Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0023 | 0.005 | 0.005 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0323 | 0.3687 | 0.3687 |
Mycobacterium ulcerans | oxidoreductase | 0.0096 | 0.0939 | 0.0751 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0096 | 0.0939 | 0.0901 |
Brugia malayi | glutathione reductase | 0.0023 | 0.005 | 0.005 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0323 | 0.3687 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0035 | 0.0203 | 0.0203 |
Leishmania major | nitrate reductase, putative | 0.0096 | 0.0939 | 0.0901 |
Loa Loa (eye worm) | glutathione reductase | 0.0023 | 0.005 | 0.005 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0023 | 0.005 | 0.005 |
Brugia malayi | FAD binding domain containing protein | 0.0846 | 1 | 1 |
Trypanosoma cruzi | malonyl-CoA decarboxylase, mitochondrial precursor, putative | 0.0124 | 0.127 | 0.1234 |
Plasmodium falciparum | glutathione reductase | 0.0023 | 0.005 | 0.0008 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0022 | 0.0042 | 0.0042 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0323 | 0.3687 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.075 | 0.8838 | 1 |
Echinococcus granulosus | methionine synthase reductase | 0.0522 | 0.6089 | 0.6089 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0096 | 0.0939 | 0.0939 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0846 | 1 | 1 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0096 | 0.0939 | 0.0894 |
Leishmania major | hypothetical protein, conserved | 0.0323 | 0.3687 | 0.3661 |
Toxoplasma gondii | ferredoxin NADP+ oxidoreductase FNR | 0.0096 | 0.0939 | 0.1866 |
Brugia malayi | flavodoxin family protein | 0.0323 | 0.3687 | 0.3687 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0096 | 0.0939 | 1 |
Loa Loa (eye worm) | diaphorase | 0.0096 | 0.0939 | 0.0939 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0846 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0035 | 0.0203 | 0.0162 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0846 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0522 | 0.6089 | 1 |
Schistosoma mansoni | NADH-cytochrome B5 reductase | 0.0096 | 0.0939 | 0.0939 |
Schistosoma mansoni | cytochrome B5 | 0.0096 | 0.0939 | 0.0939 |
Echinococcus multilocularis | methionine synthase reductase | 0.0522 | 0.6089 | 0.6089 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 0.3578 | 0.3578 |
Plasmodium vivax | oxidoreductase NAD-binding domain containing protein | 0.0096 | 0.0939 | 0.0901 |
Brugia malayi | Cytochrome b5-like Heme/Steroid binding domain containing protein | 0.0096 | 0.0939 | 0.0939 |
Trypanosoma brucei | cytochrome P450, putative | 0.0035 | 0.0203 | 0.0154 |
Trypanosoma cruzi | p450 reductase, putative | 0.0846 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0846 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0846 | 1 | 1 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0096 | 0.0939 | 0.0901 |
Trypanosoma brucei | oxidoreductase-protein, putative | 0.0096 | 0.0939 | 0.0894 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0323 | 0.3687 | 0.3661 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0323 | 0.3687 | 0.3661 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0323 | 0.3687 | 0.3527 |
Plasmodium vivax | glutathione reductase, putative | 0.0023 | 0.005 | 0.0008 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0846 | 1 | 1 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0096 | 0.0939 | 0.0894 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0323 | 0.3687 | 0.3656 |
Plasmodium vivax | hypothetical protein, conserved | 0.0323 | 0.3687 | 0.3661 |
Echinococcus multilocularis | NADH cytochrome b5 reductase 3 | 0.0096 | 0.0939 | 0.0939 |
Mycobacterium tuberculosis | Hypothetical oxidoreductase | 0.0096 | 0.0939 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0035 | 0.0203 | 0.0162 |
Brugia malayi | Thioredoxin reductase | 0.0023 | 0.005 | 0.005 |
Loa Loa (eye worm) | cytochrome b5 reductase 4 | 0.0096 | 0.0939 | 0.0939 |
Brugia malayi | FAD binding domain containing protein | 0.0522 | 0.6089 | 0.6089 |
Trypanosoma cruzi | cytochrome-b5 reductase, putative | 0.0096 | 0.0939 | 0.0901 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0023 | 0.005 | 0.0008 |
Leishmania major | cytochrome P450 reductase, putative | 0.075 | 0.8838 | 0.8833 |
Trypanosoma cruzi | cytochrome-b5 reductase, putative | 0.0096 | 0.0939 | 0.0901 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0323 | 0.3687 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0846 | 1 | 1 |
Trypanosoma cruzi | oxidoreductase-protein, putative | 0.0096 | 0.0939 | 0.0901 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0846 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0046 | 0.0327 | 0.0327 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0035 | 0.0203 | 0.0203 |
Trypanosoma brucei | malonyl-CoA decarboxylase, mitochondrial precursor, putative | 0.0124 | 0.127 | 0.1227 |
Trypanosoma brucei | NADH-dependent fumarate reductase | 0.0096 | 0.0939 | 0.0894 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0096 | 0.0939 | 0.0901 |
Mycobacterium tuberculosis | Probable monooxygenase | 0.0096 | 0.0939 | 1 |
Mycobacterium ulcerans | oxygenase | 0.0096 | 0.0939 | 0.0751 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0846 | 1 | 1 |
Leishmania major | malonyl-coa decarboxylase-like protein | 0.0124 | 0.127 | 0.1234 |
Brugia malayi | Cytochrome P450 family protein | 0.0035 | 0.0203 | 0.0203 |
Leishmania major | cytochrome-b5 reductase, putative | 0.0096 | 0.0939 | 0.0901 |
Plasmodium falciparum | thioredoxin reductase | 0.0023 | 0.005 | 0.0008 |
Echinococcus multilocularis | cytochrome b5 reductase 4 | 0.0096 | 0.0939 | 0.0939 |
Brugia malayi | Kringle domain containing protein | 0.0022 | 0.0042 | 0.0042 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0846 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0846 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0846 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0846 | 1 | 1 |
Leishmania major | oxidoreductase-like protein | 0.0096 | 0.0939 | 0.0901 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0096 | 0.0939 | 0.0894 |
Toxoplasma gondii | NADH-cytochrome b5 reductase 1, putative | 0.0096 | 0.0939 | 0.1866 |
Trypanosoma cruzi | nitrate reductase, putative | 0.0096 | 0.0939 | 0.0901 |
Trypanosoma cruzi | p450 reductase, putative | 0.0096 | 0.0939 | 0.0901 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0846 | 1 | 1 |
Trypanosoma brucei | NADH-dependent fumarate reductase | 0.0096 | 0.0939 | 0.0894 |
Leishmania major | trypanothione reductase | 0.0023 | 0.005 | 0.0008 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0096 | 0.0939 | 0.0901 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0214 | 0.0214 |
Plasmodium vivax | flavodoxin domain containing protein | 0.075 | 0.8838 | 0.8833 |
Onchocerca volvulus | 0.0022 | 0.0042 | 0.0444 | |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0323 | 0.3687 | 0.3527 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0042 | 0.0281 | 0.0281 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0522 | 0.6089 | 0.6089 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0426 | 0.4927 | 0.4927 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0042 | 0.0281 | 0.0281 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0846 | 1 | 1 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0096 | 0.0939 | 0.0901 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0096 | 0.0939 | 0.0894 |
Toxoplasma gondii | thioredoxin reductase | 0.0023 | 0.005 | 0.0016 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0096 | 0.0939 | 0.0901 |
Onchocerca volvulus | 0.0096 | 0.0939 | 1 | |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0058 | 0.0481 | 0.0481 |
Brugia malayi | putative malonyl-CoA decarboxylase | 0.0314 | 0.3578 | 0.3578 |
Wolbachia endosymbiont of Brugia malayi | malonyl-CoA decarboxylase | 0.0314 | 0.3578 | 0.5 |
Schistosoma mansoni | diflavin oxidoreductase | 0.042 | 0.485 | 0.485 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0323 | 0.3687 | 0.3527 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.075 | 0.8838 | 0.8808 |
Trypanosoma brucei | NADH-cytochrome b5 reductase-like protein | 0.0096 | 0.0939 | 0.0894 |
Leishmania major | NADH-cytochrome b5 reductase, putative | 0.0096 | 0.0939 | 0.0901 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0096 | 0.0939 | 0.0901 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0323 | 0.3687 | 0.5 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0096 | 0.0939 | 0.0901 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0323 | 0.3687 | 0.5 |
Mycobacterium ulcerans | monooxygenase | 0.0096 | 0.0939 | 0.0751 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0042 | 0.0042 |
Giardia lamblia | Hypothetical protein | 0.075 | 0.8838 | 1 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0096 | 0.0939 | 0.0751 |
Trypanosoma cruzi | reductase, putative | 0.0096 | 0.0939 | 0.0901 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0022 | 0.0042 | 0.0042 |
Leishmania major | reductase, putative | 0.0096 | 0.0939 | 0.0901 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0846 | 1 | 1 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0323 | 0.3687 | 0.3527 |
Trypanosoma cruzi | malonyl-CoA decarboxylase, mitochondrial precursor, putative | 0.0124 | 0.127 | 0.1234 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0096 | 0.0939 | 0.0901 |
Leishmania major | NADH-cytochrome b5 reductase, putative | 0.0096 | 0.0939 | 0.0901 |
Mycobacterium ulcerans | flavodoxin reductase Hmp | 0.0096 | 0.0939 | 0.0751 |
Plasmodium vivax | ferredoxin--NADP reductase, putative | 0.0096 | 0.0939 | 0.0901 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0096 | 0.0939 | 0.0894 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0013 | 0.0013 |
Leishmania major | cytochrome-b5 reductase, putative | 0.0096 | 0.0939 | 0.0901 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0096 | 0.0939 | 0.0901 |
Trypanosoma brucei | NADH-dependent fumarate reductase, putative | 0.0096 | 0.0939 | 0.0894 |
Leishmania major | NADH-dependent fumarate reductase, putative | 0.0096 | 0.0939 | 0.0901 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0096 | 0.0939 | 1 |
Leishmania major | NADH-cytochrome b5 reductase, putative | 0.0096 | 0.0939 | 0.0901 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0096 | 0.0939 | 0.0894 |
Leishmania major | cytochrome p450-like protein | 0.0035 | 0.0203 | 0.0162 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0096 | 0.0939 | 0.0901 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0042 | 0.0281 | 0.0281 |
Echinococcus granulosus | NADH cytochrome b5 reductase 3 | 0.0096 | 0.0939 | 0.0939 |
Brugia malayi | diaphorase | 0.0096 | 0.0939 | 0.0939 |
Chlamydia trachomatis | Na(+)-translocating NADH-quinone reductase subunit F | 0.0096 | 0.0939 | 0.1542 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0846 | 1 | 1 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0096 | 0.0939 | 0.0901 |
Treponema pallidum | flavodoxin | 0.0323 | 0.3687 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.042 | 0.485 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0035 | 0.0203 | 0.0203 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0096 | 0.0939 | 0.0939 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0846 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0023 | 0.005 | 0.0008 |
Trypanosoma brucei | NADH-dependent fumarate reductase, putative | 0.0096 | 0.0939 | 0.0894 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0846 | 1 | 1 |
Mycobacterium ulcerans | flavodoxin oxidoreductase | 0.0096 | 0.0939 | 0.0751 |
Leishmania major | NADH-dependent fumarate reductase-like protein | 0.0096 | 0.0939 | 0.0901 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0323 | 0.3687 | 0.3661 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0323 | 0.3687 | 0.3661 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0042 | 0.0281 | 0.0281 |
Brugia malayi | Cytochrome P450 family protein | 0.0058 | 0.0481 | 0.0481 |
Mycobacterium tuberculosis | Possible oxygenase | 0.0096 | 0.0939 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0022 | 0.0042 | 0.0042 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0522 | 0.6089 | 0.6089 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0046 | 0.0327 | 0.0327 |
Trypanosoma brucei | nitrate reductase, putative | 0.0096 | 0.0939 | 0.0894 |
Plasmodium falciparum | ferredoxin--NADP reductase | 0.0096 | 0.0939 | 0.0901 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0096 | 0.0939 | 0.0901 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0846 | 1 | 1 |
Plasmodium falciparum | NADH-cytochrome b5 reductase, putative | 0.0096 | 0.0939 | 0.0901 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0023 | 0.005 | 0.005 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0022 | 0.0042 | 0.0042 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0323 | 0.3687 | 0.3661 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.042 | 0.485 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0042 | 0.0042 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0035 | 0.0203 | 0.0203 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.