TDR Targets

Basic information

Technical information

TDR Targets ID: 876653
Name: N-[2-(5-bromo-2-methoxyphenyl)ethyl]-4-fluoro benzenesulfonamide
MW: 388.252 | Formula: C15H15BrFNO3S
H donors: 1 H acceptors: 2 LogP: 3.61 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1CCNS(=O)(=O)c1ccc(cc1)F)Br
InChi: 1S/C15H15BrFNO3S/c1-21-15-7-2-12(16)10-11(15)8-9-18-22(19,20)14-5-3-13(17)4-6-14/h2-7,10,18H,8-9H2,1H3
InChiKey: LQEIRDWRFPNJFU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[2-(5-bromo-2-methoxy-phenyl)ethyl]-4-fluoro-benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	S-adenosylmethionine decarboxylase	0.0911	1	1
Echinococcus multilocularis		0.0021	0.0075	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Schistosoma mansoni	biogenic amine receptor	0.0054	0.0448	0.118
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Echinococcus granulosus	orexin receptor type 2	0.0054	0.0448	0.041
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0259	0.023
Brugia malayi	G protein-coupled receptor	0.0054	0.0448	0.041
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0058	0.0084
Echinococcus granulosus	protein arginine N methyltransferase 8	0.0031	0.019	0.0151
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.0031	0.019	0.4222
Trypanosoma cruzi	S-adenosylmethionine decarboxylase proenzyme, putative	0.0911	1	1
Schistosoma mansoni	hypothetical protein	0.0054	0.0448	0.118
Brugia malayi	PXA domain containing protein	0.0019	0.0053	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Onchocerca volvulus		0.0054	0.0448	1
Loa Loa (eye worm)	PXA domain-containing protein	0.0019	0.0053	0.0023
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.0053	0.0013
Toxoplasma gondii	histone arginine methyltransferase PRMT3	0.0017	0.004	0.101
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0021	0.0075	0.0035
Schistosoma mansoni	protein arginine N-methyltransferase 1	0.0031	0.019	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Echinococcus granulosus	neuropeptide Y receptor	0.0054	0.0448	0.041
Loa Loa (eye worm)	G-protein coupled receptor	0.0054	0.0448	0.042
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0049	0.0395	0.0357
Echinococcus multilocularis	neuropeptide receptor A26	0.0054	0.0448	0.041
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0021	0.0075	0.5
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0054	0.0448	0.041
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0054	0.0448	0.041
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Loa Loa (eye worm)	cytochrome P450 family protein	0.0057	0.0486	0.0458
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0054	0.0448	0.042
Echinococcus multilocularis	axis inhibition protein axin	0.0019	0.0053	0.0013
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0021	0.0075	0.5
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0054	0.0448	0.118
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0448	0.041
Schistosoma mansoni	protein arginine N-methyltransferase 1	0.0031	0.019	0.0455
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0019	0.0053	0.0365
Schistosoma mansoni	opsin-like receptor	0.0054	0.0448	0.118
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0019	0.0058	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Onchocerca volvulus		0.0054	0.0448	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0054	0.0448	0.118
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0049	0.0395	0.0357
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0019	0.0058	0.0028
Brugia malayi	GnHR receptor homolog	0.0054	0.0448	0.041
Loa Loa (eye worm)	hypothetical protein	0.0182	0.1874	0.1849
Echinococcus granulosus	axis inhibition protein axin	0.0019	0.0053	0.0013
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0054	0.0448	0.118
Brugia malayi	Dopamine receptor protein 1	0.0054	0.0448	0.041
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Echinococcus granulosus	neuropeptide receptor A26	0.0054	0.0448	0.041
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0053	0.0023
Echinococcus granulosus	solute carrier family 5	0.0037	0.0259	0.022
Loa Loa (eye worm)	Carm1-pending protein	0.0017	0.004	0.001
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Schistosoma mansoni	z-protein (S1r protein)	0.0019	0.0053	0.007
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0021	0.0075	0.5
Echinococcus multilocularis	mitogen activated protein kinase	0.0049	0.0395	0.0357
Schistosoma mansoni	neuropeptide receptor	0.0054	0.0448	0.118
Trypanosoma brucei	protein kinase, putative	0.0049	0.0395	0.0357
Schistosoma mansoni	neuropeptide F-like receptor	0.0054	0.0448	0.118
Loa Loa (eye worm)	protein arginine N-methyltransferase	0.0017	0.004	0.001
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Brugia malayi	larval opioid receptor	0.0054	0.0448	0.041
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0054	0.0448	0.041
Echinococcus multilocularis	neuropeptide receptor	0.0054	0.0448	0.041
Echinococcus multilocularis	orexin receptor type 2	0.0054	0.0448	0.041
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.0395	1
Trypanosoma brucei	histone-lysine n-methyltransferase	0.0032	0.0203	0.0164
Onchocerca volvulus		0.0054	0.0448	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0448	0.041
Plasmodium falciparum	S-adenosylmethionine decarboxylase/ornithine decarboxylase	0.0444	0.4792	1
Brugia malayi	Dopamine receptor	0.0054	0.0448	0.041
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0054	0.0448	0.118
Echinococcus granulosus	somatostatin receptor	0.0054	0.0448	0.041
Echinococcus multilocularis	neuropeptide Y receptor	0.0054	0.0448	0.041
Brugia malayi	Cytochrome P450 family protein	0.0021	0.0075	0.0035
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0019	0.0053	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0049	0.0395	0.0357
Loa Loa (eye worm)	cytochrome P450	0.0021	0.0075	0.0046
Trichomonas vaginalis	DNA helicase recq, putative	0.0021	0.0076	0.1023
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0019	0.0053	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0053	0.0023
Echinococcus granulosus	serotonin receptor	0.0054	0.0448	0.041
Brugia malayi	G-protein coupled receptor	0.0054	0.0448	0.041
Echinococcus granulosus	hypothetical protein	0.0054	0.0448	0.041
Onchocerca volvulus		0.0054	0.0448	1
Echinococcus granulosus	sodium:glucose cotransporter	0.0037	0.0259	0.022
Brugia malayi	Bloom's syndrome protein homolog	0.0021	0.0076	0.0036
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0054	0.0448	0.041
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0054	0.0448	0.042
Brugia malayi	hypothetical protein	0.0054	0.0448	0.041
Brugia malayi	hypothetical protein	0.0054	0.0448	0.041
Echinococcus multilocularis	histone h3 methyltransferase	0.0252	0.2655	0.2626
Echinococcus granulosus	regulator of G protein signaling 3	0.0019	0.0053	0.0013
Schistosoma mansoni	serine/threonine protein kinase	0.0049	0.0395	0.1031
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0053	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0053	0.0023
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0053	0.0365
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0021	0.0075	0.5
Brugia malayi	Serotonin receptor	0.0054	0.0448	0.041
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0054	0.0448	0.041
Trypanosoma brucei	S-adenosylmethionine decarboxylase	0.0911	1	1
Giardia lamblia	Kinase, CMGC MAPK	0.0049	0.0395	0.5
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Plasmodium vivax	protein arginine N-methyltransferase 1, putative	0.0031	0.019	0.0393
Echinococcus multilocularis	protein arginine N methyltransferase 8	0.0031	0.019	0.0151
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0019	0.0053	0.0013
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0448	0.118
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0448	0.118
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0054	0.0448	0.041
Echinococcus multilocularis	sodium coupled monocarboxylate transporter 1	0.0037	0.0259	0.022
Echinococcus granulosus	bloom syndrome protein	0.0021	0.0076	0.0036
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0448	0.041
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.0395	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0054	0.0448	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0021	0.0075	0.5
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Trypanosoma cruzi	Histone methylation protein DOT1, putative	0.0032	0.0203	0.0164
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0054	0.0448	0.041
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0021	0.0075	0.5
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.0031	0.019	0.4222
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0356	0.3813	0.3788
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0448	0.041
Echinococcus multilocularis	sex peptide receptor	0.0054	0.0448	0.041
Loa Loa (eye worm)	G-protein coupled receptor	0.0054	0.0448	0.042
Brugia malayi	Dopamine receptor protein 2	0.0054	0.0448	0.041
Echinococcus multilocularis	geminin	0.0333	0.3556	0.353
Schistosoma mansoni	hypothetical protein	0.0021	0.0075	0.0133
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0021	0.0075	0.5
Onchocerca volvulus		0.0054	0.0448	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0054	0.0448	0.041
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0021	0.0075	0.5
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Schistosoma mansoni	neuropeptide receptor	0.0054	0.0448	0.118
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0054	0.0448	0.041
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Schistosoma mansoni	cytochrome P450	0.0021	0.0075	0.0133
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0448	0.041
Echinococcus multilocularis	somatostatin receptor	0.0054	0.0448	0.041
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0021	0.0075	0.0035
Loa Loa (eye worm)	RGS-3 protein	0.0019	0.0053	0.0023
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0054	0.0448	0.042
Brugia malayi	sulfakinin receptor protein	0.0054	0.0448	0.041
Onchocerca volvulus		0.0054	0.0448	1
Schistosoma mansoni	amine GPCR	0.0054	0.0448	0.118
Brugia malayi	putative neuropeptide receptor NPR1	0.0054	0.0448	0.041
Entamoeba histolytica	hypothetical protein	0.0048	0.0383	1
Leishmania major	cytochrome p450-like protein	0.0021	0.0075	0.0035
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0054	0.0448	0.041
Brugia malayi	PXA domain containing protein	0.0019	0.0053	0.0013
Schistosoma mansoni	opsin-like receptor	0.0054	0.0448	0.118
Onchocerca volvulus		0.0054	0.0448	1
Loa Loa (eye worm)	RecQ helicase	0.0021	0.0076	0.0047
Loa Loa (eye worm)	neuropeptide F receptor	0.0054	0.0448	0.042
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0053	0.007
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0054	0.0448	0.041
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0448	0.041
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0054	0.0448	0.118
Brugia malayi	hypothetical protein	0.0054	0.0448	0.041
Echinococcus multilocularis	neuropeptide receptor	0.0054	0.0448	0.041
Brugia malayi	RE15519p	0.0054	0.0448	0.041
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0049	0.0395	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0252	0.2655	0.2633
Schistosoma mansoni	inositol transporter	0.0037	0.0259	0.065
Onchocerca volvulus		0.0054	0.0448	1
Echinococcus granulosus	neuropeptides capa receptor	0.0054	0.0448	0.041
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0054	0.0448	0.041
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0021	0.0075	0.5
Echinococcus multilocularis	fmrfamide receptor	0.0054	0.0448	0.041
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0053	0.007
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0054	0.0448	0.041
Onchocerca volvulus		0.0054	0.0448	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0054	0.0448	0.041
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Brugia malayi	hypothetical protein	0.0054	0.0448	0.041
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.0053	0.0013
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0049	0.0395	0.0357
Brugia malayi	AKH receptor	0.0054	0.0448	0.041
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.0053	0.0013
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0448	0.041
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0021	0.0075	0.5
Onchocerca volvulus		0.0054	0.0448	1
Echinococcus multilocularis	regulator of G protein signaling 3	0.0019	0.0053	0.0013
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0019	0.0058	0.0018
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0054	0.0448	0.041
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0049	0.0395	0.0357
Brugia malayi	putative neuropeptide receptor	0.0054	0.0448	0.041
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0054	0.0448	0.041
Loa Loa (eye worm)	cytochrome P450 family protein	0.0037	0.0264	0.0235
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0054	0.0448	0.041
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0019	0.0053	0.0013
Onchocerca volvulus		0.0054	0.0448	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0448	0.041
Echinococcus granulosus	neuropeptide s receptor	0.0054	0.0448	0.041
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0021	0.0075	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0054	0.0448	0.041
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0054	0.0448	0.041
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0049	0.0395	0.0357
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0054	0.0448	0.118
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0356	0.3813	0.3788
Brugia malayi	hypothetical protein	0.0048	0.0383	0.0345
Brugia malayi	Histone-lysine N-methyltransferase, H3 lysine-79 specific	0.0252	0.2655	0.2626
Brugia malayi	hypothetical protein	0.0054	0.0448	0.041
Schistosoma mansoni	neuropeptide receptor	0.0054	0.0448	0.118
Echinococcus multilocularis	solute carrier family 5	0.0037	0.0259	0.022
Brugia malayi	hypothetical protein	0.0054	0.0448	0.041
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0054	0.0448	0.118
Schistosoma mansoni	axis inhibition protein axin	0.0019	0.0053	0.007
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0448	0.041
Trypanosoma brucei	Histone-lysine N-methyltransferase, H3 lysine-76 specific	0.0032	0.0203	0.0164
Toxoplasma gondii	transporter, solute:sodium symporter (SSS) family protein	0.0037	0.0259	0.6562
Brugia malayi	MAP kinase sur-1	0.0049	0.0395	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0021	0.0075	0.5
Schistosoma mansoni	amine GPCR	0.0054	0.0448	0.118
Echinococcus multilocularis	neuropeptide s receptor	0.0054	0.0448	0.041
Schistosoma mansoni	hypothetical protein	0.0017	0.004	0.0034
Schistosoma mansoni	adenoreceptor	0.0054	0.0448	0.118
Echinococcus multilocularis	protein arginine methyltransferase	0.0031	0.019	0.0151
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0053	0.007
Onchocerca volvulus		0.0054	0.0448	1
Trypanosoma cruzi	arginine N-methyltransferase, putative	0.0048	0.0383	0.0345
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0054	0.0448	0.118
Brugia malayi	hypothetical protein	0.0019	0.0053	0.0013
Trypanosoma brucei	S-adenosylmethionine decarboxylase proenzyme, putative	0.0911	1	1
Echinococcus multilocularis	regulator of G protein signaling	0.0019	0.0053	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Echinococcus granulosus	Regulator of G protein signaling 20	0.0019	0.0053	0.0013
Echinococcus granulosus	neuropeptide receptor	0.0054	0.0448	0.041
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Brugia malayi	neuropeptide F receptor	0.0054	0.0448	0.041
Echinococcus multilocularis	axis inhibition protein axin	0.0019	0.0053	0.0013
Echinococcus granulosus	g protein coupled receptor	0.0054	0.0448	0.041
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0448	0.041
Echinococcus multilocularis	G protein coupled receptor 139	0.0054	0.0448	0.041
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0021	0.0075	0.5
Entamoeba histolytica	arginine N-methyltransferase protein, putative	0.0048	0.0383	1
Echinococcus granulosus	expressed protein	0.0361	0.3867	0.3842
Echinococcus multilocularis	g protein coupled receptor	0.0054	0.0448	0.041
Echinococcus granulosus	neuropeptide Y receptor	0.0054	0.0448	0.041
Brugia malayi	neuropeptide F receptor	0.0054	0.0448	0.041
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0054	0.0448	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Echinococcus granulosus	mitogen activated protein kinase 3	0.0049	0.0395	0.0357
Echinococcus granulosus	protein arginine methyltransferase	0.0031	0.019	0.0151
Brugia malayi	hypothetical protein	0.0054	0.0448	0.041
Echinococcus granulosus	g protein coupled receptor	0.0054	0.0448	0.041
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0054	0.0448	0.041
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0053	0.007
Echinococcus granulosus	S adenosylmethionine decarboxylase proenzyme	0.0911	1	1
Leishmania major	histone-lysine N-methyltransferase, putative	0.0032	0.0203	0.0164
Echinococcus granulosus	sex peptide receptor	0.0054	0.0448	0.041
Echinococcus granulosus	7TM GPCR rhodopsin	0.0054	0.0448	0.041
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0021	0.0075	0.1901
Schistosoma mansoni	sodium/solute symporter	0.0037	0.0259	0.065
Echinococcus granulosus	histone h3 methyltransferase	0.0252	0.2655	0.2626
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Echinococcus multilocularis	expressed protein	0.0361	0.3867	0.3842
Trypanosoma cruzi	arginine N-methyltransferase, putative	0.0048	0.0383	0.0345
Echinococcus granulosus	tm gpcr rhodopsin	0.0054	0.0448	0.041
Loa Loa (eye worm)	hypothetical protein	0.0336	0.3591	0.3571
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0054	0.0448	0.118
Echinococcus granulosus	regulator of G protein signaling 3	0.0019	0.0053	0.0013
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0019	0.0053	0.007
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Echinococcus granulosus	g-protein coupled receptor	0.0054	0.0448	0.041
Entamoeba histolytica	hypothetical protein	0.0019	0.0053	0.0378
Loa Loa (eye worm)	S-adenosylmethionine decarboxylase proenzyme	0.0911	1	1
Schistosoma mansoni	histone J3 methyltransferase	0.0252	0.2655	0.7374
Trypanosoma cruzi	cytochrome P450, putative	0.0037	0.0264	0.0225
Onchocerca volvulus		0.0054	0.0448	1
Schistosoma mansoni	myosin xvIII	0.0054	0.0448	0.118
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0448	0.118
Schistosoma mansoni	growth hormone secretagogue receptor	0.0054	0.0448	0.118
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0448	0.118
Schistosoma mansoni	protein arginine N-methyltransferase 1	0.0031	0.019	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Echinococcus granulosus	sodium:glucose cotransporter 2	0.0037	0.0259	0.022
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0053	0.0023
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0049	0.0395	0.0357
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0019	0.0053	0.0023
Entamoeba histolytica	hypothetical protein	0.0019	0.0053	0.0378
Loa Loa (eye worm)	cytochrome P450 family protein	0.0037	0.0264	0.0235
Trypanosoma cruzi	Histone-lysine N-methyltransferase, H3 lysine-76 specific	0.0032	0.0203	0.0164
Trypanosoma brucei	Histone methylation protein DOT1, putative	0.0032	0.0203	0.0164
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0021	0.0075	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0035	0.0005
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0448	0.118
Schistosoma mansoni	protein arginine n-methyltransferase	0.0017	0.004	0.0034
Loa Loa (eye worm)	CYP4Cod1	0.0037	0.0264	0.0235
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.0395	1
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.0053	0.0013
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0053	0.0365
Echinococcus multilocularis	fmrfamide receptor	0.0054	0.0448	0.041
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0053	0.0023
Echinococcus granulosus	neuropeptides capa receptor	0.0054	0.0448	0.041
Loa Loa (eye worm)	TYRA-2 protein	0.0054	0.0448	0.042
Brugia malayi	GH02984p	0.0336	0.3591	0.3565
Brugia malayi	cytochrome P450	0.0021	0.0075	0.0035
Brugia malayi	hypothetical protein	0.0054	0.0448	0.041
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.0395	1
Brugia malayi	regulator of G-protein signaling rgs-7	0.0019	0.0053	0.0013
Schistosoma mansoni	hypothetical protein	0.0333	0.3556	0.9902
Trypanosoma brucei	S-adenosylmethionine decarboxylase	0.0911	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0053	0.0365
Echinococcus granulosus	g protein coupled receptor	0.0054	0.0448	0.041
Schistosoma mansoni	hypothetical protein	0.0333	0.3556	0.9902
Brugia malayi	Melatonin receptor type 1A	0.0054	0.0448	0.041
Onchocerca volvulus		0.0054	0.0448	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0054	0.0448	0.118
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0448	0.041
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0054	0.0448	0.118
Brugia malayi	Cytochrome P450 family protein	0.0037	0.0264	0.0225
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0021	0.0075	0.5
Leishmania major	arginine N-methyltransferase-like protein	0.0031	0.019	0.0151
Brugia malayi	Sodium:solute symporter family protein	0.0037	0.0259	0.022
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Toxoplasma gondii	histone arginine methyltransferase PRMT4/CARM1	0.0017	0.004	0.101
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0019	0.0058	0.0018
Entamoeba histolytica	hypothetical protein	0.0019	0.0053	0.0378
Echinococcus multilocularis	sodium:glucose cotransporter 2	0.0037	0.0259	0.022
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0448	0.041
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0037	0.0264	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0054	0.0448	0.118
Schistosoma mansoni	histamine h1 receptor	0.0054	0.0448	0.118
Schistosoma mansoni	axis inhibition protein axin	0.0019	0.0053	0.007
Brugia malayi	A-kinase anchor protein 10, precursor	0.0019	0.0053	0.0013
Echinococcus granulosus	geminin	0.0333	0.3556	0.353
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0053	0.0365
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0054	0.0448	0.041
Mycobacterium leprae	Conserved hypothetical protein	0.0021	0.0075	0.5
Echinococcus multilocularis	bloom syndrome protein	0.0021	0.0076	0.0036
Brugia malayi	hypothetical protein	0.0054	0.0448	0.041
Brugia malayi	follicle stimulating hormone receptor	0.0276	0.2926	0.2898
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0054	0.0448	0.041
Schistosoma mansoni	biogenic amine receptor	0.0054	0.0448	0.118
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0054	0.0448	0.118
Schistosoma mansoni	opsin-like receptor	0.0054	0.0448	0.118
Echinococcus multilocularis	allatostatin A receptor	0.0054	0.0448	0.041
Echinococcus multilocularis	serotonin receptor	0.0054	0.0448	0.041
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Echinococcus multilocularis	S adenosylmethionine decarboxylase proenzyme	0.0911	1	1
Brugia malayi	hypothetical protein	0.0019	0.0053	0.0013
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0054	0.0448	0.041
Schistosoma mansoni	inositol transporter	0.0037	0.0259	0.065
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0448	0.041
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Onchocerca volvulus		0.0054	0.0448	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0054	0.0448	0.041
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Loa Loa (eye worm)	neuropeptide F receptor	0.0054	0.0448	0.042
Plasmodium falciparum	protein arginine N-methyltransferase 1	0.0031	0.019	0.0299
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0448	0.041
Schistosoma mansoni	high-affinity choline transporter	0.0336	0.3591	1
Echinococcus granulosus	neuropeptide receptor	0.0054	0.0448	0.041
Schistosoma mansoni	neuropeptide f receptor 76f	0.0054	0.0448	0.118
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0053	0.0365
Trypanosoma cruzi	histone-lysine N-methyltransferase, putative	0.0032	0.0203	0.0164
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0054	0.0448	0.041
Echinococcus multilocularis	sodium:myo inositol cotransporter	0.0037	0.0259	0.022
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0021	0.0075	0.5
Brugia malayi	G protein-coupled receptor F59B2.13	0.0054	0.0448	0.041
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0021	0.0075	0.0035
Trypanosoma cruzi	Histone methylation protein DOT1, putative	0.0032	0.0203	0.0164
Schistosoma mansoni	biogenic amine receptor	0.0054	0.0448	0.118
Brugia malayi	ORL1-like opioid receptor	0.0054	0.0448	0.041
Brugia malayi	Cytochrome P450 family protein	0.0057	0.0486	0.0448
Brugia malayi	Cytochrome P450 family protein	0.0037	0.0264	0.0225
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0019	0.0053	0.0013
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0054	0.0448	0.041
Echinococcus multilocularis	g protein coupled receptor	0.0054	0.0448	0.041
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0054	0.0448	0.041
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Toxoplasma gondii	hypothetical protein	0.0032	0.0203	0.5135
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0054	0.0448	0.042
Brugia malayi	G-protein coupled receptor	0.0054	0.0448	0.041
Trypanosoma brucei	Protein arginine N-methyltransferase 1 catalytic subunit	0.0048	0.0383	0.0345
Schistosoma mansoni	neuropeptide F-like receptor	0.0054	0.0448	0.118
Leishmania major	hypothetical protein, conserved	0.0032	0.0203	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0448	0.118
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0783	0.8581	0.8575
Echinococcus granulosus	fmrfamide receptor	0.0054	0.0448	0.041
Brugia malayi	hypothetical protein	0.0054	0.0448	0.041
Echinococcus granulosus	7tm_1 domain containing protein	0.0054	0.0448	0.041
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0054	0.0448	0.041
Loa Loa (eye worm)	hypothetical protein	0.0356	0.3813	0.3794
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Toxoplasma gondii	bicoid-interacting protein BIN3	0.0017	0.004	0.101
Schistosoma mansoni	amine GPCR	0.0054	0.0448	0.118
Trypanosoma cruzi	S-adenosylmethionine decarboxylase proenzyme, putative	0.0911	1	1
Echinococcus granulosus	cytochrome P450 2K1	0.0021	0.0075	0.0035
Schistosoma mansoni	hypothetical protein	0.0054	0.0448	0.118
Echinococcus granulosus	sodium:myo inositol cotransporter	0.0037	0.0259	0.022
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0054	0.0448	0.041
Echinococcus multilocularis	g-protein coupled receptor	0.0054	0.0448	0.041
Echinococcus granulosus	G protein coupled receptor 139	0.0054	0.0448	0.041
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0021	0.0075	0.0035
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0021	0.0075	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0054	0.0448	0.041
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Echinococcus multilocularis	high affinity choline transporter 1	0.0336	0.3591	0.3565
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0448	0.118
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0054	0.0448	0.118
Leishmania major	cytochrome p450-like protein	0.0021	0.0075	0.0035
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0448	0.118
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0054	0.0448	0.041
Echinococcus granulosus	tm gpcr rhodopsin	0.0054	0.0448	0.041
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0049	0.0395	0.0357
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0058	0.0084
Leishmania major	hypothetical protein, conserved	0.0032	0.0203	0.0164
Leishmania major	cytochrome p450-like protein	0.0037	0.0264	0.0225
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0054	0.0448	0.118
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0053	0.007
Echinococcus granulosus	allatostatin A receptor	0.0054	0.0448	0.041
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0054	0.0448	0.041
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0448	0.041
Echinococcus granulosus	biogenic amine 5HT receptor	0.0054	0.0448	0.041
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0021	0.0075	0.5
Brugia malayi	regulator of G-protein signaling egl-10	0.0019	0.0053	0.0013
Onchocerca volvulus		0.0054	0.0448	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0054	0.0448	0.041
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0054	0.0448	0.118
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0019	0.0058	0.0028
Echinococcus multilocularis	dro:myosuppressin receptor	0.0054	0.0448	0.041
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0021	0.0075	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0448	0.042
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.0031	0.019	0.4222
Schistosoma mansoni	amine GPCR	0.0054	0.0448	0.118
Echinococcus multilocularis	serotonin receptor	0.0054	0.0448	0.041
Echinococcus granulosus	neuropeptide FF receptor 2	0.0054	0.0448	0.041
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0021	0.0075	0.5
Plasmodium vivax	S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative	0.0444	0.4792	1
Echinococcus granulosus	high affinity choline transporter 1	0.0336	0.3591	0.3565
Echinococcus granulosus	tm gpcr rhodopsin	0.0054	0.0448	0.041
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0021	0.0075	0.5
Mycobacterium leprae	putative cytochrome p450	0.0021	0.0075	0.5
Schistosoma mansoni	hypothetical protein	0.0054	0.0448	0.118
Trypanosoma brucei	cytochrome P450, putative	0.0037	0.0264	0.0225
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0276	0.2926	0.2905
Echinococcus granulosus	mitogen activated protein kinase	0.0049	0.0395	0.0357
Brugia malayi	Serotonin receptor	0.0054	0.0448	0.041
Echinococcus granulosus	axis inhibition protein axin	0.0019	0.0053	0.0013
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0049	0.0395	1
Schistosoma mansoni	neuropeptide receptor	0.0054	0.0448	0.118
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0448	0.118
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0356	0.3813	0.3788
Echinococcus granulosus	dro:myosuppressin receptor	0.0054	0.0448	0.041
Echinococcus multilocularis	regulator of G protein signaling 3	0.0019	0.0053	0.0013
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0019	0.0053	0.007
Toxoplasma gondii	histone arginine methyltransferase PRMT1	0.0031	0.019	0.4806
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0058	0.0084
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0019	0.0053	0.007
Loa Loa (eye worm)	melatonin receptor type 1A	0.0054	0.0448	0.042
Trichomonas vaginalis	DNA helicase recq1, putative	0.0021	0.0076	0.1023
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0054	0.0448	0.041
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0053	0.0365
Trypanosoma cruzi	cytochrome P450, putative	0.0037	0.0264	0.0225
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0383	0.0355
Leishmania major	C-8 sterol isomerase-like protein	0.0356	0.3813	0.3788
Schistosoma mansoni	amine GPCR	0.0054	0.0448	0.118
Echinococcus multilocularis	g protein coupled receptor	0.0054	0.0448	0.041
Onchocerca volvulus		0.0054	0.0448	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0054	0.0448	0.041
Echinococcus granulosus	sodium coupled monocarboxylate transporter 1	0.0037	0.0259	0.022
Schistosoma mansoni	hypothetical protein	0.0054	0.0448	0.118

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 876653