Detailed information for compound 877529

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 282.359 | Formula: C13H18N2O3S
  • H donors: 1 H acceptors: 3 LogP: 1.33 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)S(=O)(=O)N1CCC[C@@H]1C(=O)N
  • InChi: 1S/C13H18N2O3S/c1-2-10-5-7-11(8-6-10)19(17,18)15-9-3-4-12(15)13(14)16/h5-8,12H,2-4,9H2,1H3,(H2,14,16)/t12-/m1/s1
  • InChiKey: ODWQLBSKKFNZNU-GFCCVEGCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0366 0.0257
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0033 0.0231 0.0221
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0098 0.0139
Echinococcus multilocularis methyl CpG binding domain protein 2 0.006 0.0637 0.0627
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0489 0.6441
Leishmania major hypothetical protein, conserved 0.0026 0.013 0.0736
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0324 0.0205
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0634 0.3108
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.408 0.4929
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0489 0.0479
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.006 0.005
Schistosoma mansoni hypothetical protein 0.0034 0.0244 0.0234
Brugia malayi PAS domain containing protein 0.0049 0.0477 0.0672
Schistosoma mansoni jumonji/arid domain-containing protein 0.0105 0.1329 0.132
Loa Loa (eye worm) hypothetical protein 0.0024 0.0098 0.0139
Plasmodium falciparum sentrin-specific protease 1 0.0047 0.0446 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0098 0.0139
Schistosoma mansoni lipoxygenase 0.0091 0.111 0.11
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.408 1
Schistosoma mansoni bromodomain containing protein 0.0222 0.3094 0.3086
Loa Loa (eye worm) hypothetical protein 0.0073 0.0845 0.119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0208 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0324 0.0205
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.408 0.4929
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0067 0.0748 0.0738
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0713 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0098 0.0139
Brugia malayi hypothetical protein 0.0022 0.006 0.0085
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0047 0.0446 0.0436
Schistosoma mansoni jumonji/arid domain-containing protein 0.0105 0.1329 0.132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0162 0.0001
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0129 0.1693 0.1684
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0529 0.0463
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.006 0.005
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0098 0.0139
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0244 0.0344
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.006 0.005
Echinococcus multilocularis peregrin 0.0042 0.037 0.036
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0098 0.0088
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0169 0.2288 0.228
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0024 0.0098 0.0047
Echinococcus multilocularis RUN 0.0022 0.006 0.005
Brugia malayi hypoxia-induced factor 1 0.0152 0.204 0.2876
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0053 0.0529 0.6844
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0098 0.0088
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0083 0.0118
Loa Loa (eye worm) jmjC domain-containing protein 0.0105 0.1329 0.1873
Onchocerca volvulus 0.0553 0.8112 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0203 0.0053
Schistosoma mansoni methyl-cpg binding protein mbd 0.006 0.0637 0.0627
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0098 0.0139
Echinococcus granulosus phd:f box containing protein 0.0026 0.013 0.0119
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0713 0.1005
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0098 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0098 0.0139
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0634 0.7678
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.007 0.0787 0.0777
Loa Loa (eye worm) hypothetical protein 0.0129 0.1693 0.2387
Echinococcus granulosus jumonji domain containing protein 0.0047 0.0445 0.0435
Loa Loa (eye worm) hypothetical protein 0.0058 0.0616 0.0869
Loa Loa (eye worm) bromodomain containing protein 0.0062 0.0669 0.0944
Schistosoma mansoni rab6-interacting 0.0022 0.006 0.005
Loa Loa (eye worm) hypothetical protein 0.0024 0.0098 0.0139
Plasmodium falciparum phd finger protein, putative 0.0034 0.0244 0.4765
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0489 0.0638
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.013 0.1704 0.1695
Loa Loa (eye worm) hypothetical protein 0.0024 0.0098 0.0139
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0098 0.0088
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0634 0.8749
Schistosoma mansoni jumonji domain containing protein 0.0026 0.013 0.0119
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.1855 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0098 0.0088
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0047 0.0446 0.4815
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0098 0.0139
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0791 0.1115
Onchocerca volvulus 0.0023 0.0083 0.0029
Trypanosoma cruzi target of rapamycin kinase 3 0.0042 0.0366 0.4055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0366 0.0257
Brugia malayi MAP kinase sur-1 0.005 0.0489 0.0689
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0713 1
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0098 0.0088
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0477 0.0467
Loa Loa (eye worm) hypothetical protein 0.0047 0.0446 0.0629
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0053 0.0529 0.0519
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0634 0.0624
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0634 0.3108
Loa Loa (eye worm) hypothetical protein 0.0023 0.0083 0.0118
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0098 0.0139
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.408 0.4929
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0098 0.0139
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0098 0.0139
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0299 0.0289
Echinococcus granulosus single minded 2 0.0036 0.0283 0.0272
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0489 0.6158
Echinococcus multilocularis zinc finger protein 0.0069 0.0771 0.0761
Loa Loa (eye worm) hypothetical protein 0.0026 0.013 0.0183
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0486 0.7094 1
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0244 0.253
Brugia malayi jmjC domain containing protein 0.0105 0.1329 0.1873
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0047 0.0446 0.0908
Echinococcus multilocularis phd:f box containing protein 0.0026 0.013 0.0119
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0209 0.2903 0.2896
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0713 0.1575
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0266 0.0132
Plasmodium vivax sentrin-specific protease 1, putative 0.0047 0.0446 0.531
Treponema pallidum fructose-bisphosphate aldolase 0.0287 0.408 0.5
Brugia malayi hypothetical protein 0.0165 0.2234 0.315
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0634 0.0624
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0366 0.0257
Schistosoma mansoni hypothetical protein 0.004 0.0336 0.0326
Brugia malayi Pre-SET motif family protein 0.007 0.0787 0.1109
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0489 0.6557
Trichomonas vaginalis set domain proteins, putative 0.0553 0.8112 1
Echinococcus granulosus peregrin 0.0042 0.037 0.036
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.006 0.005
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0299 0.0289
Loa Loa (eye worm) hypothetical protein 0.004 0.0336 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0412 0.0316
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0098 0.0139
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0336 0.0474
Trypanosoma brucei protein kinase, putative 0.005 0.0489 0.6557
Brugia malayi nuclear hormone receptor 0.0024 0.0098 0.0139
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0713 0.0703
Loa Loa (eye worm) PHD-finger family protein 0.0072 0.0827 0.1166
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0098 0.0139
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0713 0.0703
Loa Loa (eye worm) hypoxia-induced factor 1 0.0152 0.204 0.2876
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0098 0.0088
Schistosoma mansoni polycystin 1-related 0.0022 0.006 0.005
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0053 0.0529 0.0746
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0489 0.0479
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0053 0.0529 0.0519
Loa Loa (eye worm) hypothetical protein 0.0143 0.1896 0.2672
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.1855 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0026 0.013 0.0119
Schistosoma mansoni zinc finger protein 0.0054 0.0544 0.0533
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.013 0.0183
Loa Loa (eye worm) doublecortin family protein 0.0022 0.006 0.0085
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0713 1
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0039 0.0055
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0098 0.0088
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0489 0.5466
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.007 0.0787 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0098 0.0088
Schistosoma mansoni zinc finger protein 0.0069 0.0771 0.0761
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0529 0.0463
Onchocerca volvulus Bile acid receptor homolog 0.0024 0.0098 0.0047
Loa Loa (eye worm) hypothetical protein 0.0024 0.0098 0.0139
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0042 0.0366 0.4493
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0053 0.0529 0.1115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0366 0.0257
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.1855 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0098 0.0088
Schistosoma mansoni coup transcription factor 0.0024 0.0098 0.0088
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.013 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0324 0.0205
Toxoplasma gondii target of rapamycin (TOR), putative 0.0039 0.0324 0.2962
Loa Loa (eye worm) hypothetical protein 0.0165 0.2234 0.315
Onchocerca volvulus Protein ultraspiracle homolog 0.0024 0.0098 0.0047
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0053 0.0529 0.7077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0098 0.0139
Schistosoma mansoni microtubule-associated protein tau 0.0677 1 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0244 0.1742
Plasmodium vivax JmjC domain containing protein 0.0026 0.013 0.0954
Echinococcus granulosus RUN 0.0022 0.006 0.005
Brugia malayi Bromodomain containing protein 0.0263 0.3717 0.5239
Loa Loa (eye worm) hypothetical protein 0.0023 0.0083 0.0118
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0026 0.013 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0324 0.0205
Loa Loa (eye worm) hypothetical protein 0.0024 0.0098 0.0139
Trypanosoma brucei ISWI complex protein 0.0054 0.0544 0.7399
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0489 0.6158
Loa Loa (eye worm) hypothetical protein 0.0024 0.0098 0.0139
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0489 0.0412
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0025 0.0108 0.0706
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0098 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0208 0.0059
Schistosoma mansoni phosphatidylserine receptor 0.0026 0.013 0.0119
Loa Loa (eye worm) hypothetical protein 0.0022 0.006 0.0085
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0098 0.0139
Schistosoma mansoni hypothetical protein 0.0054 0.0544 0.0533
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0529 0.0463
Loa Loa (eye worm) hypothetical protein 0.015 0.1997 0.2815
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0489 0.0479
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0098 0.0088
Loa Loa (eye worm) hypothetical protein 0.0248 0.3489 0.4918
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0283 0.1126
Schistosoma mansoni protein phosphatase 2C 0.0026 0.013 0.0119
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.408 0.4929
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0098 0.0139
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0713 0.0703
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0015
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.007 0.0787 0.0777
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0126 0.164 0.1631
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0489 0.0479
Onchocerca volvulus Alhambra homolog 0.0034 0.0244 0.0228
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0324 0.0205
Echinococcus multilocularis microtubule associated protein 2 0.0677 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.013 0.0183
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0079 0.0929 0.0919
Echinococcus multilocularis PHD finger protein rhinoceros 0.0034 0.0244 0.0234
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0634 0.0624
Brugia malayi Bromodomain containing protein 0.0134 0.1766 0.2489
Loa Loa (eye worm) hypothetical protein 0.0023 0.0083 0.0118
Onchocerca volvulus 0.007 0.0787 0.0902
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0098 0.0088
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0098 0.0088
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0053 0.0529 0.6844
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0098 0.0088
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0209 0.2903 0.2896
Leishmania major hypothetical protein, conserved 0.0054 0.0544 0.7311
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0489 0.0412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0249 0.011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.408 0.4929
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.006 0.005
Brugia malayi jmjC domain containing protein 0.0026 0.013 0.0183
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0098 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0098 0.0139
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0047 0.0446 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0208 0.0059
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0098 0.0088
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.006 0.005
Echinococcus multilocularis jumonji domain containing 1A 0.0026 0.013 0.0119
Brugia malayi jmjC domain containing protein 0.0169 0.2288 0.3225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0324 0.0205
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0098 0.0088
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0098 0.0088
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0098 0.0088
Onchocerca volvulus 0.0036 0.0283 0.0276
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0489 0.6441
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.408 1
Schistosoma mansoni rab6-interacting 0.0022 0.006 0.005
Schistosoma mansoni methyl-cpg binding protein mbd 0.006 0.0637 0.0627
Schistosoma mansoni hypothetical protein 0.0022 0.006 0.005
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0047 0.0446 0.0629
Echinococcus granulosus sentrin specific protease 1 0.0047 0.0446 0.0436
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0244 0.1742
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0098 0.0139
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0098 0.0088
Echinococcus multilocularis thyroid hormone receptor alpha 0.0024 0.0098 0.0088
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.1693 0.1684
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.408 0.4929
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0713 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0634 0.3108
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.007 0.0787 0.0777
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.1693 0.1684
Brugia malayi jmjC domain containing protein 0.0026 0.013 0.0183
Echinococcus multilocularis lysine specific demethylase 6a 0.0026 0.013 0.0119
Plasmodium falciparum JmjC domain-containing protein, putative 0.0026 0.013 0.1797
Echinococcus granulosus lysine specific demethylase 5A 0.0105 0.1329 0.132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0366 0.0257
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0079 0.0929 0.0919
Giardia lamblia GTOR 0.0053 0.0529 0.0742
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0713 0.1005
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0098 0.0139
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0053 0.0529 0.7172
Onchocerca volvulus 0.0024 0.0098 0.0047
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0098 0.0088
Echinococcus granulosus methyl CpG binding domain protein 2 0.006 0.0637 0.0627
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0053 0.0529 0.7172
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0616 0.0869
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0203 0.0053
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0489 0.0412
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0616 0.0869
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0162 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0083 0.0118
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0283 0.0272
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0283 0.0399
Schistosoma mansoni jumonji domain containing protein 0.0146 0.1942 0.1934
Loa Loa (eye worm) hypothetical protein 0.0022 0.006 0.0085
Loa Loa (eye worm) hypothetical protein 0.0024 0.0098 0.0139
Brugia malayi Bromodomain containing protein 0.0042 0.037 0.0522
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0098 0.0139
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0098 0.0088
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0011 0.0015
Schistosoma mansoni single-minded 0.0049 0.0477 0.0467
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0098 0.0088
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0098 0.0088
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0634 0.3108
Echinococcus multilocularis lysine specific demethylase 5A 0.0099 0.1228 0.1218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0162 0.0001
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0169 0.2288 0.228
Loa Loa (eye worm) hypothetical protein 0.0034 0.0244 0.0344
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0083 0.0118
Brugia malayi jmjC domain containing protein 0.0026 0.013 0.0183
Trypanosoma cruzi ISWI complex protein 0.0054 0.0544 0.7097
Brugia malayi PHD-finger family protein 0.0087 0.1055 0.1486
Trypanosoma cruzi ISWI complex protein 0.0054 0.0544 0.7097
Brugia malayi jmjC domain containing protein 0.0026 0.013 0.0183
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0098 0.0088
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0047 0.0446 0.0436
Plasmodium vivax SET domain protein, putative 0.007 0.0787 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.013 0.1704 0.1695
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0098 0.0088
Brugia malayi nuclear receptor NHR-88 0.0024 0.0098 0.0139
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0042 0.0366 0.4672
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.408 0.4929
Brugia malayi ecdysteroid receptor 0.0024 0.0098 0.0139
Echinococcus granulosus fetal alzheimer antigen falz 0.0079 0.0929 0.0919
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0489 0.0479
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0489 0.0689
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0034 0.0244 0.0234
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.408 0.4929
Echinococcus multilocularis sentrin specific protease 1 0.0047 0.0446 0.0436
Echinococcus granulosus histone lysine methyltransferase setb 0.0129 0.1693 0.1684
Brugia malayi Pre-SET motif family protein 0.0486 0.7094 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0287 0.408 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.0244 0.0234
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0011 0.0015
Loa Loa (eye worm) hypothetical protein 0.0024 0.0098 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0162 0.0001
Echinococcus granulosus JmjC domain containing protein 4 0.0026 0.013 0.0119
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0489 0.6158
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0489 0.0412
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0033 0.0231 0.0221
Schistosoma mansoni hypothetical protein 0.0072 0.0827 0.0817
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0098 0.0139
Schistosoma mansoni phd/f-box containing protein 0.0026 0.013 0.0119
Brugia malayi PHD-finger family protein 0.0034 0.0244 0.0344
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0489 0.6158
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0053 0.0529 0.7077
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0098 0.0088
Brugia malayi hypothetical protein 0.0022 0.006 0.0085
Brugia malayi Doublecortin family protein 0.0022 0.006 0.0085
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0634 0.0624
Brugia malayi steroid hormone receptor 0.0024 0.0098 0.0139
Echinococcus granulosus zinc finger protein 0.0069 0.0771 0.0761
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0026 0.013 0.1039
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0616 0.0869
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0098 0.0088
Loa Loa (eye worm) phosphatidylinositol 3 0.0053 0.0529 0.0746
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0098 0.0139
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0011 0.0015
Echinococcus granulosus lysine specific demethylase 6a 0.0026 0.013 0.0119
Loa Loa (eye worm) hypothetical protein 0.0135 0.177 0.2495
Echinococcus granulosus jumonji domain containing 1A 0.0026 0.013 0.0119
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0126 0.164 0.1631
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0053 0.0529 0.1115
Schistosoma mansoni loxhd1 0.0022 0.006 0.005
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0053 0.0529 0.0519
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0098 0.0088
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0098 0.0088
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0098 0.0139
Loa Loa (eye worm) hypothetical protein 0.0026 0.013 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0324 0.0205
Schistosoma mansoni lipoxygenase 0.013 0.1704 0.1695
Echinococcus multilocularis jumonji domain containing protein 0.0047 0.0445 0.0435

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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