Detailed information for compound 877617

Basic information

Technical information
  • TDR Targets ID: 877617
  • Name: 3-(2,4-dimethylphenyl)-1-(furan-2-ylmethyl)-1 -methylurea
  • MW: 258.316 | Formula: C15H18N2O2
  • H donors: 1 H acceptors: 1 LogP: 2.43 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(c1)C)NC(=O)N(Cc1ccco1)C
  • InChi: 1S/C15H18N2O2/c1-11-6-7-14(12(2)9-11)16-15(18)17(3)10-13-5-4-8-19-13/h4-9H,10H2,1-3H3,(H,16,18)
  • InChiKey: GLLXLDKCZRPUNM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(2,4-dimethylphenyl)-1-(2-furylmethyl)-1-methyl-urea
  • 3-(2,4-dimethylphenyl)-1-(2-furylmethyl)-1-methylurea
  • 3-(2,4-dimethylphenyl)-1-(furan-2-ylmethyl)-1-methyl-urea
  • Oprea1_725377

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0048 0.0578 1
Echinococcus granulosus GPCR family 2 0.0034 0.0284 0.0063
Schistosoma mansoni amine GPCR 0.0042 0.0453 0.0326
Brugia malayi putative neuropeptide receptor 0.0042 0.0453 0.0212
Echinococcus granulosus 7tm_1 domain containing protein 0.0042 0.0453 0.0237
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0453 0.0212
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0284 0.0038
Loa Loa (eye worm) hypothetical protein 0.0503 1 1
Echinococcus granulosus serotonin receptor 0.0042 0.0453 0.0237
Brugia malayi G protein-coupled receptor 0.0042 0.0453 0.0212
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0453 0.0326
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0042 0.0453 0.0212
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0453 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.018 0.0123
Brugia malayi Pre-SET motif family protein 0.0221 0.4171 0.4023
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0284 0.0038
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0453 0.0326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0376 0.0542
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0042 0.0453 0.0212
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0042 0.0453 0.0326
Echinococcus granulosus neuropeptides capa receptor 0.0042 0.0453 0.0237
Echinococcus multilocularis neuropeptide s receptor 0.0042 0.0453 0.0212
Brugia malayi Serotonin receptor 0.0042 0.0453 0.0212
Brugia malayi hypothetical protein 0.0042 0.0453 0.0212
Schistosoma mansoni neuropeptide receptor 0.0042 0.0453 0.0326
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0042 0.0453 0.0212
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Loa Loa (eye worm) hypothetical protein 0.0072 0.1089 0.0864
Echinococcus granulosus hypothetical protein 0.0042 0.0453 0.0237
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0042 0.0453 0.0237
Entamoeba histolytica hypothetical protein 0.0076 0.1163 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0284 0.0063
Echinococcus granulosus 7TM GPCR rhodopsin 0.0042 0.0453 0.0237
Schistosoma mansoni hypothetical protein 0.0042 0.0453 0.0326
Onchocerca volvulus 0.0042 0.0453 0.0454
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0578 0.0974
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Schistosoma mansoni hypothetical protein 0.0042 0.0453 0.0326
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.0453 0.0326
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0377 0.6514
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0174 0.0111
Brugia malayi neuropeptide F receptor 0.0042 0.0453 0.0212
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Schistosoma mansoni amine GPCR 0.0042 0.0453 0.0326
Echinococcus multilocularis neuropeptide FF receptor 2 0.0042 0.0453 0.0212
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0042 0.0453 0.0326
Echinococcus multilocularis neuropeptide receptor A26 0.0042 0.0453 0.0212
Brugia malayi hypothetical protein 0.0042 0.0453 0.0212
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.1784 0.1576
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0325 0.0432
Echinococcus granulosus G protein coupled receptor 139 0.0042 0.0453 0.0237
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0453 0.0212
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0042 0.0453 0.0326
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0453 0.0326
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0123 0.0002
Onchocerca volvulus 0.0042 0.0453 0.0454
Echinococcus granulosus peptide allatostatin:somatostatin 0.0042 0.0453 0.0237
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0042 0.0453 0.0326
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0042 0.0453 0.0237
Echinococcus multilocularis neuropeptides capa receptor 0.0042 0.0453 0.0212
Schistosoma mansoni hypothetical protein 0.0034 0.0284 0.0059
Onchocerca volvulus 0.0252 0.4803 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0042 0.0453 0.0326
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Echinococcus granulosus g protein coupled receptor 0.0042 0.0453 0.0237
Brugia malayi neuropeptide F receptor 0.0042 0.0453 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0325 0.0432
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0042 0.0453 0.0237
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0048 0.0578 0.0341
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Entamoeba histolytica hypothetical protein 0.0076 0.1163 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0453 0.0212
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0042 0.0453 0.0212
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0042 0.0453 0.0212
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0048 0.0578 1
Schistosoma mansoni tar DNA-binding protein 0.0339 0.6601 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0246 0.0025
Brugia malayi Dopamine receptor protein 1 0.0042 0.0453 0.0212
Brugia malayi hypothetical protein 0.0042 0.0453 0.0212
Echinococcus granulosus g-protein coupled receptor 0.0042 0.0453 0.0237
Brugia malayi Melatonin receptor type 1A 0.0042 0.0453 0.0212
Plasmodium vivax SET domain protein, putative 0.0032 0.0246 0.5
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0042 0.0453 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0376 0.0542
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0453 0.0326
Schistosoma mansoni alpha-1 adrenergic receptor 0.0042 0.0453 0.0326
Onchocerca volvulus 0.0042 0.0453 0.0454
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0042 0.0453 0.0212
Echinococcus multilocularis serotonin receptor 0.0042 0.0453 0.0212
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0042 0.0453 0.0212
Echinococcus granulosus neuropeptide s receptor 0.0042 0.0453 0.0237
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.1163 0.094
Echinococcus granulosus sex peptide receptor 0.0042 0.0453 0.0237
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.018 0.0123
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Schistosoma mansoni amine GPCR 0.0042 0.0453 0.0326
Echinococcus granulosus orexin receptor type 2 0.0042 0.0453 0.0237
Echinococcus granulosus neuropeptides capa receptor 0.0042 0.0453 0.0237
Brugia malayi Dopamine receptor protein 2 0.0042 0.0453 0.0212
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0453 0.0237
Schistosoma mansoni neuropeptide receptor 0.0042 0.0453 0.0326
Echinococcus multilocularis G-protein coupled receptor, putative 0.0042 0.0453 0.0212
Brugia malayi GnHR receptor homolog 0.0042 0.0453 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0231 0.0233
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0339 0.6601 0.6516
Schistosoma mansoni adenoreceptor 0.0042 0.0453 0.0326
Schistosoma mansoni hypothetical protein 0.0072 0.1089 0.1327
Echinococcus granulosus g protein coupled receptor 0.0042 0.0453 0.0237
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0453 0.0212
Echinococcus granulosus tachykinin peptides receptor 99D 0.0042 0.0453 0.0237
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0578 0.0974
Onchocerca volvulus 0.0042 0.0453 0.0454
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0453 0.0212
Brugia malayi hypothetical protein 0.0076 0.1163 0.094
Brugia malayi RNA binding protein 0.0339 0.6601 0.6516
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0042 0.0453 0.0237
Brugia malayi AKH receptor 0.0042 0.0453 0.0212
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0057 0.0985
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0048 0.0578 1
Echinococcus granulosus neuropeptide receptor 0.0042 0.0453 0.0237
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0325 0.0432
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0453 0.0212
Onchocerca volvulus 0.0042 0.0453 0.0454
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0042 0.0453 0.0237
Brugia malayi hypothetical protein 0.0042 0.0453 0.0212
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Brugia malayi larval opioid receptor 0.0042 0.0453 0.0212
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Schistosoma mansoni tar DNA-binding protein 0.0339 0.6601 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0042 0.0453 0.0326
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0325 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.1163 0.0963
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.018 0.0123
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.1784 0.1576
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.1163 0.1443
Echinococcus multilocularis fmrfamide receptor 0.0042 0.0453 0.0212
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Schistosoma mansoni biogenic amine receptor 0.0042 0.0453 0.0326
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0123 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0376 0.0542
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.0453 0.0212
Loa Loa (eye worm) RNA binding protein 0.0339 0.6601 0.6516
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0325 0.0432
Schistosoma mansoni amine GPCR 0.0042 0.0453 0.0326
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Brugia malayi putative neuropeptide receptor NPR1 0.0042 0.0453 0.0212
Giardia lamblia GTOR 0.0048 0.0578 0.5
Echinococcus granulosus neuropeptide receptor A26 0.0042 0.0453 0.0237
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0042 0.0453 0.0237
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0042 0.0453 0.0212
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0453 0.0237
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0042 0.0453 0.0212
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Onchocerca volvulus 0.0042 0.0453 0.0454
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0453 0.0237
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0453 0.0237
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.0453 0.0326
Onchocerca volvulus 0.0042 0.0453 0.0454
Echinococcus granulosus somatostatin receptor 0.0042 0.0453 0.0237
Onchocerca volvulus 0.0042 0.0453 0.0454
Echinococcus granulosus dro:myosuppressin receptor 0.0042 0.0453 0.0237
Onchocerca volvulus 0.0042 0.0453 0.0454
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Onchocerca volvulus 0.0103 0.1713 0.3218
Echinococcus granulosus g protein coupled receptor 0.0042 0.0453 0.0237
Onchocerca volvulus 0.0042 0.0453 0.0454
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0042 0.0453 0.0212
Brugia malayi G protein-coupled receptor F59B2.13 0.0042 0.0453 0.0212
Schistosoma mansoni tar DNA-binding protein 0.0339 0.6601 1
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0453 0.0237
Schistosoma mansoni opsin-like receptor 0.0042 0.0453 0.0326
Schistosoma mansoni histamine h1 receptor 0.0042 0.0453 0.0326
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0042 0.0453 0.0212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0048 0.0578 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0042 0.0453 0.0237
Loa Loa (eye worm) TYRA-2 protein 0.0042 0.0453 0.0212
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0042 0.0453 0.0212
Echinococcus granulosus survival motor neuron protein 1 0.0503 1 1
Schistosoma mansoni hypothetical protein 0.0042 0.0453 0.0326
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0042 0.0453 0.0212
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0042 0.0453 0.0212
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.0453 0.0212
Onchocerca volvulus Neuropeptide F receptor homolog 0.0042 0.0453 0.0454
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0284 0.0063
Loa Loa (eye worm) melatonin receptor type 1A 0.0042 0.0453 0.0212
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0453 0.0237
Echinococcus multilocularis G protein coupled receptor 139 0.0042 0.0453 0.0212
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0284 0.0038
Onchocerca volvulus 0.0042 0.0453 0.0454
Schistosoma mansoni hypothetical protein 0.0034 0.0284 0.0059
Echinococcus granulosus neuropeptide Y receptor 0.0042 0.0453 0.0237
Schistosoma mansoni tar DNA-binding protein 0.0339 0.6601 1
Echinococcus multilocularis tar DNA binding protein 0.0339 0.6601 0.6516
Schistosoma mansoni survival motor neuron protein 0.0103 0.1713 0.2307
Brugia malayi TAR-binding protein 0.0339 0.6601 0.6516
Schistosoma mansoni opsin-like receptor 0.0042 0.0453 0.0326
Schistosoma mansoni amine GPCR 0.0042 0.0453 0.0326
Schistosoma mansoni biogenic amine (5HT) receptor 0.0042 0.0453 0.0326
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0453 0.0326
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0453 0.0212
Schistosoma mansoni neuropeptide receptor 0.0042 0.0453 0.0326
Brugia malayi sulfakinin receptor protein 0.0042 0.0453 0.0212
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0042 0.0453 0.0212
Schistosoma mansoni biogenic amine receptor 0.0042 0.0453 0.0326
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0453 0.0237
Loa Loa (eye worm) hypothetical protein 0.0106 0.1784 0.1576
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Echinococcus multilocularis survival motor neuron protein 1 0.0503 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0123 0.0002
Echinococcus multilocularis orexin receptor type 2 0.0042 0.0453 0.0212
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Brugia malayi hypothetical protein 0.0042 0.0453 0.0212
Loa Loa (eye worm) hypothetical protein 0.0034 0.0284 0.0038
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Brugia malayi hypothetical protein 0.0042 0.0453 0.0212
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0453 0.0237
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0042 0.0453 0.0454
Trichomonas vaginalis set domain proteins, putative 0.0252 0.4803 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0253 0.0278
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.0453 0.0212
Schistosoma mansoni hypothetical protein 0.0042 0.0453 0.0326
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0453 0.0326
Brugia malayi hypothetical protein 0.0042 0.0453 0.0212
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0042 0.0453 0.0326
Brugia malayi Dopamine receptor 0.0042 0.0453 0.0212
Brugia malayi RNA recognition motif domain containing protein 0.0339 0.6601 0.6516
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0376 0.0542
Echinococcus multilocularis allatostatin A receptor 0.0042 0.0453 0.0212
Schistosoma mansoni growth hormone secretagogue receptor 0.0042 0.0453 0.0326
Echinococcus multilocularis somatostatin receptor 0.0042 0.0453 0.0212
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.0453 0.0212
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0453 0.0237
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0048 0.0578 0.0364
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Echinococcus granulosus fmrfamide receptor 0.0042 0.0453 0.0237
Brugia malayi G-protein coupled receptor 0.0042 0.0453 0.0212
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0284 0.0038
Brugia malayi ORL1-like opioid receptor 0.0042 0.0453 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0325 0.0432
Schistosoma mansoni biogenic amine (5HT) receptor 0.0042 0.0453 0.0326
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0453 0.0212
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0453 0.0212
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0042 0.0453 0.0212
Loa Loa (eye worm) TAR-binding protein 0.0339 0.6601 0.6516
Brugia malayi hypothetical protein 0.0042 0.0453 0.0212
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0453 0.0237
Schistosoma mansoni neuropeptide receptor 0.0042 0.0453 0.0326
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Entamoeba histolytica hypothetical protein 0.0076 0.1163 1
Onchocerca volvulus 0.0042 0.0453 0.0454
Brugia malayi hypothetical protein 0.0042 0.0453 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0174 0.0111
Echinococcus granulosus biogenic amine 5HT receptor 0.0042 0.0453 0.0237
Schistosoma mansoni myosin xvIII 0.0042 0.0453 0.0326
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0434 0.0665
Onchocerca volvulus 0.0042 0.0453 0.0454
Brugia malayi follicle stimulating hormone receptor 0.0042 0.0453 0.0212
Schistosoma mansoni hypothetical protein 0.0034 0.0284 0.0059
Brugia malayi RE15519p 0.0042 0.0453 0.0212
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.0453 0.0326
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0453 0.0326
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0048 0.0578 0.0523
Echinococcus multilocularis serotonin receptor 0.0042 0.0453 0.0212
Brugia malayi Serotonin receptor 0.0042 0.0453 0.0212
Schistosoma mansoni biogenic amine receptor 0.0042 0.0453 0.0326
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0284 0.0038
Echinococcus multilocularis g-protein coupled receptor 0.0042 0.0453 0.0212
Onchocerca volvulus 0.0042 0.0453 0.0454
Brugia malayi G-protein coupled receptor 0.0042 0.0453 0.0212
Echinococcus multilocularis sex peptide receptor 0.0042 0.0453 0.0212
Echinococcus multilocularis fmrfamide receptor 0.0042 0.0453 0.0212
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0453 0.0212
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0453 0.0326
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0042 0.0453 0.0212
Onchocerca volvulus 0.0042 0.0453 0.0454
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.4171 0.4023
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0103 0.1713 0.1503
Brugia malayi Tachykinin-like peptides receptor 99D 0.0042 0.0453 0.0212
Brugia malayi hypothetical protein 0.0042 0.0453 0.0212
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.1089 0.0864
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0453 0.0212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0048 0.0578 1
Schistosoma mansoni hypothetical protein 0.0103 0.1713 0.2307
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0453 0.0212
Echinococcus multilocularis neuropeptides capa receptor 0.0042 0.0453 0.0212
Echinococcus multilocularis neuropeptide Y receptor 0.0042 0.0453 0.0212
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.0453 0.0326
Entamoeba histolytica hypothetical protein 0.0076 0.1163 1
Schistosoma mansoni opsin-like receptor 0.0042 0.0453 0.0326
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0042 0.0453 0.0212
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0453 0.0326
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0453 0.0326
Onchocerca volvulus 0.0042 0.0453 0.0454
Onchocerca volvulus 0.0042 0.0453 0.0454
Echinococcus granulosus tar DNA binding protein 0.0339 0.6601 0.6524
Echinococcus granulosus alpha 1A adrenergic receptor 0.0042 0.0453 0.0237
Echinococcus multilocularis neuropeptide Y receptor 0.0042 0.0453 0.0212
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0042 0.0453 0.0326
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0578 0.0341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0123 0.0002
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0376 0.0542
Schistosoma mansoni hypothetical protein 0.0034 0.0284 0.0059
Echinococcus multilocularis neuropeptide receptor 0.0042 0.0453 0.0212
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0453 0.0326
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0042 0.0453 0.0212
Schistosoma mansoni tar DNA-binding protein 0.0339 0.6601 1
Schistosoma mansoni hypothetical protein 0.0076 0.1163 0.1443
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0453 0.0212
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0048 0.0578 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0325 0.0432
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.1784 0.1576
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Echinococcus multilocularis dro:myosuppressin receptor 0.0042 0.0453 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0325 0.0432
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0578 0.0974
Echinococcus multilocularis neuropeptide receptor 0.0042 0.0453 0.0212
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0578 0.0341
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0453 0.0326
Echinococcus granulosus neuropeptide FF receptor 2 0.0042 0.0453 0.0237
Echinococcus multilocularis GPCR, family 2 0.0034 0.0284 0.0038
Echinococcus granulosus allatostatin A receptor 0.0042 0.0453 0.0237
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0042 0.0453 0.0212
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0042 0.0453 0.0326
Echinococcus granulosus neuropeptide Y receptor 0.0042 0.0453 0.0237
Echinococcus granulosus neuropeptide receptor 0.0042 0.0453 0.0237

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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