Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Aberrant vpr protein | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | K(lysine) acetyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.1915 | 0.4051 | 0.8746 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.4652 | 1 | 0.5 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.1915 | 0.4051 | 0.3887 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0051 | 0 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.4652 | 1 | 0.5 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.4652 | 1 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.2182 | 0.4632 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.0258 | 0.0258 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.1915 | 0.4051 | 0.3887 |
Loa Loa (eye worm) | hypothetical protein | 0.1915 | 0.4051 | 0.3887 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.2182 | 0.4632 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.1915 | 0.4051 | 0.4051 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.1915 | 0.4051 | 0.3887 |
Schistosoma mansoni | patched 1 | 0.1915 | 0.4051 | 0.3887 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.4652 | 1 | 0.5 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0051 | 0 | 0.5 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.4652 | 1 | 0.5 |
Echinococcus multilocularis | protein patched | 0.1915 | 0.4051 | 0.3887 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.1915 | 0.4051 | 0.3887 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.4652 | 1 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.4652 | 1 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.4652 | 1 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.1915 | 0.4051 | 0.3887 |
Brugia malayi | CHE-14 protein | 0.1915 | 0.4051 | 0.3887 |
Loa Loa (eye worm) | hypothetical protein | 0.4652 | 1 | 1 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0051 | 0 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.1915 | 0.4051 | 0.4051 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.2182 | 0.4632 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.2182 | 0.4632 | 0.5 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.1915 | 0.4051 | 0.4051 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7943 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (functional) | 2.2387 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.8184 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 35.4813 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.