Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0064 | 0.0283 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0028 | 0.0064 | 0.0283 |
Brugia malayi | Cytochrome P450 family protein | 0.0031 | 0.0088 | 0.0102 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0031 | 0.0088 | 0.0388 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0064 | 0.0283 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.007 | 0.0396 | 1 |
Onchocerca volvulus | 0.005 | 0.0238 | 0.0792 | |
Echinococcus granulosus | tumor protein p63 | 0.0341 | 0.2584 | 1 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.003 | 0.0075 | 1 |
Brugia malayi | GnHR receptor homolog | 0.1083 | 0.8558 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.007 | 0.0396 | 1 |
Mycobacterium ulcerans | 3-phosphoshikimate 1-carboxyvinyltransferase | 0.0356 | 0.2701 | 0.2701 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0064 | 0.0283 |
Brugia malayi | Peroxidasin | 0.0028 | 0.0064 | 0.0075 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0028 | 0.0064 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0064 | 0.0283 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0241 | 0.1067 |
Echinococcus granulosus | transcription factor Dp 1 | 0.004 | 0.016 | 0.0381 |
Echinococcus multilocularis | geminin | 0.0166 | 0.1175 | 0.4409 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0064 | 0.0283 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.003 | 0.0075 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0113 | 0.044 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0241 | 0.0282 |
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1262 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0028 | 0.0064 | 0.0075 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0241 | 0.0282 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.1175 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0064 | 0.0283 |
Brugia malayi | Animal haem peroxidase family protein | 0.0028 | 0.0064 | 0.0075 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.007 | 0.0396 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.007 | 0.0396 | 0.1318 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.007 | 0.0396 | 0.1753 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 0.2259 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.007 | 0.0396 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0028 | 0.0064 | 0.0283 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.0356 | 0.2701 | 1 |
Onchocerca volvulus | 0.0243 | 0.1793 | 0.7878 | |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1262 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0064 | 0.0075 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0064 | 0.0283 |
Brugia malayi | Animal haem peroxidase family protein | 0.0028 | 0.0064 | 0.0075 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0064 | 0.0283 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA | 0.0906 | 0.7134 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0028 | 0.0064 | 0.0075 |
Trichomonas vaginalis | MYB, putative | 0.003 | 0.0075 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0064 | 0.0283 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0243 | 0.1793 | 0.7938 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.1175 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0238 | 0.1052 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.005 | 0.0238 | 0.1565 |
Echinococcus granulosus | geminin | 0.0166 | 0.1175 | 0.4409 |
Mycobacterium leprae | PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA | 0.0906 | 0.7134 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0241 | 0.1067 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0113 | 0.0132 |
Brugia malayi | hypothetical protein | 0.0301 | 0.2259 | 0.264 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.007 | 0.0396 | 0.2989 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.007 | 0.0396 | 0.1318 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0028 | 0.0064 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0064 | 0.0283 |
Brugia malayi | Animal haem peroxidase family protein | 0.0028 | 0.0064 | 0.0075 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.007 | 0.0396 | 0.0463 |
Giardia lamblia | Myb 1-like protein | 0.003 | 0.0075 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0113 | 0.0499 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.007 | 0.0396 | 1 |
Brugia malayi | Pax transcription factor protein 2 | 0.0243 | 0.1793 | 0.2095 |
Onchocerca volvulus | 0.0301 | 0.2259 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0064 | 0.0283 |
Brugia malayi | Blistered cuticle protein 3 | 0.0028 | 0.0064 | 0.0075 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.004 | 0.016 | 0.0381 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0064 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0064 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0064 | 0.0283 |
Echinococcus multilocularis | tumor protein p63 | 0.0341 | 0.2584 | 1 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1262 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0028 | 0.0064 | 0.0283 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.