Detailed information for compound 878773

Basic information

Technical information
  • TDR Targets ID: 878773
  • Name: N-(4-ethoxyphenyl)-6-methyl-3-methylsulfanyl- 1,2,4-triazin-5-amine
  • MW: 276.357 | Formula: C13H16N4OS
  • H donors: 1 H acceptors: 3 LogP: 2.65 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)Nc1nc(SC)nnc1C
  • InChi: 1S/C13H16N4OS/c1-4-18-11-7-5-10(6-8-11)14-12-9(2)16-17-13(15-12)19-3/h5-8H,4H2,1-3H3,(H,14,15,17)
  • InChiKey: FXJDYHZAYPOCFB-UHFFFAOYSA-N  

Network

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Synonyms

  • N-(4-ethoxyphenyl)-6-methyl-3-(methylthio)-1,2,4-triazin-5-amine
  • (4-ethoxyphenyl)-[6-methyl-3-(methylthio)-1,2,4-triazin-5-yl]amine
  • ZINC01792399
  • ST5208874

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0028 0.0064 0.0283
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0113 0.0132
Loa Loa (eye worm) animal heme peroxidase 0.0028 0.0064 0.0283
Onchocerca volvulus 0.005 0.0238 0.0792
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.0396 0.1318
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.0396 0.0463
Loa Loa (eye worm) hypothetical protein 0.0028 0.0064 0.0283
Loa Loa (eye worm) hypothetical protein 0.0028 0.0064 0.0283
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0064 0.0075
Loa Loa (eye worm) animal heme peroxidase 0.0028 0.0064 0.0283
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0064 0.0075
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0241 0.1067
Loa Loa (eye worm) animal heme peroxidase 0.0028 0.0064 0.0283
Schistosoma mansoni hypothetical protein 0.0166 0.1175 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0064 0.0283
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0906 0.7134 0.5
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0396 1
Giardia lamblia Myb 1-like protein 0.003 0.0075 0.5
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0238 0.1565
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0075 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0064 0.0283
Loa Loa (eye worm) hypothetical protein 0.0028 0.0064 0.0283
Onchocerca volvulus 0.0301 0.2259 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0064 0.0283
Echinococcus multilocularis geminin 0.0166 0.1175 0.4409
Brugia malayi Cytochrome P450 family protein 0.0031 0.0088 0.0102
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.0396 1
Schistosoma mansoni hypothetical protein 0.0166 0.1175 1
Brugia malayi Peroxidasin 0.0028 0.0064 0.0075
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0396 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.0396 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0064 0.0283
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0906 0.7134 1
Onchocerca volvulus 0.0243 0.1793 0.7878
Brugia malayi Blistered cuticle protein 3 0.0028 0.0064 0.0075
Loa Loa (eye worm) hypothetical protein 0.0028 0.0064 0.0283
Loa Loa (eye worm) hypothetical protein 0.0028 0.0064 0.0283
Brugia malayi Pax transcription factor protein 2 0.0243 0.1793 0.2095
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0356 0.2701 1
Brugia malayi GnHR receptor homolog 0.1083 0.8558 1
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0356 0.2701 0.2701
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0088 0.0388
Loa Loa (eye worm) animal heme peroxidase 0.0028 0.0064 0.0283
Trichomonas vaginalis MYB, putative 0.003 0.0075 1
Echinococcus granulosus tumor protein p63 0.0341 0.2584 1
Echinococcus multilocularis transcription factor Dp 1 0.004 0.016 0.0381
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0064 0.0075
Echinococcus granulosus geminin 0.0166 0.1175 0.4409
Echinococcus granulosus transcription factor Dp 1 0.004 0.016 0.0381
Schistosoma mansoni hypothetical protein 0.0034 0.0113 0.044
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0396 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0238 0.1052
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.0396 0.2989
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0064 0.0075
Brugia malayi hypothetical protein 0.0028 0.0064 0.0075
Loa Loa (eye worm) hypothetical protein 0.0028 0.0064 0.0283
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0241 0.0282
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.0396 0.1318
Loa Loa (eye worm) hypothetical protein 0.0028 0.0064 0.0283
Loa Loa (eye worm) hypothetical protein 0.0301 0.2259 1
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1262 1 1
Echinococcus multilocularis tumor protein p63 0.0341 0.2584 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.0396 0.1753
Loa Loa (eye worm) blistered cuticle protein 3 0.0028 0.0064 0.0283
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0075 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0064 0.0283
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1262 1 0.5
Loa Loa (eye worm) hypothetical protein 0.005 0.0241 0.1067
Brugia malayi hypothetical protein 0.0301 0.2259 0.264
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0241 0.0282
Loa Loa (eye worm) pax transcription factor protein 2 0.0243 0.1793 0.7938
Loa Loa (eye worm) hypothetical protein 0.0034 0.0113 0.0499
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0064 0.0075
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1262 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0028 0.0064 0.0283

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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