kinase domain containing protein 0.0326 0.2538 0.2494
Loa Loa (eye worm) hypothetical protein 0.049 0.4058 0.4023
Brugia malayi Cyclin, N-terminal domain containing protein 0.0118 0.061 0.0555
Echinococcus multilocularis N chimaerin 0.0075 0.0211 0.0154
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0075 0.0211 0.0154
Loa Loa (eye worm) cyclin domain-containing protein 0.0118 0.061 0.0555
Echinococcus multilocularis cyclins 0.049 0.4058 0.4023
Brugia malayi RhoGAP domain containing protein 0.0075 0.0211 0.0154
Schistosoma mansoni hypothetical protein 0.0118 0.061 0.0555
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.076 0.6562 1
Trichomonas vaginalis AGC family protein kinase 0.0178 0.1161 0.1696
Echinococcus granulosus protein kinase c eta type 0.0075 0.0211 0.0211
Brugia malayi Cyclin, N-terminal domain containing protein 0.0118 0.061 0.0555
Echinococcus granulosus cyclin b3 0.049 0.4058 0.4058
Echinococcus granulosus myotubularin protein 13 0.0085 0.0297 0.0297
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0064 0.0109 0.0109
Trypanosoma brucei cyclin 9 0.0118 0.061 0.0848
Trypanosoma brucei mitotic cyclin 6 0.076 0.6562 1
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0317 0.2451 0.2407
Brugia malayi MAP kinase sur-1 0.0068 0.014 0.0082
Echinococcus multilocularis raf serine:threonine protein kinase 0.0082 0.0271 0.0215
Schistosoma mansoni protein kinase C mu 0.0075 0.0211 0.0154
Loa Loa (eye worm) TK protein kinase 0.0397 0.3192 0.3153
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.014 0.0126
Entamoeba histolytica hypothetical protein 0.0118 0.061 0.0848
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0118 0.061 0.0555
Loa Loa (eye worm) hypothetical protein 0.1131 1 1
Onchocerca volvulus 0.0118 0.061 0.0775
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0064 0.0109 0.0052
Echinococcus granulosus cyclin dependent kinase 0.0059 0.0058 0.0058
Trichomonas vaginalis cyclins, putative 0.049 0.4058 0.615
Echinococcus multilocularis mitogen activated protein kinase 3 0.0068 0.014 0.0082
Echinococcus multilocularis cyclins 0.049 0.4058 0.4023
Echinococcus granulosus Cyclin L1 0.0118 0.061 0.061
Trichomonas vaginalis cyclins, putative 0.0388 0.3114 0.4698
Echinococcus granulosus protein kinase c epsilon type 0.0416 0.3373 0.3373
Echinococcus granulosus cyclin 0.0118 0.061 0.061
Plasmodium vivax cyclin homologue, putative 0.0118 0.061 0.6547
Echinococcus multilocularis Glutaredoxin protein 5 0.0139 0.0803 0.075
Schistosoma mansoni serine/threonine protein kinase 0.0416 0.3373 0.3334
Toxoplasma gondii hypothetical protein 0.0372 0.2961 1
Onchocerca volvulus 0.0082 0.0276 0.0259
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0186 0.1236 0.1185
Trichomonas vaginalis CMGC family protein kinase 0.0064 0.0109 0.0079
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0064 0.0109 0.0079
Trichomonas vaginalis cyclin A, putative 0.0118 0.061 0.0848
Loa Loa (eye worm) hypothetical protein 0.076 0.6562 0.6542
Loa Loa (eye worm) hypothetical protein 0.0388 0.3107 0.3067
Entamoeba histolytica cyclin, domain containing protein 0.0118 0.061 0.0848
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0075 0.0211 0.0154
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0118 0.061 0.6547
Brugia malayi map kinase activated protein kinase protein 2 0.0214 0.1495 0.1445
Echinococcus granulosus c-Jun N-terminal kinases 0.0531 0.4438 0.4438
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0178 0.1161 0.1109
Entamoeba histolytica cyclin family protein 0.049 0.4058 0.615
Schistosoma mansoni unc-13 (munc13) 0.0082 0.0276 0.022
Toxoplasma gondii cyclin 4, putative 0.0118 0.061 0.19
Schistosoma mansoni serine/threonine kinase 0.0178 0.1161 0.1109
Giardia lamblia Kinase, CMGC MAPK 0.0068 0.014 0.0126
Entamoeba histolytica cyclin C, putative 0.0118 0.061 0.0848
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0437 0.356 0.5385
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0068 0.014 0.0126
Trichomonas vaginalis AGC family protein kinase 0.021 0.146 0.2156
Echinococcus multilocularis serine:threonine protein kinase 38 0.0178 0.1161 0.1109

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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