Detailed information for compound 876980

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 401.44 | Formula: C18H19N5O4S
  • H donors: 3 H acceptors: 4 LogP: -0.09 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC/N=C/c1c(Nc2ccc(cc2)S(=O)(=O)N)nc2n(c1=O)cccc2C
  • InChi: 1S/C18H19N5O4S/c1-12-3-2-9-23-17(12)22-16(15(18(23)25)11-20-8-10-24)21-13-4-6-14(7-5-13)28(19,26)27/h2-7,9,11,21,24H,8,10H2,1H3,(H2,19,26,27)/b20-11+
  • InChiKey: QEUPOYDKKCOCBC-RGVLZGJSSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus GPCR family 2 0.0031 0.011 0.0231
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0025 0.2095
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0037 0.023
Leishmania major heat shock protein 83-1 0.0032 0.0118 1
Trypanosoma brucei unspecified product 0.0019 0.0025 0.2095
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.011 0.0687
Trichomonas vaginalis C-MYB, putative 0.0028 0.0091 0.4103
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0439
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0037 0.0077
Giardia lamblia Grp94/Hsp90 0.0026 0.0071 0.4987
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0025 0.2095
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0037 0.0077
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0585 0.104
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0005 0.0011
Leishmania major heat shock protein 83-1 0.0032 0.0118 1
Loa Loa (eye worm) Smad1 0.0016 0.0005 0.0031
Loa Loa (eye worm) endoplasmin 0.0032 0.0118 0.0737
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0439
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.011 0.0687
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0118 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0037 0.023
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.011 0.0196
Onchocerca volvulus 0.0025 0.007 0.0334
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0037 0.0065
Onchocerca volvulus Peroxidasin homolog 0.0025 0.007 0.0334
Echinococcus multilocularis protein dispatched 1 0.0048 0.023 0.0408
Loa Loa (eye worm) hypothetical protein 0.0021 0.0037 0.023
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0025 0.2095
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0037 0.0077
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0118 1
Brugia malayi heat shock protein 90 0.0032 0.0118 0.0737
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0091 0.4103
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0092 0.4163
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0025 0.2095
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0067 0.5632
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.059 0.3679
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0067 0.5632
Plasmodium falciparum heat shock protein 90 0.0032 0.0118 1
Echinococcus multilocularis heat shock protein 0.0032 0.0118 0.021
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0071 0.6037
Trichomonas vaginalis pc-MYB2, putative 0.0028 0.0091 0.4103
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0091 0.4103
Leishmania major DNA polymerase kappa, putative 0.0019 0.0025 0.2095
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0037 0.0077
Onchocerca volvulus Huntingtin homolog 0.0121 0.0756 0.7154
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0005 0.0011
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0118 0.1668
Echinococcus multilocularis geminin 0.0513 0.3568 0.6337
Echinococcus granulosus microtubule associated protein 2 0.0681 0.4774 1
Onchocerca volvulus Chorion peroxidase homolog 0.0025 0.007 0.0334
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0439
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0037 0.023
Leishmania major heat shock protein 83-1 0.0032 0.0118 1
Leishmania major heat shock protein 83-1 0.0032 0.0118 1
Brugia malayi hypothetical protein 0.0121 0.0756 0.4711
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0206 0.0432
Brugia malayi steroid hormone receptor 0.0021 0.0037 0.023
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0439
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0037 0.023
Loa Loa (eye worm) blistered cuticle protein 3 0.0025 0.007 0.0439
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0037 0.023
Loa Loa (eye worm) hypothetical protein 0.0121 0.0756 0.4711
Leishmania major heat shock protein 83-1 0.0032 0.0118 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.011 0.0687
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0037 0.0077
Loa Loa (eye worm) animal heme peroxidase 0.0025 0.007 0.0439
Brugia malayi hypothetical protein 0.0025 0.0067 0.0415
Trichomonas vaginalis pc-MYB2, putative 0.0028 0.0091 0.4103
Loa Loa (eye worm) hypothetical protein 0.0021 0.0037 0.023
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0118 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.0585 0.3649
Schistosoma mansoni Smad4 0.0016 0.0005 0.0011
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0025 0.0154
Loa Loa (eye worm) animal heme peroxidase 0.0025 0.007 0.0439
Leishmania major hypothetical protein, conserved 0.0025 0.0067 0.5632
Echinococcus multilocularis microtubule associated protein 2 0.0681 0.4774 0.848
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1012 0.7149 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.0005 0.0011
Brugia malayi Endoplasmin precursor 0.0032 0.0118 0.0737
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0037 0.0077
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0091 0.4103
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0037 0.023
Trypanosoma brucei heat shock protein, putative 0.0032 0.0118 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0005 0.0031
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0187 0.0333
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0024 0.2027
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0037 0.0077
Loa Loa (eye worm) hypothetical protein 0.0121 0.0756 0.4711
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0037 0.0065
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0187 0.0392
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0028 0.0091 0.119
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0037 0.023
Echinococcus multilocularis peroxidasin 0.0025 0.007 0.0125
Echinococcus granulosus dna polymerase eta 0.0019 0.0025 0.0052
Echinococcus granulosus geminin 0.0513 0.3568 0.7473
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0187 0.1168
Trichomonas vaginalis MYB3r3, putative 0.0028 0.0091 0.4103
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0118 0.0737
Loa Loa (eye worm) hypothetical protein 0.0051 0.0255 0.1587
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0028 0.0092 0.0337
Echinococcus granulosus smad 0.0016 0.0005 0.0011
Leishmania major heat shock protein 83-1 0.0032 0.0118 1
Brugia malayi Peroxidasin 0.0025 0.007 0.0439
Onchocerca volvulus Huntingtin homolog 0.0121 0.0756 0.7154
Schistosoma mansoni hypothetical protein 0.0031 0.011 0.0231
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0037 0.023
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0037 0.0077
Loa Loa (eye worm) hypothetical protein 0.0025 0.0067 0.0415
Leishmania major heat shock protein 83-1 0.0032 0.0118 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0206 0.0432
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0585 1
Schistosoma mansoni endoplasmin 0.0032 0.0118 0.0248
Brugia malayi Blistered cuticle protein 3 0.0025 0.007 0.0439
Schistosoma mansoni DNA polymerase eta 0.0019 0.0025 0.0052
Echinococcus multilocularis expressed conserved protein 0.0091 0.0543 0.0964
Leishmania major heat shock protein 83-1 0.0032 0.0118 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0439
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0091 0.4103
Onchocerca volvulus Dual oxidase homolog 0.0025 0.007 0.0334
Plasmodium falciparum endoplasmin, putative 0.002 0.0029 0.2478
Schistosoma mansoni hypothetical protein 0.0513 0.3568 0.7473
Echinococcus multilocularis heat shock protein 90 0.0032 0.0118 0.021
Schistosoma mansoni peroxidasin 0.0025 0.007 0.0148
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.011 0.0231
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1409 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0037 0.0077
Brugia malayi Smad1 0.0016 0.0005 0.0031
Schistosoma mansoni hypothetical protein 0.0067 0.0368 0.0771
Schistosoma mansoni hypothetical protein 0.0031 0.011 0.0231
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0037 0.023
Onchocerca volvulus 0.0025 0.007 0.0334
Brugia malayi hypothetical protein 0.0161 0.1042 0.6493
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0037 0.023
Trypanosoma brucei heat shock protein, putative 0.0032 0.0118 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0037 0.023
Schistosoma mansoni hypothetical protein 0.0284 0.1928 0.4038
Echinococcus multilocularis endoplasmin 0.0026 0.0071 0.0127
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.08 0.563 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0439
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0037 0.023
Onchocerca volvulus Peroxidase homolog 0.0025 0.007 0.0334
Brugia malayi MH1 domain containing protein 0.0016 0.0005 0.0031
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0439
Brugia malayi CHE-14 protein 0.0042 0.0187 0.1168
Echinococcus multilocularis heat shock protein 90 0.0026 0.0071 0.0127
Leishmania major heat shock protein 83-1 0.0032 0.0118 1
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0028 0.0091 0.119
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0091 0.4103
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0037 0.023
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0118 0.5753
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0005 0.0031
Loa Loa (eye worm) hypothetical protein 0.0021 0.0037 0.023
Leishmania major heat shock protein 83-1 0.0032 0.0118 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.0005 0.0011
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0397 0.2739 1
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0118 0.1668
Schistosoma mansoni hypothetical protein 0.0031 0.011 0.0231
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0028 0.0091 0.119
Schistosoma mansoni heat shock protein 0.0032 0.0118 0.0248
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0025 0.2095
Loa Loa (eye worm) hypothetical protein 0.0042 0.0187 0.1168
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0037 0.0065
Brugia malayi nuclear receptor NHR-88 0.0021 0.0037 0.023
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0025 0.2095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0037 0.023
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0439
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0025 0.2095
Leishmania major heat shock protein 83-1 0.0032 0.0118 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0037 0.023
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0037 0.023
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0206 0.1287
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0037 0.0065
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0439
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0397 0.2739 0.3769
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0067 0.5632
Onchocerca volvulus 0.0161 0.1042 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0091 0.4103
Trichomonas vaginalis C-MYB, putative 0.0028 0.0091 0.4103
Brugia malayi MH2 domain containing protein 0.0239 0.1604 1
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0071 0.2869
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0037 0.0065
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0206 0.1287
Loa Loa (eye worm) animal heme peroxidase 0.0025 0.007 0.0439
Schistosoma mansoni heat shock protein 0.0032 0.0118 0.0248
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0005 0.0011
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0118 0.0432
Plasmodium vivax endoplasmin, putative 0.0032 0.0118 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0025 0.2095
Loa Loa (eye worm) animal heme peroxidase 0.0025 0.007 0.0439
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0206 0.0432
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0206 0.0367
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0025 0.2095
Leishmania major heat shock protein 83-1 0.0032 0.0118 1
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0585 0.1226
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0071 0.2869
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0118 1
Schistosoma mansoni hypothetical protein 0.0031 0.011 0.0231
Trypanosoma brucei heat shock protein, putative 0.0032 0.0118 1
Trichomonas vaginalis heat shock protein, putative 0.002 0.0029 0.0278
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0118 1
Leishmania major heat shock protein 83-1 0.0032 0.0118 1
Giardia lamblia Myb 1-like protein 0.0028 0.0092 0.7231
Loa Loa (eye worm) hypothetical protein 0.0067 0.0368 0.2294
Loa Loa (eye worm) hypothetical protein 0.0021 0.0037 0.023
Schistosoma mansoni patched 1 0.0042 0.0187 0.0392
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0025 0.0044
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0037 0.023
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1409 1 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0005 0.0009
Schistosoma mansoni endoplasmin 0.0032 0.0118 0.0248
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0397 0.2739 0.2721
Trypanosoma brucei heat shock protein, putative 0.0032 0.0118 1
Onchocerca volvulus 0.0025 0.007 0.0334
Brugia malayi Animal haem peroxidase family protein 0.0025 0.007 0.0439
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0596 0.1248
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0037 0.0065
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0067 0.0243
Loa Loa (eye worm) hypothetical protein 0.0021 0.0037 0.023
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0025 0.2095
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1409 1 1
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0118 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0025 0.2095
Leishmania major DNA polymerase eta, putative 0.0019 0.0025 0.2095
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0037 0.0077
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.059 0.3679
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0368 0.2294
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0037 0.0065
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0025 0.0052
Brugia malayi Animal haem peroxidase family protein 0.0025 0.007 0.0439
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0206 0.0432
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0037 0.0077
Trypanosoma brucei heat shock protein, putative 0.0032 0.0118 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0037 0.023
Brugia malayi hypothetical protein 0.0025 0.007 0.0439
Brugia malayi Animal haem peroxidase family protein 0.0025 0.007 0.0439
Echinococcus multilocularis GPCR, family 2 0.0031 0.011 0.0196
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.011 0.0231
Trichomonas vaginalis MYB72, putative 0.0028 0.0091 0.4103
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0187 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0439
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0071 0.6037
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0037 0.0077
Schistosoma mansoni smad 0.0016 0.0005 0.0011
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0025 0.0035
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0067 0.5632
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0118 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0037 0.0077
Schistosoma mansoni coup transcription factor 0.0021 0.0037 0.0077
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0037 0.023
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0025 0.2095
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0439
Brugia malayi MH1 domain containing protein 0.0016 0.0005 0.0031
Schistosoma mansoni hypothetical protein 0.004 0.0177 0.037
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.0884 0.1571
Brugia malayi MH2 domain containing protein 0.0016 0.0005 0.0031
Loa Loa (eye worm) hypothetical protein 0.0021 0.0037 0.023
Trypanosoma brucei heat shock protein, putative 0.0032 0.0118 1
Schistosoma mansoni microtubule-associated protein tau 0.0681 0.4774 1
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0071 0.015
Leishmania major heat shock protein 83-1 0.0032 0.0118 1
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0037 0.0077
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0037 0.023
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0071 0.2869
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.1604 1
Echinococcus multilocularis protein patched 0.0042 0.0187 0.0333
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1012 0.7149 1
Echinococcus granulosus X box binding protein 1 0.0284 0.1928 0.4038
Leishmania major heat shock protein 83-1 0.0032 0.0118 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0025 0.2095
Echinococcus granulosus heat shock protein 0.0032 0.0118 0.0248
Schistosoma mansoni hypothetical protein 0.004 0.0177 0.037
Echinococcus granulosus heat shock protein 90 0.0026 0.0071 0.015
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0025 0.2095
Echinococcus multilocularis smad 0.0016 0.0005 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0025 0.2095
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0439
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0025 0.0052
Loa Loa (eye worm) hypothetical protein 0.0161 0.1042 0.6493
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0025 0.0154
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.0884 0.1852
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0439
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0025 0.0052
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0037 0.0077
Echinococcus granulosus dna polymerase kappa 0.0019 0.0025 0.0052
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0118 1
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0118 1
Echinococcus multilocularis X box binding protein 1 0.0284 0.1928 0.3425
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0025 0.2095
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0118 1
Echinococcus granulosus heat shock protein 90 0.0032 0.0118 0.0248
Schistosoma mansoni hypothetical protein 0.0513 0.3568 0.7473
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0037 0.023
Onchocerca volvulus Peroxidase homolog 0.0025 0.007 0.0334
Trypanosoma brucei heat shock protein, putative 0.0032 0.0118 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0037 0.0065
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.0071 0.01
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0025 0.2095
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0037 0.023
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.011 0.0196
Echinococcus multilocularis Smad4 0.0016 0.0005 0.0009
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0037 0.0077
Brugia malayi hypothetical protein 0.0016 0.0003 0.0021
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0585 0.3649
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0037 0.023
Onchocerca volvulus Peroxidasin homolog 0.0025 0.007 0.0334
Trichomonas vaginalis endoplasmin, putative 0.002 0.0029 0.0278
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0187 0.0392
Brugia malayi Latrophilin receptor protein 2 0.0031 0.011 0.0687
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0025 0.2095
Echinococcus multilocularis dna polymerase eta 0.0019 0.0025 0.0044
Brugia malayi ecdysteroid receptor 0.0021 0.0037 0.023
Schistosoma mansoni hypothetical protein 0.004 0.0177 0.037
Brugia malayi MH2 domain containing protein 0.0016 0.0005 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0025 0.2095
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0206 0.0367
Schistosoma mansoni peroxidasin 0.0025 0.007 0.0148
Leishmania major heat shock protein 83-1 0.0032 0.0118 1
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.1604 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0037 0.0077
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0206 0.0432
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0037 0.0077
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0439
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0037 0.0077
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0118 0.0432
Loa Loa (eye worm) hypothetical protein 0.0021 0.0037 0.023
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0037 0.0065
Schistosoma mansoni hypothetical protein 0.004 0.0177 0.037
Echinococcus granulosus Smad4 0.0016 0.0005 0.0011
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0037 0.0077
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0028 0.0091 0.119
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0025 0.2095
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0028 0.0091 0.119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0037 0.023
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0067 0.5632
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0025 0.0154
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.059 0.3679
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0037 0.0077
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.0071 0.6037
Brugia malayi nuclear hormone receptor 0.0021 0.0037 0.023
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0071 0.4987
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0092 0.4163
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0037 0.023
Brugia malayi Animal haem peroxidase family protein 0.0025 0.007 0.0439
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0025 0.0044
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0067 0.5632
Echinococcus granulosus endoplasmin 0.0026 0.0071 0.015
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0005 0.0009
Trichomonas vaginalis MYB, putative 0.0028 0.0092 0.4163
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0025 0.0035
Echinococcus granulosus expressed conserved protein 0.0091 0.0543 0.1137
Schistosoma mansoni smad1 5 8 and 0.0016 0.0005 0.0011
Mycobacterium ulcerans heat shock protein 90 0.0026 0.0071 0.0047
Trypanosoma brucei heat shock protein, putative 0.0032 0.0118 1
Brugia malayi Animal haem peroxidase family protein 0.0025 0.007 0.0439
Loa Loa (eye worm) hypothetical protein 0.0098 0.059 0.3679
Echinococcus granulosus peroxidasin 0.0025 0.007 0.0148
Leishmania major heat shock protein 83-1 0.0032 0.0118 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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