TDR Targets

Basic information

Technical information

TDR Targets ID: 878171
Name: (5Z)-5-[(4-hexoxy-3-methoxyphenyl)methylidene ]-1,3-thiazolidine-2,4-dione
MW: 335.418 | Formula: C17H21NO4S
H donors: 1 H acceptors: 2 LogP: 4.47 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCOc1ccc(cc1OC)C=C1SC(=O)NC1=O
InChi: 1S/C17H21NO4S/c1-3-4-5-6-9-22-13-8-7-12(10-14(13)21-2)11-15-16(19)18-17(20)23-15/h7-8,10-11H,3-6,9H2,1-2H3,(H,18,19,20)/b15-11-
InChiKey: IYHBLOSJUWYRMQ-PTNGSMBKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(5Z)-5-[(4-hexoxy-3-methoxy-phenyl)methylene]thiazolidine-2,4-dione
(5Z)-5-[(4-hexoxy-3-methoxyphenyl)methylene]thiazolidine-2,4-dione
(5Z)-5-(4-hexoxy-3-methoxy-benzylidene)thiazolidine-2,4-quinone
(5Z)-5-[(4-hexoxy-3-methoxy-phenyl)methylidene]-1,3-thiazolidine-2,4-dione
ZINC01747848
ST5182571

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	cyclin-dependent kinase 9	0.0056	0.0352	0.0311
Echinococcus granulosus	cyclin dependent kinase 5	0.0053	0.0251	0.0327
Brugia malayi	Methionine aminopeptidase protein type I	0.0241	0.7655	1
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.005	0.0117	0.0153
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.005	0.0117	0.0153
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.0241	0.7655	1
Leishmania major	methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	0.0241	0.7655	1
Trypanosoma brucei	hypothetical protein, conserved	0.0088	0.1632	0.201
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M)	0.0153	0.4174	0.5
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0251	0.0241
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.005	0.0117	0.0153
Onchocerca volvulus		0.019	0.5643	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0088	0.1632	0.201
Echinococcus granulosus	cyclin dependent kinase	0.0053	0.0251	0.0327
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP)	0.0153	0.4174	0.5
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.005	0.0117	0.0153
Trypanosoma brucei	methionine aminopeptidase, putative	0.0241	0.7655	1
Trichomonas vaginalis	CMGC family protein kinase	0.019	0.5643	1
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0053	0.0251	0.0327
Echinococcus multilocularis	cyclin dependent kinase 1	0.0053	0.0251	0.0327
Trypanosoma cruzi	hypothetical protein, conserved	0.0088	0.1632	0.201
Echinococcus granulosus	methionyl aminopeptidase 1 M24 family	0.0241	0.7655	1
Mycobacterium ulcerans	methionine aminopeptidase	0.0153	0.4174	0.5
Chlamydia trachomatis	methionine aminopeptidase	0.0153	0.4174	0.5
Wolbachia endosymbiont of Brugia malayi	methionine aminopeptidase	0.0153	0.4174	0.5
Echinococcus multilocularis	CDC7 cell division cycle 7	0.019	0.5643	0.7371
Trichomonas vaginalis	CMGC family protein kinase	0.019	0.5643	1
Echinococcus multilocularis	cyclin dependent kinase 9	0.0056	0.0352	0.046
Trypanosoma brucei	cdc2-related kinase 1	0.0053	0.0251	0.0177
Schistosoma mansoni	kinase	0.0056	0.0352	0.0425
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.0251	0.0241
Onchocerca volvulus		0.019	0.5643	0.5
Mycobacterium ulcerans	methionine aminopeptidase MapB	0.0153	0.4174	0.5
Echinococcus multilocularis	cyclin dependent kinase 5	0.0053	0.0251	0.0327
Loa Loa (eye worm)	hypothetical protein	0.005	0.0133	0.0016
Toxoplasma gondii	methionine aminopeptidase, type i, putative	0.0153	0.4174	0.5382
Brugia malayi	Protein kinase domain containing protein	0.0053	0.0251	0.0177
Plasmodium vivax	methionine aminopeptidase 1b, putative	0.0241	0.7655	1
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0053	0.0251	0.0135
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.0153	0.4174	0.7342
Entamoeba histolytica	cell division protein kinase 2, putative	0.0053	0.0251	0.2675
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0153	0.4174	0.5453
Echinococcus granulosus	cyclin dependent kinase 1	0.0053	0.0251	0.0327
Trypanosoma brucei	methionine aminopeptidase, type I, putative	0.0241	0.7655	1
Trichomonas vaginalis	CMGC family protein kinase	0.019	0.5643	1
Schistosoma mansoni	serine/threonine protein kinase	0.0056	0.0352	0.0425
Brugia malayi	cell division control protein 2 homolog	0.0053	0.0251	0.0177
Mycobacterium tuberculosis	Methionine aminopeptidase MapA (map) (peptidase M) (MetAP)	0.0153	0.4174	0.5
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0053	0.0251	0.0177
Loa Loa (eye worm)	CDC7 protein kinase	0.019	0.5643	0.5591
Plasmodium vivax	protein kinase Crk2	0.0053	0.0251	0.0177
Treponema pallidum	methionine aminopeptidase (map)	0.0153	0.4174	0.5
Trypanosoma cruzi	cdc2-related kinase 1	0.0053	0.0251	0.0177
Trypanosoma cruzi	cdc2-related kinase 3	0.0053	0.0251	0.0177
Trypanosoma cruzi	cdc2-related kinase 3	0.0053	0.0251	0.0177
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0241	0.7655	1
Schistosoma mansoni	serine/threonine protein kinase	0.019	0.5643	1
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0251	0.0241
Trypanosoma cruzi	cdc2-related kinase 1	0.0053	0.0251	0.0177
Loa Loa (eye worm)	methionine aminopeptidase type I	0.0241	0.7655	0.7627
Echinococcus granulosus	cyclin dependent kinase 9	0.0065	0.0717	0.0937
Toxoplasma gondii	methionine aminopeptidase	0.0241	0.7655	1
Giardia lamblia	Kinase, CDC7	0.019	0.5643	1
Plasmodium falciparum	HP12 protein homolog, putative	0.0088	0.1632	0.201
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0251	0.0241
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0053	0.0251	0.0177
Plasmodium falciparum	methionine aminopeptidase 1b, putative	0.0241	0.7655	1
Trypanosoma brucei	cdc2-related kinase 3	0.0053	0.0251	0.0177
Mycobacterium tuberculosis	Methionine aminopeptidase MapB (map) (peptidase M)	0.0153	0.4174	0.5
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.005	0.0117	0.0153
Toxoplasma gondii	methionine aminopeptidase	0.0153	0.4174	0.5382
Entamoeba histolytica	protein kinase domain containing protein	0.0056	0.0352	0.4707
Plasmodium falciparum	protein kinase 5	0.0053	0.0251	0.0177
Plasmodium vivax	hypothetical protein, conserved	0.0088	0.1632	0.201
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0053	0.0251	0.0135
Echinococcus granulosus	cyclin dependent kinase 9	0.0056	0.0352	0.046
Giardia lamblia	Kinase, CMGC CDK	0.0053	0.0251	0.0241
Echinococcus granulosus	CDC7 cell division cycle 7	0.019	0.5643	0.7371
Trypanosoma brucei	metallo- peptidase, Clan MG, Family M24	0.0241	0.7655	1
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0053	0.0251	0.0135
Toxoplasma gondii	hypothetical protein	0.0088	0.1632	0.201
Loa Loa (eye worm)	CMGC/CDK/CDK9 protein kinase	0.0056	0.0352	0.0238
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.0241	0.7655	1
Leishmania major	hypothetical protein, conserved	0.0088	0.1632	0.201
Giardia lamblia	Kinase, CMGC CDK	0.0053	0.0251	0.0241
Echinococcus multilocularis	cyclin dependent kinase 9	0.0065	0.0717	0.0937
Echinococcus multilocularis	cyclin dependent kinase	0.0053	0.0251	0.0327
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.0251	0.0241
Plasmodium vivax	methionine aminopeptidase 1a, putative	0.0153	0.4174	0.5382
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.005	0.0117	0.0153
Brugia malayi	Protein kinase domain containing protein	0.019	0.5643	0.733
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.005	0.0117	0.0153
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.0153	0.4174	0.7342
Entamoeba histolytica	cell division protein kinase 2, putative	0.0063	0.0616	1
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0053	0.0251	0.0177
Echinococcus multilocularis	cyclin dependent kinase 1	0.0053	0.0251	0.0327
Plasmodium falciparum	methionine aminopeptidase 1a, putative	0.0153	0.4174	0.5382

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 878171