Detailed information for compound 877695

Basic information

Technical information
  • TDR Targets ID: 877695
  • Name: 4-chloro-N-(2-methylpyrazol-3-yl)benzenesulfo namide
  • MW: 271.723 | Formula: C10H10ClN3O2S
  • H donors: 1 H acceptors: 3 LogP: 1.72 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)S(=O)(=O)Nc1ccnn1C
  • InChi: 1S/C10H10ClN3O2S/c1-14-10(6-7-12-14)13-17(15,16)9-4-2-8(11)3-5-9/h2-7,13H,1H3
  • InChiKey: JUGZPBNQEQTHMX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-chloro-N-(2-methyl-3-pyrazolyl)benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0099 0.0438 0.0438
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0115 0.0252
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0214 0.0214
Mycobacterium ulcerans aminopeptidase N PepN 0.0099 0.0438 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0214 0.047
Onchocerca volvulus 0.0099 0.0438 0.5
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0103 0.0103
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0099 0.0438 0.0438
Brugia malayi hypothetical protein 0.086 0.4544 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0115 0.0115
Toxoplasma gondii aminopeptidase N protein 0.0099 0.0438 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0122 0.0122
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0122 0.0122
Entamoeba histolytica aminopeptidase, putative 0.0099 0.0438 0.5
Onchocerca volvulus 0.0099 0.0438 0.5
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0099 0.0438 0.5
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0099 0.0438 0.0438
Loa Loa (eye worm) hypothetical protein 0.0058 0.0214 0.0214
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0099 0.0438 0.0438
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0099 0.0438 0.5
Mycobacterium ulcerans aminopeptidase N PepN 0.0099 0.0438 0.5
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0099 0.0438 1
Brugia malayi Peptidase family M1 containing protein 0.0099 0.0438 0.0963
Loa Loa (eye worm) peptidase family M1 containing protein 0.0099 0.0438 0.0438
Trypanosoma cruzi aminopeptidase, putative 0.0099 0.0438 0.5
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0099 0.0438 0.0438
Trypanosoma brucei aminopeptidase, putative 0.0099 0.0438 0.5
Brugia malayi TATA binding protein associated factor 0.0099 0.0438 0.0963
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0099 0.0438 0.5
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0099 0.0438 0.0438
Onchocerca volvulus 0.0099 0.0438 0.5
Trypanosoma brucei Aminopeptidase M1, putative 0.0099 0.0438 0.5
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0099 0.0438 0.5
Brugia malayi hypothetical protein 0.0099 0.0438 0.0963
Loa Loa (eye worm) hypothetical protein 0.0032 0.0076 0.0076
Trypanosoma cruzi aminopeptidase, putative 0.0099 0.0438 0.5
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0099 0.0438 0.5
Echinococcus granulosus microtubule associated protein 2 0.0801 0.4225 0.4225
Brugia malayi Peptidase family M1 containing protein 0.0099 0.0438 0.0963
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0103 0.0227
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0099 0.0438 0.0438
Echinococcus granulosus aminopeptidase N 0.0099 0.0438 0.0438
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0099 0.0438 0.0438
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0099 0.0438 0.5
Toxoplasma gondii aminopeptidase N, putative 0.0099 0.0438 0.5
Loa Loa (eye worm) hypothetical protein 0.0099 0.0438 0.0438
Schistosoma mansoni hypothetical protein 0.004 0.0115 0.0115
Trypanosoma brucei Aminopeptidase M1, putative 0.0099 0.0438 0.5
Loa Loa (eye worm) leukotriene A4 hydrolase 0.1871 1 1
Schistosoma mansoni microtubule-associated protein tau 0.0801 0.4225 0.4225
Echinococcus multilocularis leukotriene A 4 hydrolase 0.1871 1 1
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0099 0.0438 0.5
Trypanosoma cruzi Aminopeptidase M1, putative 0.0099 0.0438 0.5
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0099 0.0438 0.5
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0099 0.0438 0.0438
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0099 0.0438 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0099 0.0438 0.0438
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0099 0.0438 0.5
Schistosoma mansoni aminopeptidase A (M01 family) 0.0099 0.0438 0.0438
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0099 0.0438 0.5
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0099 0.0438 1
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0099 0.0438 0.5
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0099 0.0438 0.0438
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0099 0.0438 0.0438
Echinococcus multilocularis aminopeptidase N 0.0099 0.0438 0.0438
Loa Loa (eye worm) hypothetical protein 0.0099 0.0438 0.0438
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0099 0.0438 0.5
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0099 0.0438 0.0438
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0103 0.0103
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0103 0.0103
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0099 0.0438 0.5
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0099 0.0438 0.0438
Loa Loa (eye worm) TATA binding protein associated factor 0.0099 0.0438 0.0438
Brugia malayi hypothetical protein 0.0099 0.0438 0.0963
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0099 0.0438 0.0438
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0099 0.0438 0.0438
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0214 0.047
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.1871 1 1
Toxoplasma gondii aminopeptidase n, putative 0.0099 0.0438 0.5
Echinococcus multilocularis microtubule associated protein 2 0.0801 0.4225 0.4225
Brugia malayi Peptidase family M1 containing protein 0.0099 0.0438 0.0963
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0099 0.0438 0.5
Loa Loa (eye worm) aminopeptidase N 0.0099 0.0438 0.0438

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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