Detailed information for compound 877441

Basic information

Technical information
  • TDR Targets ID: 877441
  • Name: 3-(6-bromo-4H-1,3-benzodioxin-8-yl)-1-(2-hydr oxy-5-methylphenyl)prop-2-en-1-one
  • MW: 375.213 | Formula: C18H15BrO4
  • H donors: 1 H acceptors: 2 LogP: 4.43 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1cc(C=CC(=O)c2cc(C)ccc2O)c2c(c1)COCO2
  • InChi: 1S/C18H15BrO4/c1-11-2-4-16(20)15(6-11)17(21)5-3-12-7-14(19)8-13-9-22-10-23-18(12)13/h2-8,20H,9-10H2,1H3/b5-3+
  • InChiKey: VNPPMVHBQZPIFM-HWKANZROSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (E)-3-(6-bromo-4H-1,3-benzodioxin-8-yl)-1-(2-hydroxy-5-methylphenyl)prop-2-en-1-one
  • (E)-3-(6-bromo-4H-1,3-benzodioxin-8-yl)-1-(2-hydroxy-5-methyl-phenyl)prop-2-en-1-one
  • 3-(6-bromo-4H-1,3-benzodioxin-8-yl)-1-(2-hydroxy-5-methyl-phenyl)prop-2-en-1-one
  • ZINC04024658
  • STOCK1N-04008

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.005 0.003
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.0536 0.0517
Toxoplasma gondii exonuclease III APE 0.0022 0.0091 0.1244
Brugia malayi nuclear hormone receptor 0.0656 0.9496 1
Onchocerca volvulus 0.0029 0.0193 0.0147
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0561 0.059
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0642 0.0623
Brugia malayi conserved hypotetical protein 0.0019 0.005 0.0053
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0367 0.0324
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0532 0.0513
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0084 0.0088
Loa Loa (eye worm) hypothetical protein 0.0021 0.0084 0.0088
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0618 0.0599
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0021 0.0023
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0044 0.0024
Schistosoma mansoni lipoxygenase 0.0102 0.1282 0.1265
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0367 0.0348
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0021 0.0023
Brugia malayi hypothetical protein 0.0039 0.0352 0.0371
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.057 0.0601
Echinococcus granulosus GPCR family 2 0.0017 0.0021 0.0001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0084 0.0088
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.005 0.003
Loa Loa (eye worm) hypothetical protein 0.0039 0.0352 0.0371
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0532 0.0513
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0367 0.0386
Echinococcus granulosus RUN 0.0039 0.0352 0.0333
Brugia malayi hypothetical protein 0.0021 0.0084 0.0088
Onchocerca volvulus 0.0033 0.0257 0.0212
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0367 0.0348
Loa Loa (eye worm) hypothetical protein 0.0052 0.0536 0.0564
Brugia malayi jmjC domain containing protein 0.0017 0.002 0.0021
Schistosoma mansoni thyroid hormone receptor 0.004 0.0367 0.0348
Schistosoma mansoni lamin 0.0029 0.0202 0.0182
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.0739 0.072
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0367 0.0348
Loa Loa (eye worm) hypothetical protein 0.0019 0.005 0.0053
Brugia malayi hypothetical protein 0.0021 0.0084 0.0088
Brugia malayi nuclear hormone receptor 0.004 0.0367 0.0386
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0064 0.0715 0.0696
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.005 0.003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0367 0.0386
Schistosoma mansoni nuclear hormone receptor 0.004 0.0367 0.0348
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0642 0.0623
Schistosoma mansoni cpg binding protein 0.0029 0.0193 0.0174
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0021 0.0001
Echinococcus granulosus dnaJ subfamily B 0.0409 0.5832 0.5824
Onchocerca volvulus 0.0258 0.3592 0.3628
Schistosoma mansoni survival motor neuron protein 0.0057 0.0605 0.0586
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.005 0.0053
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.005 0.003
Loa Loa (eye worm) hypothetical protein 0.0049 0.0501 0.0527
Loa Loa (eye worm) hypothetical protein 0.0039 0.0352 0.0371
Echinococcus multilocularis musashi 0.0029 0.0202 0.0182
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0367 0.0348
Schistosoma mansoni thyroid hormone receptor 0.004 0.0367 0.0348
Echinococcus multilocularis tumor protein p63 0.0338 0.4778 0.4767
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0352 0.0333
Schistosoma mansoni ap endonuclease 0.0022 0.0091 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0367 0.0386
Echinococcus multilocularis lamin 0.0029 0.0202 0.0182
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0367 0.0348
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0642 0.0623
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.005 0.003
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0618 0.0599
Brugia malayi intermediate filament protein 0.0029 0.0202 0.0212
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0209 0.286 0.2846
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.005 0.003
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0352 0.0333
Schistosoma mansoni hypothetical protein 0.0409 0.5832 0.5824
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0532 0.0513
Schistosoma mansoni loxhd1 0.0039 0.0352 0.0333
Echinococcus granulosus lamin dm0 0.0029 0.0202 0.0182
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0618 1
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0367 0.0386
Loa Loa (eye worm) hypothetical protein 0.0021 0.0084 0.0088
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0021 0.0001
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.0536 0.0517
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0352 0.0333
Brugia malayi jmjC domain containing protein 0.0066 0.0739 0.0778
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0367 0.0386
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0173 0.2335 0.2319
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0084 0.0088
Onchocerca volvulus 0.0039 0.0352 0.0309
Onchocerca volvulus 0.0039 0.0352 0.0309
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.005 0.003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0202 0.0212
Loa Loa (eye worm) hypothetical protein 0.0019 0.005 0.0053
Brugia malayi mbt repeat family protein 0.0052 0.0536 0.0564
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.057 0.0601
Loa Loa (eye worm) hypothetical protein 0.0019 0.005 0.0053
Loa Loa (eye worm) hypothetical protein 0.004 0.0367 0.0386
Loa Loa (eye worm) hypothetical protein 0.0019 0.005 0.0053
Brugia malayi Doublecortin family protein 0.0039 0.0352 0.0371
Loa Loa (eye worm) hypothetical protein 0.0021 0.0084 0.0088
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0367 0.0348
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.005 0.003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0194 0.0204
Schistosoma mansoni ap endonuclease 0.0022 0.0091 0.0071
Loa Loa (eye worm) hypothetical protein 0.0277 0.3873 0.4078
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0257 0.0238
Brugia malayi tailless protein 0.0019 0.005 0.0053
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0367 0.0348
Echinococcus granulosus lysine specific demethylase 5A 0.0066 0.0739 0.072
Loa Loa (eye worm) hypothetical protein 0.004 0.0367 0.0386
Loa Loa (eye worm) hypothetical protein 0.004 0.0367 0.0386
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0091 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.002 0.0021
Brugia malayi hypothetical protein 0.0277 0.3873 0.4078
Loa Loa (eye worm) hypothetical protein 0.004 0.0367 0.0386
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0084 0.0064
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.023 0.0211
Echinococcus multilocularis microtubule associated protein 2 0.069 1 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0091 0.5
Echinococcus multilocularis GPCR, family 2 0.0017 0.0021 0.0001
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0084 0.0088
Brugia malayi hypothetical protein 0.0019 0.005 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0367 0.0386
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0367 0.0348
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.005 0.0053
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0352 0.0333
Loa Loa (eye worm) hypothetical protein 0.0019 0.005 0.0053
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0367 0.0348
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0257 0.0238
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0057 0.0605 0.0637
Brugia malayi nuclear receptor NHR-88 0.004 0.0367 0.0386
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0257 0.0238
Echinococcus multilocularis lamin dm0 0.0029 0.0202 0.0182
Loa Loa (eye worm) hypothetical protein 0.0637 0.9213 0.9702
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.0536 0.0517
Brugia malayi jmjC domain containing protein 0.0017 0.002 0.0021
Loa Loa (eye worm) hypothetical protein 0.0037 0.0316 0.0333
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0021
Echinococcus granulosus tumor protein p63 0.0338 0.4778 0.4767
Echinococcus multilocularis geminin 0.0381 0.5414 0.5405
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0173 0.2335 0.2319
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0257 0.0238
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.0536 0.0517
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0367 0.0386
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0202 0.0212
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0367 0.0386
Brugia malayi Pre-SET motif family protein 0.0227 0.3129 0.3295
Schistosoma mansoni nuclear receptor 0.0019 0.005 0.003
Brugia malayi ecdysteroid receptor 0.004 0.0367 0.0386
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0367 0.0386
Brugia malayi nuclear receptor NHR-88 0.0019 0.005 0.0053
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0021
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0367 0.0386
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0501 0.0482
Schistosoma mansoni coup transcription factor 0.004 0.0367 0.0348
Loa Loa (eye worm) hypothetical protein 0.004 0.0367 0.0386
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0367 0.0348
Schistosoma mansoni lipoxygenase 0.0173 0.2335 0.2319
Loa Loa (eye worm) hypothetical protein 0.0019 0.005 0.0053
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0532 0.056
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.0536 0.0564
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0592 1
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.005 0.003
Brugia malayi Nuclear hormone receptor E75 0.0019 0.005 0.0053
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0367 0.0348
Loa Loa (eye worm) hypothetical protein 0.0019 0.005 0.0053
Schistosoma mansoni hypothetical protein 0.0017 0.0021 0.0001
Brugia malayi mbt repeat family protein 0.0052 0.0536 0.0564
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0091 0.0096
Onchocerca volvulus 0.0029 0.0202 0.0155
Loa Loa (eye worm) hypothetical protein 0.004 0.0367 0.0386
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0367 0.0348
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0739 0.0778
Brugia malayi jmjC domain containing protein 0.0064 0.0715 0.0753
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0367 0.0348
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0678 0.9812 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0352 0.0333
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0021 0.0023
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0352 0.0371
Schistosoma mansoni rab6-interacting 0.0039 0.0352 0.0333
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0532 0.0513
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0367 0.0348
Schistosoma mansoni polycystin 1-related 0.0039 0.0352 0.0333
Brugia malayi nuclear receptor RXR 0.0019 0.005 0.0053
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0352 0.0333
Plasmodium falciparum LCCL domain-containing protein 0.0039 0.0352 1
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0316 0.0333
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0642 0.0623
Schistosoma mansoni hypothetical protein 0.0381 0.5414 0.5405
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0044 0.0024
Schistosoma mansoni nuclear hormone receptor 0.0019 0.005 0.003
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0091 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0084 0.0064
Loa Loa (eye worm) hypothetical protein 0.0054 0.057 0.0601
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0193 0.0203
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0642 0.0676
Onchocerca volvulus 0.0052 0.0536 0.0497
Echinococcus granulosus FTZ F1 alpha 0.004 0.0367 0.0348
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0257 0.4153
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.005 0.003
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0367 0.0386
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.005 0.0053
Loa Loa (eye worm) DR-78 0.0019 0.005 0.0053
Echinococcus multilocularis RUN 0.0039 0.0352 0.0333
Schistosoma mansoni hypothetical protein 0.0017 0.0021 0.0001
Schistosoma mansoni cpg binding protein 0.003 0.0217 0.0198
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.002 0.0021
Brugia malayi steroid hormone receptor 0.004 0.0367 0.0386
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0367 0.0386
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.5832 0.5824
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0367 0.0348
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0536 0.0517
Schistosoma mansoni nuclear hormone receptor 0.0019 0.005 0.003
Brugia malayi nuclear receptor RXR 0.0021 0.0084 0.0088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0367 0.0386
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0202 0.0212
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0367 0.0348
Schistosoma mansoni hypothetical protein 0.0017 0.0021 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0367 0.0386
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0367 0.0348
Echinococcus granulosus lamin 0.0029 0.0202 0.0182
Loa Loa (eye worm) hypothetical protein 0.004 0.0367 0.0386
Plasmodium vivax multidomain scavenger receptor, putative 0.0039 0.0352 1
Onchocerca volvulus 0.0057 0.0605 0.0568
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0618 1
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.005 0.0053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0532 0.0513
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.0367 0.0348
Onchocerca volvulus 0.0049 0.0501 0.0462
Echinococcus granulosus cpg binding protein 0.003 0.0217 0.0198
Schistosoma mansoni microtubule-associated protein tau 0.069 1 1
Onchocerca volvulus 0.0029 0.0202 0.0155
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0618 0.0651
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0532 0.0513
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.005 0.003
Echinococcus granulosus survival motor neuron protein 1 0.0277 0.3873 0.386
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0091 0.0071
Echinococcus multilocularis cpg binding protein 0.003 0.0217 0.0198
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0367 0.0386
Schistosoma mansoni hypothetical protein 0.0037 0.0316 0.0297
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.057 0.0601
Loa Loa (eye worm) MBCTL1 0.0059 0.0642 0.0676
Loa Loa (eye worm) hypothetical protein 0.0019 0.005 0.0053
Brugia malayi CXXC zinc finger family protein 0.0029 0.0193 0.0203
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0091 0.0071
Brugia malayi jmjC domain containing protein 0.0017 0.002 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0367 0.0386
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.005 0.003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0084 0.0088
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0227 0.3129 0.3295
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0091 0.5
Loa Loa (eye worm) hypothetical protein 0.0019 0.005 0.0053
Loa Loa (eye worm) hypothetical protein 0.0019 0.005 0.0053
Loa Loa (eye worm) hypothetical protein 0.0017 0.0021 0.0023
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0532 0.056
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0064 0.0715 0.0696
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0367 0.0348
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0257 0.0238
Echinococcus granulosus geminin 0.0381 0.5414 0.5405
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0367 0.0348
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0367 0.0386
Loa Loa (eye worm) hypothetical protein 0.0019 0.005 0.0053
Trichomonas vaginalis set domain proteins, putative 0.0258 0.3592 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0021 0.0001
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.005 0.0053
Brugia malayi Nuclear hormone receptor E75 0.0019 0.005 0.0053
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0091 1
Onchocerca volvulus 0.004 0.0367 0.0324
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0532 0.0513
Loa Loa (eye worm) hypothetical protein 0.0019 0.005 0.0053
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0536 0.0517
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0618 1
Echinococcus granulosus intermediate filament protein 0.0029 0.0202 0.0182
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0091 0.5
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0367 0.0324
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0367 0.0348
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0367 0.0348
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0367 0.0386
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0257 0.0238
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0091 1
Schistosoma mansoni hypothetical protein 0.0017 0.0021 0.0001
Brugia malayi jmjC domain containing protein 0.0017 0.002 0.0021
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.005 0.003
Schistosoma mansoni jumonji domain containing protein 0.0064 0.0715 0.0696
Schistosoma mansoni hypothetical protein 0.0039 0.0352 0.0333
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0367 0.0386
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0021 0.0001
Schistosoma mansoni intermediate filament proteins 0.0029 0.0202 0.0182
Echinococcus multilocularis lysine specific demethylase 5A 0.0064 0.0715 0.0696
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0091 0.2142
Brugia malayi nuclear receptor NHR-67 0.0019 0.005 0.0053
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0367 0.0386
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0367 0.0386
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.002 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0367 0.0386
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0091 0.1189
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0642 0.0623
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0618 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0202 0.0212
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.0536 0.0497
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0084 0.0064
Brugia malayi ecdysone receptor 0.0019 0.005 0.0053
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0367 0.0348
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0021
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0091 0.0096
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0367 0.0348
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0257 0.0238
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0209 0.286 0.2846
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.0739 0.072
Brugia malayi Pre-SET motif family protein 0.0033 0.0257 0.0271
Plasmodium vivax SET domain protein, putative 0.0033 0.0257 0.7152
Schistosoma mansoni nuclear receptor 0.0019 0.005 0.003
Schistosoma mansoni zinc finger protein 0.0019 0.005 0.003
Brugia malayi hypothetical protein 0.0039 0.0352 0.0371
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0084 0.0064
Loa Loa (eye worm) hypothetical protein 0.004 0.0367 0.0386
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0367 0.0348
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0618 0.0599
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.005 0.003
Schistosoma mansoni lamin 0.0029 0.0202 0.0182
Loa Loa (eye worm) hypothetical protein 0.0019 0.005 0.0053
Schistosoma mansoni cpg binding protein 0.003 0.0217 0.0198
Loa Loa (eye worm) hypothetical protein 0.0059 0.0642 0.0676
Schistosoma mansoni hypothetical protein 0.0381 0.5414 0.5405
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0367 0.0386
Loa Loa (eye worm) hypothetical protein 0.0033 0.0257 0.0271
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0656 0.9496 1
Echinococcus multilocularis survival motor neuron protein 1 0.0277 0.3873 0.386
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.0536 0.0517
Brugia malayi hypothetical protein 0.0019 0.005 0.0053
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0091 0.2142
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0367 0.0386
Schistosoma mansoni hypothetical protein 0.0057 0.0605 0.0586
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0367 0.0348
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.005 0.003
Schistosoma mansoni rab6-interacting 0.0039 0.0352 0.0333
Schistosoma mansoni hypothetical protein 0.032 0.4503 0.4492
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.005 0.0053
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0688 0.067

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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