TDR Targets

Basic information

Technical information

TDR Targets ID: 877719
Name: 2-fluoro-N-(2-methylsulfanylphenyl)benzenesul fonamide
MW: 297.368 | Formula: C13H12FNO2S2
H donors: 1 H acceptors: 2 LogP: 3.06 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CSc1ccccc1NS(=O)(=O)c1ccccc1F
InChi: 1S/C13H12FNO2S2/c1-18-12-8-4-3-7-11(12)15-19(16,17)13-9-5-2-6-10(13)14/h2-9,15H,1H3
InChiKey: WRTBYVJOVVDALH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-fluoro-N-[2-(methylthio)phenyl]benzenesulfonamide
ZINC05601777
T5349519

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0048	0.0002	1
Brugia malayi	UPF0017 protein CG3488	0.0048	0.0002	0.0002
Mycobacterium ulcerans	acyl-CoA synthetase	0.0048	0.0002	0.0016
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0008	1
Mycobacterium ulcerans	homoserine O-acetyltransferase	0.0048	0.0002	0.0016
Entamoeba histolytica	hypothetical protein	0.0048	0.0002	1
Brugia malayi	MH2 domain containing protein	0.0143	0.0082	0.0082
Trypanosoma cruzi	hydrolase-like protein, putative	0.0048	0.0002	0.0006
Mycobacterium tuberculosis	Possible epoxide hydrolase EphF (epoxide hydratase) (arene-oxide hydratase)	0.0048	0.0002	0.0016
Mycobacterium tuberculosis	Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase)	0.0048	0.0002	0.0016
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0008	0.0008
Trypanosoma brucei	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.4667	0.3906	1
Mycobacterium ulcerans	lipase/esterase	0.0048	0.0002	0.0016
Trichomonas vaginalis	hydrolase, putative	0.0048	0.0002	1
Trypanosoma cruzi	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.4667	0.3906	1
Mycobacterium ulcerans	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD	0.0048	0.0002	0.0016
Loa Loa (eye worm)	ab-hydrolase associated lipase region family protein	0.0048	0.0002	0.0002
Chlamydia trachomatis	phosphoglycolate phosphatase	0.0046	0	0.5
Echinococcus multilocularis	abhydrolase domain containing protein 16A	0.0048	0.0002	0.305
Plasmodium vivax	hypothetical protein, conserved	0.0048	0.0002	1
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0048	0.0002	1
Mycobacterium ulcerans	epoxide hydrolase EphF	0.0048	0.0002	0.0016
Mycobacterium ulcerans	proline iminopeptidase PIP	0.0048	0.0002	0.0016
Brugia malayi	Hypothetical 54.7 kDa protein F37A4.1 in chromosome III	0.0048	0.0002	0.0002
Mycobacterium ulcerans	exported protease	0.0048	0.0002	0.0016
Mycobacterium ulcerans	hypothetical protein	0.0048	0.0002	0.0016
Trypanosoma cruzi	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.4667	0.3906	1
Mycobacterium ulcerans	epoxide hydrolase EphB	0.0048	0.0002	0.0016
Trypanosoma brucei	hydrolase, alpha/beta fold family, putative	0.0048	0.0002	0.0006
Mycobacterium ulcerans	peroxidase BpoB	0.0048	0.0002	0.0016
Giardia lamblia	ENC6 protein	0.0048	0.0002	1
Mycobacterium ulcerans	epoxide hydrolase EphA	0.1762	0.145	1
Mycobacterium ulcerans	epoxide hydrolase EphE	0.0048	0.0002	0.0016
Leishmania major	malonyl-coa decarboxylase-like protein	0.4667	0.3906	1
Entamoeba histolytica	alpha/beta hydrolase fold protein, putative	0.0048	0.0002	1
Plasmodium falciparum	acid cluster protein 33 homologue, putative	0.0048	0.0002	1
Echinococcus multilocularis	abhydrolase domain containing protein	0.0048	0.0002	0.305
Mycobacterium tuberculosis	Probable homoserine O-acetyltransferase MetA (homoserine O-trans-acetylase) (homoserine transacetylase) (HTA)	0.0048	0.0002	0.0016
Mycobacterium leprae	Probable homoserine o-acetyltransferase MetA	0.0048	0.0002	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0008	1
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0048	0.0002	1
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0048	0.0002	1
Mycobacterium ulcerans	hydrolase	0.0048	0.0002	0.0016
Treponema pallidum	phosphoglycolate phosphatase	0.0046	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0002	0.0002
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0008	1
Mycobacterium ulcerans	exported protease	0.0048	0.0002	0.0016
Mycobacterium ulcerans	hypothetical protein	0.0048	0.0002	0.0016
Trypanosoma cruzi	hypothetical protein, conserved	0.0048	0.0002	0.0006
Trypanosoma cruzi	hydrolase-like protein, putative	0.0048	0.0002	0.0006
Mycobacterium ulcerans	lipase/esterase	0.0048	0.0002	0.0016
Mycobacterium ulcerans	lignin peroxidase LipJ	0.0048	0.0002	0.0016
Echinococcus multilocularis	abhydrolase domain containing 3	0.0048	0.0002	0.305
Loa Loa (eye worm)	hypothetical protein	1.1879	1	1
Onchocerca volvulus	Lipase homolog	0.0048	0.0002	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0048	0.0002	0.0006
Mycobacterium tuberculosis	Possible epoxide hydrolase EphE (epoxide hydratase) (arene-oxide hydratase)	0.0048	0.0002	0.0016
Toxoplasma gondii	homoserine O-acetyltransferase, putative	0.0048	0.0002	0.5
Mycobacterium ulcerans	haloalkane dehalogenase	0.0048	0.0002	0.0016
Mycobacterium tuberculosis	Conserved protein	0.0048	0.0002	0.0016
Mycobacterium ulcerans	haloalkane dehalogenase	0.0048	0.0002	0.0016
Brugia malayi	hydrolase, alpha/beta fold family protein	0.0048	0.0002	0.0002
Mycobacterium tuberculosis	Possible haloalkane dehalogenase	0.0048	0.0002	0.0016
Trypanosoma cruzi	hypothetical protein, conserved	0.0048	0.0002	0.0006
Toxoplasma gondii	alpha/beta hydrolase, putative	0.0048	0.0002	0.5
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0048	0.0002	1
Echinococcus granulosus	abhydrolase domain containing protein 3	0.0048	0.0002	0.305
Mycobacterium tuberculosis	Probable oxidoreductase	0.0048	0.0002	0.0016
Loa Loa (eye worm)	abhydrolase domain-containing protein 2	0.0048	0.0002	0.0002
Mycobacterium tuberculosis	Possible short-chain dehydrogenase EphD	0.0048	0.0002	0.0016
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0008	0.0008
Schistosoma mansoni	family S33 non-peptidase homologue (S33 family)	0.0048	0.0002	0.305
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0048	0.0002	1
Echinococcus multilocularis	abhydrolase domain containing protein 3	0.0048	0.0002	0.305
Brugia malayi	alpha/beta hydrolase	0.0048	0.0002	0.0002
Plasmodium falciparum	epoxide hydrolase 1	0.0048	0.0002	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0008	1
Loa Loa (eye worm)	hydrolase	0.0048	0.0002	0.0002
Echinococcus granulosus	abhydrolase domain containing protein	0.0048	0.0002	0.305
Mycobacterium ulcerans	non-heme haloperoxidase Hpx	0.0048	0.0002	0.0016
Echinococcus multilocularis	lysosomal acid lipase:cholesteryl ester	0.0048	0.0002	0.305
Mycobacterium tuberculosis	Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase)	0.1762	0.145	1
Brugia malayi	Alpha/beta hydrolase	0.0048	0.0002	0.0002
Mycobacterium ulcerans	short chain dehydrogenase	0.0048	0.0002	0.0016
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0008	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0002	0.0002
Mycobacterium ulcerans	hypothetical protein	0.0048	0.0002	0.0016
Mycobacterium ulcerans	oxidoreductase	0.0048	0.0002	0.0016
Echinococcus multilocularis	abhydrolase domain containing protein 11	0.0048	0.0002	0.305
Echinococcus multilocularis	lysosomal acid lipase:cholesteryl ester	0.0048	0.0002	0.305
Plasmodium vivax	alpha/beta hydrolase, putative	0.0048	0.0002	1
Onchocerca volvulus	Epoxide hydrolase 1 homolog	0.0048	0.0002	1
Trypanosoma brucei	hydrolase, alpha/beta fold family, putative	0.0048	0.0002	0.0006
Wolbachia endosymbiont of Brugia malayi	malonyl-CoA decarboxylase	1.1879	1	1
Trypanosoma cruzi	hydrolase, alpha/beta fold family, putative	0.0048	0.0002	0.0006
Trypanosoma cruzi	hydrolase-like protein	0.0048	0.0002	0.0006
Entamoeba histolytica	alpha/beta hydrolase domain protein, putative	0.0048	0.0002	1
Mycobacterium ulcerans	hydrolase	0.0048	0.0002	0.0016
Mycobacterium tuberculosis	Probable haloalkane dehalogenase	0.0048	0.0002	0.0016
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0008	1
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.0048	0.0002	1
Mycobacterium tuberculosis	Possible peroxidase BpoB (non-haem peroxidase)	0.0048	0.0002	0.0016
Treponema pallidum	phosphoglycolate phosphatase	0.0046	0	0.5
Mycobacterium leprae	POSSIBLE EPOXIDE HYDROLASE EPHE (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE)	0.0048	0.0002	1
Echinococcus granulosus	lysosomal acid lipase:cholesteryl ester	0.0048	0.0002	0.305
Loa Loa (eye worm)	MH2 domain-containing protein	0.0143	0.0082	0.0082
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0048	0.0002	1
Mycobacterium tuberculosis	Probable carboxylesterase CaeA	0.0048	0.0002	0.0016
Mycobacterium tuberculosis	Probable exported protease	0.0048	0.0002	0.0016
Echinococcus granulosus	abhydrolase domain containing protein 11	0.0048	0.0002	0.305
Mycobacterium ulcerans	hypothetical protein	0.0048	0.0002	0.0016
Plasmodium vivax	hypothetical protein, conserved	0.0048	0.0002	1
Mycobacterium leprae	POSSIBLE SECRETED PROTEASE	0.0048	0.0002	1
Brugia malayi	hydrolase, alpha/beta fold family protein	0.0048	0.0002	0.0002
Plasmodium vivax	hypothetical protein, conserved	0.0048	0.0002	1
Schistosoma mansoni	hydrolase	0.0048	0.0002	0.305
Loa Loa (eye worm)	transcription factor SMAD2	0.0143	0.0082	0.0082
Mycobacterium leprae	Possible short-chain dehydrogenase EphD	0.0048	0.0002	1
Mycobacterium ulcerans	bromoperoxidase BpoC	0.0048	0.0002	0.0016
Mycobacterium leprae	Probable exported protease	0.0048	0.0002	1
Mycobacterium leprae	Probable exported protease	0.0048	0.0002	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0008	1
Onchocerca volvulus	Lipase homolog	0.0048	0.0002	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 877719