TDR Targets

Basic information

Technical information

TDR Targets ID: 877856
Name: 4-fluoro-N-[3-(3-methylbutylamino)quinoxalin- 2-yl]benzenesulfonamide
MW: 388.459 | Formula: C19H21FN4O2S
H donors: 2 H acceptors: 4 LogP: 4.17 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CC(CCNc1nc2ccccc2nc1NS(=O)(=O)c1ccc(cc1)F)C
InChi: 1S/C19H21FN4O2S/c1-13(2)11-12-21-18-19(23-17-6-4-3-5-16(17)22-18)24-27(25,26)15-9-7-14(20)8-10-15/h3-10,13H,11-12H2,1-2H3,(H,21,22)(H,23,24)
InChiKey: VFPPICWSQZGIAI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-fluoro-N-[3-(isopentylamino)quinoxalin-2-yl]benzenesulfonamide
4-fluoro-N-[3-(isopentylamino)-2-quinoxalinyl]benzenesulfonamide
4-fluoro-N-[3-(isoamylamino)quinoxalin-2-yl]benzenesulfonamide
STOCK4S-25820
ZINC02389708

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0055	0.0537	0.077
Schistosoma mansoni	amine GPCR	0.0055	0.0537	0.077
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0055	0.0537	0.077
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0055	0.0537	0.0537
Schistosoma mansoni	amine GPCR	0.0376	0.4322	0.6201
Loa Loa (eye worm)	hypothetical protein	0.06	0.697	0.697
Brugia malayi	larval opioid receptor	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0055	0.0537	0.077
Onchocerca volvulus		0.06	0.697	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Echinococcus granulosus	g-protein coupled receptor	0.0055	0.0537	0.077
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.1586	0.1586
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0537	0.077
Schistosoma mansoni	neuropeptide receptor	0.0055	0.0537	0.077
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Schistosoma mansoni	opsin-like receptor	0.0055	0.0537	0.077
Echinococcus granulosus	7tm_1 domain containing protein	0.0055	0.0537	0.077
Schistosoma mansoni	hypothetical protein	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0055	0.0537	0.077
Echinococcus multilocularis	somatostatin receptor	0.0055	0.0537	0.077
Brugia malayi	Blistered cuticle protein 3	0.06	0.697	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0055	0.0537	0.077
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0055	0.0537	0.077
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.0537	0.077
Onchocerca volvulus	Peroxidasin homolog	0.06	0.697	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0055	0.0537	0.077
Echinococcus granulosus	fmrfamide receptor	0.0055	0.0537	0.077
Brugia malayi	ORL1-like opioid receptor	0.0055	0.0537	0.077
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Brugia malayi	Peroxidasin	0.06	0.697	1
Loa Loa (eye worm)	animal heme peroxidase	0.06	0.697	0.697
Brugia malayi	hypothetical protein	0.0055	0.0537	0.077
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0055	0.0537	0.077
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.1586	0.1586
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0051	0.0492	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0055	0.0537	0.077
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0055	0.0537	0.077
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0055	0.0537	0.077
Schistosoma mansoni	biogenic amine receptor	0.0055	0.0537	0.077
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.06	0.697	0.697
Loa Loa (eye worm)	neuropeptide F receptor	0.0055	0.0537	0.0537
Brugia malayi	GnHR receptor homolog	0.0055	0.0537	0.077
Schistosoma mansoni	amine GPCR	0.0055	0.0537	0.077
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0537	0.077
Onchocerca volvulus	Peroxidase homolog	0.06	0.697	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.0537	0.077
Loa Loa (eye worm)	G-protein coupled receptor	0.0055	0.0537	0.0537
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0055	0.0537	0.077
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0175	0.195	0.2798
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0537	0.077
Schistosoma mansoni	adenoreceptor	0.0055	0.0537	0.077
Brugia malayi	G protein-coupled receptor	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Echinococcus granulosus	g protein coupled receptor	0.0055	0.0537	0.077
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0055	0.0537	0.077
Loa Loa (eye worm)	neuropeptide F receptor	0.0055	0.0537	0.0537
Brugia malayi	Dopamine receptor	0.0055	0.0537	0.077
Schistosoma mansoni	myosin xvIII	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.06	0.697	0.697
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Schistosoma mansoni	opsin-like receptor	0.0055	0.0537	0.077
Echinococcus granulosus	allatostatin A receptor	0.0055	0.0537	0.077
Schistosoma mansoni	biogenic amine receptor	0.0055	0.0537	0.077
Schistosoma mansoni	opsin-like receptor	0.0055	0.0537	0.077
Brugia malayi	hypothetical protein	0.06	0.697	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0055	0.0537	0.077
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0055	0.0537	0.077
Schistosoma mansoni	neuropeptide receptor	0.0055	0.0537	0.077
Brugia malayi	Animal haem peroxidase family protein	0.06	0.697	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0055	0.0537	0.077
Echinococcus granulosus	g protein coupled receptor	0.0055	0.0537	0.077
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0055	0.0537	0.0537
Echinococcus multilocularis	neuropeptide receptor	0.0055	0.0537	0.077
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0055	0.0537	0.077
Onchocerca volvulus	Chorion peroxidase homolog	0.06	0.697	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0055	0.0537	0.0537
Loa Loa (eye worm)	hypothetical protein	0.06	0.697	0.697
Brugia malayi	hypothetical protein	0.0055	0.0537	0.077
Brugia malayi	neuropeptide F receptor	0.0055	0.0537	0.077
Echinococcus granulosus	G protein coupled receptor 139	0.0055	0.0537	0.077
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0055	0.0537	0.077
Brugia malayi	putative neuropeptide receptor NPR1	0.0055	0.0537	0.077
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0537	0.077
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0051	0.0492	0.0705
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Echinococcus multilocularis	dro:myosuppressin receptor	0.0055	0.0537	0.077
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.0537	0.077
Entamoeba histolytica	acetyltransferase, GNAT family	0.0047	0.0441	0.5
Echinococcus granulosus	neuropeptide receptor	0.0055	0.0537	0.077
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.0857	1	1
Brugia malayi	hypothetical protein	0.0055	0.0537	0.077
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.06	0.697	0.697
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0055	0.0537	0.077
Echinococcus granulosus	dro:myosuppressin receptor	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.06	0.697	0.697
Schistosoma mansoni	neuropeptide receptor	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0055	0.0537	0.077
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0537	0.077
Brugia malayi	Animal haem peroxidase family protein	0.06	0.697	1
Onchocerca volvulus	Dual oxidase homolog	0.06	0.697	1
Loa Loa (eye worm)	animal heme peroxidase	0.06	0.697	0.697
Brugia malayi	hypothetical protein	0.0055	0.0537	0.077
Echinococcus multilocularis	neuropeptide Y receptor	0.0055	0.0537	0.077
Brugia malayi	hypothetical protein	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Echinococcus granulosus	biogenic amine 5HT receptor	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.06	0.697	0.697
Brugia malayi	G-protein coupled receptor	0.0055	0.0537	0.077
Brugia malayi	MH2 domain containing protein	0.0144	0.1586	0.2275
Echinococcus multilocularis	neuropeptide Y receptor	0.0055	0.0537	0.077
Echinococcus multilocularis	g protein coupled receptor	0.0055	0.0537	0.077
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0055	0.0537	0.077
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0051	0.0492	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0055	0.0537	0.077
Echinococcus multilocularis	allatostatin A receptor	0.0055	0.0537	0.077
Schistosoma mansoni	growth hormone secretagogue receptor	0.0055	0.0537	0.077
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0055	0.0537	0.0537
Onchocerca volvulus	Peroxidase homolog	0.06	0.697	1
Loa Loa (eye worm)	hypothetical protein	0.06	0.697	0.697
Echinococcus granulosus	somatostatin receptor	0.0055	0.0537	0.077
Echinococcus multilocularis	neuropeptide receptor A26	0.0055	0.0537	0.077
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Echinococcus granulosus	tm gpcr rhodopsin	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Echinococcus granulosus	neuropeptide receptor	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Onchocerca volvulus		0.06	0.697	1
Echinococcus multilocularis	g protein coupled receptor	0.0055	0.0537	0.077
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0055	0.0537	0.0537
Brugia malayi	Melatonin receptor type 1A	0.0055	0.0537	0.077
Schistosoma mansoni	hypothetical protein	0.0055	0.0537	0.077
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0051	0.0492	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0537	0.077
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0055	0.0537	0.077
Echinococcus multilocularis	g protein coupled receptor	0.0055	0.0537	0.077
Schistosoma mansoni	hypothetical protein	0.0055	0.0537	0.077
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0055	0.0537	0.077
Onchocerca volvulus	Peroxidasin homolog	0.06	0.697	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0055	0.0537	0.0537
Echinococcus multilocularis	neuropeptide s receptor	0.0055	0.0537	0.077
Loa Loa (eye worm)	melatonin receptor type 1A	0.0055	0.0537	0.0537
Brugia malayi	acetyltransferase, GNAT family protein	0.0175	0.195	0.2798
Echinococcus granulosus	neuropeptide Y receptor	0.0055	0.0537	0.077
Echinococcus granulosus	hypothetical protein	0.0055	0.0537	0.077
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0055	0.0537	0.077
Schistosoma mansoni	hypothetical protein	0.0055	0.0537	0.077
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0055	0.0537	0.077
Loa Loa (eye worm)	acetyltransferase	0.0175	0.195	0.195
Brugia malayi	Animal haem peroxidase family protein	0.06	0.697	1
Brugia malayi	Animal haem peroxidase family protein	0.06	0.697	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0055	0.0537	0.077
Loa Loa (eye worm)	TYRA-2 protein	0.0055	0.0537	0.0537
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0055	0.0537	0.077
Brugia malayi	follicle stimulating hormone receptor	0.0055	0.0537	0.077
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0537	0.077
Plasmodium falciparum	histone acetyltransferase GCN5	0.0047	0.0441	0.5
Brugia malayi	RE15519p	0.0055	0.0537	0.077
Echinococcus granulosus	sex peptide receptor	0.0055	0.0537	0.077
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0055	0.0537	0.077
Echinococcus multilocularis	neuropeptides capa receptor	0.0055	0.0537	0.077
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0537	0.077
Brugia malayi	Dopamine receptor protein 2	0.0055	0.0537	0.077
Echinococcus multilocularis	fmrfamide receptor	0.0055	0.0537	0.077
Brugia malayi	sulfakinin receptor protein	0.0055	0.0537	0.077
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0537	0.077
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0055	0.0537	0.077
Echinococcus granulosus	neuropeptides capa receptor	0.0055	0.0537	0.077
Echinococcus granulosus	neuropeptide s receptor	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0051	0.0492	0.5
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Schistosoma mansoni	biogenic amine receptor	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0537	0.077
Schistosoma mansoni	peroxidasin	0.06	0.697	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Brugia malayi	AKH receptor	0.0055	0.0537	0.077
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0175	0.195	0.2798
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0055	0.0537	0.077
Brugia malayi	G protein-coupled receptor F59B2.13	0.0055	0.0537	0.077
Brugia malayi	hypothetical protein	0.0055	0.0537	0.077
Echinococcus granulosus	neuropeptide FF receptor 2	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.06	0.697	0.697
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Echinococcus granulosus	serotonin receptor	0.0055	0.0537	0.077
Loa Loa (eye worm)	animal heme peroxidase	0.06	0.697	0.697
Echinococcus granulosus	orexin receptor type 2	0.0055	0.0537	0.077
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0055	0.0537	0.077
Schistosoma mansoni	histamine h1 receptor	0.0055	0.0537	0.077
Echinococcus granulosus	neuropeptides capa receptor	0.0055	0.0537	0.077
Brugia malayi	hypothetical protein	0.0055	0.0537	0.077
Giardia lamblia	Histone acetyltransferase GCN5	0.0047	0.0441	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0055	0.0537	0.077
Schistosoma mansoni	peroxidasin	0.06	0.697	1
Echinococcus multilocularis	serotonin receptor	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.06	0.697	0.697
Echinococcus granulosus	peroxidasin	0.06	0.697	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0055	0.0537	0.077
Echinococcus multilocularis	G protein coupled receptor 139	0.0055	0.0537	0.077
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0051	0.0492	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0055	0.0537	0.077
Brugia malayi	hypothetical protein	0.0055	0.0537	0.077
Echinococcus multilocularis	serotonin receptor	0.0055	0.0537	0.077
Echinococcus multilocularis	sex peptide receptor	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Echinococcus granulosus	neuropeptide Y receptor	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Brugia malayi	Dopamine receptor protein 1	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Echinococcus granulosus	biogenic amine 5HT receptor	0.0055	0.0537	0.077
Schistosoma mansoni	neuropeptide F-like receptor	0.0055	0.0537	0.077
Echinococcus multilocularis	peroxidasin	0.06	0.697	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0537	0.077
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0537	0.077
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0055	0.0537	0.077
Echinococcus granulosus	histone acetyltransferase KAT2B	0.017	0.1892	0.2715
Echinococcus multilocularis	g-protein coupled receptor	0.0055	0.0537	0.077
Echinococcus multilocularis	orexin receptor type 2	0.0055	0.0537	0.077
Echinococcus multilocularis	neuropeptide receptor	0.0055	0.0537	0.077
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.06	0.697	0.697
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0055	0.0537	0.077
Onchocerca volvulus		0.06	0.697	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0055	0.0537	0.077
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.0537	0.077
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Echinococcus granulosus	tm gpcr rhodopsin	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Brugia malayi	hypothetical protein	0.0055	0.0537	0.077
Schistosoma mansoni	amine GPCR	0.0055	0.0537	0.077
Brugia malayi	Serotonin receptor	0.0055	0.0537	0.077
Schistosoma mansoni	neuropeptide receptor	0.0055	0.0537	0.077
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0055	0.0537	0.077
Brugia malayi	neuropeptide F receptor	0.0055	0.0537	0.077
Brugia malayi	putative neuropeptide receptor	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.06	0.697	0.697
Brugia malayi	Serotonin receptor	0.0501	0.5794	0.8313
Brugia malayi	G-protein coupled receptor	0.0055	0.0537	0.077
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.06	0.697	0.697
Loa Loa (eye worm)	hypothetical protein	0.06	0.697	0.697
Loa Loa (eye worm)	animal heme peroxidase	0.06	0.697	0.697
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0055	0.0537	0.077
Brugia malayi	hypothetical protein	0.0055	0.0537	0.077
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Echinococcus multilocularis	fmrfamide receptor	0.0055	0.0537	0.077
Brugia malayi	Animal haem peroxidase family protein	0.06	0.697	1
Echinococcus granulosus	g protein coupled receptor	0.0055	0.0537	0.077
Echinococcus granulosus	7TM GPCR rhodopsin	0.0055	0.0537	0.077
Schistosoma mansoni	amine GPCR	0.0055	0.0537	0.077
Loa Loa (eye worm)	blistered cuticle protein 3	0.06	0.697	0.697
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0055	0.0537	0.077
Echinococcus granulosus	neuropeptide receptor A26	0.0055	0.0537	0.077
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0055	0.0537	0.077
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0537	0.0537

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 877856