Detailed information for compound 877365

Basic information

Technical information
  • TDR Targets ID: 877365
  • Name: N-(1,1-dioxothiolan-3-yl)-2-(4-methylsulfanyl -2-nitrophenyl)sulfanylacetamide
  • MW: 376.472 | Formula: C13H16N2O5S3
  • H donors: 1 H acceptors: 5 LogP: 1.69 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1ccc(c(c1)[N+](=O)[O-])SCC(=O)NC1CCS(=O)(=O)C1
  • InChi: 1S/C13H16N2O5S3/c1-21-10-2-3-12(11(6-10)15(17)18)22-7-13(16)14-9-4-5-23(19,20)8-9/h2-3,6,9H,4-5,7-8H2,1H3,(H,14,16)
  • InChiKey: BMFHRHWZISVUHZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(1,1-dioxothiolan-3-yl)-2-(4-methylsulfanyl-2-nitro-phenyl)sulfanyl-acetamide
  • N-(1,1-dioxo-3-thiolanyl)-2-[[4-(methylthio)-2-nitrophenyl]thio]acetamide
  • N-(1,1-diketothiolan-3-yl)-2-[[4-(methylthio)-2-nitro-phenyl]thio]acetamide
  • N-(1,1-dioxothiolan-3-yl)-2-(4-methylsulfanyl-2-nitro-phenyl)sulfanyl-ethanamide
  • ST5324668
  • Oprea1_671571

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0152 0.5
Schistosoma mansoni opsin-like receptor 0.0098 0.0704 0.3412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.007 0.0023
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0098 0.0704 0.3412
Schistosoma mansoni biogenic amine (5HT) receptor 0.0098 0.0704 0.3412
Schistosoma mansoni neuropeptide receptor 0.0098 0.0704 0.3412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0225 0.0178
Echinococcus granulosus tm gpcr rhodopsin 0.0098 0.0704 0.3412
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Loa Loa (eye worm) hypothetical protein 0.0735 0.6345 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0043 0.0225 0.0354
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0098 0.0704 0.3412
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0043 0.0225 0.0268
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Schistosoma mansoni adenoreceptor 0.0098 0.0704 0.3412
Echinococcus granulosus g protein coupled receptor 0.0098 0.0704 0.3412
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0098 0.0704 0.3412
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0043 0.0225 0.0268
Echinococcus multilocularis serotonin receptor 0.0218 0.1771 1
Schistosoma mansoni neuropeptide receptor 0.0098 0.0704 0.3412
Brugia malayi Thioredoxin reductase 0.0046 0.0245 0.03
Trichomonas vaginalis modulator of drug activity B, putative 0.0287 0.2379 0.2342
Trichomonas vaginalis modulator of drug activity B, putative 0.0287 0.2379 0.2342
Echinococcus multilocularis fmrfamide receptor 0.0098 0.0704 0.3412
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0098 0.0704 0.3412
Loa Loa (eye worm) G-protein coupled receptor 0.0098 0.0704 0.1031
Trichomonas vaginalis modulator of drug activity B, putative 0.0287 0.2379 0.2342
Giardia lamblia NADPH oxidoreductase, putative 0.1148 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0098 0.0704 0.3412
Trichomonas vaginalis esterase, putative 0.0035 0.0152 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.1148 1 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0098 0.0704 0.3412
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0098 0.0704 0.3412
Echinococcus granulosus g protein coupled receptor 0.0098 0.0704 0.3412
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Onchocerca volvulus 0.0098 0.0704 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.0763 0.3638
Giardia lamblia NADPH oxidoreductase, putative 0.1148 1 1
Brugia malayi beta-lactamase family protein 0.0035 0.0152 0.0153
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0152 0.0105
Echinococcus granulosus biogenic amine 5HT receptor 0.0218 0.1771 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0287 0.2379 0.2342
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0735 0.6345 1
Brugia malayi GnHR receptor homolog 0.0098 0.0704 0.1031
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0098 0.0704 0.3412
Echinococcus multilocularis neuropeptide s receptor 0.0098 0.0704 0.3412
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0245 0.03
Echinococcus multilocularis orexin receptor type 2 0.0098 0.0704 0.3412
Echinococcus multilocularis G protein coupled receptor 139 0.0098 0.0704 0.3412
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0098 0.0704 0.3412
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0098 0.0704 0.3412
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Echinococcus granulosus g-protein coupled receptor 0.0098 0.0704 0.3412
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0098 0.0704 0.3412
Echinococcus multilocularis g protein coupled receptor 0.0098 0.0704 0.3412
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0098 0.0704 0.3412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0146 0.0099
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0043 0.0225 0.0268
Echinococcus granulosus G protein coupled receptor 139 0.0098 0.0704 0.3412
Schistosoma mansoni neuropeptide receptor 0.0098 0.0704 0.3412
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Loa Loa (eye worm) hypothetical protein 0.0035 0.0152 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0146 0.0099
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0098 0.0704 0.3412
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0152 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.1148 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0098 0.0704 0.3412
Schistosoma mansoni myosin xvIII 0.0098 0.0704 0.3412
Echinococcus multilocularis neuropeptides capa receptor 0.0098 0.0704 0.3412
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Echinococcus granulosus rhodopsin orphan GPCR 0.0098 0.0704 0.3412
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.009 0.0042
Echinococcus multilocularis neuropeptide receptor 0.0098 0.0704 0.3412
Echinococcus multilocularis g protein coupled receptor 0.0098 0.0704 0.3412
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0098 0.0704 0.3412
Trichomonas vaginalis conserved hypothetical protein 0.1148 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0098 0.0704 0.3412
Schistosoma mansoni biogenic amine receptor 0.0098 0.0704 0.3412
Echinococcus granulosus tm gpcr rhodopsin 0.0098 0.0704 0.3412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0126 0.0079
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0866 0.4251
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0126 0.0079
Trypanosoma brucei C-8 sterol isomerase, putative 0.0735 0.6345 1
Brugia malayi larval opioid receptor 0.0098 0.0704 0.1031
Trichomonas vaginalis modulator of drug activity B, putative 0.0287 0.2379 0.2342
Echinococcus granulosus neuropeptides capa receptor 0.0098 0.0704 0.3412
Echinococcus granulosus neuropeptide s receptor 0.0098 0.0704 0.3412
Onchocerca volvulus 0.0098 0.0704 1
Brugia malayi hypothetical protein 0.0098 0.0704 0.1031
Trichomonas vaginalis conserved hypothetical protein 0.0861 0.7462 0.7449
Schistosoma mansoni hypothetical protein 0.0098 0.0704 0.3412
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0098 0.0704 0.3412
Toxoplasma gondii thioredoxin reductase 0.0046 0.0245 1
Onchocerca volvulus 0.0098 0.0704 1
Brugia malayi RE15519p 0.0098 0.0704 0.1031
Echinococcus multilocularis serotonin receptor 0.0218 0.1771 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0146 0.0144
Leishmania major trypanothione reductase 0.0046 0.0245 0.03
Schistosoma mansoni growth hormone secretagogue receptor 0.0098 0.0704 0.3412
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0152 0.0105
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0098 0.0704 0.1031
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Trichomonas vaginalis conserved hypothetical protein 0.1148 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0098 0.0704 0.1031
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0098 0.0704 0.3412
Echinococcus granulosus rhodopsin orphan GPCR 0.0098 0.0704 0.3412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0098 0.0051
Echinococcus multilocularis g-protein coupled receptor 0.0098 0.0704 0.3412
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Schistosoma mansoni opsin-like receptor 0.0098 0.0704 0.3412
Onchocerca volvulus 0.0098 0.0704 1
Loa Loa (eye worm) beta-lactamase 0.0035 0.0152 0.0153
Loa Loa (eye worm) hypothetical protein 0.0218 0.1771 0.2727
Brugia malayi hypothetical protein 0.0098 0.0704 0.1031
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.1148 1 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.0763 0.3638
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.0763 0.8558
Onchocerca volvulus Neuropeptide F receptor homolog 0.0098 0.0704 1
Loa Loa (eye worm) glutathione reductase 0.0046 0.0245 0.03
Brugia malayi beta-lactamase family protein 0.0035 0.0152 0.0153
Loa Loa (eye worm) G-protein coupled receptor 0.0098 0.0704 0.1031
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0043 0.0225 0.0449
Trichomonas vaginalis conserved hypothetical protein 0.1148 1 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Onchocerca volvulus 0.0098 0.0704 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0098 0.0704 0.3412
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Brugia malayi hypothetical protein 0.0098 0.0704 0.1031
Loa Loa (eye worm) hypothetical protein 0.0035 0.0152 0.0153
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0098 0.0704 0.3412
Schistosoma mansoni amine GPCR 0.0098 0.0704 0.3412
Onchocerca volvulus 0.0098 0.0704 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0287 0.2379 0.2342
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0245 0.0573
Trichomonas vaginalis conserved hypothetical protein 0.1148 1 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0146 0.0231
Brugia malayi ORL1-like opioid receptor 0.0098 0.0704 0.1031
Schistosoma mansoni hypothetical protein 0.0098 0.0704 0.3412
Echinococcus granulosus serotonin receptor 0.0098 0.0704 0.3412
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0098 0.0704 0.3412
Leishmania major C-8 sterol isomerase-like protein 0.0735 0.6345 1
Trichomonas vaginalis conserved hypothetical protein 0.1148 1 1
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0287 0.2379 0.2342
Trichomonas vaginalis modulator of drug activity B, putative 0.0287 0.2379 0.2342
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.0763 0.3638
Schistosoma mansoni amine GPCR 0.0098 0.0704 0.3412
Echinococcus multilocularis rhodopsin orphan GPCR 0.0098 0.0704 0.3412
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0098 0.0704 0.1031
Echinococcus granulosus neuropeptide receptor 0.0098 0.0704 0.3412
Brugia malayi follicle stimulating hormone receptor 0.0098 0.0704 0.1031
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0043 0.0225 0.0449
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0068 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0225 0.0178
Echinococcus granulosus biogenic amine 5HT receptor 0.0098 0.0704 0.3412
Echinococcus granulosus somatostatin receptor 0.0098 0.0704 0.3412
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0245 0.0573
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.0287 0.2379 0.2342
Plasmodium vivax glutathione reductase, putative 0.0046 0.0245 1
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.1148 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0287 0.2379 0.2342
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0098 0.0704 0.3412
Echinococcus granulosus 7tm_1 domain containing protein 0.0098 0.0704 0.3412
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Loa Loa (eye worm) melatonin receptor type 1A 0.0098 0.0704 0.1031
Schistosoma mansoni biogenic amine receptor 0.0098 0.0704 0.3412
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0152 0.0153
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0735 0.6345 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0152 0.0153
Loa Loa (eye worm) hypothetical protein 0.0035 0.0152 0.0153
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0043 0.0225 0.0449
Trichomonas vaginalis conserved hypothetical protein 0.0287 0.2379 0.2342
Trichomonas vaginalis modulator of drug activity B, putative 0.0287 0.2379 0.2342
Brugia malayi glutathione reductase 0.0046 0.0245 0.03
Brugia malayi Dopamine receptor protein 2 0.0098 0.0704 0.1031
Loa Loa (eye worm) hypothetical protein 0.0376 0.3165 0.4944
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Echinococcus granulosus hypothetical protein 0.0098 0.0704 0.3412
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Echinococcus multilocularis neuropeptide receptor 0.0098 0.0704 0.3412
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0098 0.0704 0.3412
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Brugia malayi neuropeptide F receptor 0.0098 0.0704 0.1031
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0152 0.5
Brugia malayi beta-lactamase 0.0035 0.0152 0.0153
Echinococcus granulosus neuropeptide Y receptor 0.0098 0.0704 0.3412
Echinococcus multilocularis allatostatin A receptor 0.0098 0.0704 0.3412
Entamoeba histolytica hypothetical protein 0.0287 0.2379 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0287 0.2379 0.2342
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0098 0.0704 0.3412
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0245 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0287 0.2379 0.2342
Brugia malayi G protein-coupled receptor 0.0098 0.0704 0.1031
Brugia malayi hypothetical protein 0.0098 0.0704 0.1031
Trypanosoma brucei trypanothione reductase 0.0046 0.0245 0.0386
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.0287 0.2379 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0245 0.0553
Schistosoma mansoni neuropeptide F-like receptor 0.0098 0.0704 0.3412
Schistosoma mansoni biogenic amine (5HT) receptor 0.0218 0.1771 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0152 0.0153
Mycobacterium tuberculosis Probable reductase 0.0104 0.0763 0.3638
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0098 0.0704 0.3412
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0098 0.0704 0.3412
Trichomonas vaginalis modulator of drug activity B, putative 0.0287 0.2379 0.2342
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0098 0.0704 0.3412
Onchocerca volvulus 0.0098 0.0704 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0098 0.0704 0.3412
Schistosoma mansoni biogenic amine receptor 0.0098 0.0704 0.3412
Brugia malayi putative neuropeptide receptor NPR1 0.0098 0.0704 0.1031
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.1148 1 1
Plasmodium falciparum glutathione reductase 0.0046 0.0245 1
Mycobacterium ulcerans beta-lactamase 0.0035 0.0152 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0098 0.0704 0.3412
Echinococcus granulosus alpha 1A adrenergic receptor 0.0098 0.0704 0.3412
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.007 0.0023
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Entamoeba histolytica modulator of drug activity B homolog, putative 0.0287 0.2379 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0098 0.0704 0.3412
Echinococcus granulosus neuropeptides capa receptor 0.0098 0.0704 0.3412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0146 0.0099
Schistosoma mansoni neuropeptide F-like receptor 0.0098 0.0704 0.3412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0146 0.0099
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.1831 1
Schistosoma mansoni hypothetical protein 0.0098 0.0704 0.3412
Brugia malayi hypothetical protein 0.0098 0.0704 0.1031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0126 0.0079
Onchocerca volvulus 0.0098 0.0704 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0152 0.0153
Trichomonas vaginalis modulator of drug activity B, putative 0.0287 0.2379 0.2342
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0146 0.0144
Echinococcus multilocularis sex peptide receptor 0.0098 0.0704 0.3412
Trichomonas vaginalis conserved hypothetical protein 0.1148 1 1
Loa Loa (eye worm) hypothetical protein 0.0218 0.1771 0.2727
Echinococcus multilocularis g protein coupled receptor 0.0098 0.0704 0.3412
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0098 0.0704 0.3412
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0152 0.0239
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0022 0.0035
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0098 0.0704 0.3412
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0043 0.0225 0.0354
Trichomonas vaginalis modulator of drug activity B, putative 0.0287 0.2379 0.2342
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0098 0.0704 0.3412
Onchocerca volvulus 0.0098 0.0704 1
Onchocerca volvulus 0.0098 0.0704 1
Toxoplasma gondii ABC1 family protein 0.0035 0.0152 0.5085
Echinococcus granulosus g protein coupled receptor 0.0098 0.0704 0.3412
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0098 0.0704 0.1031
Brugia malayi Tachykinin-like peptides receptor 99D 0.0098 0.0704 0.1031
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0098 0.0704 0.3412
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Echinococcus multilocularis neuropeptides capa receptor 0.0098 0.0704 0.3412
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0098 0.0704 0.3412
Mycobacterium ulcerans hypothetical protein 0.0035 0.0152 0.5
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.0763 0.3638
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0098 0.0704 0.1031
Brugia malayi putative neuropeptide receptor 0.0098 0.0704 0.1031
Schistosoma mansoni amine GPCR 0.0098 0.0704 0.3412
Trichomonas vaginalis conserved hypothetical protein 0.0287 0.2379 0.2342
Brugia malayi Dopamine receptor 0.0098 0.0704 0.1031
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0098 0.0704 0.3412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0126 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.007 0.0023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0098 0.0704 0.3412
Trichomonas vaginalis conserved hypothetical protein 0.0287 0.2379 0.2342
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Onchocerca volvulus 0.0098 0.0704 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0098 0.0704 0.1031
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0098 0.0704 0.3412
Echinococcus granulosus neuropeptide receptor 0.0098 0.0704 0.3412
Trichomonas vaginalis conserved hypothetical protein 0.0287 0.2379 0.2342
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0098 0.0704 0.3412
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Loa Loa (eye worm) TYRA-2 protein 0.0098 0.0704 0.1031
Echinococcus granulosus rhodopsin orphan GPCR 0.0098 0.0704 0.3412
Trichomonas vaginalis conserved hypothetical protein 0.0287 0.2379 0.2342
Echinococcus multilocularis neuropeptide receptor A26 0.0098 0.0704 0.3412
Onchocerca volvulus 0.0098 0.0704 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0152 0.0105
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0098 0.0704 0.1031
Brugia malayi G protein-coupled receptor F59B2.13 0.0098 0.0704 0.1031
Brugia malayi sulfakinin receptor protein 0.0098 0.0704 0.1031
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0098 0.0704 0.3412
Echinococcus granulosus rhodopsin orphan GPCR 0.0098 0.0704 0.3412
Brugia malayi hypothetical protein 0.0098 0.0704 0.1031
Brugia malayi G-protein coupled receptor 0.0098 0.0704 0.1031
Schistosoma mansoni alpha-1 adrenergic receptor 0.0098 0.0704 0.3412
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Echinococcus granulosus allatostatin A receptor 0.0098 0.0704 0.3412
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Echinococcus granulosus rhodopsin orphan GPCR 0.0098 0.0704 0.3412
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0098 0.0704 0.3412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0126 0.0079
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Onchocerca volvulus 0.0098 0.0704 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0287 0.2379 0.2342
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0126 0.0079
Echinococcus granulosus tm gpcr rhodopsin 0.0098 0.0704 0.3412
Trichomonas vaginalis modulator of drug activity B, putative 0.0287 0.2379 0.2342
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.0225 0.0268
Echinococcus granulosus rhodopsin orphan GPCR 0.0098 0.0704 0.3412
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0098 0.0704 0.3412
Echinococcus granulosus neuropeptide FF receptor 2 0.0098 0.0704 0.3412
Echinococcus multilocularis neuropeptide Y receptor 0.0098 0.0704 0.3412
Echinococcus granulosus 7TM GPCR rhodopsin 0.0098 0.0704 0.3412
Trichomonas vaginalis modulator of drug activity B, putative 0.0287 0.2379 0.2342
Brugia malayi Serotonin receptor 0.0098 0.0704 0.1031
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0098 0.0704 0.1031
Trichomonas vaginalis conserved hypothetical protein 0.1148 1 1
Schistosoma mansoni histamine h1 receptor 0.0098 0.0704 0.3412
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.0763 0.3638
Trichomonas vaginalis modulator of drug activity B, putative 0.0287 0.2379 0.2342
Schistosoma mansoni amine GPCR 0.0098 0.0704 0.3412
Schistosoma mansoni opsin-like receptor 0.0098 0.0704 0.3412
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0098 0.0704 0.3412
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0866 0.4251
Onchocerca volvulus 0.0098 0.0704 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0098 0.0704 0.3412
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0287 0.2379 0.2342
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Leishmania major hypothetical protein, conserved 0.0035 0.0152 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.1148 1 1
Trichomonas vaginalis conserved hypothetical protein 0.1148 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0152 0.0105
Loa Loa (eye worm) hypothetical protein 0.0035 0.0152 0.0153
Brugia malayi AKH receptor 0.0098 0.0704 0.1031
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0043 0.0225 0.0268
Trichomonas vaginalis conserved hypothetical protein 0.0287 0.2379 0.2342
Trichomonas vaginalis modulator of drug activity B, putative 0.0287 0.2379 0.2342
Onchocerca volvulus 0.0098 0.0704 1
Echinococcus multilocularis neuropeptide Y receptor 0.0098 0.0704 0.3412
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0866 0.4251
Schistosoma mansoni amine GPCR 0.0098 0.0704 0.3412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0146 0.0099
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0168 0.0121
Echinococcus multilocularis somatostatin receptor 0.0098 0.0704 0.3412
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0152 0.0153
Echinococcus multilocularis rhodopsin orphan GPCR 0.0098 0.0704 0.3412
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0126 0.3722
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Onchocerca volvulus 0.0098 0.0704 1
Echinococcus granulosus dro:myosuppressin receptor 0.0098 0.0704 0.3412
Loa Loa (eye worm) neuropeptide F receptor 0.0098 0.0704 0.1031
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0098 0.0704 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0098 0.0704 0.3412
Echinococcus granulosus neuropeptide receptor A26 0.0098 0.0704 0.3412
Loa Loa (eye worm) phosphatidylinositol 3 0.0043 0.0225 0.0268
Schistosoma mansoni hypothetical protein 0.0098 0.0704 0.3412
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0098 0.0704 0.3412
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0245 0.03
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Brugia malayi Melatonin receptor type 1A 0.0098 0.0704 0.1031
Trichomonas vaginalis modulator of drug activity B, putative 0.0287 0.2379 0.2342
Brugia malayi hypothetical protein 0.0098 0.0704 0.1031
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Trichomonas vaginalis conserved hypothetical protein 0.0287 0.2379 0.2342
Brugia malayi hypothetical protein 0.0098 0.0704 0.1031
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0098 0.0704 0.1031
Echinococcus granulosus orexin receptor type 2 0.0098 0.0704 0.3412
Schistosoma mansoni neuropeptide receptor 0.0098 0.0704 0.3412
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0152 0.5085
Brugia malayi hypothetical protein 0.0098 0.0704 0.1031
Echinococcus granulosus fmrfamide receptor 0.0098 0.0704 0.3412
Echinococcus multilocularis rhodopsin orphan GPCR 0.0098 0.0704 0.3412
Brugia malayi Dopamine receptor protein 1 0.0098 0.0704 0.1031
Brugia malayi hypothetical protein 0.0098 0.0704 0.1031
Trichomonas vaginalis conserved hypothetical protein 0.1148 1 1
Echinococcus multilocularis fmrfamide receptor 0.0098 0.0704 0.3412
Echinococcus multilocularis rhodopsin orphan GPCR 0.0098 0.0704 0.3412
Onchocerca volvulus 0.0098 0.0704 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0098 0.0704 0.3412
Echinococcus multilocularis rhodopsin orphan GPCR 0.0098 0.0704 0.3412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0225 0.0178
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Echinococcus granulosus sex peptide receptor 0.0098 0.0704 0.3412
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0152 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0068 0.002
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0098 0.0704 0.1031
Mycobacterium ulcerans lipase LipD 0.0035 0.0152 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0098 0.0704 0.3412
Brugia malayi Serotonin receptor 0.0098 0.0704 0.1031
Echinococcus multilocularis dro:myosuppressin receptor 0.0098 0.0704 0.3412
Echinococcus granulosus peptide allatostatin:somatostatin 0.0098 0.0704 0.3412
Trichomonas vaginalis conserved hypothetical protein 0.0287 0.2379 0.2342
Brugia malayi G-protein coupled receptor 0.0098 0.0704 0.1031
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0866 1
Trichomonas vaginalis conserved hypothetical protein 0.1148 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0098 0.0704 0.3412
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Brugia malayi neuropeptide F receptor 0.0098 0.0704 0.1031
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0056 0.0088
Plasmodium falciparum thioredoxin reductase 0.0046 0.0245 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Loa Loa (eye worm) hypothetical protein 0.0098 0.0704 0.1031
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0098 0.0704 0.1031
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0098 0.0704 0.3412
Trichomonas vaginalis modulator of drug activity B, putative 0.0287 0.2379 0.2342
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0126 0.0079
Echinococcus granulosus rhodopsin orphan GPCR 0.0098 0.0704 0.3412

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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