Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cyclin dependent kinase | 0.0051 | 0.2103 | 0.2133 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase small chain CoxS | 0.0034 | 0.1135 | 0.0568 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0103 | 0.5149 | 0.5143 |
Schistosoma mansoni | tyrosine kinase | 0.0103 | 0.5149 | 0.5223 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0051 | 0.2103 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.007 | 0.321 | 0.3143 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0103 | 0.5149 | 0.5223 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0174 | 0.932 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.007 | 0.321 | 0.3143 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0184 | 0.9859 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0016 | 0.0107 | 0.0108 |
Echinococcus multilocularis | insulin receptor | 0.0065 | 0.2933 | 0.2857 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0051 | 0.2103 | 0.2103 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase medium chain CoxM | 0.006 | 0.2655 | 0.3502 |
Echinococcus granulosus | acetylcholinesterase | 0.007 | 0.321 | 0.3255 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0051 | 0.2103 | 0.2133 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0162 | 0.0162 |
Schistosoma mansoni | tyrosine kinase | 0.0184 | 0.9859 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0051 | 0.2103 | 0.2001 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0065 | 0.2933 | 0.2857 |
Schistosoma mansoni | tyrosine kinase | 0.0065 | 0.2933 | 0.2975 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0051 | 0.2103 | 0.5 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0184 | 0.9859 | 0.9822 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0051 | 0.2103 | 0.5 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (medium chain) | 0.006 | 0.2655 | 0.5229 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0051 | 0.2103 | 0.5 |
Plasmodium vivax | protein kinase Crk2 | 0.0051 | 0.2103 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0051 | 0.2103 | 0.2001 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0065 | 0.2933 | 0.2975 |
Loa Loa (eye worm) | carboxylesterase | 0.007 | 0.321 | 0.321 |
Schistosoma mansoni | tyrosine kinase | 0.0103 | 0.5149 | 0.5223 |
Brugia malayi | Carboxylesterase family protein | 0.007 | 0.321 | 0.1402 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0051 | 0.2103 | 0.2001 |
Echinococcus granulosus | carboxylesterase 5A | 0.007 | 0.321 | 0.3255 |
Echinococcus multilocularis | acetylcholinesterase | 0.007 | 0.321 | 0.3143 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0051 | 0.2103 | 0.2001 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase small chain CoxS | 0.0034 | 0.1135 | 0.0568 |
Schistosoma mansoni | tyrosine kinase | 0.0093 | 0.4569 | 0.4635 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.007 | 0.321 | 0.3255 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0051 | 0.2103 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0051 | 0.2103 | 0.2103 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0053 | 0.2228 | 0.2678 |
Plasmodium falciparum | protein kinase 5 | 0.0051 | 0.2103 | 0.5 |
Giardia lamblia | Kinase, CMGC CDK | 0.0051 | 0.2103 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.007 | 0.321 | 0.3255 |
Echinococcus granulosus | roundabout 2 | 0.0017 | 0.0162 | 0.0164 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0103 | 0.5149 | 0.5223 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0051 | 0.2103 | 0.5 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0051 | 0.2103 | 0.5 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0065 | 0.2933 | 0.2933 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.321 | 0.321 |
Brugia malayi | Carboxylesterase family protein | 0.007 | 0.321 | 0.1402 |
Treponema pallidum | hypothetical protein | 0.0029 | 0.0841 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.2071 | 0.2071 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0051 | 0.2103 | 0.2103 |
Echinococcus multilocularis | 0.0054 | 0.2309 | 0.2213 | |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | 0.0118 | 0.6018 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0051 | 0.2103 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0051 | 0.2103 | 0.5 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0051 | 0.2103 | 0.5 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0084 | 0.4041 | 0.618 |
Echinococcus granulosus | insulin receptor | 0.0065 | 0.2933 | 0.2975 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0178 | 0.9515 | 1 |
Trichomonas vaginalis | aldehyde oxidase, putative | 0.0178 | 0.9515 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0184 | 0.9859 | 0.9859 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0184 | 0.9859 | 1 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0178 | 0.9515 | 1 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0051 | 0.2103 | 0.5 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0051 | 0.2103 | 0.2133 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.321 | 0.321 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.007 | 0.321 | 0.321 |
Treponema pallidum | quinoline 2-oxidoreductase | 0.0028 | 0.0802 | 0.8682 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0051 | 0.2103 | 0.2133 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | 0.0084 | 0.4041 | 0.618 |
Schistosoma mansoni | tyrosine kinase | 0.0093 | 0.4569 | 0.4635 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0051 | 0.2103 | 0.2133 |
Schistosoma mansoni | tyrosine kinase | 0.0093 | 0.4569 | 0.4635 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0051 | 0.2103 | 0.5 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0051 | 0.2103 | 0.2133 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0186 | 1 | 1 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | 0.0084 | 0.4041 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0065 | 0.2933 | 0.2975 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 | 0.006 | 0.2655 | 0.3502 |
Brugia malayi | Protein kinase domain containing protein | 0.0065 | 0.2933 | 0.1051 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.