TDR Targets

Basic information

Technical information

TDR Targets ID: 878651
Name: 3-(2-bromophenyl)-1-cyclobutylurea
MW: 269.138 | Formula: C11H13BrN2O
H donors: 2 H acceptors: 1 LogP: 2.53 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccccc1Br)NC1CCC1
InChi: 1S/C11H13BrN2O/c12-9-6-1-2-7-10(9)14-11(15)13-8-4-3-5-8/h1-2,6-8H,3-5H2,(H2,13,14,15)
InChiKey: MFDMFKNQQSMHDS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-(2-bromophenyl)-1-cyclobutyl-urea

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0052	0.0111	0.0111
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0052	0.0111	0.0111
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0052	0.0111	0.0111
Echinococcus granulosus	epidermal growth factor receptor	0.0146	0.068	0.068
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0052	0.0111	0.0111
Echinococcus granulosus	sterol regulatory element binding protein	0.0698	0.3999	0.3999
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0796	0.4585	1
Brugia malayi	Protein kinase domain containing protein	0.0052	0.0111	0.0111
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0039	0.0032	0.0032
Schistosoma mansoni	tyrosine kinase	0.0303	0.1619	0.1619
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0179	0.0878	0.0878
Echinococcus multilocularis	c src tyrosine kinase	0.0052	0.0111	0.0111
Leishmania major	3-hydroxy-3-methylglutaryl-CoA reductase	0.1696	1	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0146	0.068	0.068
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0303	0.1619	0.1619
Schistosoma mansoni	patched 1	0.0698	0.3999	0.3999
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0052	0.0111	0.0111
Onchocerca volvulus		0.0052	0.0111	0.1261
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0052	0.0111	0.0111
Brugia malayi	Cytochrome P450 family protein	0.0059	0.0152	0.0152
Echinococcus multilocularis	Niemann Pick C1 protein	0.0698	0.3999	0.3999
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.1696	1	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.0052	0.0111	0.0111
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0052	0.0111	0.0111
Brugia malayi	Protein kinase domain containing protein	0.0052	0.0111	0.0111
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0052	0.0111	0.0111
Echinococcus granulosus	tyrosine protein kinase Blk	0.0052	0.0111	0.0111
Echinococcus granulosus	MAM	0.0179	0.0878	0.0878
Brugia malayi	protein-tyrosine kinase	0.0052	0.0111	0.0111
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0052	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0179	0.0878	0.0878
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0052	0.0111	0.0111
Schistosoma mansoni	hypothetical protein	0.0179	0.0878	0.0878
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0052	0.0111	0.0111
Onchocerca volvulus		0.0052	0.0111	0.1261
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0052	0.0111	0.0111
Brugia malayi	CHE-14 protein	0.0698	0.3999	0.3999
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0052	0.0111	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0052	0.0111	0.0111
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0052	0.0111	0.0111
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0052	0.0111	0.0111
Brugia malayi	Protein kinase domain containing protein	0.0175	0.0849	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0179	0.0878	0.0878
Echinococcus granulosus	c src tyrosine kinase	0.0052	0.0111	0.0111
Schistosoma mansoni	tyrosine kinase	0.0052	0.0111	0.0111
Echinococcus granulosus	epidermal growth factor receptor	0.0146	0.068	0.068
Loa Loa (eye worm)	cytochrome P450 family protein	0.0059	0.0152	0.0152
Schistosoma mansoni	tyrosine kinase	0.0052	0.0111	0.0111
Trichomonas vaginalis	conserved hypothetical protein	0.0698	0.3999	0.8717
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0052	0.0111	0.0111
Echinococcus multilocularis	epidermal growth factor receptor	0.0146	0.068	0.068
Brugia malayi	Protein kinase domain containing protein	0.0052	0.0111	0.0111
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0039	0.0032	0.0032
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0796	0.4585	1
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase	0.1696	1	0.5
Mycobacterium ulcerans	hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase	0.1696	1	0.5
Loa Loa (eye worm)	SRC-1	0.0052	0.0111	0.0111
Loa Loa (eye worm)	TK/FER protein kinase	0.0052	0.0111	0.0111
Echinococcus granulosus	insulin receptor	0.0303	0.1619	0.1619
Loa Loa (eye worm)	TK/ABL protein kinase	0.0052	0.0111	0.0111
Loa Loa (eye worm)	TK/FER protein kinase	0.0052	0.0111	0.0111
Echinococcus multilocularis	sterol regulatory element binding protein	0.0698	0.3999	0.3999
Schistosoma mansoni	tyrosine kinase	0.0303	0.1619	0.1619
Onchocerca volvulus		0.0052	0.0111	0.1261
Echinococcus multilocularis		0.0037	0.0024	0.0024
Brugia malayi	Furin-like cysteine rich region family protein	0.0146	0.068	0.068
Loa Loa (eye worm)	TK/FER protein kinase	0.0052	0.0111	0.0111
Loa Loa (eye worm)	TK/FER protein kinase	0.0052	0.0111	0.0111
Schistosoma mansoni	tyrosine kinase	0.0052	0.0111	0.0111
Loa Loa (eye worm)	TK/ALK protein kinase	0.1516	0.8917	0.8917
Echinococcus multilocularis	insulin receptor	0.0303	0.1619	0.1619
Loa Loa (eye worm)	TK/FER protein kinase	0.0052	0.0111	0.0111
Onchocerca volvulus		0.0179	0.0878	1
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0738	0.0738
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0146	0.068	0.068
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0698	0.3999	0.3999
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0698	0.3999	0.3999
Schistosoma mansoni	tyrosine kinase	0.0052	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.1318	0.7727	0.7727
Brugia malayi	hypothetical protein	0.0179	0.0878	0.0878
Echinococcus granulosus	Niemann Pick C1 protein	0.0698	0.3999	0.3999
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0039	0.0032	0.0032
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0052	0.0111	0.0111
Echinococcus granulosus	tyrosine protein kinase shark	0.0052	0.0111	0.0111
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0052	0.0111	0.0111
Echinococcus multilocularis	hydroxymethylglutaryl coenzyme A reductase	0.1696	1	1
Schistosoma mansoni	tyrosine kinase	0.0128	0.0569	0.0569
Brugia malayi	SH2 domain containing protein	0.0052	0.0111	0.0111
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0053	0.0053
Echinococcus granulosus	tyrosine protein kinase Srms	0.0052	0.0111	0.0111
Echinococcus granulosus	tyrosine kinase	0.0052	0.0111	0.0111
Echinococcus multilocularis	protein dispatched 1	0.0698	0.3999	0.3999
Trypanosoma brucei	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.1696	1	0.5
Brugia malayi	Protein kinase domain containing protein	0.0052	0.0111	0.0111
Brugia malayi	Protein kinase domain containing protein	0.0052	0.0111	0.0111
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0052	0.0111	0.0111
Schistosoma mansoni	tyrosine kinase	0.0146	0.068	0.068
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0052	0.0111	0.0111
Echinococcus granulosus	hydroxymethylglutaryl coenzyme A reductase	0.1696	1	1
Echinococcus granulosus	tyrosine kinase	0.0052	0.0111	0.0111
Loa Loa (eye worm)	TK/FER protein kinase	0.0052	0.0111	0.0111
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0052	0.0111	0.0111
Schistosoma mansoni	tyrosine kinase	0.0128	0.0569	0.0569
Loa Loa (eye worm)	TK/FER protein kinase	0.0052	0.0111	0.0111
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.1696	1	0.5
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0796	0.4585	1
Schistosoma mansoni	hypothetical protein	0.0179	0.0878	0.0878
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0052	0.0111	0.0111
Echinococcus granulosus	Protein patched homolog 1	0.0698	0.3999	0.3999
Schistosoma mansoni	tyrosine kinase	0.0052	0.0111	0.0111
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0039	0.0032	0.0032
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0146	0.068	0.068
Loa Loa (eye worm)	TK protein kinase	0.0052	0.0111	0.0111
Brugia malayi	SH2 domain containing protein	0.0052	0.0111	0.0111
Schistosoma mansoni	hydroxymethylglutaryl-CoA reductase (NADPH)	0.1696	1	1
Brugia malayi	SRC-1	0.0052	0.0111	0.0111
Echinococcus multilocularis	MAM	0.0179	0.0878	0.0878
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0052	0.0111	0.0111
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0052	0.0111	0.0111
Schistosoma mansoni	tyrosine kinase	0.0146	0.068	0.068
Giardia lamblia	3-hydroxy-3-methylglutaryl-coenzyme A reductase	0.0796	0.4585	0.5
Schistosoma mansoni	tyrosine kinase	0.0128	0.0569	0.0569
Brugia malayi	Protein kinase domain containing protein	0.0303	0.1619	0.1619
Echinococcus multilocularis	tyrosine kinase	0.0052	0.0111	0.0111
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0052	0.0111	0.0111
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0303	0.1619	0.1619
Loa Loa (eye worm)	TK/FER protein kinase	0.0052	0.0111	0.0111
Echinococcus multilocularis	protein patched	0.0698	0.3999	0.3999
Schistosoma mansoni	tyrosine kinase	0.0146	0.068	0.068
Loa Loa (eye worm)	TK/FER protein kinase	0.0052	0.0111	0.0111
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0052	0.0111	0.0111
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0052	0.0111	0.0111
Brugia malayi	Tyrosine-protein kinase abl-1	0.0052	0.0111	0.0111
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0052	0.0111	0.0111
Schistosoma mansoni	tyrosine kinase	0.0052	0.0111	0.0111
Onchocerca volvulus		0.0179	0.0878	1
Onchocerca volvulus		0.0052	0.0111	0.1261
Loa Loa (eye worm)	TK/FER protein kinase	0.0052	0.0111	0.0111
Loa Loa (eye worm)	TK/INSR protein kinase	0.0303	0.1619	0.1619
Brugia malayi	hypothetical protein	0.0052	0.0111	0.0111
Onchocerca volvulus		0.0052	0.0111	0.1261
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0052	0.0111	0.0111
Onchocerca volvulus		0.0052	0.0111	0.1261
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0698	0.3999	0.3999
Brugia malayi	Protein kinase domain containing protein	0.1517	0.892	0.892

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 878651