Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0121 | 0.0054 | 0.014 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.0054 | 0.0054 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0685 | 0.3877 | 1 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0584 | 0.3193 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0584 | 0.3193 | 0.8236 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.0054 | 0.014 |
Echinococcus multilocularis | caspase 2 | 0.1589 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0685 | 0.3877 | 0.3877 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0753 | 0.4336 | 0.4305 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0584 | 0.3193 | 0.3193 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0121 | 0.0054 | 0.014 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0301 | 0.127 | 0.3276 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0584 | 0.3193 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0301 | 0.127 | 0.127 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.0685 | 0.3877 | 0.3843 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.0054 | 0.014 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0121 | 0.0054 | 0.014 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.0054 | 0.014 |
Leishmania major | cathepsin L-like protease | 0.0121 | 0.0054 | 0.014 |
Loa Loa (eye worm) | hypothetical protein | 0.1589 | 1 | 1 |
Echinococcus multilocularis | caspase 3 | 0.07 | 0.3975 | 0.3942 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0685 | 0.3877 | 1 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0685 | 0.3877 | 1 |
Trypanosoma brucei | metacaspase MCA3 | 0.0685 | 0.3877 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0121 | 0.0054 | 0.014 |
Brugia malayi | hypothetical protein | 0.0753 | 0.4336 | 0.4305 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0121 | 0.0054 | 0.014 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0301 | 0.127 | 0.127 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0121 | 0.0054 | 0.014 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0685 | 0.3877 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0121 | 0.0054 | 0.0054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0121 | 0.0054 | 0.014 |
Leishmania major | cathepsin L-like protease | 0.0121 | 0.0054 | 0.014 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0753 | 0.4336 | 0.4305 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0121 | 0.0054 | 0.0054 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.1385 | 0.8618 | 0.8618 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0584 | 0.3193 | 0.8211 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0301 | 0.127 | 0.127 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0121 | 0.0054 | 0.014 |
Trypanosoma cruzi | metacaspase, putative | 0.0685 | 0.3877 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0685 | 0.3877 | 1 |
Trypanosoma cruzi | metacaspase, putative | 0.0685 | 0.3877 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0685 | 0.3877 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0121 | 0.0054 | 0.014 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0584 | 0.3193 | 0.3193 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0685 | 0.3877 | 1 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.1385 | 0.8618 | 0.8618 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0121 | 0.0054 | 0.014 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.1589 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0121 | 0.0054 | 0.014 |
Echinococcus granulosus | caspase 3 | 0.07 | 0.3975 | 0.3942 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0685 | 0.3877 | 1 |
Plasmodium falciparum | metacaspase-like protein | 0.0685 | 0.3877 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0121 | 0.0054 | 0.014 |
Toxoplasma gondii | cathepsin CPL | 0.0121 | 0.0054 | 0.014 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.0054 | 0.014 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0121 | 0.0054 | 0.014 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0121 | 0.0054 | 0.014 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0121 | 0.0054 | 0.014 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0121 | 0.0054 | 0.014 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0121 | 0.0054 | 0.014 |
Schistosoma mansoni | subfamily C14A unassigned peptidase (C14 family) | 0.0685 | 0.3877 | 0.3877 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0685 | 0.3877 | 1 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0685 | 0.3877 | 1 |
Leishmania major | cathepsin L-like protease | 0.0121 | 0.0054 | 0.014 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.0054 | 0.014 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.0054 | 0.014 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0584 | 0.3193 | 0.8236 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0584 | 0.3193 | 0.8236 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0584 | 0.3193 | 0.8236 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0121 | 0.0054 | 0.014 |
Loa Loa (eye worm) | fibroinase | 0.0121 | 0.0054 | 0.0054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.0054 | 0.014 |
Loa Loa (eye worm) | ctsf protein | 0.0121 | 0.0054 | 0.0054 |
Plasmodium vivax | hypothetical protein, conserved | 0.0685 | 0.3877 | 1 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0584 | 0.3193 | 0.3156 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0121 | 0.0054 | 0.0054 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0685 | 0.3877 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0685 | 0.3877 | 1 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0584 | 0.3193 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0584 | 0.3193 | 0.8236 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0584 | 0.3193 | 0.8211 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.1385 | 0.8618 | 0.8611 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0685 | 0.3877 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.0054 | 0.014 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0301 | 0.127 | 0.1222 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0121 | 0.0054 | 0.014 |
Onchocerca volvulus | 0.0753 | 0.4336 | 0.4305 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.0054 | 0.014 |
Trypanosoma cruzi | metacaspase, putative | 0.0685 | 0.3877 | 1 |
Leishmania major | cathepsin L-like protease | 0.0121 | 0.0054 | 0.014 |
Trypanosoma brucei | Metacaspase-4 | 0.0685 | 0.3877 | 1 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0685 | 0.3877 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0685 | 0.3877 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0753 | 0.4336 | 0.4336 |
Brugia malayi | hypothetical protein | 0.0249 | 0.0917 | 0.0867 |
Echinococcus multilocularis | cathepsin b | 0.0301 | 0.127 | 0.1222 |
Trypanosoma brucei | metacaspase 5, putative | 0.0685 | 0.3877 | 1 |
Echinococcus granulosus | proteasome prosome macropain | 0.0584 | 0.3193 | 0.3156 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.0054 | 0.014 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0121 | 0.0054 | 0.014 |
Loa Loa (eye worm) | hypothetical protein | 0.0753 | 0.4336 | 0.4336 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.0054 | 0.014 |
Leishmania major | cathepsin L-like protease | 0.0121 | 0.0054 | 0.014 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0685 | 0.3877 | 1 |
Echinococcus granulosus | caspase 2 | 0.1589 | 1 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0249 | 0.0917 | 0.0867 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0685 | 0.3877 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0121 | 0.0054 | 0.014 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0685 | 0.3877 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0685 | 0.3877 | 1 |
Echinococcus multilocularis | caspase | 0.1385 | 0.8618 | 0.8611 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.0054 | 0.014 |
Echinococcus granulosus | cathepsin b | 0.0301 | 0.127 | 0.1222 |
Trypanosoma cruzi | metacaspase, putative | 0.0685 | 0.3877 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0685 | 0.3877 | 1 |
Leishmania major | cathepsin L-like protease | 0.0121 | 0.0054 | 0.014 |
Leishmania major | metacaspase, putative | 0.0685 | 0.3877 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0121 | 0.0054 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 0.127 | 0.127 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0121 | 0.0054 | 0.0054 |
Plasmodium vivax | metacaspase 1, putative | 0.0685 | 0.3877 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0121 | 0.0054 | 0.014 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0584 | 0.3193 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0301 | 0.127 | 0.127 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0121 | 0.0054 | 0.014 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0121 | 0.0054 | 0.014 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0121 | 0.0054 | 0.014 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0121 | 0.0054 | 0.014 |
Echinococcus multilocularis | cathepsin b | 0.0301 | 0.127 | 0.1222 |
Leishmania major | cathepsin L-like protease | 0.0121 | 0.0054 | 0.014 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.0054 | 0.014 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.0054 | 0.014 |
Echinococcus granulosus | caspase | 0.1385 | 0.8618 | 0.8611 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0121 | 0.0054 | 0.014 |
Echinococcus granulosus | caspase 8 | 0.0685 | 0.3877 | 0.3843 |
Plasmodium falciparum | metacaspase 1 | 0.0685 | 0.3877 | 1 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.1385 | 0.8618 | 0.8611 |
Trypanosoma brucei | metacaspase | 0.0685 | 0.3877 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.1589 | 1 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0249 | 0.0917 | 0.0867 |
Leishmania major | cathepsin L-like protease | 0.0121 | 0.0054 | 0.014 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0584 | 0.3193 | 0.8236 |
Echinococcus granulosus | cathepsin b | 0.0301 | 0.127 | 0.1222 |
Mycobacterium ulcerans | proteasome PrcB | 0.0584 | 0.3193 | 0.5 |
Echinococcus multilocularis | caspase 8 | 0.0685 | 0.3877 | 0.3843 |
Leishmania major | cysteine peptidase A (CPA) | 0.0121 | 0.0054 | 0.014 |
Trypanosoma brucei | metacaspase MCA2 | 0.0685 | 0.3877 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0584 | 0.3193 | 0.3156 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.