TDR Targets

Basic information

Technical information

TDR Targets ID: 877113
Name: 3-[(2,6-dichlorophenyl)methyl]-5-methyl-4-oxo thieno[5,4-d]pyrimidine-6-carboxamide
MW: 368.238 | Formula: C15H11Cl2N3O2S
H donors: 1 H acceptors: 2 LogP: 3.23 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cccc(c1Cn1cnc2c(c1=O)c(C)c(s2)C(=O)N)Cl
InChi: 1S/C15H11Cl2N3O2S/c1-7-11-14(23-12(7)13(18)21)19-6-20(15(11)22)5-8-9(16)3-2-4-10(8)17/h2-4,6H,5H2,1H3,(H2,18,21)
InChiKey: BLFNGILRNFGZNZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-[(2,6-dichlorophenyl)methyl]-5-methyl-4-oxo-thieno[5,4-d]pyrimidine-6-carboxamide
3-[(2,6-dichlorophenyl)methyl]-5-methyl-4-oxo-6-thieno[5,4-d]pyrimidinecarboxamide
3-(2,6-dichlorobenzyl)-4-keto-5-methyl-thieno[5,4-d]pyrimidine-6-carboxamide
ST5202206
BAS 08766418
ZINC00812766

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	peroxidasin	0.4521	1	1
Chlamydia trachomatis	DNA polymerase III subunit alpha	0.1215	0.2605	0.7234
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0073	0.005	0.005
Echinococcus multilocularis	neurogenic locus protein delta	0.1033	0.2197	0.2197
Echinococcus multilocularis	tar DNA binding protein	0.0073	0.005	0.005
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.012	0.0154	0.0418
Toxoplasma gondii	DNA gyrase/topoisomerase IV, A subunit domain-containing protein	0.166	0.3601	1
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.1033	0.2197	0.2197
Schistosoma mansoni	notch	0.1033	0.2197	0.2197
Brugia malayi	Animal haem peroxidase family protein	0.4521	1	1
Plasmodium falciparum	DNA topoisomerase 2	0.0338	0.0643	0.1787
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.005	0.005
Echinococcus multilocularis	lysine specific demethylase 5A	0.0133	0.0184	0.0184
Brugia malayi	Cadherin domain containing protein	0.1033	0.2197	0.2197
Chlamydia trachomatis	DNA gyrase subunit B	0.0466	0.0928	0.2577
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.005	0.005
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.0338	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.1033	0.2197	0.2197
Onchocerca volvulus		0.4521	1	1
Mycobacterium ulcerans	isocitrate lyase Icl	0.0938	0.1984	0.551
Plasmodium vivax	glutathione reductase, putative	0.0053	0.0004	0.0011
Echinococcus granulosus	tar DNA binding protein	0.0073	0.005	0.005
Echinococcus multilocularis	geminin	0.0196	0.0324	0.0324
Brugia malayi	Probable DNA topoisomerase II	0.0338	0.0643	0.0643
Mycobacterium leprae	PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL)	0.0938	0.1984	0.7577
Toxoplasma gondii	EGF family domain-containing protein	0.1033	0.2197	0.6102
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0583	0.119	1
Echinococcus multilocularis	notch	0.1033	0.2197	0.2197
Onchocerca volvulus	Dual oxidase homolog	0.4521	1	1
Plasmodium falciparum	glutathione reductase	0.0053	0.0004	0.0011
Loa Loa (eye worm)	hypothetical protein	0.1033	0.2197	0.2197
Loa Loa (eye worm)	hypothetical protein	0.1033	0.2197	0.2197
Echinococcus multilocularis	neurogenic locus protein delta	0.1033	0.2197	0.2197
Brugia malayi	GCC2 and GCC3 family protein	0.1033	0.2197	0.2197
Echinococcus multilocularis	neural cadherin	0.1033	0.2197	0.2197
Schistosoma mansoni	hypothetical protein	0.1033	0.2197	0.2197
Brugia malayi	notch-like transmembrane receptor	0.1033	0.2197	0.2197
Onchocerca volvulus		0.1033	0.2197	0.2197
Loa Loa (eye worm)	hypothetical protein	0.1033	0.2197	0.2197
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0338	0.0643	0.0643
Chlamydia trachomatis	DNA gyrase subunit B	0.071	0.1475	0.4096
Loa Loa (eye worm)	hypothetical protein	0.4521	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.005	0.005
Mycobacterium ulcerans	hypothetical protein	0.023	0.0401	0.1113
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0133	0.0184	0.0502
Plasmodium vivax	thioredoxin reductase, putative	0.0053	0.0004	0.0011
Trypanosoma brucei	trypanothione reductase	0.0053	0.0004	0.0033
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.012	0.0154	0.0418
Brugia malayi	Blistered cuticle protein 3	0.4521	1	1
Loa Loa (eye worm)	animal heme peroxidase	0.4521	1	1
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0133	0.0184	0.0184
Loa Loa (eye worm)	hypothetical protein	0.1033	0.2197	0.2197
Trichomonas vaginalis	DNA topoisomerase II, putative	0.0338	0.0643	1
Echinococcus multilocularis	slit 2 protein	0.1033	0.2197	0.2197
Loa Loa (eye worm)	hypothetical protein	0.1033	0.2197	0.2197
Onchocerca volvulus	Putative cubilin	0.1033	0.2197	0.2197
Onchocerca volvulus	Chorion peroxidase homolog	0.4521	1	1
Trypanosoma brucei	DNA topoisomerase II beta, putative	0.0288	0.053	0.4451
Schistosoma mansoni	hypothetical protein	0.1033	0.2197	0.2197
Mycobacterium tuberculosis	DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.071	0.1475	0.4089
Echinococcus granulosus	protein jagged 1	0.1033	0.2197	0.2197
Mycobacterium tuberculosis	DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.166	0.3601	1
Plasmodium vivax	DNA gyrase subunit A, putative	0.166	0.3601	1
Schistosoma mansoni	slit	0.1033	0.2197	0.2197
Plasmodium vivax	DNA topoisomerase II, putative	0.0338	0.0643	0.1787
Loa Loa (eye worm)	hypothetical protein	0.0172	0.0272	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0172	0.0272	0.0272
Loa Loa (eye worm)	hypothetical protein	0.1033	0.2197	0.2197
Loa Loa (eye worm)	hypothetical protein	0.4521	1	1
Loa Loa (eye worm)	hypothetical protein	0.4521	1	1
Onchocerca volvulus	Peroxidasin homolog	0.4521	1	1
Brugia malayi	RNA recognition motif domain containing protein	0.0073	0.005	0.005
Echinococcus granulosus	slit 2 protein	0.1033	0.2197	0.2197
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0133	0.0184	0.0502
Echinococcus granulosus	fibropellin Ia	0.1033	0.2197	0.2197
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0583	0.119	1
Brugia malayi	jmjC domain containing protein	0.0133	0.0184	0.0184
Chlamydia trachomatis	DNA gyrase subunit A	0.0172	0.0272	0.0756
Loa Loa (eye worm)	jmjC domain-containing protein	0.0133	0.0184	0.0184
Loa Loa (eye worm)	hypothetical protein	0.4521	1	1
Schistosoma mansoni	jumonji domain containing protein	0.0133	0.0184	0.0184
Brugia malayi	EGF-like domain containing protein	0.1033	0.2197	0.2197
Schistosoma mansoni	hypothetical protein	0.1033	0.2197	0.2197
Brugia malayi	jmjC domain containing protein	0.0133	0.0184	0.0184
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.012	0.0154	0.059
Loa Loa (eye worm)	hypothetical protein	0.1033	0.2197	0.2197
Loa Loa (eye worm)	Notch2	0.1033	0.2197	0.2197
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.0338	0.0643	0.0643
Plasmodium falciparum	DNA gyrase subunit B	0.071	0.1475	0.4096
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.005	0.005
Loa Loa (eye worm)	animal heme peroxidase	0.4521	1	1
Loa Loa (eye worm)	hypothetical protein	0.1033	0.2197	0.2197
Loa Loa (eye worm)	hypothetical protein	0.1033	0.2197	0.2197
Onchocerca volvulus		0.1033	0.2197	0.2197
Mycobacterium leprae	Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase)	0.0244	0.0433	0.1655
Echinococcus granulosus	thioredoxin glutathione reductase	0.0053	0.0004	0.0004
Schistosoma mansoni	hypothetical protein	0.1033	0.2197	0.2197
Echinococcus multilocularis	neurogenic locus notch protein 4	0.1033	0.2197	0.2197
Loa Loa (eye worm)	hypothetical protein	0.4521	1	1
Loa Loa (eye worm)	TOPoisomerase family member	0.0338	0.0643	0.0643
Brugia malayi	Calcium binding EGF domain containing protein	0.1033	0.2197	0.2197
Brugia malayi	TAR-binding protein	0.0073	0.005	0.005
Brugia malayi	Delta serrate ligand family protein	0.1033	0.2197	0.2197
Schistosoma mansoni	septate junction protein	0.1033	0.2197	0.2197
Loa Loa (eye worm)	hypothetical protein	0.4521	1	1
Mycobacterium ulcerans	error-prone DNA polymerase	0.1215	0.2605	0.7234
Schistosoma mansoni	hypothetical protein	0.0196	0.0324	0.0324
Echinococcus multilocularis	protein jagged 1	0.1033	0.2197	0.2197
Loa Loa (eye worm)	hypothetical protein	0.1033	0.2197	0.2197
Brugia malayi	Muscle positioning protein 4	0.1033	0.2197	0.2197
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.005	0.005
Loa Loa (eye worm)	animal heme peroxidase	0.4521	1	1
Toxoplasma gondii	DNA topoisomerase 2, putative	0.0338	0.0643	0.1787
Mycobacterium tuberculosis	Conserved hypothetical protein	0.023	0.0401	0.1103
Brugia malayi	EGF-like domain containing protein	0.1033	0.2197	0.2197
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0133	0.0184	0.0704
Giardia lamblia	High cysteine protein	0.1033	0.2197	1
Schistosoma mansoni	notch	0.1033	0.2197	0.2197
Plasmodium falciparum	thioredoxin reductase	0.0053	0.0004	0.0011
Loa Loa (eye worm)	hypothetical protein	0.1033	0.2197	0.2197
Loa Loa (eye worm)	hypothetical protein	0.4521	1	1
Onchocerca volvulus		0.1033	0.2197	0.2197
Onchocerca volvulus	Peroxidase homolog	0.4521	1	1
Loa Loa (eye worm)	hypothetical protein	0.4521	1	1
Brugia malayi	Animal haem peroxidase family protein	0.4521	1	1
Trypanosoma brucei	DNA topoisomerase II alpha, putative	0.0288	0.053	0.4451
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0144	0.0144
Brugia malayi	EGF-like domain containing protein	0.1033	0.2197	0.2197
Echinococcus granulosus	neurogenic locus notch protein	0.1033	0.2197	0.2197
Plasmodium vivax	DNA gyrase subunit B, putative	0.071	0.1475	0.4096
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.1033	0.2197	0.2197
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.0338	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.4521	1	1
Loa Loa (eye worm)	hypothetical protein	0.1033	0.2197	0.2197
Echinococcus granulosus	protein jagged 2	0.1033	0.2197	0.2197
Treponema pallidum	DNA polymerase III subunit alpha	0.1215	0.2605	0.7234
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.0338	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.1033	0.2197	0.2197
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.1033	0.2197	0.2197
Mycobacterium tuberculosis	Probable dehydrogenase	0.012	0.0154	0.0418
Echinococcus multilocularis	neurogenic locus notch protein	0.1033	0.2197	0.2197
Schistosoma mansoni	notch	0.1033	0.2197	0.2197
Wolbachia endosymbiont of Brugia malayi	DNA gyrase subunit A	0.166	0.3601	1
Mycobacterium tuberculosis	Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase)	0.1221	0.2619	0.727
Loa Loa (eye worm)	hypothetical protein	0.1033	0.2197	0.2197
Schistosoma mansoni	notch	0.1033	0.2197	0.2197
Echinococcus multilocularis	peroxidasin	0.4521	1	1
Mycobacterium tuberculosis	Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl)	0.0938	0.1984	0.5505
Echinococcus granulosus	neurogenic locus protein delta	0.1033	0.2197	0.2197
Echinococcus multilocularis	fibropellin Ia	0.1033	0.2197	0.2197
Onchocerca volvulus	Slit protein homolog	0.1033	0.2197	0.2197
Loa Loa (eye worm)	animal heme peroxidase	0.4521	1	1
Loa Loa (eye worm)	glutathione reductase	0.0053	0.0004	0.0004
Schistosoma mansoni	hypothetical protein	0.1033	0.2197	0.2197
Echinococcus granulosus	protein jagged 1	0.1033	0.2197	0.2197
Mycobacterium tuberculosis	Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase)	0.1221	0.2619	0.727
Schistosoma mansoni	notch	0.1033	0.2197	0.2197
Echinococcus granulosus	geminin	0.0196	0.0324	0.0324
Mycobacterium tuberculosis	Probable reductase	0.012	0.0154	0.0418
Echinococcus granulosus	neurogenic locus notch protein	0.1033	0.2197	0.2197
Entamoeba histolytica	DNA topoisomerase II, putative	0.0338	0.0643	1
Onchocerca volvulus		0.4521	1	1
Loa Loa (eye worm)	hypothetical protein	0.4521	1	1
Schistosoma mansoni	hypothetical protein	0.1033	0.2197	0.2197
Echinococcus granulosus	notch	0.1033	0.2197	0.2197
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.041	0.0804	0.2234
Loa Loa (eye worm)	hypothetical protein	0.4521	1	1
Loa Loa (eye worm)	hypothetical protein	0.1033	0.2197	0.2197
Loa Loa (eye worm)	hypothetical protein	0.1033	0.2197	0.2197
Mycobacterium leprae	Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase)	0.0791	0.1657	0.6328
Brugia malayi	Peroxidasin	0.4521	1	1
Mycobacterium tuberculosis	Isocitrate lyase Icl (isocitrase) (isocitratase)	0.0938	0.1984	0.5505
Mycobacterium tuberculosis	Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl)	0.0938	0.1984	0.5505
Loa Loa (eye worm)	RNA binding protein	0.0073	0.005	0.005
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0288	0.053	0.4451
Giardia lamblia	DNA topoisomerase II	0.0316	0.0593	0.2701
Onchocerca volvulus	Putative DNA topoisomerase 2, mitochondrial	0.0338	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.4521	1	1
Mycobacterium leprae	PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE1 (DNA NUCLEOTIDYLTRANSFERASE)	0.1221	0.2619	1
Plasmodium falciparum	DNA gyrase subunit A	0.166	0.3601	1
Loa Loa (eye worm)	thioredoxin reductase	0.0053	0.0004	0.0004
Schistosoma mansoni	hypothetical protein	0.0196	0.0324	0.0324
Wolbachia endosymbiont of Brugia malayi	DNA gyrase, topoisomerase II, B subunit, GyrB	0.071	0.1475	0.4096
Loa Loa (eye worm)	hypothetical protein	0.1033	0.2197	0.2197
Onchocerca volvulus	Peroxidase homolog	0.4521	1	1
Brugia malayi	Animal haem peroxidase family protein	0.4521	1	1
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0288	0.053	0.4451
Schistosoma mansoni	laminin gamma-3 chain	0.1033	0.2197	0.2197
Loa Loa (eye worm)	notch protein	0.1033	0.2197	0.2197
Brugia malayi	EGF-like domain containing protein	0.1033	0.2197	0.2197
Treponema pallidum	DNA gyrase, subunit B (gyrB)	0.071	0.1475	0.4096
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0144	0.0144
Echinococcus granulosus	neural cadherin	0.1033	0.2197	0.2197
Echinococcus multilocularis	neurogenic locus notch protein	0.1033	0.2197	0.2197
Echinococcus granulosus	protein jagged 2	0.1033	0.2197	0.2197
Leishmania major	DNA topoisomerase ii	0.0288	0.053	0.4451
Onchocerca volvulus		0.4521	1	1
Mycobacterium ulcerans	DNA gyrase subunit B	0.071	0.1475	0.4096
Schistosoma mansoni	hypothetical protein	0.1033	0.2197	0.2197
Brugia malayi	EGF-like domain containing protein	0.1033	0.2197	0.2197
Loa Loa (eye worm)	hypothetical protein	0.4521	1	1
Loa Loa (eye worm)	TAR-binding protein	0.0073	0.005	0.005
Loa Loa (eye worm)	blistered cuticle protein 3	0.4521	1	1
Loa Loa (eye worm)	hypothetical protein	0.1033	0.2197	0.2197
Mycobacterium ulcerans	DNA polymerase III subunit alpha	0.1215	0.2605	0.7234
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0338	0.0643	0.0643
Brugia malayi	glutathione reductase	0.0053	0.0004	0.0004
Echinococcus multilocularis	protein jagged 1	0.1033	0.2197	0.2197
Mycobacterium leprae	Isocitrate lyase	0.044	0.087	0.3321
Brugia malayi	EGF-like domain containing protein	0.1033	0.2197	0.2197
Echinococcus multilocularis	fat cadherin tumor suppressor	0.1033	0.2197	0.2197
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0053	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.4521	1	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0053	0.0004	0.0033
Echinococcus granulosus	delta-like protein 1	0.1033	0.2197	0.2197
Loa Loa (eye worm)	hypothetical protein	0.1033	0.2197	0.2197
Leishmania major	mitochondrial DNA topoisomerase II	0.0583	0.119	1
Brugia malayi	Calcium binding EGF domain containing protein	0.1033	0.2197	0.2197
Echinococcus granulosus	neurogenic locus notch protein 4	0.1033	0.2197	0.2197
Mycobacterium tuberculosis	Probable oxidoreductase	0.0133	0.0184	0.0502
Echinococcus granulosus	peroxidasin	0.4521	1	1
Schistosoma mansoni	peroxidasin	0.4521	1	1
Brugia malayi	RNA binding protein	0.0073	0.005	0.005
Wolbachia endosymbiont of Brugia malayi	DNA polymerase III alpha subunit	0.1215	0.2605	0.7234
Brugia malayi	Calcium binding EGF domain containing protein	0.1033	0.2197	0.2197
Treponema pallidum	DNA gyrase, subunit A (gyrA)	0.166	0.3601	1
Onchocerca volvulus		0.1033	0.2197	0.2197
Brugia malayi	Animal haem peroxidase family protein	0.4521	1	1
Leishmania major	trypanothione reductase	0.0053	0.0004	0.0033
Brugia malayi	Thioredoxin reductase	0.0053	0.0004	0.0004
Onchocerca volvulus	Neurogenic locus notch homolog	0.1033	0.2197	0.2197
Mycobacterium ulcerans	isocitrate lyase AceAb	0.0938	0.1984	0.551
Brugia malayi	Animal haem peroxidase family protein	0.4521	1	1
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.012	0.0154	0.0418
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.012	0.0154	0.0418
Echinococcus granulosus	lysine specific demethylase 5A	0.0133	0.0184	0.0184
Schistosoma mansoni	notch	0.1033	0.2197	0.2197
Brugia malayi	EGF-like domain containing protein	0.1033	0.2197	0.2197
Trypanosoma brucei	DNA topoisomerase ii	0.0583	0.119	1
Onchocerca volvulus	Peroxidasin homolog	0.4521	1	1
Toxoplasma gondii	thioredoxin reductase	0.0053	0.0004	0.0011
Chlamydia trachomatis	DNA gyrase subunit A	0.166	0.3601	1
Schistosoma mansoni	DNA topoisomerase II	0.0338	0.0643	0.0643
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0133	0.0184	0.0184
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0133	0.0184	0.0184
Echinococcus multilocularis	protein jagged 2	0.1033	0.2197	0.2197
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0133	0.0184	0.0184
Loa Loa (eye worm)	hypothetical protein	0.1033	0.2197	0.2197
Mycobacterium ulcerans	DNA gyrase subunit A	0.166	0.3601	1
Onchocerca volvulus		0.1033	0.2197	0.2197
Schistosoma mansoni	cell polarity protein	0.1033	0.2197	0.2197
Loa Loa (eye worm)	hypothetical protein	0.1033	0.2197	0.2197
Brugia malayi	Cadherin domain containing protein	0.1033	0.2197	0.2197

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 877113