Detailed information for compound 878009

Basic information

Technical information
  • TDR Targets ID: 878009
  • Name: N-(3-butylaminoquinoxalin-2-yl)-3-methylbenze nesulfonamide
  • MW: 370.469 | Formula: C19H22N4O2S
  • H donors: 2 H acceptors: 4 LogP: 4 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCNc1nc2ccccc2nc1NS(=O)(=O)c1cccc(c1)C
  • InChi: 1S/C19H22N4O2S/c1-3-4-12-20-18-19(22-17-11-6-5-10-16(17)21-18)23-26(24,25)15-9-7-8-14(2)13-15/h5-11,13H,3-4,12H2,1-2H3,(H,20,21)(H,22,23)
  • InChiKey: IAWJNRNNYWKPLG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-butylaminoquinoxalin-2-yl)-3-methyl-benzenesulfonamide
  • N-(3-butylamino-2-quinoxalinyl)-3-methylbenzenesulfonamide
  • ZINC02427589

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.004 0.1223 0.1634
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.0563 0.7003
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0014 0.0247 0.0247
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0014 0.0247 0.033
Schistosoma mansoni inositol monophosphatase 0.0028 0.0769 0.1424
Entamoeba histolytica hypothetical protein 0.0032 0.0925 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0032 0.0925 0.0925
Schistosoma mansoni hypothetical protein 0.0014 0.0247 0.0457
Echinococcus multilocularis geminin 0.0149 0.5401 0.5401
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0028 0.0769 0.8151
Loa Loa (eye worm) hypothetical protein 0.0044 0.139 0.1857
Brugia malayi hypothetical protein 0.0032 0.0925 0.1235
Plasmodium vivax ataxin-2 like protein, putative 0.0022 0.0563 1
Schistosoma mansoni hypothetical protein 0.003 0.0861 0.1594
Echinococcus granulosus geminin 0.0149 0.5401 0.5401
Brugia malayi hypothetical protein 0.0022 0.0563 0.0753
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0014 0.0247 0.0247
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.0563 1
Toxoplasma gondii LsmAD domain-containing protein 0.0022 0.0563 0.7326
Onchocerca volvulus 0.004 0.1223 0.5
Echinococcus granulosus bloom syndrome protein 0.0018 0.0401 0.0401
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0204 0.7485 1
Schistosoma mansoni cellular tumor antigen P53 0.004 0.1223 0.2264
Entamoeba histolytica hypothetical protein 0.0032 0.0925 1
Schistosoma mansoni hypothetical protein 0.0032 0.0925 0.1712
Schistosoma mansoni hypothetical protein 0.001 0.0097 0.018
Brugia malayi Inositol-1 0.0028 0.0769 0.1027
Brugia malayi Latrophilin receptor protein 2 0.0014 0.0247 0.033
Loa Loa (eye worm) latrophilin receptor protein 2 0.0014 0.0247 0.033
Echinococcus granulosus GPCR family 2 0.0014 0.0247 0.0247
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0044 0.139 0.1857
Brugia malayi follicle stimulating hormone receptor 0.0204 0.7485 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0028 0.0769 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0018 0.0401 0.4637
Schistosoma mansoni hypothetical protein 0.0014 0.0247 0.0457
Trypanosoma brucei PAB1-binding protein , putative 0.0022 0.0563 0.7003
Loa Loa (eye worm) hypothetical protein 0.003 0.0861 0.115
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0174 0.2268
Entamoeba histolytica hypothetical protein 0.0032 0.0925 1
Entamoeba histolytica hypothetical protein 0.0032 0.0925 1
Schistosoma mansoni hypothetical protein 0.0149 0.5401 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0028 0.0769 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0028 0.0769 1
Loa Loa (eye worm) inositol-1 0.0028 0.0769 0.1027
Brugia malayi Calcitonin receptor-like protein seb-1 0.0044 0.139 0.1857
Echinococcus multilocularis inositol monophosphatase 1 0.0028 0.0769 0.0769
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0025 0.0659 0.5
Leishmania major hypothetical protein, conserved 0.0022 0.0563 0.7003
Echinococcus multilocularis bloom syndrome protein 0.0018 0.0401 0.0401
Loa Loa (eye worm) RecQ helicase 0.0018 0.0401 0.0536
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.001 0.0097 0.0097
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.001 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0022 0.0563 0.0753
Loa Loa (eye worm) hypothetical protein 0.009 0.3156 0.4217
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0028 0.0769 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.033
Trichomonas vaginalis DNA helicase recq, putative 0.0018 0.0401 0.4637
Schistosoma mansoni blooms syndrome DNA helicase 0.0014 0.0257 0.0477
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0028 0.0769 1
Brugia malayi latrophilin 2 splice variant baaae 0.003 0.0861 0.115
Echinococcus multilocularis GPCR, family 2 0.0014 0.0247 0.0247
Giardia lamblia Sgs1 DNA helicase, putative 0.0007 0.00000000012841 0.5
Schistosoma mansoni hypothetical protein 0.0014 0.0247 0.0457
Schistosoma mansoni hypothetical protein 0.0014 0.0247 0.0457
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0028 0.0769 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0014 0.0247 0.0247
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0044 0.139 0.1857
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0025 0.0659 0.5
Schistosoma mansoni hypothetical protein 0.0149 0.5401 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0028 0.0769 1
Echinococcus granulosus inositol monophosphatase 1 0.0028 0.0769 0.0769
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0028 0.0769 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.0563 0.7003
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0014 0.0247 0.0247
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.0563 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0032 0.0925 0.0925
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0028 0.0769 1
Brugia malayi Bloom's syndrome protein homolog 0.0018 0.0401 0.0536
Echinococcus multilocularis tumor protein p63 0.027 1 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0007 0.00000000012841 0.0000000016699
Brugia malayi hypothetical protein 0.0014 0.0264 0.0352
Schistosoma mansoni transcription factor LCR-F1 0.0032 0.0925 0.1712
Schistosoma mansoni inositol monophosphatase 0.0028 0.0769 0.1424
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0028 0.0769 0.5
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0016 0.0318 0.5647

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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