Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glutathione reductase | 0.0107 | 0.1069 | 0.1658 |
Mycobacterium ulcerans | glutaminase | 0.0307 | 0.3741 | 0.6563 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.006 | 0.0439 | 0.0507 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0185 | 0.2104 | 0.1998 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0042 | 0.019 | 0.0105 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0083 | 0.074 | 0.1107 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0185 | 0.2104 | 0.1998 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0245 | 0.2905 | 0.8837 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0083 | 0.074 | 0.0617 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0083 | 0.074 | 0.0617 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0064 | 0.0497 | 0.037 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0107 | 0.1069 | 0.0949 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0083 | 0.074 | 0.0617 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0057 | 0.04 | 0.0272 |
Plasmodium falciparum | thioredoxin reductase | 0.0107 | 0.1069 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0083 | 0.074 | 0.0617 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0272 | 0.327 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0245 | 0.2905 | 0.8837 |
Brugia malayi | Thioredoxin reductase | 0.0107 | 0.1069 | 0.1898 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0211 | 0.2448 | 0.6418 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0064 | 0.0497 | 0.037 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0064 | 0.0497 | 0.0882 |
Mycobacterium tuberculosis | Probable reductase | 0.0245 | 0.2905 | 0.8837 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0449 | 0.5631 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0449 | 0.5631 | 0.5573 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0042 | 0.019 | 0.0105 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0057 | 0.04 | 0.0488 |
Schistosoma mansoni | glutaminase | 0.0307 | 0.3741 | 0.3657 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0449 | 0.5631 | 0.5573 |
Trichomonas vaginalis | glutaminase, putative | 0.0307 | 0.3741 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0042 | 0.019 | 0.0161 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0083 | 0.074 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0107 | 0.1069 | 0.2985 |
Brugia malayi | glutathione reductase | 0.0107 | 0.1069 | 0.1898 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0185 | 0.2104 | 0.1998 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0185 | 0.2104 | 0.3551 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0107 | 0.1069 | 0.1658 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0042 | 0.019 | 0.0059 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0449 | 0.5631 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0057 | 0.04 | 0.0272 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0064 | 0.0497 | 0.0663 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0245 | 0.2905 | 0.8837 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0037 | 0.0132 | 0.0234 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0211 | 0.2448 | 1 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0083 | 0.074 | 0.2627 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0272 | 0.327 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0042 | 0.019 | 0.0059 |
Echinococcus multilocularis | protein patched | 0.0185 | 0.2104 | 0.1998 |
Schistosoma mansoni | inositol monophosphatase | 0.0042 | 0.019 | 0.0059 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0057 | 0.04 | 0.116 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0083 | 0.074 | 0.0617 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0272 | 0.327 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.074 | 0.1058 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0449 | 0.5631 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0083 | 0.074 | 0.0617 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0083 | 0.074 | 0.1686 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0057 | 0.04 | 0.0488 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0083 | 0.074 | 0.1686 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0062 | 0.0464 | 0.0337 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0449 | 0.5631 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0449 | 0.5631 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0449 | 0.5631 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0449 | 0.5631 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0272 | 0.327 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0057 | 0.04 | 0.0744 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0042 | 0.019 | 0.0105 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0042 | 0.019 | 1 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0083 | 0.074 | 0.1686 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0057 | 0.04 | 0.0744 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0405 | 0.0445 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0245 | 0.2905 | 0.8837 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0042 | 0.019 | 0.0161 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0185 | 0.2104 | 0.1998 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0211 | 0.2448 | 0.6418 |
Plasmodium vivax | glutathione reductase, putative | 0.0107 | 0.1069 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0107 | 0.1069 | 0.1703 |
Treponema pallidum | NADH oxidase | 0.0037 | 0.0132 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0062 | 0.0464 | 0.0337 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0042 | 0.019 | 0.0105 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0042 | 0.019 | 0.0619 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0162 | 0.003 |
Loa Loa (eye worm) | glutaminase 2 | 0.0307 | 0.3741 | 0.6544 |
Brugia malayi | Inositol-1 | 0.0042 | 0.019 | 0.0337 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.0405 | 0.072 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0245 | 0.2905 | 0.8837 |
Schistosoma mansoni | patched 1 | 0.0185 | 0.2104 | 0.1998 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0107 | 0.1069 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0107 | 0.1069 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0185 | 0.2104 | 0.5464 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0057 | 0.04 | 0.0488 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0185 | 0.2104 | 0.1998 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0057 | 0.04 | 0.0488 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0083 | 0.074 | 0.1107 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.0162 | 0.0287 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0245 | 0.2905 | 0.8837 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0083 | 0.074 | 0.0617 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0042 | 0.019 | 0.0161 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0057 | 0.04 | 0.0488 |
Toxoplasma gondii | thioredoxin reductase | 0.0107 | 0.1069 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0185 | 0.2104 | 0.1998 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0776 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0057 | 0.04 | 0.0488 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0057 | 0.04 | 0.2867 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0064 | 0.0497 | 0.037 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0083 | 0.074 | 0.1107 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0057 | 0.04 | 0.0272 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.0405 | 0.072 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0064 | 0.0497 | 0.0663 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.0405 | 0.0445 |
Brugia malayi | MAP kinase sur-1 | 0.0057 | 0.04 | 0.0711 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0057 | 0.04 | 0.0272 |
Trypanosoma brucei | protein kinase, putative | 0.0057 | 0.04 | 0.0488 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0057 | 0.04 | 0.0272 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.2104 | 0.3551 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0185 | 0.2104 | 0.1998 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0042 | 0.019 | 0.0059 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0776 | 1 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0042 | 0.019 | 0.0105 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0083 | 0.074 | 0.1315 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0064 | 0.0497 | 0.1163 |
Brugia malayi | glutaminase DH11.1 | 0.0307 | 0.3741 | 0.6643 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0083 | 0.074 | 0.1107 |
Loa Loa (eye worm) | glutaminase | 0.0307 | 0.3741 | 0.6544 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0083 | 0.074 | 0.0617 |
Trypanosoma brucei | trypanothione reductase | 0.0107 | 0.1069 | 0.1703 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0107 | 0.1069 | 0.0949 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0064 | 0.0497 | 0.0663 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0057 | 0.04 | 0.0437 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0057 | 0.04 | 0.0744 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0062 | 0.0464 | 0.0337 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0211 | 0.2448 | 0.6418 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0057 | 0.04 | 0.0488 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0037 | 0.0132 | 0.5 |
Leishmania major | trypanothione reductase | 0.0107 | 0.1069 | 0.1703 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0449 | 0.5631 | 0.5573 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0057 | 0.04 | 0.0744 |
Loa Loa (eye worm) | inositol-1 | 0.0042 | 0.019 | 0.0052 |
Brugia malayi | CHE-14 protein | 0.0185 | 0.2104 | 0.3736 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.