Detailed information for compound 877610

Basic information

Technical information
  • TDR Targets ID: 877610
  • Name: N-[4-[3-[(3,4-difluorophenyl)methyl]-4-oxo-1, 3-thiazolidin-2-yl]phenyl]acetamide
  • MW: 362.394 | Formula: C18H16F2N2O2S
  • H donors: 1 H acceptors: 2 LogP: 2.67 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Nc1ccc(cc1)C1SCC(=O)N1Cc1ccc(c(c1)F)F
  • InChi: 1S/C18H16F2N2O2S/c1-11(23)21-14-5-3-13(4-6-14)18-22(17(24)10-25-18)9-12-2-7-15(19)16(20)8-12/h2-8,18H,9-10H2,1H3,(H,21,23)
  • InChiKey: SLWVKHDYPNXWIQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-[3-[(3,4-difluorophenyl)methyl]-4-oxo-thiazolidin-2-yl]phenyl]acetamide
  • N-[4-[3-[(3,4-difluorophenyl)methyl]-4-oxo-2-thiazolidinyl]phenyl]acetamide
  • N-[4-[3-(3,4-difluorobenzyl)-4-keto-thiazolidin-2-yl]phenyl]acetamide
  • N-[4-[3-[(3,4-difluorophenyl)methyl]-4-oxo-1,3-thiazolidin-2-yl]phenyl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0152 0.172
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.003 0.0046
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.003 0.0827
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0065 0.0217
Treponema pallidum glutamate/aspartate transporter 0.047 0.2889 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.007 0.0067
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0065 0.0092
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0152 0.0867
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0042 0.0059
Loa Loa (eye worm) hypothetical protein 0.0029 0.0116 0.0172
Brugia malayi beta-lactamase family protein 0.0151 0.0885 0.1335
Echinococcus granulosus excitatory amino acid transporter 3 0.106 0.6603 1
Echinococcus multilocularis neutral amino acid transporter A 0.106 0.6603 0.6602
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0015 0.0142
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0015 0.0023
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0182 0.0272
Brugia malayi nuclear receptor RXR 0.0012 0.0007 0.0004
Echinococcus multilocularis snurportin 1 0.0648 0.4012 0.401
Schistosoma mansoni lamin 0.003 0.012 0.0182
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0122 0.07 0.0697
Echinococcus granulosus excitatory amino acid transporter 2 0.106 0.6603 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0065 0.0095
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0152 0.0507
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.0025
Brugia malayi hypothetical protein 0.004 0.0182 0.0269
Mycobacterium tuberculosis Probable oxidoreductase 0.0096 0.0538 0.0793
Plasmodium falciparum thioredoxin reductase 0.0013 0.0015 0.0338
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0014 0.0032
Echinococcus granulosus lamin 0.003 0.012 0.0177
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0074 0.0108
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.009 0.2745
Brugia malayi jmjC domain containing protein 0.0016 0.003 0.0039
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0015 0.0142
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0015 0.0036
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0226 0.1356 0.205
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0007 0.0004
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.007 0.0793
Echinococcus granulosus excitatory amino acid transporter 2 0.106 0.6603 1
Echinococcus multilocularis protein dispatched 1 0.0047 0.023 0.0227
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0065 0.0208
Schistosoma mansoni alpha-glucosidase 0.0135 0.0785 0.1189
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0074 0.0108
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0152 0.0507
Plasmodium vivax JmjC domain containing protein 0.0016 0.003 0.0343
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.003 0.0042
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0074 0.0071
Echinococcus multilocularis excitatory amino acid transporter 2 0.106 0.6603 0.6602
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.0835 0.1261
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0014 0.0032
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0074 0.0113
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0074 0.0397 0.1347
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0065 0.0371
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0151 0.0885 0.1321
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.054 0.3075
Echinococcus multilocularis translational activator gcn1 0.0011 0.0005 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0014 0.0032
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.106 0.6603 0.6602
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.007 0.0793
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0015 0.0018
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0074 0.0397 0.0596
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0045 0.0214 0.2414
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.032 0.0485
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0042
Trypanosoma cruzi hypothetical protein, conserved 0.0151 0.0885 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0074 0.0397 0.2191
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.0658 0.0993
Plasmodium falciparum importin beta, putative 0.0061 0.0315 1
Schistosoma mansoni ap endonuclease 0.0021 0.0065 0.0099
Brugia malayi hypothetical protein 0.0016 0.0034 0.0044
Echinococcus granulosus transportin 1 0.0011 0.0005 0.0003
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.012 0.0174
Schistosoma mansoni hypothetical protein 0.0816 0.5068 0.7674
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0014 0.0032
Echinococcus granulosus neuropeptide s receptor 0.046 0.2829 0.4281
Loa Loa (eye worm) hypothetical protein 0.0051 0.0252 0.0378
Schistosoma mansoni hypothetical protein 0.0017 0.0042 0.0064
Loa Loa (eye worm) beta-lactamase 0.0151 0.0885 0.1337
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0074 0.0109
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0074 0.0113
Loa Loa (eye worm) hypothetical protein 0.0151 0.0885 0.1337
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.0658 0.0993
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0193 0.0288
Schistosoma mansoni hypothetical protein 0.0017 0.0042 0.0064
Echinococcus granulosus Excitatory amino acid transporter 0.106 0.6603 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0051 0.0073
Loa Loa (eye worm) hypothetical protein 0.0309 0.1877 0.284
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1757 0.6022
Schistosoma mansoni intermediate filament proteins 0.003 0.012 0.0182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0074 0.0109
Schistosoma mansoni hypothetical protein 0.0011 0.0003 0.0005
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.012 0.0178
Brugia malayi Excitatory amino acid transporter 0.106 0.6603 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0015 0.0012
Schistosoma mansoni coup transcription factor 0.0023 0.0074 0.0113
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0014 0.0033
Echinococcus granulosus expressed conserved protein 0.0091 0.0503 0.0758
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0065 0.0575
Mycobacterium tuberculosis Conserved protein 0.0151 0.0885 0.1321
Chlamydia trachomatis glutamate symporter 0.106 0.6603 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0065 0.0737
Loa Loa (eye worm) kap beta 3 protein 0.0011 0.0005 0.0003
Brugia malayi jmjC domain containing protein 0.0016 0.003 0.0039
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0015 0.0119
Mycobacterium tuberculosis Probable hydrolase 0.0151 0.0885 0.1321
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0015 0.0142
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0015 0.0172
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0015 0.0338
Brugia malayi hypothetical protein 0.0012 0.0007 0.0004
Brugia malayi CHE-14 protein 0.0041 0.0193 0.0286
Toxoplasma gondii HEAT repeat-containing protein 0.0011 0.0005 0.0054
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.106 0.6603 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0087 0.0477 0.0701
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0074 0.0105
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0014 0.0033
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1757 0.6022
Echinococcus multilocularis sodium:dicarboxylate symporter 0.047 0.2889 0.2887
Brugia malayi RNA, U transporter 1 0.0173 0.1019 0.1537
Echinococcus multilocularis Excitatory amino acid transporter 0.106 0.6603 0.6602
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0014 0.0032
Echinococcus multilocularis muscleblind protein 1 0.0309 0.1877 0.1875
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0074 0.0397 0.4451
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1757 0.6022
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0152 0.0507
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0065 0.0708
Brugia malayi jmjC domain containing protein 0.0058 0.03 0.0447
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0042 0.006
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0152 0.1676
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0014 0.0032
Toxoplasma gondii exonuclease III APE 0.0021 0.0065 0.0737
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0315 0.0473
Entamoeba histolytica hypothetical protein 0.004 0.0182 0.1039
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0151 0.0885 0.1335
Loa Loa (eye worm) hypothetical protein 0.0061 0.0315 0.0473
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0074 0.0071
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0293 0.044
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0152 0.1695
Schistosoma mansoni hypothetical protein 0.0017 0.0042 0.0064
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0065 0.0208
Schistosoma mansoni cpg binding protein 0.0061 0.0314 0.0475
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.029 0.1757 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0152 0.0507
Echinococcus multilocularis transportin 1 0.0011 0.0005 0.0002
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.0801 0.1209
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0279 0.0415
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0214 0.2391
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0045 0.0214 0.0317
Schistosoma mansoni alpha glucosidase 0.0035 0.0152 0.0231
Echinococcus granulosus dnaJ subfamily B 0.0816 0.5068 0.7673
Echinococcus granulosus survival motor neuron protein 1 0.0261 0.1576 0.2383
Echinococcus granulosus Excitatory amino acid transporter 0.106 0.6603 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.007 0.0102
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0065 0.1951
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0042 0.0057
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0315 0.0477
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.106 0.6603 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0315 0.0477
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0074 0.0071
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0182 0.0276
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.007 0.0102
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0015 0.0036
Trichomonas vaginalis D-aminoacylase, putative 0.0151 0.0885 0.3027
Echinococcus granulosus neutral amino acid transporter A 0.106 0.6603 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.032 0.0485
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0033 0.0046
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0074 0.0109
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0007 0.0011
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0315 0.0312
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0074 0.0113
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0014 0.0033
Leishmania major hypothetical protein, conserved 0.0025 0.009 0.0966
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0074 0.0105
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0152 0.0507
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0015 0.0119
Mycobacterium leprae Probable lipase LipE 0.0151 0.0885 1
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0042 0.0057
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0171 0.1934
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0151 0.0885 0.1321
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0065 0.0076
Schistosoma mansoni protein phosphatase 2C 0.0016 0.003 0.0046
Schistosoma mansoni hypothetical protein 0.0017 0.0042 0.0064
Trichomonas vaginalis set domain proteins, putative 0.0474 0.2914 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0042 0.0039
Echinococcus granulosus lamin dm0 0.003 0.012 0.0177
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0087 0.0477 0.0701
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0315 0.0477
Loa Loa (eye worm) hypothetical protein 0.0022 0.007 0.0102
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0065 0.0287
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.009 0.1014
Schistosoma mansoni DNA helicase recq5 0.0022 0.007 0.0106
Schistosoma mansoni hypothetical protein 0.004 0.0184 0.0278
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0014 0.0015
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0074 0.0397 0.2258
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0096 0.0538 0.0793
Plasmodium falciparum glutathione reductase 0.0038 0.0171 0.5374
Trypanosoma brucei hypothetical protein, conserved 0.0151 0.0885 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0051 0.0048
Echinococcus granulosus importin 5 0.0011 0.0005 0.0003
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0003 0.003
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0074 0.0397 0.0601
Echinococcus multilocularis importin subunit beta 1 0.0061 0.0315 0.0312
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0074 0.0397 0.0596
Treponema pallidum glutamate transporter 0.047 0.2889 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0074 0.0105
Brugia malayi hypothetical protein 0.0025 0.009 0.0129
Schistosoma mansoni lamin 0.003 0.012 0.0182
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.007 0.0316
Leishmania major GTP-binding protein, putative 0.0045 0.0214 0.2373
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.003 0.0041
Loa Loa (eye worm) hypothetical protein 0.0023 0.0074 0.0109
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Brugia malayi hypothetical protein 0.0261 0.1576 0.2381
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0014 0.0109
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.007 0.0225
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.0074 0.0091
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0015 0.0142
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0014 0.0032
Brugia malayi Pre-SET motif family protein 0.0416 0.2553 0.3862
Plasmodium vivax SET domain protein, putative 0.0061 0.0315 0.3559
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0074 0.0113
Entamoeba histolytica hypothetical protein 0.004 0.0182 0.1039
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0122 0.07 0.1039
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0152 0.0507
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0015 0.0119
Onchocerca volvulus 0.0053 0.0268 0.0384
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0014 0.0082
Onchocerca volvulus Excitatory amino acid transporter homolog 0.106 0.6603 1
Trichomonas vaginalis helicase, putative 0.0013 0.0014 0.0032
Trichomonas vaginalis ran, putative 0.0045 0.0214 0.0718
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0065 0.0687
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0074 0.0108
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0074 0.0108
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.007 0.0743
Echinococcus granulosus ubiquitin specific protease 41 0.0074 0.0397 0.0596
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0045 0.0214 0.0211
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0015 0.0338
Schistosoma mansoni jumonji domain containing protein 0.0016 0.003 0.0046
Schistosoma mansoni DNA helicase recq1 0.0022 0.007 0.0106
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0074 0.0113
Echinococcus multilocularis lamin dm0 0.003 0.012 0.0117
Trypanosoma brucei trypanothione reductase 0.0038 0.0171 0.1891
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0835 0.1265
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.003 0.0041
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0007 0.0004
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0023 0.002
Loa Loa (eye worm) hypothetical protein 0.0151 0.0885 0.1337
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0014 0.0032
Schistosoma mansoni patched 1 0.0041 0.0193 0.0293
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0014 0.0032
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0018
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0007 0.0004
Brugia malayi Importin beta-1 subunit 0.0061 0.0315 0.047
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.003 0.0027
Loa Loa (eye worm) histone methyltransferase 0.002 0.0058 0.0084
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0169 0.0249
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0268 0.0398
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0087 0.0477 0.0701
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0074 0.0113
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0279 0.0419
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0015 0.0016
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0074 0.0397 0.0594
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.0923 0.092
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0074 0.0397 0.1347
Treponema pallidum NADH oxidase 0.0013 0.0015 0.0043
Brugia malayi Pre-SET motif family protein 0.0061 0.0315 0.047
Loa Loa (eye worm) hypothetical protein 0.0023 0.0074 0.0109
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0074 0.0397 0.4464
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0014 0.0032
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.003 0.0314
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0152 0.0507
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0074 0.0113
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.07 0.7867
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0182 0.018
Echinococcus multilocularis Excitatory amino acid transporter 0.106 0.6603 0.6602
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0014 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0074 0.0109
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0835 0.1265
Echinococcus multilocularis beta LACTamase domain containing family member 0.0151 0.0885 0.0883
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0014 0.0033
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.009 0.0987
Trypanosoma cruzi hypothetical protein, conserved 0.0151 0.0885 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0074 0.0109
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.029 0.1757 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0074 0.0109
Toxoplasma gondii HEAT repeat-containing protein 0.0011 0.0005 0.0054
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.07 0.106
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0242 0.0817
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0074 0.0105
Schistosoma mansoni cpg binding protein 0.0061 0.0314 0.0475
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0015 0.0119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0074 0.0109
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0087 0.0477 0.0701
Mycobacterium ulcerans esterase/lipase LipP 0.0151 0.0885 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0152 0.0507
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0014 0.0032
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.055 0.0832
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0074 0.0105
Brugia malayi intermediate filament protein 0.003 0.012 0.0174
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.003 0.0027
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.0923 0.092
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.047 0.2889 0.4375
Brugia malayi CXXC zinc finger family protein 0.0057 0.0293 0.0437
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0152 0.0149
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0152 0.0227
Echinococcus multilocularis neutral amino acid transporter A 0.106 0.6603 0.6602
Entamoeba histolytica hypothetical protein 0.0049 0.0242 0.1379
Schistosoma mansoni hypothetical protein 0.0648 0.4012 0.6075
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0045 0.0214 0.2373
Brugia malayi jmjC domain containing protein 0.0016 0.003 0.0039
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.0835 0.0832
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0036 0.0033
Brugia malayi glutathione reductase 0.0038 0.0171 0.0252
Echinococcus granulosus muscleblind protein 0.0309 0.1877 0.284
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0416 0.2553 0.3864
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0074 0.0113
Onchocerca volvulus 0.003 0.012 0.016
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0003 0.003
Schistosoma mansoni alpha-glucosidase 0.0135 0.0785 0.1189
Brugia malayi nuclear receptor NHR-88 0.0023 0.0074 0.0105
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0152 0.1695
Toxoplasma gondii thioredoxin reductase 0.0038 0.0171 0.1934
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0007 0.0007
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0003 0.0015
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.007 0.2113
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0015 0.0119
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.0074 0.0091
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0242 0.0817
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0014 0.0032
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.003 0.0042
Loa Loa (eye worm) hypothetical protein 0.0151 0.0885 0.1337
Brugia malayi MH2 domain containing protein 0.0115 0.0658 0.0991
Echinococcus granulosus snurportin 1 0.0648 0.4012 0.6074
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.03 0.0449
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1757 0.6022
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0023 0.003
Echinococcus multilocularis muscleblind protein 0.0309 0.1877 0.1875
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.032 0.0481
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.007 0.0765
Onchocerca volvulus 0.0151 0.0885 0.1322
Echinococcus multilocularis ubiquitin specific protease 41 0.0074 0.0397 0.0394
Schistosoma mansoni importin-beta 2 0.0011 0.0005 0.0007
Plasmodium vivax glutathione reductase, putative 0.0038 0.0171 0.1934
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.007 0.0102
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0015 0.0142
Echinococcus multilocularis lamin 0.003 0.012 0.0117
Loa Loa (eye worm) hypothetical protein 0.0038 0.0169 0.0252
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0058 0.0055
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0279 0.0415
Echinococcus granulosus phd:f box containing protein 0.0016 0.003 0.0041
Loa Loa (eye worm) hypothetical protein 0.003 0.012 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0074 0.0105
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.054 0.0537
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0074 0.0105
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0065 0.0076
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1757 0.6022
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0152 0.0224
Brugia malayi Glycosyl hydrolases family 31 protein 0.0157 0.0923 0.1392
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0648 0.4012 0.6074
Schistosoma mansoni cpg binding protein 0.0057 0.0293 0.0444
Echinococcus granulosus cpg binding protein 0.0061 0.0314 0.047
Leishmania major importin beta-1 subunit, putative 0.0049 0.0242 0.2698
Loa Loa (eye worm) hypothetical protein 0.0023 0.0074 0.0109
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.003 0.0314
Toxoplasma gondii HEAT repeat-containing protein 0.0061 0.0315 0.3553
Schistosoma mansoni ran 0.0045 0.0214 0.0324
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0074 0.0109
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.07 0.7867
Mycobacterium tuberculosis Probable lipase LipE 0.0151 0.0885 0.1321
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0014 0.0033
Brugia malayi beta-lactamase family protein 0.0151 0.0885 0.1335
Trichomonas vaginalis D-aminoacylase, putative 0.0151 0.0885 0.3027
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0074 0.0105
Echinococcus granulosus neutral amino acid transporter 0.106 0.6603 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0157 0.0923 0.1395
Treponema pallidum fructose-bisphosphate aldolase 0.029 0.1757 0.6077
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0074 0.0105
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0031
Echinococcus granulosus beta LACTamase domain containing family member 0.0151 0.0885 0.1337
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0152 0.0867
Onchocerca volvulus 0.0151 0.0885 0.1322
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0242 0.0817
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0015 0.0172
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.0835 0.1258
Schistosoma mansoni jumonji domain containing protein 0.0058 0.03 0.0454
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0042 0.0059
Loa Loa (eye worm) hypothetical protein 0.0023 0.0074 0.0109
Brugia malayi follicle stimulating hormone receptor 0.0226 0.1356 0.2047
Brugia malayi Muscleblind-like protein 0.0309 0.1877 0.2838
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1757 0.6022
Echinococcus multilocularis musashi 0.003 0.012 0.0117
Echinococcus granulosus neuropeptide receptor A26 0.046 0.2829 0.4281
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.007 0.0099
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0967 0.602 0.9115
Loa Loa (eye worm) intermediate filament protein 0.003 0.012 0.0178
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0045 0.0214 0.2414
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0214 0.2391
Mycobacterium tuberculosis Probable lipase LipD 0.0151 0.0885 0.1321
Brugia malayi nuclear hormone receptor 0.0023 0.0074 0.0105
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0065 0.0708
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.003 0.0046
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0074 0.0397 0.0394
Schistosoma mansoni hypothetical protein 0.004 0.0184 0.0278
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0065 0.0062
Echinococcus multilocularis importin 5 0.0011 0.0005 0.0002
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0074 0.0397 0.4464
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0315 0.0477
Schistosoma mansoni hypothetical protein 0.004 0.0182 0.0276
Schistosoma mansoni phd/f-box containing protein 0.0016 0.003 0.0046
Leishmania major hypothetical protein, conserved 0.0151 0.0885 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.0025
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0033 0.0043
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0015 0.0142
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0074 0.0071
Onchocerca volvulus 0.0061 0.0315 0.0456
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.007 0.2113
Echinococcus multilocularis dnaJ subfamily B 0.0816 0.5068 0.5066
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.007 0.0225
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0171 0.0237
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0293 0.044
Mycobacterium tuberculosis Conserved protein 0.0151 0.0885 0.1321
Onchocerca volvulus 0.003 0.012 0.016
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0151 0.0885 0.1341
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0074 0.0105
Entamoeba histolytica hypothetical protein 0.004 0.0182 0.1039
Brugia malayi beta-lactamase 0.0151 0.0885 0.1335
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0142 0.0824 0.9291
Echinococcus granulosus translational activator gcn1 0.0011 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0042
Onchocerca volvulus 0.0057 0.0293 0.0423
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0015 0.0142
Loa Loa (eye worm) hypothetical protein 0.0023 0.0074 0.0109
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0193 0.0289
Echinococcus multilocularis excitatory amino acid transporter 3 0.106 0.6603 0.6602
Plasmodium vivax importin-beta 2, putative 0.0061 0.0315 0.3553
Echinococcus multilocularis GPCR, family 2 0.0017 0.0042 0.0039
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.106 0.6603 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0058 0.0083
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0014 0.0032
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0074 0.0397 0.4451
Loa Loa (eye worm) hypothetical protein 0.0097 0.054 0.0814
Plasmodium falciparum glutathione reductase 0.0013 0.0015 0.0338
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.047 0.2889 0.2887
Echinococcus granulosus importin subunit beta 1 0.0061 0.0315 0.0472
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.009 0.1014
Mycobacterium tuberculosis Probable dehydrogenase 0.0087 0.0477 0.0701
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.009 0.2745
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1757 0.6022
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.03 0.0297
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0096 0.0538 0.1489
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.003 0.0291
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.009 0.0966
Echinococcus granulosus sodium:dicarboxylate symporter 0.106 0.6603 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.009 0.0132
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.03 0.0297
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0074 0.0108
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Echinococcus granulosus intermediate filament protein 0.003 0.012 0.0177
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0074 0.0071
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0074 0.0108
Loa Loa (eye worm) hypothetical protein 0.0023 0.0074 0.0109
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0074 0.0071
Brugia malayi hypothetical protein 0.0012 0.0007 0.0004
Schistosoma mansoni importin beta-1 0.0061 0.0315 0.0476
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.003 0.0041
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0835 0.1265
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0015 0.0172
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0152 0.0507
Echinococcus granulosus neutral amino acid transporter A 0.106 0.6603 1
Loa Loa (eye worm) glutathione reductase 0.0038 0.0171 0.0255
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0074 0.0113
Trichomonas vaginalis penicillin-binding protein, putative 0.0151 0.0885 0.3027
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0074 0.0105
Mycobacterium ulcerans hypothetical protein 0.0151 0.0885 1
Brugia malayi Thioredoxin reductase 0.0038 0.0171 0.0252
Mycobacterium ulcerans lipase LipD 0.0151 0.0885 1
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.007 0.0225
Trichomonas vaginalis penicillin-binding protein, putative 0.0151 0.0885 0.3027
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0074 0.0105
Toxoplasma gondii aldehyde dehydrogenase 0.0122 0.07 0.7904
Loa Loa (eye worm) hypothetical protein 0.0151 0.0885 0.1337
Mycobacterium ulcerans beta-lactamase 0.0151 0.0885 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0014 0.0033
Brugia malayi steroid hormone receptor 0.0023 0.0074 0.0105
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0036 0.0033
Echinococcus multilocularis expressed conserved protein 0.0091 0.0503 0.05
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0074 0.0397 0.0601
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0074 0.0071
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0315 0.3519
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0397 0.1347
Schistosoma mansoni hypothetical protein 0.004 0.0184 0.0278
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0014 0.0032
Echinococcus multilocularis cpg binding protein 0.0061 0.0314 0.0311
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0151 0.0885 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0045 0.0214 0.0319
Echinococcus multilocularis neuropeptide receptor A26 0.046 0.2829 0.2826
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0065 0.0094
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0045 0.0214 0.6744
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0045 0.0214 0.032
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0096 0.0538 0.0793
Echinococcus granulosus GPCR family 2 0.0017 0.0042 0.0059
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0015 0.0119
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.007 0.0067
Entamoeba histolytica HEAT repeat domain containing protein 0.0011 0.0005 0.0027
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.032 0.048
Leishmania major trypanothione reductase 0.0038 0.0171 0.1891
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0015 0.0119
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.0801 0.0798
Onchocerca volvulus 0.0091 0.0505 0.0745
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0074 0.0113
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.07 0.7867
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0015 0.0142
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0074 0.0109
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.009 0.0987
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0003 0.0004
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0014 0.0033
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0015 0.0172
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0074 0.0108
Echinococcus multilocularis survival motor neuron protein 1 0.0261 0.1576 0.1573
Loa Loa (eye worm) hypothetical protein 0.0017 0.0042 0.006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.0835 0.0832
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.047 0.2889 0.4375
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0014 0.0132
Echinococcus multilocularis excitatory amino acid transporter 2 0.106 0.6603 0.6602
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0074 0.0105
Loa Loa (eye worm) hypothetical protein 0.0061 0.0315 0.0473
Loa Loa (eye worm) hypothetical protein 0.0309 0.1877 0.284
Mycobacterium tuberculosis Conserved protein 0.0151 0.0885 0.1321
Loa Loa (eye worm) excitatory amino acid transporter 0.106 0.6603 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.054 0.0811
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.07 0.106
Echinococcus granulosus bloom syndrome protein 0.0022 0.007 0.0102
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0315 0.3559
Trichomonas vaginalis D-aminoacylase, putative 0.0151 0.0885 0.3027
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0171 0.191
Loa Loa (eye worm) hypothetical protein 0.0261 0.1576 0.2383
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0151 0.0885 0.1337
Entamoeba histolytica hypothetical protein 0.004 0.0182 0.1039
Echinococcus multilocularis bloom syndrome protein 0.0022 0.007 0.0067
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0242 0.2715
Loa Loa (eye worm) importin-beta domain-containing protein 0.0011 0.0005 0.0003
Onchocerca volvulus 0.0474 0.2914 0.4401
Schistosoma mansoni hypothetical protein 0.0038 0.0169 0.0256
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0042
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.007 0.0099
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0074 0.0113
Echinococcus granulosus lysosomal alpha glucosidase 0.0157 0.0923 0.1394
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.007 0.0743
Leishmania major hypothetical protein, conserved 0.0016 0.003 0.0291
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0074 0.0113
Toxoplasma gondii histone lysine methyltransferase SET1 0.0111 0.0629 0.7109
Trichomonas vaginalis esterase, putative 0.0151 0.0885 0.3027
Mycobacterium tuberculosis Probable esterase LipL 0.0151 0.0885 0.1321
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0122 0.07 0.7893
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0036 0.0054
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0074 0.0397 0.0394
Echinococcus multilocularis neutral amino acid transporter A 0.106 0.6603 0.6602
Loa Loa (eye worm) hypothetical protein 0.0041 0.0193 0.0289
Loa Loa (eye worm) hypothetical protein 0.0055 0.0279 0.0419
Plasmodium falciparum thioredoxin reductase 0.0038 0.0171 0.5374
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.0074 0.0091
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0074 0.0108
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.054 0.0814
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0122 0.07 0.1056
Schistosoma mansoni ap endonuclease 0.0021 0.0065 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0193 0.0648
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.003 0.0042
Entamoeba histolytica Ran family GTPase 0.0045 0.0214 0.1216
Chlamydia trachomatis neutral amino acid transporter 0.047 0.2889 0.4362
Loa Loa (eye worm) RecQ helicase 0.0022 0.007 0.0102
Entamoeba histolytica recQ family helicase, putative 0.0022 0.007 0.04
Loa Loa (eye worm) hypothetical protein 0.0151 0.0885 0.1337
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0007 0.0011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.0835 0.1261
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0193 0.019
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0045 0.0214 0.114
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1757 0.6022
Echinococcus multilocularis sodium:dicarboxylate symporter 0.106 0.6603 0.6602
Loa Loa (eye worm) hypothetical protein 0.0074 0.0397 0.0597
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0074 0.0071
Plasmodium vivax transportin, putative 0.0011 0.0005 0.0054
Echinococcus multilocularis phd:f box containing protein 0.0016 0.003 0.0027
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0315 0.3519
Giardia lamblia Fructose-bisphosphate aldolase 0.029 0.1757 1
Brugia malayi ecdysteroid receptor 0.0023 0.0074 0.0105
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.003 0.0343
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0074 0.0109
Onchocerca volvulus 0.0023 0.0074 0.0091
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.003 0.0343
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0036 0.005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0015 0.0142
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0014 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0074 0.0105
Echinococcus multilocularis neuropeptide s receptor 0.046 0.2829 0.2826
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0014 0.0109
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.0835 0.1261
Schistosoma mansoni hypothetical protein 0.004 0.0184 0.0278
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0074 0.0108
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0036 0.005
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0315 0.0312
Schistosoma mansoni ran 0.0045 0.0214 0.0324
Echinococcus multilocularis protein patched 0.0041 0.0193 0.019
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0042 0.0039
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0056 0.0078
Trypanosoma brucei glucosidase, putative 0.0035 0.0152 0.1676
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0014 0.0032
Toxoplasma gondii ABC1 family protein 0.0151 0.0885 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0074 0.0071
Onchocerca volvulus 0.0151 0.0885 0.1322
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0151 0.0885 0.1341
Mycobacterium leprae conserved hypothetical protein 0.0151 0.0885 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.0885 0.1337
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0015 0.0119
Brugia malayi jmjC domain containing protein 0.0062 0.032 0.0478
Mycobacterium tuberculosis Probable reductase 0.0087 0.0477 0.0701
Brugia malayi jmjC domain containing protein 0.0016 0.003 0.0039
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0174 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0014 0.0032
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0193 0.0288
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0151 0.0885 0.1321
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.00000000008604
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0171 0.0255
Schistosoma mansoni survival motor neuron protein 0.0053 0.0268 0.0405
Schistosoma mansoni hypothetical protein 0.0053 0.0268 0.0405
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.0711 0.1077
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0065 0.0687
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.007 0.0099
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0142 0.0824 0.1227
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0074 0.0105
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0152 0.0226
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0014 0.0032
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0174 0.026
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0142 0.0824 0.8489
Plasmodium vivax hypothetical protein, conserved 0.0151 0.0885 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0074 0.0105

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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