Detailed information for compound 878011

Basic information

Technical information
  • TDR Targets ID: 878011
  • Name: 4-fluoro-N-[3-(3-methoxypropylamino)quinoxali n-2-yl]benzenesulfonamide
  • MW: 390.432 | Formula: C18H19FN4O3S
  • H donors: 2 H acceptors: 4 LogP: 2.69 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCCNc1nc2ccccc2nc1NS(=O)(=O)c1ccc(cc1)F
  • InChi: 1S/C18H19FN4O3S/c1-26-12-4-11-20-17-18(22-16-6-3-2-5-15(16)21-17)23-27(24,25)14-9-7-13(19)8-10-14/h2-3,5-10H,4,11-12H2,1H3,(H,20,21)(H,22,23)
  • InChiKey: MBGBCCLPAZTXNO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-fluoro-N-[3-(3-methoxypropylamino)-2-quinoxalinyl]benzenesulfonamide
  • ZINC02323321
  • STOCK4S-15125

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear hormone receptor family member odr-7 0.0041 0.0127 0.045
Loa Loa (eye worm) hypothetical protein 0.0041 0.0127 0.0619
Loa Loa (eye worm) hypothetical protein 0.0028 0.0075 0.0362
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.1198 1
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0677 0.2679 1
Echinococcus granulosus smad 0.0034 0.0101 0.0589
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0034 0.0101 0.0101
Schistosoma mansoni survival motor neuron protein 0.0052 0.0172 0.0643
Brugia malayi Zinc finger, C2H2 type family protein 0.0264 0.1025 0.3808
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.1198 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0222 0.0857 0.4246
Brugia malayi hypothetical protein 0.0131 0.0492 0.1814
Schistosoma mansoni cpg binding protein 0.0033 0.0095 0.0355
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0166 0.0963
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0156 0.0903
Loa Loa (eye worm) hypothetical protein 0.0041 0.0127 0.0619
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0053 0.0198
Brugia malayi MH1 domain containing protein 0.0019 0.004 0.0125
Loa Loa (eye worm) hypothetical protein 0.0067 0.0232 0.1139
Brugia malayi ecdysone receptor 0.0041 0.0127 0.045
Schistosoma mansoni hypothetical protein 0.0067 0.0232 0.0865
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.013 0.0393
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0086 0.0309 0.1525
Loa Loa (eye worm) hypothetical protein 0.0041 0.0127 0.0619
Brugia malayi nuclear hormone receptor 0.0086 0.0309 0.1132
Loa Loa (eye worm) hypothetical protein 0.0086 0.0309 0.1525
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0677 0.2679 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0117 0.0556
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.015 0.0567 0.1958
Echinococcus granulosus mothers against decapentaplegic 2 0.0015 0.0026 0.015
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.013 0.0671
Schistosoma mansoni lamin 0.0059 0.0203 0.0759
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0053 0.0103
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0045 0.0147 0.0548
Echinococcus multilocularis thyroid hormone receptor alpha 0.0086 0.0309 0.0309
Schistosoma mansoni smad 0.0034 0.0101 0.0379
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0157 0.0596 0.0596
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0053 0.0172
Loa Loa (eye worm) hypothetical protein 0.0041 0.0127 0.0619
Schistosoma mansoni CREB-binding protein 2 0.0114 0.0421 0.1572
Schistosoma mansoni smad1 5 8 and 0.0034 0.0101 0.0379
Loa Loa (eye worm) hypothetical protein 0.0058 0.0199 0.0975
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0086 0.0309 0.2974
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0194 0.0194
Onchocerca volvulus Huntingtin homolog 0.0131 0.0492 0.4887
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0127 0.0475
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0086 0.0309 0.1132
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0086 0.0309 0.1132
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0053 0.0053
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0264 0.1025 0.5946
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0307 0.1198 1
Loa Loa (eye worm) nuclear factor I 0.0019 0.004 0.0187
Loa Loa (eye worm) hypothetical protein 0.0211 0.0809 0.401
Loa Loa (eye worm) hypothetical protein 0.0041 0.0127 0.0619
Echinococcus granulosus dna polymerase eta 0.0022 0.0053 0.0307
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0086 0.0309 0.1795
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0264 0.1025 0.8484
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0194 0.0194
Leishmania major dihydroorotate dehydrogenase 0.0677 0.2679 1
Echinococcus granulosus intermediate filament protein 0.0059 0.0203 0.1179
Echinococcus granulosus histone acetyltransferase KAT2B 0.0151 0.057 0.331
Echinococcus multilocularis Smad4 0.0034 0.0101 0.0101
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0095 0.0354
Echinococcus multilocularis smad 0.0034 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0053 0.0103
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0053 0.025
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0511 0.2014 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0034 0.0101 0.0101
Brugia malayi mbt repeat family protein 0.005 0.0166 0.0595
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0211 0.0809 0.3002
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0117 0.0677
Echinococcus multilocularis nuclear receptor nhr 48 0.0041 0.0127 0.0127
Schistosoma mansoni lamin 0.0059 0.0203 0.0759
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0086 0.0309 0.1525
Echinococcus granulosus GPCR family 2 0.0067 0.0232 0.1345
Brugia malayi MH2 domain containing protein 0.0034 0.0101 0.0353
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0264 0.1025 0.8484
Loa Loa (eye worm) hypothetical protein 0.0028 0.0075 0.0362
Treponema pallidum fructose-bisphosphate aldolase 0.0307 0.1198 0.5
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0088 0.0425
Loa Loa (eye worm) hypothetical protein 0.005 0.0166 0.0812
Echinococcus granulosus thyroid hormone receptor alpha 0.0041 0.0127 0.0738
Loa Loa (eye worm) hypothetical protein 0.0029 0.008 0.0383
Loa Loa (eye worm) hypothetical protein 0.0045 0.0147 0.0716
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0086 0.0309 0.1132
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0041 0.0127 0.045
Loa Loa (eye worm) hypothetical protein 0.0041 0.0127 0.0619
Onchocerca volvulus 0.0059 0.0203 0.1861
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.0101 0.0491
Schistosoma mansoni nuclear receptor nhr-48 0.0041 0.0127 0.0475
Brugia malayi TAR-binding protein 0.0405 0.1589 0.592
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0095 0.0354
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0166 0.147
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0117 0.0243
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.013 0.0753
Brugia malayi hypothetical protein 0.0254 0.0982 0.3649
Echinococcus granulosus geminin 0.0366 0.1431 0.8304
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.013 0.013
Trypanosoma brucei unspecified product 0.0022 0.0053 0.0103
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.013 0.046
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0086 0.0309 0.1795
Brugia malayi nuclear receptor RXR 0.0041 0.0127 0.045
Onchocerca volvulus 0.0086 0.0309 0.2974
Echinococcus granulosus dnaJ subfamily B 0.0438 0.1723 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0026 0.0115
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0086 0.0309 0.1155
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0053 0.0103
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0677 0.2679 1
Echinococcus multilocularis lamin dm0 0.0059 0.0203 0.0203
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0117 0.0556
Brugia malayi hypothetical protein 0.0041 0.0127 0.045
Brugia malayi nuclear hormone receptor 0.0041 0.0127 0.045
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0157 0.0596 0.2223
Echinococcus multilocularis survival motor neuron protein 1 0.0254 0.0982 0.0982
Loa Loa (eye worm) hypothetical protein 0.0041 0.0127 0.0619
Brugia malayi tailless protein 0.0041 0.0127 0.045
Loa Loa (eye worm) hypothetical protein 0.0041 0.0127 0.0619
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0131 0.0492 0.2432
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0008 0.0008
Brugia malayi MH1 domain containing protein 0.0034 0.0101 0.0353
Schistosoma mansoni DNA polymerase eta 0.0022 0.0053 0.0198
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.016 0.0597
Echinococcus multilocularis FTZ F1 alpha 0.0086 0.0309 0.0309
Schistosoma mansoni steroid hormone receptor ad4bp 0.0086 0.0309 0.1155
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0264 0.1025 0.8484
Onchocerca volvulus 0.0059 0.0203 0.1861
Schistosoma mansoni Smad4 0.0034 0.0101 0.0379
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0166 0.0619
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0117 0.0343
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.013 0.0671
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0086 0.0309 0.1132
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0086 0.0309 0.1155
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0226 0.0508
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.013 0.0293
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0127 0.0475
Schistosoma mansoni hypothetical protein 0.0366 0.1431 0.5341
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0067 0.0232 0.1345
Brugia malayi photoreceptor-specific nuclear receptor 0.0086 0.0309 0.1132
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.013 0.0671
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0166 0.0166
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.013 0.013
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0086 0.0309 0.1795
Schistosoma mansoni hypothetical protein 0.0366 0.1431 0.5341
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0117 0.0556
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.0101 0.0491
Brugia malayi mbt repeat family protein 0.005 0.0166 0.0595
Schistosoma mansoni RAR-like nuclear receptor 0.0086 0.0309 0.1155
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0166 0.0963
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.1198 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0086 0.0309 0.1155
Schistosoma mansoni cpg binding protein 0.0033 0.0095 0.0355
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0053 0.0172
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0041 0.0127 0.0738
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0041 0.0127 0.0127
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0117 0.0243
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0086 0.0309 0.1132
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0307 0.1198 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0194 0.0699
Brugia malayi acetyltransferase, GNAT family protein 0.0157 0.0596 0.2202
Brugia malayi CXXC zinc finger family protein 0.0031 0.0088 0.0303
Brugia malayi Inositol-1 0.0038 0.0117 0.041
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0045 0.0147 0.0716
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0053 0.0103
Schistosoma mansoni intermediate filament proteins 0.0059 0.0203 0.0759
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0405 0.1589 0.7886
Schistosoma mansoni inositol monophosphatase 0.0038 0.0117 0.0435
Schistosoma mansoni nuclear receptor 0.0041 0.0127 0.0475
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0166 0.0619
Echinococcus granulosus CREB binding protein 0.0114 0.0421 0.2444
Schistosoma mansoni hypothetical protein 0.0067 0.0232 0.0865
Schistosoma mansoni inositol monophosphatase 0.0038 0.0117 0.0435
Schistosoma mansoni hypothetical protein 0.0067 0.0232 0.0865
Schistosoma mansoni tar DNA-binding protein 0.0405 0.1589 0.593
Loa Loa (eye worm) nuclear receptor NHR-67 0.0041 0.0127 0.0619
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0147 0.0523
Loa Loa (eye worm) hypothetical protein 0.0041 0.0127 0.0619
Brugia malayi hypothetical protein 0.0045 0.0147 0.0523
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0086 0.0309 0.0309
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0133 0.0696
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0264 0.1025 0.1025
Brugia malayi steroid hormone receptor 0.0086 0.0309 0.1132
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0086 0.0309 0.1132
Echinococcus multilocularis CREB binding protein 0.0018 0.0037 0.0037
Echinococcus granulosus lamin dm0 0.0059 0.0203 0.1179
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0086 0.0309 0.1132
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0677 0.2679 1
Echinococcus granulosus tumor protein p63 0.0333 0.1299 0.7539
Echinococcus multilocularis lamin 0.0059 0.0203 0.0203
Loa Loa (eye worm) MH2 domain-containing protein 0.0501 0.1973 0.9798
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0677 0.2679 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0053 0.025
Loa Loa (eye worm) hypothetical protein 0.0057 0.0194 0.095
Echinococcus granulosus cpg binding protein 0.0033 0.0095 0.0552
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0117 0.0556
Brugia malayi Nuclear hormone receptor E75 0.0041 0.0127 0.045
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0101 0.0182
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0264 0.1025 0.8484
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0053 0.0103
Brugia malayi TAZ zinc finger family protein 0.0114 0.0421 0.155
Loa Loa (eye worm) hypothetical protein 0.0254 0.0982 0.487
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0156 0.0235
Brugia malayi nuclear hormone receptor family member nhr-6 0.0041 0.0127 0.045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0086 0.0309 0.1525
Echinococcus multilocularis tumor protein p63 0.0333 0.1299 0.1299
Schistosoma mansoni cpg binding protein 0.0031 0.0088 0.0329
Onchocerca volvulus 0.0041 0.0127 0.1064
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0086 0.0309 0.0309
Brugia malayi follicle stimulating hormone receptor 0.0511 0.2014 0.7511
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0041 0.0127 0.1064
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0053 0.0103
Echinococcus granulosus dna polymerase kappa 0.0022 0.0053 0.0307
Brugia malayi hypothetical protein 0.0041 0.0127 0.045
Brugia malayi MH2 domain containing protein 0.0034 0.0101 0.0353
Loa Loa (eye worm) acetyltransferase 0.0157 0.0596 0.2948
Onchocerca volvulus 0.005 0.0166 0.147
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0677 0.2679 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0194 0.1125
Onchocerca volvulus 0.0162 0.0614 0.6171
Loa Loa (eye worm) hypothetical protein 0.0045 0.0147 0.0716
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0264 0.1025 0.1025
Giardia lamblia Fructose-bisphosphate aldolase 0.0307 0.1198 1
Schistosoma mansoni smad1 5 8 and 0.0034 0.0101 0.0379
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0147 0.0523
Schistosoma mansoni hypothetical protein 0.0144 0.0542 0.2023
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0045 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0187
Brugia malayi RNA binding protein 0.0405 0.1589 0.592
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0086 0.0309 0.0309
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0095 0.0095
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.013 0.0753
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0034 0.0101 0.0379
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.1198 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0041 0.0127 0.0475
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0008 0.0024
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0041 0.0127 0.0127
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0029 0.008 0.0463
Loa Loa (eye worm) hypothetical protein 0.0045 0.0147 0.0716
Echinococcus multilocularis cpg binding protein 0.0033 0.0095 0.0095
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0041 0.0127 0.1064
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0086 0.0309 0.1525
Loa Loa (eye worm) hypothetical protein 0.0086 0.0309 0.1525
Echinococcus multilocularis mothers against decapentaplegic 2 0.0015 0.0026 0.0026
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0264 0.1025 0.8484
Schistosoma mansoni nuclear receptor 0.0041 0.0127 0.0475
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0086 0.0309 0.1132
Brugia malayi Calcitonin receptor-like protein seb-1 0.0211 0.0809 0.3002
Loa Loa (eye worm) Smad1 0.0034 0.0101 0.0491
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0086 0.0309 0.1525
Brugia malayi hypothetical protein 0.0162 0.0614 0.2273
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0114 0.0421 0.1572
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0041 0.0127 0.0475
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0086 0.0309 0.1132
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0053 0.0103
Loa Loa (eye worm) hypothetical protein 0.0045 0.0147 0.0716
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0053 0.0198
Loa Loa (eye worm) hypothetical protein 0.0059 0.0203 0.0997
Echinococcus granulosus Smad4 0.0034 0.0101 0.0589
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0086 0.0309 0.1132
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0156 0.0897
Echinococcus multilocularis geminin 0.0366 0.1431 0.1431
Onchocerca volvulus 0.0052 0.0172 0.1535
Echinococcus multilocularis dna polymerase eta 0.0022 0.0053 0.0053
Echinococcus granulosus tar DNA binding protein 0.0405 0.1589 0.922
Brugia malayi nuclear receptor NHR-67 0.0041 0.0127 0.045
Brugia malayi latrophilin 2 splice variant baaae 0.0144 0.0542 0.2002
Loa Loa (eye worm) intermediate filament protein 0.0059 0.0203 0.0997
Echinococcus granulosus Nuclear hormone receptor HR96 0.0041 0.0127 0.0738
Loa Loa (eye worm) nuclear hormone receptor 0.0041 0.0127 0.0619
Loa Loa (eye worm) hypothetical protein 0.0086 0.0309 0.1525
Loa Loa (eye worm) hypothetical protein 0.0086 0.0309 0.1525
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.1198 1
Schistosoma mansoni hypothetical protein 0.0305 0.1188 0.4436
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.013 0.0293
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0095 0.0095
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0677 0.2679 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0053 0.0053
Echinococcus multilocularis dnaJ subfamily B 0.0438 0.1723 0.1723
Brugia malayi ecdysteroid receptor 0.0086 0.0309 0.1132
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.0203 0.0997
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0092 0.032
Brugia malayi orphan nuclear receptor NR2E1 0.0041 0.0127 0.045
Brugia malayi MH1 domain containing protein 0.0019 0.004 0.0125
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.015 0.0567 0.1809
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0053 0.0103
Brugia malayi MH1 domain containing protein 0.0034 0.0101 0.0353
Onchocerca volvulus 0.0049 0.016 0.1407
Loa Loa (eye worm) hypothetical protein 0.0086 0.0309 0.1525
Schistosoma mansoni smad1 5 8 and 0.0034 0.0101 0.0379
Loa Loa (eye worm) hypothetical protein 0.0086 0.0309 0.1525
Loa Loa (eye worm) hypothetical protein 0.0131 0.0492 0.2432
Echinococcus multilocularis GPCR, family 2 0.0067 0.0232 0.0232
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0008 0.0044
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0677 0.2679 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0117 0.0243
Loa Loa (eye worm) MBCTL1 0.0057 0.0194 0.095
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.1198 1
Echinococcus multilocularis musashi 0.0059 0.0203 0.0203
Schistosoma mansoni thyroid hormone receptor 0.0086 0.0309 0.1155
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.1198 1
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0045 0.0147 0.0716
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0086 0.0309 0.1132
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0127 0.0738
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0117 0.0084
Loa Loa (eye worm) hypothetical protein 0.0041 0.0127 0.0619
Schistosoma mansoni tar DNA-binding protein 0.0405 0.1589 0.593
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.0203 0.0734
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0053 0.0103
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0264 0.1025 0.5946
Loa Loa (eye worm) hypothetical protein 0.0032 0.0095 0.0458
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0677 0.2679 1
Trichomonas vaginalis set domain proteins, putative 0.0253 0.098 0.809
Loa Loa (eye worm) latrophilin receptor protein 2 0.0067 0.0232 0.1139
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0156 0.0235
Schistosoma mansoni zinc finger protein 0.0041 0.0127 0.0475
Loa Loa (eye worm) hypothetical protein 0.0162 0.0614 0.3041
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0086 0.0309 0.1132
Onchocerca volvulus 0.0031 0.0088 0.0653
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0086 0.0309 0.1132
Loa Loa (eye worm) hypothetical protein 0.0086 0.0309 0.1525
Schistosoma mansoni tar DNA-binding protein 0.0405 0.1589 0.593
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0133 0.0696
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0172 0.0618
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.013 0.0753
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0092 0.0446
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0045 0.0147 0.0548
Brugia malayi RNA recognition motif domain containing protein 0.0405 0.1589 0.592
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0067 0.0232 0.0232
Echinococcus granulosus CREB binding protein 0.0072 0.0252 0.1463
Brugia malayi MH2 domain containing protein 0.0015 0.0026 0.007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0086 0.0309 0.1795
Echinococcus granulosus survival motor neuron protein 1 0.0254 0.0982 0.57
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0095 0.0354
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0264 0.1025 0.37
Brugia malayi Smad1 0.0034 0.0101 0.0353
Loa Loa (eye worm) DR-78 0.0041 0.0127 0.0619
Echinococcus multilocularis CREB binding protein 0.0018 0.0037 0.0037
Brugia malayi nuclear receptor RXR 0.0045 0.0147 0.0523
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0086 0.0309 0.1155
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0127 0.0127
Brugia malayi Steroid receptor seven-up type 2 0.0086 0.0309 0.1132
Echinococcus granulosus CREB binding protein 0.0018 0.0037 0.0215
Echinococcus granulosus CREB binding protein 0.0018 0.0037 0.0215
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0194 0.0723
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0166 0.0812
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.013 0.0485
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0041 0.0127 0.0127
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0053 0.0307
Echinococcus multilocularis tar DNA binding protein 0.0405 0.1589 0.1589
Echinococcus granulosus FTZ F1 alpha 0.0086 0.0309 0.1795
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0086 0.0309 0.0309
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0086 0.0309 0.1155
Loa Loa (eye worm) transcription factor SMAD2 0.0501 0.1973 0.9798
Schistosoma mansoni hypothetical protein 0.0067 0.0232 0.0865
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0041 0.0127 0.0619
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0053 0.0103
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0095 0.0354
Echinococcus multilocularis mothers against decapentaplegic 6 0.0015 0.0026 0.0026
Echinococcus granulosus TGF beta signal transducer SmadC 0.0034 0.0101 0.0589
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0029 0.008 0.008
Schistosoma mansoni retinoic acid receptor RXR 0.0086 0.0309 0.1155
Brugia malayi hypothetical protein 0.0045 0.0147 0.0523
Brugia malayi intermediate filament protein 0.0059 0.0203 0.0734
Plasmodium falciparum dihydroorotate dehydrogenase 0.0677 0.2679 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0127 0.0619
Loa Loa (eye worm) hypothetical protein 0.0049 0.016 0.0782
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0156 0.0235
Echinococcus granulosus Nuclear hormone receptor HR96 0.0041 0.0127 0.0738
Brugia malayi MH2 domain containing protein 0.0501 0.1973 0.7359
Echinococcus granulosus mothers against decapentaplegic 6 0.0015 0.0026 0.015
Brugia malayi nuclear receptor NHR-88 0.0041 0.0127 0.045
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0086 0.0309 0.1155
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0067 0.0232 0.0232
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0086 0.0309 0.1795
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.013 0.0485
Schistosoma mansoni smad 0.0015 0.0026 0.0096
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0156 0.0897
Brugia malayi conserved hypotetical protein 0.0041 0.0127 0.045
Loa Loa (eye worm) hypothetical protein 0.0086 0.0309 0.1525
Brugia malayi Pre-SET motif family protein 0.0032 0.0095 0.0329
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.013 0.0671
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0067 0.0232 0.1345
Schistosoma mansoni dihydroorotate dehydrogenase 0.0677 0.2679 1
Echinococcus granulosus nuclear receptor nhr 48 0.0041 0.0127 0.0738
Echinococcus granulosus lamin 0.0059 0.0203 0.1179
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.1198 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0067 0.0232 0.0841
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0086 0.0309 0.1525
Onchocerca volvulus 0.0253 0.098 1
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0677 0.2679 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0172 0.0841
Onchocerca volvulus 0.0032 0.0095 0.0724
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0053 0.0103
Schistosoma mansoni hypothetical protein 0.0438 0.1723 0.6432
Schistosoma mansoni hypothetical protein 0.0052 0.0172 0.0643
Brugia malayi Nuclear hormone receptor-like 1 0.0086 0.0309 0.1132
Schistosoma mansoni Smad4 0.0015 0.0026 0.0096
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0677 0.2679 1
Loa Loa (eye worm) TAR-binding protein 0.0405 0.1589 0.7886
Brugia malayi Pre-SET motif family protein 0.0222 0.0857 0.3179
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0231 0.0863
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0086 0.0309 0.0309
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0045 0.0147 0.0852
Schistosoma mansoni Smad4 0.0015 0.0026 0.0096
Echinococcus multilocularis ecdysone induced protein 78C 0.0086 0.0309 0.0309
Brugia malayi nuclear receptor NHR-88 0.0086 0.0309 0.1132
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.013 0.0671
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.015 0.0567 0.1958
Schistosoma mansoni coup transcription factor 0.0086 0.0309 0.1155
Onchocerca volvulus Huntingtin homolog 0.0131 0.0492 0.4887
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0053 0.0103
Onchocerca volvulus 0.0041 0.0127 0.1064
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0053 0.0103
Brugia malayi mothers against decapentaplegic homolog 3 0.0015 0.0026 0.007
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0198 0.0758 0.4398
Brugia malayi Nuclear hormone receptor E75 0.0041 0.0127 0.045
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0198 0.0758 0.0758
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0264 0.1025 0.8484
Onchocerca volvulus Protein ultraspiracle homolog 0.0086 0.0309 0.2974
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.013 0.0293
Schistosoma mansoni thyroid hormone receptor 0.0086 0.0309 0.1155
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0086 0.0309 0.1795
Loa Loa (eye worm) RNA binding protein 0.0405 0.1589 0.7886
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0041 0.0127 0.0127
Loa Loa (eye worm) inositol-1 0.0038 0.0117 0.0566
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0053 0.0103
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0166 0.0619
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0194 0.1125
Onchocerca volvulus Bile acid receptor homolog 0.0086 0.0309 0.2974
Schistosoma mansoni tar DNA-binding protein 0.0405 0.1589 0.593
Echinococcus granulosus ecdysone induced protein 78C 0.0086 0.0309 0.1795
Schistosoma mansoni tar DNA-binding protein 0.0405 0.1589 0.593
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0117 0.0243
Loa Loa (eye worm) hypothetical protein 0.0041 0.0127 0.0619
Loa Loa (eye worm) hypothetical protein 0.0041 0.013 0.0632
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0211 0.0809 0.401
Loa Loa (eye worm) hypothetical protein 0.0144 0.0542 0.2681
Echinococcus multilocularis CREB binding protein 0.0018 0.0037 0.0037
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0087 0.0508
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0026 0.0115
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0677 0.2679 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0086 0.0309 0.1525
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0086 0.0309 0.1795
Loa Loa (eye worm) hypothetical protein 0.0041 0.0127 0.0619
Schistosoma mansoni nuclear hormone receptor 0.0086 0.0309 0.1155
Echinococcus granulosus mothers against decapentaplegic 5 0.0034 0.0101 0.0589
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0264 0.1025 0.8484
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0086 0.0309 0.0309
Brugia malayi Latrophilin receptor protein 2 0.0067 0.0232 0.0841
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0095 0.0551
Loa Loa (eye worm) CBP-B 0.008 0.0286 0.1411
Loa Loa (eye worm) steroid hormone receptor 0.0086 0.0309 0.1525
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.013 0.013
Echinococcus multilocularis CREB binding protein 0.0079 0.0283 0.0283

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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