Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | transport to inner mitochondrial membrane family member | 0.0054 | 0.025 | 0.0529 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0342 | 0.2092 | 0.2089 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 0.472 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 0.472 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0342 | 0.2092 | 0.2089 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0362 | 0.0338 |
Brugia malayi | Mitochondrial import inner membrane translocase subunit TIM10 | 0.0054 | 0.025 | 0.05 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0071 | 0.0362 | 0.0738 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0247 | 0.0224 |
Echinococcus granulosus | chromobox protein 1 | 0.0078 | 0.0407 | 0.0404 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.2092 | 0.4432 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0247 | 0.0244 |
Brugia malayi | Animal haem peroxidase family protein | 0.0752 | 0.472 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0104 | 0.022 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 0.472 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.0247 | 0.0524 |
Echinococcus granulosus | geminin | 0.0197 | 0.1168 | 0.1165 |
Onchocerca volvulus | 0.0034 | 0.0127 | 0.0042 | |
Schistosoma mansoni | mitochondrial import inner membrane translocase subunit tim10 | 0.0054 | 0.025 | 0.0226 |
Echinococcus multilocularis | chromobox protein 1 | 0.0078 | 0.0407 | 0.0404 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.0209 | 0.0219 |
Echinococcus granulosus | lamin | 0.0031 | 0.0108 | 0.0104 |
Trichomonas vaginalis | chromobox protein, putative | 0.0047 | 0.0209 | 0.3419 |
Echinococcus granulosus | tar DNA binding protein | 0.0071 | 0.0362 | 0.0358 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0024 | 0.0051 |
Trichomonas vaginalis | chromobox protein, putative | 0.0047 | 0.0209 | 0.3419 |
Echinococcus granulosus | expressed protein | 0.0054 | 0.025 | 0.0246 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0078 | 0.0407 | 0.0863 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0134 | 0.0764 | 0.1619 |
Brugia malayi | RNA binding protein | 0.0071 | 0.0362 | 0.0738 |
Onchocerca volvulus | 0.0752 | 0.472 | 1 | |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0108 | 0.0104 |
Brugia malayi | Animal haem peroxidase family protein | 0.0752 | 0.472 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0247 | 0.0244 |
Schistosoma mansoni | microtubule-associated protein tau | 0.1578 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0078 | 0.0407 | 1 |
Echinococcus multilocularis | expressed protein | 0.0054 | 0.025 | 0.0246 |
Echinococcus multilocularis | geminin | 0.0197 | 0.1168 | 0.1165 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0134 | 0.0764 | 0.1619 |
Onchocerca volvulus | 0.0752 | 0.472 | 1 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0752 | 0.472 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 0.472 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.0278 | 0.056 |
Toxoplasma gondii | mitochondrial import inner membrane translocase subunit TIM10, putative | 0.0054 | 0.025 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0071 | 0.0362 | 0.0738 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.2092 | 0.4432 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0024 | 0.0021 |
Echinococcus granulosus | peroxidasin | 0.0752 | 0.472 | 0.4718 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.0247 | 0.0495 |
Schistosoma mansoni | hypothetical protein | 0.0197 | 0.1168 | 0.1147 |
Echinococcus multilocularis | muscleblind protein | 0.0342 | 0.2092 | 0.2089 |
Schistosoma mansoni | lamin | 0.0031 | 0.0108 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 0.472 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 0.472 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0362 | 0.0338 |
Brugia malayi | Heterochromatin protein 1 | 0.0078 | 0.0407 | 0.0835 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0752 | 0.472 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0752 | 0.472 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0071 | 0.0362 | 0.0767 |
Brugia malayi | chromobox protein homolog 3 | 0.0044 | 0.0187 | 0.0368 |
Echinococcus multilocularis | lamin | 0.0031 | 0.0108 | 0.0104 |
Toxoplasma gondii | TIM10 family protein, putative | 0.0054 | 0.025 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0752 | 0.472 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0024 | 0.0051 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 0.472 | 1 |
Schistosoma mansoni | lamin | 0.0031 | 0.0108 | 0.0084 |
Brugia malayi | Animal haem peroxidase family protein | 0.0752 | 0.472 | 1 |
Plasmodium falciparum | mitochondrial import inner membrane translocase subunit TIM10, putative | 0.0054 | 0.025 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0071 | 0.0362 | 0.0767 |
Onchocerca volvulus | Peroxidase homolog | 0.0752 | 0.472 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0247 | 0.0224 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0024 | 0.0021 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0024 | 0.0021 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0024 | 0.0021 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0362 | 0.0338 |
Echinococcus multilocularis | chromobox protein 1 | 0.0078 | 0.0407 | 0.0404 |
Schistosoma mansoni | chromobox protein | 0.0078 | 0.0407 | 0.0384 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.016 | 0.0311 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0108 | 0.0228 |
Onchocerca volvulus | 0.0752 | 0.472 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0752 | 0.472 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0024 | 0.0021 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0044 | 0.0187 | 0.0173 |
Echinococcus multilocularis | musashi | 0.0031 | 0.0108 | 0.0104 |
Schistosoma mansoni | peroxidasin | 0.0752 | 0.472 | 0.4707 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0108 | 0.0198 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1578 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0108 | 0.0228 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 0.472 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 0.472 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0024 | 0.0021 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.0108 | 0.0084 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.0187 | 0.2714 |
Brugia malayi | Muscleblind-like protein | 0.0342 | 0.2092 | 0.4415 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0127 | 0.0268 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0014 | 0.003 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0752 | 0.472 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0134 | 0.0764 | 0.1594 |
Schistosoma mansoni | hypothetical protein | 0.0197 | 0.1168 | 0.1147 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0004 | 0.0008 |
Plasmodium vivax | mitochondrial import inner membrane translocase subunit TIM10, putative | 0.0054 | 0.025 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 0.472 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0362 | 0.0338 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 0.472 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0752 | 0.472 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0752 | 0.472 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0752 | 0.472 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0071 | 0.0362 | 0.0358 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.0187 | 0.2714 |
Brugia malayi | hypothetical protein | 0.0752 | 0.472 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0247 | 0.0244 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.016 | 0.0137 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0247 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0278 | 0.0589 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.0278 | 0.0589 |
Echinococcus granulosus | chromobox protein 1 | 0.0078 | 0.0407 | 0.0404 |
Schistosoma mansoni | chromobox protein | 0.0078 | 0.0407 | 0.0384 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0108 | 0.0104 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0108 | 0.0198 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0108 | 0.0228 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0024 | 0.0021 |
Brugia malayi | Blistered cuticle protein 3 | 0.0752 | 0.472 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.016 | 0.034 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0108 | 0.0104 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 0.472 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0752 | 0.472 | 0.4718 |
Onchocerca volvulus | Peroxidasin homolog | 0.0752 | 0.472 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0752 | 0.472 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 0.472 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0752 | 0.472 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.0278 | 0.056 |
Trichomonas vaginalis | chromobox protein, putative | 0.0078 | 0.0407 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0187 | 0.0397 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0247 | 0.0244 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0024 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 0.472 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0362 | 0.0338 |
Loa Loa (eye worm) | TAR-binding protein | 0.0071 | 0.0362 | 0.0767 |
Brugia malayi | Peroxidasin | 0.0752 | 0.472 | 1 |
Schistosoma mansoni | peroxidasin | 0.0752 | 0.472 | 0.4707 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.