Detailed information for compound 876951

Basic information

Technical information
  • TDR Targets ID: 876951
  • Name: 4-[[2-[(4-fluorophenyl)amino]-2-oxoethyl]sulf anylmethyl]benzoic acid
  • MW: 319.351 | Formula: C16H14FNO3S
  • H donors: 2 H acceptors: 3 LogP: 2.9 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)F)CSCc1ccc(cc1)C(=O)O
  • InChi: 1S/C16H14FNO3S/c17-13-5-7-14(8-6-13)18-15(19)10-22-9-11-1-3-12(4-2-11)16(20)21/h1-8H,9-10H2,(H,18,19)(H,20,21)
  • InChiKey: IRRMCEDRCRRSQU-UHFFFAOYSA-N  

Network

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Synonyms

  • 4-[[2-[(4-fluorophenyl)amino]-2-oxo-ethyl]sulfanylmethyl]benzoic acid
  • 4-[[[2-[(4-fluorophenyl)amino]-2-oxoethyl]thio]methyl]benzoic acid
  • 4-[[[2-[(4-fluorophenyl)amino]-2-keto-ethyl]thio]methyl]benzoic acid
  • SBB015937

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma cruzi Aminopeptidase M1, putative 0.0153 0.0465 1
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0123 0.0361 0.0361
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.002 0.0001 0.0001
Brugia malayi Protein kinase domain containing protein 0.062 0.21 0.4604
Echinococcus granulosus cyclic nucleotide gated cation channel 0.003 0.0036 0.0036
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.004 0.0039
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.003 0.0036 0.0035
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.004 0.0039
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0153 0.0465 1
Loa Loa (eye worm) SRC-1 0.0075 0.0192 0.0192
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0021 0.0002 0.0038
Loa Loa (eye worm) TK protein kinase 0.0126 0.0372 0.0371
Brugia malayi Peptidase family M1 containing protein 0.0153 0.0465 0.1019
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0153 0.0464 0.0464
Schistosoma mansoni hypothetical protein 0.0031 0.0039 0.0038
Schistosoma mansoni tyrosine kinase 0.0075 0.0192 0.0192
Trypanosoma brucei Aminopeptidase M1, putative 0.0153 0.0465 1
Onchocerca volvulus 0.0031 0.0039 0.0826
Brugia malayi Cyclic-nucleotide gated cation channel 0.003 0.0036 0.0077
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0153 0.0465 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0085 0.0084
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0153 0.0465 1
Echinococcus granulosus cGMP dependent protein kinase 1 0.0021 0.0002 0.0002
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0044 0.0085 0.0085
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0002 0.0002
Echinococcus granulosus voltage gated potassium channel 0.0044 0.0085 0.0085
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.003 0.0036 0.0035
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.003 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0031 0.004 0.0039
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0014 0.0014
Echinococcus granulosus c src tyrosine kinase 0.0043 0.0079 0.0079
Loa Loa (eye worm) aminopeptidase N 0.0153 0.0465 0.0464
Schistosoma mansoni nck2/grb4 0.0029 0.003 0.0029
Schistosoma mansoni 60S ribosomal protein L21 0.0024 0.0014 0.0014
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.002 0.0001 0.0001
Echinococcus granulosus tyrosine protein kinase Lyn 0.0075 0.0194 0.0194
Leishmania major protein kinase, putative 0.0021 0.0002 0.0038
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0153 0.0465 0.0465
Echinococcus multilocularis growth factor receptor bound protein 2 0.0029 0.003 0.003
Brugia malayi Sex muscle abnormal protein 5 0.0029 0.003 0.0064
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.002 0.0001 0.0001
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0153 0.0465 1
Loa Loa (eye worm) TATA binding protein associated factor 0.0153 0.0465 0.0464
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0153 0.0464 0.0463
Brugia malayi Protein kinase domain containing protein 0.0274 0.0889 0.1948
Echinococcus multilocularis MAM 0.0031 0.0039 0.0039
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0259 0.0837 0.0837
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.004 0.0039
Echinococcus granulosus tyrosine protein kinase Src42A 0.0075 0.0192 0.0192
Schistosoma mansoni hypothetical protein 0.0031 0.0039 0.0038
Brugia malayi Protein kinase domain containing protein 0.0031 0.004 0.0086
Echinococcus granulosus tyrosine protein kinase Src64B 0.0075 0.0192 0.0192
Brugia malayi Protein kinase domain containing protein 0.0185 0.0577 0.1264
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0029 0.003 0.0029
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0153 0.0465 0.0465
Brugia malayi Protein kinase domain containing protein 0.0031 0.004 0.0086
Echinococcus granulosus hyperpolarization activated cyclic 0.003 0.0036 0.0036
Onchocerca volvulus 0.0153 0.0465 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.003 0.0036 0.0035
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0027 0.0025 0.0024
Loa Loa (eye worm) hypothetical protein 0.0263 0.0851 0.0851
Brugia malayi Egg laying defective protein 4 0.0021 0.0002 0.0004
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.002 0.0001 0.5
Loa Loa (eye worm) hypothetical protein 0.0031 0.0039 0.0038
Schistosoma mansoni voltage-gated potassium channel 0.0167 0.0513 0.0513
Schistosoma mansoni tyrosine kinase 0.0037 0.006 0.006
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0153 0.0465 0.0465
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.004 0.0039
Echinococcus granulosus tyrosine protein kinase shark 0.0031 0.004 0.004
Loa Loa (eye worm) TK/ABL protein kinase 0.0259 0.0837 0.0836
Onchocerca volvulus 0.0031 0.004 0.0842
Treponema pallidum cyclic nucleotide binding protein 0.002 0.0001 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0085 0.0084
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0153 0.0465 0.0465
Brugia malayi hypothetical protein 0.0031 0.0039 0.0084
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.004 0.0039
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0153 0.0465 0.0464
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.002 0.0001 0.5
Loa Loa (eye worm) TK protein kinase 0.0277 0.0901 0.09
Loa Loa (eye worm) hypothetical protein 0.0233 0.0746 0.0746
Onchocerca volvulus 0.0031 0.004 0.0842
Toxoplasma gondii aminopeptidase n, putative 0.0153 0.0465 1
Echinococcus multilocularis c src tyrosine kinase 0.0043 0.0079 0.0079
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.003 0.0036 0.0756
Echinococcus multilocularis protein KINase family member (kin 25) 0.0247 0.0796 0.0796
Loa Loa (eye worm) hypothetical protein 0.003 0.0036 0.0035
Brugia malayi Protein kinase domain containing protein 0.0031 0.004 0.0086
Onchocerca volvulus 0.0031 0.004 0.0842
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0029 0.003 0.0029
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0153 0.0465 0.0464
Echinococcus granulosus tyrosine protein kinase Srms 0.0031 0.004 0.004
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0153 0.0465 1
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.004 0.0039
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0185 0.0577 0.0576
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0021 0.0002 0.0002
Brugia malayi hypothetical protein 0.0153 0.0465 0.1019
Echinococcus multilocularis patatin phospholipase domain containing protein 0.002 0.0001 0.0001
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0021 0.0002 0.0002
Echinococcus multilocularis tyrosine protein kinase Srms 0.0064 0.0152 0.0152
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0075 0.0192 0.0192
Echinococcus granulosus tyrosine protein kinase Fyn 0.0075 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0031 0.0039 0.0038
Brugia malayi protein-tyrosine kinase 0.0064 0.0152 0.0333
Mycobacterium tuberculosis Conserved protein 0.002 0.0001 0.5
Echinococcus granulosus tyrosine protein kinase ABL1 0.0259 0.0837 0.0837
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.002 0.0001 0.5
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0153 0.0465 1
Brugia malayi Variant SH3 domain containing protein 0.0029 0.003 0.0064
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0029 0.003 0.0029
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0153 0.0465 0.0465
Loa Loa (eye worm) hypothetical protein 0.0101 0.0284 0.0284
Echinococcus multilocularis transfer RNA-Thr 0.062 0.21 0.21
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.002 0.0001 0.0001
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.004 0.0039
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.002 0.0001 0.0001
Brugia malayi hypothetical protein 0.1323 0.456 1
Brugia malayi TATA binding protein associated factor 0.0153 0.0465 0.1019
Onchocerca volvulus 0.0031 0.004 0.0842
Echinococcus granulosus growth factor receptor bound protein 2 0.0034 0.005 0.005
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0153 0.0465 1
Brugia malayi Protein kinase domain containing protein 0.0277 0.0901 0.1975
Echinococcus multilocularis expressed conserved protein 0.0021 0.0002 0.0002
Toxoplasma gondii aminopeptidase N protein 0.0153 0.0465 1
Schistosoma mansoni growth factor receptor-bound protein 0.0029 0.003 0.0029
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.002 0.0001 0.5
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.003 0.0036 0.0035
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0153 0.0465 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0143 0.0429 0.9221
Loa Loa (eye worm) hypothetical protein 0.0247 0.0796 0.0795
Echinococcus multilocularis tyrosine protein kinase Blk 0.0064 0.0152 0.0152
Trypanosoma brucei aminopeptidase, putative 0.0153 0.0465 1
Echinococcus multilocularis tyrosine kinase 0.0031 0.004 0.004
Loa Loa (eye worm) TK/ALK protein kinase 0.0274 0.0888 0.0888
Loa Loa (eye worm) hypothetical protein 0.0132 0.0394 0.0393
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0031 0.004 0.004
Echinococcus granulosus activated cdc42 kinase 1 0.062 0.21 0.21
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.002 0.0001 0.5
Echinococcus granulosus tyrosine protein kinase Blk 0.0064 0.0152 0.0152
Trypanosoma brucei Aminopeptidase M1, putative 0.0153 0.0465 1
Brugia malayi SH2 domain containing protein 0.0031 0.004 0.0086
Brugia malayi Protein kinase domain containing protein 0.0031 0.004 0.0086
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0044 0.0085 0.0185
Echinococcus multilocularis tyrosine protein kinase 0.0277 0.0901 0.0901
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.004 0.0039
Echinococcus multilocularis hyperpolarization activated cyclic 0.003 0.0036 0.0036
Echinococcus multilocularis leukotriene A 4 hydrolase 0.2878 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0167 0.0513 0.0513
Echinococcus granulosus hyperpolarization activated cyclic 0.003 0.0036 0.0036
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0153 0.0465 0.0465
Echinococcus granulosus cGMP dependent protein kinase 0.0021 0.0002 0.0002
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0075 0.0192 0.0192
Echinococcus granulosus fibroblast growth factor receptor 4 0.0123 0.0361 0.0361
Echinococcus multilocularis roundabout 2 0.0021 0.0005 0.0005
Echinococcus granulosus cyclic nucleotide gated cation channel 0.002 0.0001 0.0001
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.003 0.0036 0.0036
Brugia malayi Immunoglobulin I-set domain containing protein 0.0027 0.0025 0.0053
Schistosoma mansoni aminopeptidase A (M01 family) 0.0153 0.0465 0.0464
Brugia malayi SRC-1 0.0075 0.0192 0.042
Echinococcus multilocularis tyrosine protein kinase Abl 0.013 0.0384 0.0384
Onchocerca volvulus 0.0036 0.0057 0.1224
Echinococcus granulosus tyrosine protein kinase HCK 0.0046 0.0092 0.0092
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0153 0.0465 1
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.003 0.0036 0.0036
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0153 0.0465 1
Brugia malayi Peptidase family M1 containing protein 0.0153 0.0465 0.1019
Schistosoma mansoni tyrosine kinase 0.0043 0.0079 0.0079
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0123 0.0361 0.0361
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0153 0.0465 0.0465
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.002 0.0001 0.0001
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0247 0.0796 0.0796
Echinococcus granulosus cGMP dependent protein kinase 1 0.0021 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0233 0.0746 0.0746
Echinococcus granulosus tyrosine kinase 0.0064 0.0152 0.0152
Echinococcus multilocularis activated cdc42 kinase 1 0.062 0.21 0.21
Echinococcus granulosus tyrosine protein kinase 0.0277 0.0901 0.0901
Schistosoma mansoni serine/threonine protein kinase 0.0185 0.0577 0.0576
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0044 0.0085 0.0085
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0075 0.0192 0.0192
Schistosoma mansoni tyrosine kinase 0.0123 0.0361 0.036
Loa Loa (eye worm) hypothetical protein 0.0031 0.0039 0.0038
Echinococcus multilocularis hyperpolarization activated cyclic 0.003 0.0036 0.0036
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0153 0.0465 1
Onchocerca volvulus 0.0153 0.0465 1
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0153 0.0465 1
Echinococcus granulosus activated cdc42 kinase 1 0.062 0.21 0.21
Schistosoma mansoni tyrosine kinase 0.0075 0.0192 0.0192
Echinococcus multilocularis voltage gated potassium channel 0.0044 0.0085 0.0085
Treponema pallidum catabolite gene activator 0.002 0.0001 0.5
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0143 0.0429 0.9221
Brugia malayi Protein kinase domain containing protein 0.0031 0.004 0.0086
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0075 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0029 0.003 0.0029
Brugia malayi hypothetical protein 0.0031 0.004 0.0086
Echinococcus multilocularis tyrosine protein kinase shark 0.0031 0.004 0.004
Echinococcus granulosus cyclic nucleotide gated cation channel 0.003 0.0036 0.0036
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0085 0.0084
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0153 0.0465 1
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.002 0.0001 0.0001
Onchocerca volvulus 0.0031 0.004 0.0842
Schistosoma mansoni tyrosine kinase 0.0247 0.0796 0.0795
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0153 0.0465 0.0465
Entamoeba histolytica protein kinase, putative 0.0046 0.0092 0.1236
Loa Loa (eye worm) TK protein kinase 0.0046 0.0092 0.0092
Echinococcus multilocularis aminopeptidase N 0.0153 0.0465 0.0465
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0153 0.0465 1
Onchocerca volvulus 0.0031 0.004 0.0842
Loa Loa (eye worm) peptidase family M1 containing protein 0.0153 0.0465 0.0464
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0043 0.0079 0.0079
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0153 0.0465 0.0465
Schistosoma mansoni nephrin 0.0021 0.0005 0.0004
Echinococcus granulosus tyrosine protein kinase Src42A 0.0055 0.0123 0.0123
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.003 0.0036 0.0036
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0075 0.0192 0.0192
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0153 0.0465 1
Mycobacterium ulcerans aminopeptidase N PepN 0.0153 0.0465 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0075 0.0192 0.0192
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0075 0.0192 0.0192
Schistosoma mansoni tyrosine kinase 0.0242 0.0777 0.0776
Schistosoma mansoni adapter molecule crk 0.0029 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0606 0.205 0.205
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0043 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0153 0.0465 0.0464
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.003 0.0036 0.0036
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0123 0.0361 0.0361
Entamoeba histolytica aminopeptidase, putative 0.0153 0.0465 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0153 0.0465 0.0464
Echinococcus granulosus patatin phospholipase domain containing protein 0.002 0.0001 0.0001
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0075 0.0192 0.0192
Brugia malayi SH2 domain containing protein 0.0031 0.004 0.0086
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0153 0.0465 0.0465
Schistosoma mansoni vesicular amine transporter 0.0023 0.001 0.001
Echinococcus granulosus roundabout 2 0.0021 0.0005 0.0005
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.003 0.0036 0.0756
Onchocerca volvulus 0.0153 0.0465 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.003 0.0036 0.0035
Schistosoma mansoni tyrosine kinase 0.0031 0.004 0.0039
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0229 0.073 0.073
Brugia malayi Peptidase family M1 containing protein 0.0153 0.0465 0.1019
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.003 0.0036 0.0035
Loa Loa (eye worm) hypothetical protein 0.0153 0.0465 0.0464
Loa Loa (eye worm) TK protein kinase 0.0064 0.0152 0.0152
Schistosoma mansoni growth factor receptor-bound protein 0.0034 0.005 0.005
Loa Loa (eye worm) leukotriene A4 hydrolase 0.2878 1 1
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0064 0.0152 0.0152
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0002 0.0002
Brugia malayi hypothetical protein 0.0153 0.0465 0.1019
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.004 0.0039
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0019 0.0019
Mycobacterium ulcerans aminopeptidase N PepN 0.0153 0.0465 1
Trypanosoma cruzi aminopeptidase, putative 0.0153 0.0465 1
Treponema pallidum catabolite gene activator (Crp) 0.002 0.0001 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.004 0.0039
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0153 0.0465 0.0465
Echinococcus multilocularis tyrosine protein kinase HCK 0.0046 0.0092 0.0092
Toxoplasma gondii aminopeptidase N, putative 0.0153 0.0465 1
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0153 0.0465 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0064 0.0152 0.0152
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0001 0.5
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0055 0.0123 0.0123
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0001 0.5
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0031 0.004 0.004
Leishmania major protein kinase, putative 0.0021 0.0002 0.0038
Brugia malayi Tyrosine-protein kinase abl-1 0.0141 0.0422 0.0925
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.002 0.0001 0.5
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0153 0.0465 1
Schistosoma mansoni tyrosine kinase 0.0043 0.0079 0.0079
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0153 0.0464 0.0464
Brugia malayi Tyrosine-protein kinase abl-1 0.013 0.0384 0.0841
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.2878 1 1
Mycobacterium leprae Conserved hypothetical protein 0.002 0.0001 0.5
Treponema pallidum cyclic nucleotide binding protein 0.002 0.0001 0.5
Loa Loa (eye worm) hypothetical protein 0.0153 0.0465 0.0464
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0043 0.0079 0.0079
Echinococcus granulosus MAM 0.0031 0.0039 0.0039
Echinococcus granulosus aminopeptidase N 0.0153 0.0465 0.0465
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0075 0.0192 0.0192
Loa Loa (eye worm) AGC/PKG protein kinase 0.0021 0.0002 0.0002
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0036 0.0035
Loa Loa (eye worm) hypothetical protein 0.062 0.21 0.2099
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0075 0.0192 0.0192
Echinococcus granulosus tyrosine kinase 0.0031 0.004 0.004
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0075 0.0192 0.0192
Plasmodium falciparum cGMP-dependent protein kinase 0.0021 0.0002 0.0038
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.002 0.0001 0.0001
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0153 0.0464 0.1017
Brugia malayi Variant SH3 domain containing protein 0.0029 0.003 0.0064
Brugia malayi Immunoglobulin I-set domain containing protein 0.0126 0.0372 0.0815
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.003 0.0036 0.0035
Echinococcus granulosus NCK adaptor protein 0.0029 0.003 0.003
Trypanosoma cruzi aminopeptidase, putative 0.0153 0.0465 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0075 0.0192 0.0192
Echinococcus multilocularis NCK adaptor protein 0.0034 0.005 0.005
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0153 0.0465 0.0465
Echinococcus granulosus tyrosine protein kinase Fyn 0.0075 0.0192 0.0192

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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